Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ligands in NKG2D receptor-deficient mice as they age, we propose that therapeutic interventions designed to increase cell surface presentation of NKG2D-Ls could be effective senolytic strategies to resensitize persistent SnCs to immune detection and rescue their clearance, whether in cancer or aging settings.
Stiffness in Brain Tissue Niches Causes Declining Stem Cell Activity and Myelination
https://www.fightaging.org/archives/2019/08/stiffness-in-brain-tissue-niches-causes-declining-stem-cell-activity-and-myelination/
Loss of the myelin layer that sheathes nerves is the proximate cause of severe conditions such as multiple sclerosis, but this sort of loss occurs to a lesser degree in the course of normal aging, and contributes to cognitive decline. In today's open access research materials, scientists draw a line of cause and effect bet...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More News: ALS | Alzheimer's | Babies | Babies Heart Conditions | Biochemistry | Biology | Biotechnology | Brain | Brain Cancers | Breast Cancer | Breast Needle Aspiration | Calcium | Cancer | Cancer & Oncology | Cancer Therapy | Cardiology | Chemistry | Chemotherapy | Child Abuse | Child Development | Children | Clinical Trials | Colon Cancer | Colorectal Cancer | Conferences | Environmental Health | Epithelial Cancer | Fortamet | Gastroenteritis | Gastroschisis Repair | Gene Therapy | Genetics | Geriatrics | Headache | Heart | Heart Transplant | Hepatitis | Hepatitis C | Hormones | Immunotherapy | Inflammatory Bowel Disease | Internet | Japan Health | Kidney Transplant | Laboratory Medicine | Liver | Liver Transplant | Lung Transplant | Materials Science | Medical Ethics | Merck | Metformin | Migraine | Mitochondria | Mitochondrial Disease | Molecular Biology | Multiple Sclerosis | Neuroblastoma | Neurology | Neuroscience | Neurosurgery | Organic | Ovarian Cancer | Ovaries | Parkinson's Disease | Pfizer | Physiology | Poisoning | Profits and Losses | Prostate Cancer | Research | Salmonella | Science | Skin | Sodium Chloride | Sports Medicine | Statistics | Stem Cell Therapy | Stem Cells | Stroke | Study | Substance Abuse | Toxicology | Transplants | Urology & Nephrology