Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Are Radiologists Prepared for The Future?
This article originally appeared on Medium here. (Source: The Health Care Blog)
Source: The Health Care Blog - August 9, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Technology Medical Practice Physicians AI Alex Logsdon Artificial intelligence Radiology Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vesse...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
New Organization Forms to Confront the Epidemic of Popcorn Lung
Prompted by the statements of anti-tobacco groups throughout the country claiming that vaping causes popcorn lung, a new organization was launched this past Thursday to confront this new and alarming epidemic among young people. The organization is called the American Popcorn Lung Association (APLA) and it has aTwitter feed (@LungPopcorn)." Popcorn lung " is a serious, progressive lung disease that is technically known as bronchiolitis obliterans. The disease results in obstruction of the smallest airways in the lung. The disease is irreversible and can be fatal. A lung transplant is the only definitive treatment. The most...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - July 15, 2019 Category: Addiction Source Type: blogs
Fight Aging! Newsletter, July 15th 2019
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very attractive t...
Source: Fight Aging! - July 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Could Digital Health Fight Against The Climate Catastrophe?
Climate change is the
greatest health challenge of the 21st century, and threatens all aspects of society,
says
the WHO in its COP24 Special Report. What could digital health technologies
do to support the fight against the climate crisis? How could healthcare
processes, facilities, medical devices become more sustainable? As it is
humanity’s priority to mitigate the worsening as well as the impact of rising
temperatures and extreme weather events, we tried to figure out what role
digital health could assume here. We found many options – and even more
possibilities for future development.
The climate crisis is our ...
Source: The Medical Futurist - July 11, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine air asthma climate climate catastrophe climate change climate crisis digital digital health efficient Healthcare mosquito optimize resilience solar sustainability technology Source Type: blogs
Applying Bacterial Homing Strategies to Target Stem Cells to Heart Tissue
Most classes of therapy benefit from some form of targeting or selectivity, helping to direct them to the tissue of interest, and away from other places where they might cause side-effects. Cells are difficult to work with, but they are also much more capable of selective targeting, since they can migrate. Many types of cell reliably find their way from one part of the body to another in the course of their functions, but where no suitable mechanism exists in human biochemistry, it is sometimes possible to look elsewhere. Here, researchers adapt a bacterial targeting system and apply it to the stem cells that might be used...
Source: Fight Aging! - July 10, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Artificial Bacterial Protein Allows Stem Cells to Home to the Heart
Researchers at the University of Bristol have developed a way to make stem cells move toward heart tissue when they are injected intravenously. The treatment could improve the efficacy of stem cell therapies for heart disease, which are currently hampered when most injected cells are filtered out of circulation by organs such as the lungs and spleen.
Stem cell therapies have enormous promise for regenerative medicine, including treatments to heal damaged cardiac tissue. However, so far, simply injecting cells intravenously or even into the heart tissue itself hasn’t worked all that well. Stem cells tend to be removed ...
Source: Medgadget - July 8, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Genetics Rehab Source Type: blogs
Fight Aging! Newsletter, July 8th 2019
In this study, we identify a link between members of the genus Veillonella and exercise performance. We observed an increase in Veillonella relative abundance in marathon runners postmarathon and isolated a strain of Veillonella atypica from stool samples. Inoculation of this strain into mice significantly increased exhaustive treadmill run time.
Veillonella utilize lactate as their sole carbon source, which prompted us to perform a shotgun metagenomic analysis in a cohort of elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative abundance postexercise. Us...
Source: Fight Aging! - July 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
First Cryopreservation Following Use of Assisted Death Legislation in California
Simple human dignity and self-ownership demands the right to end one's own life on one's own terms, and to be able to help others achieve this goal where they are not capable of doing so themselves. Yet these acts remain forbidden to most people in most parts of the world. Painless, effective euthanasia requires medical assistance, and providing that service remains largely illegal. This state of affairs is slowly starting to change in the US, however, and so late last year the first cryopreservation following voluntary euthanasia took place.
Cryopreservation is the only presently available end of life option that o...
Source: Fight Aging! - July 3, 2019 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
A Troublesome Cup of Tea
A 45-year-old woman presented to the emergency department with nausea and vomiting. Her symptoms had started seven days earlier and steadily worsened. She reported generalized abdominal pain and distention and that her eyes appeared yellow.The patient had no past medical history, took no medications, and said she did not drink or use drugs. Her history showed that she had been drinking an herbal preparation every day for the past five months to ameliorate her heavy menstrual periods.The patient had mild right upper quadrant tenderness but no distention, rebound, or guarding. Her lungs were clear, and her heart rate and rhy...
Source: The Tox Cave - July 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, July 1st 2019
In this study, we determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. A doxycycline-inducible AAV9-miR-294 vector was delivered to mice for activating miR-294 in myocytes for 14 days continuously after myocardial infarction. miR-294-treated mice significantly improved left ventricular functions together with decreased infarct size and apoptosis 8 weeks after MI. Myocyte cell cycle reentry increased in miR-294 hearts parallel to increased small myocyte number in the heart. Isolated adult myocytes from miR-...
Source: Fight Aging! - June 30, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Goal of Kidney Rejuvenation
The authors of this open access paper review the aging of the kidney and consider the prospects for using factors from young blood as a means of rejuvenation. This is a fairly narrow view, as there are many other approaches that should produce rejuvenation of the aged kidney, ranging from those close to realization, such as senolytic therapies to clear senescent cells, or various approaches to stem cell therapy, to those yet to be achieved, meaning much of the rest of the SENS agenda of rejuvenation biotechnologies to repair the damage that causes aging. Nonetheless, after so many years of trying to persuade the research c...
Source: Fight Aging! - June 24, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
International Bioethics Retreat (Paris)
Discussion
Research EthicsChair: Matti Hayry, PhD, Aalto University, Helsinki, FINLAND
11:00 – 11:15 AM The Ethics of What, How, and Why: Lessons from Tuskegee, Manhattan, and Beyond Tuija Takala, PhD University of Helsinki, FINLAND
11:15 – 11:30 AM Pig Brains and Pig Lungs: Novel Research ModelsSteve Latham. JD, Yale University, New Haven, Connecticut, USA
11:30 – 12:00 PM Group Discussion
12:00 – 1:30 PM Class Photo and Lunch in the Garden
In the ClinicChair: Leonard Fleck, PhD, Michigan State University, East Lansing, Michigan, USA
1:30 – 1:45 PM Code Status Ont...
Source: blog.bioethics.net - May 31, 2019 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
Delivery of Mesenchymal Stem Cell Exosomes is Protective Against D-Galactose Accelerated Cardiac Aging in Mice
In this study, we explored whether umbilical mesenchymal stem cell (UMSC) derived exosomes could prevent aging-induced cardiac dysfunction and determined whether the potential mechanism was mediated by the exosome/lncRNA MALAT1/NF-κB/TNF-α pathway.
We discovered that human umbilical cord mesenchymal stem cell- (UMSC-) derived exosomes prevent aging-induced cardiac dysfunction. Silencer RNA against lncRNA MALAT1 blocked the beneficial effects of exosomes. In summary, we discovered that UMSC-derived exosomes prevent aging-induced cardiac dysfunction by releasing novel lncRNA MALAT1, which in turn inhibits the NF-κB...
Source: Fight Aging! - May 30, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
