Digital Twins and the Promise of Personalized Medicine

Can you guess the percentage of patients with Alzheimer’s on whom medication is ineffective? What about those with arthritis? Or cardiac arrhythmia? In fact, you don’t have to guess as the US Food and Drug Administration (FDA) already has the answers: 70%, 50% and 40% respectively. The percentage of patients for whom medications are ineffective range from 38-75% for varying conditions from depression to osteoporosis.  The main cause is because of the very genetic makeup of every individual. The latter is so different and their interaction so unique that therapies for the “average patient” might very well not be adapted to the “actual patient”. Ultimately, patients with the same diagnosis will react differently to the same therapy. The natural question that follows is: isn’t there a method to turn around the treatment process to focus on the actual patient? Well, of course, that will be personalized medicine. It is the principle of revolving healthcare from diagnosis to treatment regimes around a patient tailored to their specific physiology. Forging this principle ahead is the concept of digital twins. It originated from the engineering industry but has found a new home in medicine. Know thy-(digital)-self In simple terms, a digital twin is a virtual copy of a tangible entity (such as vehicle engines or people) or an intangible system (like manufacturing processes or marketing systems) that can be analyzed independe...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Personalized Medicine digital health technology healthcare data digital twin technology design Source Type: blogs

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The absence of alloantibodies is a feature of transplantation tolerance. Although the lack of T cell help has been evoked to explain this absence, herein we provide evidence for B cell–intrinsic tolerance mechanisms. Using a murine model of heart tolerance, we showed that alloreactive B cells were not deleted but rapidly lost their ability to differentiate into germinal center B cells and secrete donor-specific antibodies. We inferred that tolerant alloreactive B cells retained their ability to sense alloantigen because they continued to drive T cell maturation into CXCR5+PD-1+ T follicular helper cells. Unexpectedly...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSION: Children with NB reported significantly more problematic behaviors compared to children without NB. Children with specific personality profile demonstrated higher tendency for problematic behavior irrespective of the frequency of NB. Therefore, accompanying personality profiles should be considered when assessing behavioral problems in children with NB. PMID: 32450625 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSION: The prevalence of psychiatric disorders among NKD was quite higher than in the general population of South Korea. PMID: 32450622 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Longest official mourning period in Spain ’s democracy; unrest grows in UK PM’s party over Dominic Cummings lockdown breach; WHO says Americas are new Covid-19 epicentre. Follow the latest updatesGlobal report: Germany to relax travel curbs as Spain mourns Covid-19 victimsTory unrest increases pressure on PM to sack Dominic CummingsAustralia coronavirus – liveCoronavirus latest: at a glance5.21amBSTIndonesia said Tuesday it is deploying 340,000 troops to clamp down on rampant social-distancing violations as coronavirus infections surge in the world ’s fourth most populous country, AFP reports.The mi...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Australia news UK news US news Infectious diseases Science Africa Middle East and North Africa Americas Asia Pacific Russia China Brazil Microbiology Medical research Europe Spain Source Type: news
Amita Sehgal, whose pioneering discoveries of mechanisms that regulate circadian rhythms and sleep have deepened scientists ’ understanding of behavioral cycles, metabolism and healthy aging, has been named the 2020 recipient of the Switzer Prize awarded by the David Geffen School of Medicine at UCLA.“I am deeply honored to be selected and to be among the distinguished group of scientists who received this influential prize before me,” said Sehgal, who is the John Herr Musser Professor of Neuroscience at the Perelman School of Medicine at the University of Pennsylvania and director of the C...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
CONCLUSION: Lung function abnormalities, psychological impairment and reduced exercise capacity were common in SARS and MERS survivors. Clinicians should anticipate and investigate similar long-term outcomes in COVID-19 survivors. PMID: 32449782 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
A new study looking at hundreds of LGBTQ youth who died by suicide finds that many were bullied before their death, adding to a growing body of evidence showing how bullying can result in deadly consequences.
Source: - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 25 May 2020Source: Brain, Behavior, and ImmunityAuthor(s): Fangping Chen, Dan Zheng, Jing Liu, Yi Gong, Zhizhong Guan, Didong Lou
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 25 May 2020Source: Brain, Behavior, and ImmunityAuthor(s): Bo Yuan, Weixin Li, Hanqing Liu, Xin Cai, Shuo Song, Jia Zhao, Xiaopeng Hu, Zhiwen Li, Yongxin Chen, Kai Zhang, Zhiyong Liu, Jing Peng, Cheng Wang, Jianchun Wang, Yawen An
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Authors: Filipčić I, Šimunović Filipčić I, Sučić S, Milovac Ž, Gereš N, Matić K, Čelić-Ružić M, Zečević Penić S, Orgulan I, Požgaj V, Bajić Ž Abstract Accelerated repetitive transcranial magnetic stimulation (rTMS) protocols are being increasingly studied because of their potential to provide quicker and enhanced treatment efficacy. However, there is a lack of accelerated deep TMS with H1-coil (adTMS) treatment research. This randomized pilot study investigated the efficacy and safety of adTMS protocols. Twenty-eight TRD patients received 20-min sessions twice daily for 10 or 15&nbs...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
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