New Bioprinting Technique to Make Artificial Cartilage Implants
Researchers at the University of Alberta have developed a method to 3D print cartilage-like materials consisting of a collagen hydrogel containing human chondrocytes. The printed structures mimic human nasal cartilage in terms of its mechanical, molecular and histological characteristics. The researchers hope the technology could lead to personalized cartilage implants for skin cancer patients who have nasal cartilage defects following surgery to remove their tumors.
The nose is a common site for skin cancer, and in many such patients, removal of the cancerous lesions will result in cartilage defects. At present, surgeo...
Source: Medgadget - May 10, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Orthopedic Surgery Plastic Surgery Source Type: blogs
Sickle cell disease in newborns and children: What families should know and do
If you’ve learned that your newborn or young child has sickle cell disease, you — and other family members and friends — may have many questions.
These days, most cases of sickle cell disease in the US are diagnosed through newborn screening. It’s important to make the diagnosis early, so that babies can be started on penicillin (or another antibiotic) to prevent infection. Getting connected early to a pediatrician for primary care — and to specialists in blood disorders who can work closely with the child as they grow, and with their families — can help prevent complications of the disease.
The basics
Hemoglob...
Source: Harvard Health Blog - May 6, 2021 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Genes Health care disparities Parenting Source Type: blogs
Wireless Sensor Measures Deep Tissue Oxygen Levels
Researchers at the University of California, Berkeley have developed an ultrasound-powered implantable sensor that can measure oxygen levels in tissues deep within the body and transmit these data to an external device. The technology could be useful in monitoring transplant viability or oxygen exposure in preterm infants. It also has potential to be adapted to measure other biochemical markers, such as carbon dioxide concentrations or pH levels.
Oxygen is crucial for living tissues, and poor oxygenation leads to cell death. This process forms the basis for various pathological phenomena, but clinicians can struggle to ...
Source: Medgadget - April 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Anesthesiology Cardiac Surgery Cardiology Critical Care Emergency Medicine Plastic Surgery Rehab Vascular Surgery Source Type: blogs
Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders.
Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health
https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Tissues with Extracellular Vescicles
Much of cellular communication takes the form of secretion and uptake of extracellular vesicles, tiny membrane-wrapped packages of molecules. The use of these vesicles as a basis for therapy is spreading. Since first generation stem cell therapies appear to produce their benefits via the signals generated by transplanted stem cells, why not use vesicles harvested from stem cells instead the cells themselves? The logistics are far less challenging, the costs lower. Further, vesicles can be engineered to contain novel contents, or given different surface features.
Researchers here discuss the degree to which vesicles ...
Source: Fight Aging! - March 24, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Targeting Tissues with Extracellular Vesicles
Much of cellular communication takes the form of secretion and uptake of extracellular vesicles, tiny membrane-wrapped packages of molecules. The use of these vesicles as a basis for therapy is spreading. Since first generation stem cell therapies appear to produce their benefits via the signals generated by transplanted stem cells, why not use vesicles harvested from stem cells instead the cells themselves? The logistics are far less challenging, the costs lower. Further, vesicles can be engineered to contain novel contents, or given different surface features.
Researchers here discuss the degree to which vesicles ...
Source: Fight Aging! - March 24, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 22nd 2021
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal.
Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - March 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
3D Bioprinting: Eradicating Transplantation Waiting Lists And Testing Drugs On Living Tissues
From time to time, news arises about 3D printed organs. On such occasions, people usually think that a machine can already create readily available, implantable human organs. However, the reality is far from this optimistic image.
Researchers worldwide are working on possible solutions: from a group that printed a miniature kidney, through technological solutions like BioAssemblyBot we wrote about earlier, to entirely new methods that can lead to patient-specific heart tissue printing. The list is long and set in a clinical setting. We checked out where the technology stands today and where it might lead us in healthcar...
Source: The Medical Futurist - March 11, 2021 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Artificial Intelligence in Medicine Biotechnology Digital Health Research Future of Medicine Future of Pharma Healthcare Design Healthcare Policy bioprinting fda Innovation Personalized medicine rna science fiction Source Type: blogs
Fight Aging! Newsletter, March 8th 2021
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The Role of Reactive Oxygen Species in Aging is Complex
https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-a...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Listen Better, See Deeper
Combining Medical Attentiveness with Artificial IntelligenceJohn Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Embracing an “ecology of attention” will significantly improve patient care, according to Mark Kissler, MD, at the University of Colorado.1Kissler and his colleagues point out that clinicians spend much of their time multi-tasking and navigating around interruptions. While such juggling acts are often unavailable, it ’s important to occasionally step back and ask: Is this the best use of my tim...
Source: Life as a Healthcare CIO - March 2, 2021 Category: Information Technology Source Type: blogs
Transpulmonary gradient and diastolic pressure gradient
In this study, elevated preoperative transpulmonary gradient was associated with significant increase in mortality at 6 months and 12 months after orthotopic heart transplantation.
Elevated transpulmonary gradient is a risk factor for right heart failure after heart transplantation. Jahanyar J et al queried the UNOS (United Network for Organ Sharing) database from 1987 to 2017 and included adults who had complete transpulmonary gradient data. Those who underwent retransplant were excluded. Their sample consisted of 38,243 patients. It was found that median survival was higher in low transpulmonary gradient group (145 month...
Source: Cardiophile MD - March 1, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Pharmacology to Target the Mechanisms of Aging is a Going Concern
Traditional pharmacological drug development involves (a) identifying a protein or protein interaction of interest in the body, (b) screening the small molecule libraries for a compound that affects that target, and then (c) making a better version of that small molecule: more effective, less harmful. That remains the bulk of the medical research and development industry, despite the proliferation of other approaches, including cell therapies, gene therapies, recombinant proteins, monoclonal antibodies, and so forth. There are goals that cannot be achieved by small molecules, and, as techniques improve and costs fall, gene...
Source: Fight Aging! - March 1, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 15th 2021
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
