Fight Aging! Newsletter, August 19th 2019

In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ligands in NKG2D receptor-deficient mice as they age, we propose that therapeutic interventions designed to increase cell surface presentation of NKG2D-Ls could be effective senolytic strategies to resensitize persistent SnCs to immune detection and rescue their clearance, whether in cancer or aging settings. Stiffness in Brain Tissue Niches Causes Declining Stem Cell Activity and Myelination https://www.fightaging.org/archives/2019/08/stiffness-in-brain-tissue-niches-causes-declining-stem-cell-activity-and-myelination/ Loss of the myelin layer that sheathes nerves is the proximate cause of severe conditions such as multiple sclerosis, but this sort of loss occurs to a lesser degree in the course of normal aging, and contributes to cognitive decline. In today's open access research materials, scientists draw a line of cause and effect betw...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 11 July 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Ermira Tartari, Joost Hopman, Benedetta Allegranzi, Bin Gao, Andreas Widmer, Vincent Chi-Chung Cheng, Shuk Ching Wong, Kalisvar Marimuthu, Folasade Ogunsola, Andreas Voss, on behalf of the International Society of Antimicrobial Chemotherapy Infection Prevention Control Working Group, (ISAC-IPC)
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We described a case of early-onset PD in a female, who on genetic analysis, was found to have a previously undescribed homozygous mutation in the PARK2 gene. PMID: 32647592 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Publication date: Available online 11 July 2020Source: Stem Cell ResearchAuthor(s): Jin Young Shin, Phil Hyu Lee
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Publication date: December 2020Source: Nano Today, Volume 35Author(s): Ling-xiao Zhang, Xia-mei Sun, Ying-bo Jia, Xiao-ge Liu, Mingdong Dong, Zhi Ping Xu, Rui-tian Liu
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Publication date: November 2020Source: Materials Science and Engineering: C, Volume 116Author(s): Yanpiao Long, Lesan Yan, Honglian Dai, Dong Yang, Xiaopei Wu, Xianzhen Dong, Kun Liu, Wenying Wei, Yuzhe Chen
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