Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Notes on the SENS Research Foundation Pitch Day, January 2020 ELOVL2 Upregulation Reverses Age-Related Decline in Vision Loss in Mice We All Age in the Same Way, but with a Distribution of Outcomes Inhibition of Autophagy in Mice Produces Signs of Accelerated Aging Hypoxia-Inducible Factors in Vascular Aging Sestrin Upregulation as an Exercise Mimetic PAR1 Inhibition Activates Remyelination Sticky Exosomes Can Worsen the Outcome of Stroke Neural Stem Cell Derived Exosomes Improves Functional Recovery from Stroke in Pigs MR1 as a Broad Signature of Cancer, Suitable for T Cell Targeting Vascular Dysfunction as a Distinct Contribution to Cognitive Decline and Dementia Immunosenescence and Loss of Resistance to Viral Infection Aging Skin as a Significant Source of Systemic...
Date: Tuesday, 09 29, 2020; Speaker: Dr. Yair Mina, NINDS; Dr. Ariel Levine, NINDS; Zoom Video Conference; CME Credit
Authors: Hwang S, Ren T, Gao B Abstract Obesity and binge drinking often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. In this mini-review, we briefly summarize clinical evidence of the synergistical effect of obesity and heavy drinking on steatohepatitis and discuss the underlying mechanisms obtained from the study of several mouse models. High-fat diet (HFD) feeding and binge ethanol synergistically induced steatohepatitis and fibrosis in mice with significant intrahepatic neutrophil infiltration; such HFD-plus-ethanol treatment markedly up-regulat...
CONCLUSIONS: The COI of liver diseases in Japan has been decreasing for the past 15 years. In the future, a further reduction in patients with hepatitis C is expected, and even if the incidence of NASH and alcoholic liver disease increases, that of cirrhosis and liver cancer will likely continue to decrease. PMID: 32942026 [PubMed - as supplied by publisher]
Publication date: November 2020Source: Research in Developmental Disabilities, Volume 106Author(s): Franceli L. Cibrian, Melisa Madrigal, Marina Avelais, Monica Tentori
CONCLUSION: Our study expands the mutation spectrum of WSF1 mutations with three novel mutations. Homozygosity mapping may provide enrichment for molecular genetic analysis and early diagnosis of WS1 patients with incomplete phenotype, particularly in consanguineous pedigrees. PMID: 32938580 [PubMed - as supplied by publisher]
CONCLUSION: Our study is important to emphasize that psychiatric disorders in DSD patients negatively affect the quality of life. Psychiatric support and counseling of multidisciplinary team are very important in DSD cases. PMID: 32938579 [PubMed - as supplied by publisher]
This study aims to determine the incidence of T1D in children under the age of 15 years, living in Tlemcen in Northwest Algeria. METHODS: A retrospective study conducted on data of children (
Publication date: Available online 17 September 2020Source: Stem Cell ResearchAuthor(s): Huifang Zhao, Lang He, Hualin Huang, Shuai Li, Na Cheng, Feng Tang, Xiaobo Han, Zuoxian Lin, Rongqi Huang, Peng Zhou, Sihao Deng, Jufang Huang, Zhiyuan Li
Publication date: Available online 17 September 2020Source: Stem Cell ReportsAuthor(s): Andrejs Ivanovs, Stanislav Rybtsov, Richard A. Anderson, Alexander Medvinsky
Publication date: Available online 17 September 2020Source: Stem Cell ReportsAuthor(s): Dominic C.H. Ng, Dominic K. Richards, Richard J. Mills, Uda Y. Ho, Hannah L. Perks, Callum R. Tucker, Holly K. Voges, Julia K. Pagan, James E. Hudson
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