Fight Aging! Newsletter, August 19th 2019

In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ligands in NKG2D receptor-deficient mice as they age, we propose that therapeutic interventions designed to increase cell surface presentation of NKG2D-Ls could be effective senolytic strategies to resensitize persistent SnCs to immune detection and rescue their clearance, whether in cancer or aging settings. Stiffness in Brain Tissue Niches Causes Declining Stem Cell Activity and Myelination https://www.fightaging.org/archives/2019/08/stiffness-in-brain-tissue-niches-causes-declining-stem-cell-activity-and-myelination/ Loss of the myelin layer that sheathes nerves is the proximate cause of severe conditions such as multiple sclerosis, but this sort of loss occurs to a lesser degree in the course of normal aging, and contributes to cognitive decline. In today's open access research materials, scientists draw a line of cause and effect betw...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 14 September 2019Source: Molecular Genetics and MetabolismAuthor(s): Róisín M. Boggan, Albert Lim, Robert W. Taylor, Robert McFarland, Sarah J. PickettAbstractMitochondrial diseases, caused by mutations in either the nuclear or mitochondrial genomes (mtDNA), are the most common form of inherited neurometabolic disorders. They are remarkably heterogeneous, both in their clinical presentation and genetic etiology, presenting challenges for diagnosis, clinical management and elucidation of molecular mechanism. The multifaceted nature of these diseases, compounded by the unique ...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Authors: Yu H, Yamashita S Abstract Pulse radiolysis was conducted to investigate several fundamental reactions of a natural flavonoid, rutin, and its glycosylated form (αG-rutin) as a basis for their radiation protection properties; the reactions with •OH (radical scavenging) and dGMP radical, dGMP• (chemical repair), which was used as a model of initial and not yet stabilized damage on DNA. Three absorption peaks were commonly seen in the reactions of the flavonoids with •OH, showing that their reactive site is the common structure, ie aglycone. One among the three peaks was attributed to the...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Source: Journal of Allied Health - Category: Universities & Medical Training Authors: Tags: International Perspectives. Source Type: research
ConclusionsREBOA use was associated with improved survival to discharge and should therefore be considered during the management of severely injured trauma patients.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Do any of you have a good method of prescribing home SPG for a migraine abortive? I’ve prescribed lidocaine drops successfully but I’m not sure what I can prescribe for equipment to administer it (dropper, syringes, etc). Thanks!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
ConclusionsFindings from this meta-analysis indicate that walking pace is inversely associated with the risk of stroke.Graphical abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Publication date: Available online 14 September 2019Source: Journal of Advanced ResearchAuthor(s): Simone Kumstel, Praveen Vasudevan, Rupert Palme, Xianbin Zhang, Edgar Heinz Uwe Wendt, Robert David, Brigitte Vollmar, Dietmar ZechnerAbstractProspective severity assessment is legally required in many countries to ensure high-quality research along with high welfare standards for laboratory animals. Mice and rats, the most common laboratory species, are prey animals that usually suppress signs of pain and suffering. Therefore, highly sensitive readout parameters are necessary to adequately quantify distress. The present stud...
Source: Journal of Advanced Research - Category: Research Source Type: research
CONCLUSION: Game-based chin-tuck against resistance exercise not only has a similar effect to head-lift exercise on swallowing function of patients with dysphagia, but is also a less strict and more enjoyable and interesting method. PMID: 31515567 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
Authors: Reinert T, Coelho GP, Mandelli J, Zimermann E, Zaffaroni F, Bines J, Barrios CH, Graudenz MS Abstract Mutations in the ESR1 gene (ESR1m) are important mechanisms of resistance to endocrine therapy in estrogen receptor-positive advanced breast cancer and have been recognized as a prognostic and predictive biomarker as well as a potential therapeutic target. However, the prevalence of ESR1m in real-world patients has not been adequately described. Therefore, we sought to evaluate the prevalence of ESR1m in metastatic samples from Brazilian patients with estrogen receptor-positive (ER+) advanced breast cancer...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Publication date: Available online 13 September 2019Source: Social Science &MedicineAuthor(s): Piper SledgeAbstractIn this paper, I draw on the narratives of 57 individuals whose gender identities and decisions about their bodies trouble the medical protocols for breast and gynecological cancer care. I focus here on the decision-making process for three groups of elective surgeries: hysterectomy, prophylactic bilateral and contralateral mastectomy, and breast reconstruction. These elective surgeries illustrate places in medical interactions where patients and providers rely on frames of gender to determine whether a gi...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
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