Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Source Type: research

Rethinking Infant Irritability and Arching
Infants hospitalized in a neonatal intensive care unit (NICU) may present with ongoing arching of the back and irritability. NICU teams may be concerned that these symptoms indicate acid gastroesophageal reflux (GER), even in the absence of regurgitation. As symptoms persist, hospital staff and parents may be concerned about infants ’ pain and suffering, and trials of acid suppression may be contemplated. However, there is growing awareness of the potential side effects of acid suppression in young infants1 and empiric therapy is increasingly difficult to justify. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Authors: Raye-Anne DeRegnier Tags: The Editors' Perspectives Source Type: research

Good News on Newborn Kidneys
The past few years have seen a number of studies suggesting that very low birth weight (VLBW) infants are at risk of chronic kidney disease. Many of these studies, however, lack long-term follow-up. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Authors: Thomas R. Welch Tags: The Editors' Perspectives Source Type: research

Wet Cough? Dry Cough? What is Your Understanding?
The Journal of Pediatrics is pleased to publish the Commentary by D.R. Liptzin et al entitled “Controversies in Antibiotic Use for Chronic Wet Cough in Children” and hope that its publication engenders discussion across the readership – from practitioners of general pediatrics and subspecialties. This Associate Editor, advocating at our biweekly meeting of the Editor-in-Chief with Asso ciate and Guest Editors to determine final acceptance of manuscripts, sparked a healthy and vigorous discussion of “chronic wet cough.”. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Next Generation Sequencing is No Longer Next
A large number of pediatricians trained in the “dark era” of Mendelian genetics--prior to next generation sequencing technology--when syndromes were paired with eponyms, such as Osler-Weber-Rendu syndrome for a rare autosomal dominant syndrome with hereditary hemorrhagic telangiectasias (HHT) affecting blood vessels throughout the body. In t his volume of The Journal, Engel et al report an historical cohort study from a single institution examining the prevalence of HHT and capillary-malformation arteriovenous malformation (CM-AVM) among children without a prior genetic diagnosis who presented with brain or spinal cord...
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research

Variations in Site-Specific Costs for Infants Born Extremely Preterm in Canadian Neonatal Intensive Care Units
To quantify site-specific costs and their association with survival without major morbidity (SWMM) in Canada for neonates (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Authors: Telford Yeung, Asma Ahmed, Jonathan Wong, Jennifer Toye, Ayman Abou Mehrem, Amit Mukerji, Anie Lapointe, Eugene Ng, Marc Beltempo, Petros Pechlivanoglou, Shoo Lee, Prakesh S. Shah, Canadian Preterm Birth Network and Canadian Neonatal Network Investigators Tags: Original Articles Source Type: research

Variations in site-specific costs for extremely preterm neonates in large Canadian NICUs
Neonatal intensive care is costly. However, variation in costs between different neonatal intensive care units (NICUs) from the perspective of the public payor is less well known. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 12, 2023 Category: Pediatrics Authors: Telford Yeung, Asma Ahmed, Jonathan Wong, Jennifer Toye, Ayman Abou Mehrem, Amit Mukerji, Anie Lapointe, Eugene Ng, Marc Beltempo, Petros Pechlivanoglou, Shoo Lee, Prakesh S. Shah, for Canadian Preterm Birth Network and Canadian Neonatal Network investiga Tags: Original Articles Source Type: research

Sunflower Syndrome
A 8-year-old typically developing girl presented with multiple spells of hand waving, suspected to be seizures yet poorly controlled with anti-seizure medications over one year. The habitual episodes were characterised by looking towards a light source and repetitive hand waving in front of her face associated with eyelid flickering along with myoclonic jerks of upper limb and trunk with intact awareness lasting for 1-2 minutes. (Video 1). The frequency of these episodes was 4 to 5 per week; most episodes were precipitated with bright light. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 11, 2023 Category: Pediatrics Authors: Rahul Sinha, Sonali Singh Tags: Insights and Images Source Type: research

Improving Neonatal Patient Outcomes Using Simulation-Based Education
Simulation-based education (SBE) has been used in neonatology for trainee education, procedural skill acquisition and maintenance, team training, leadership training, and training in complex decision-making. SBE provides an opportunity for experiential learning in a safe environment. Such education has also played a central role in the design and improvement of systems within the neonatal intensive care unit (NICU) and the delivery room (DR) eg, testing newly built NICU suites for functionality. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 11, 2023 Category: Pediatrics Authors: Lamia Soghier Tags: Editorials Source Type: research

Challenges Confronted by Orphans of Gender-Based Violence Victims
Femicide remains a pervasive global issue. In 2022 the United Nations global estimate for femicide revealed that nearly 89,000 women and girls were killed intentionally that year. 48,800 women fell victim to intimate partners or other family members, with approximately 7,900 cases occurring annually in the Americas and 2,300 in Europe1 (Figure). However, the actual number of victims is likely much higher due to the lack of reliably reported statistics2. Troubling aspects of this escalating phenomenon include the lack of a comprehensive institutional response to femicide. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 9, 2023 Category: Pediatrics Authors: Pietro Ferrara, Ignazio Cammisa, Donjeta Bali, Ida Giardino, Mehmet Vural, Maria Pastore, Clara Pettoello-Mantovani, Margherita Zona, Massimo Pettoello-Mantovani Source Type: research

Normative Magnetic Resonance Imaging Data Increase the Sensitivity to Brain Volume Abnormalities in the Classification of Fetal Alcohol Spectrum Disorder
To evaluate the use of a large magnetic resonance imaging (MRI) normative dataset to quantify structural brain anomalies that may improve diagnostic sensitivity for atypical brain volume in youth with fetal alcohol spectrum disorder (FASD). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 6, 2023 Category: Pediatrics Authors: Blake A. Gimbel, Donovan J. Roediger, Abigail M. Ernst, Mary E. Anthony, Bryon A. Mueller, Erik de Water, Madeline N. Rockhold, Collaborative Initiative on Fetal Alcohol Spectrum Disorders, Jeffrey R. Wozniak Tags: Original Articles Source Type: research

Normative MRI Data Increase the Sensitivity to Brain Volume Abnormalities in the Classification of Fetal Alcohol Spectrum Disorder
To evaluate the use of a large MRI normative dataset to quantify structural brain anomalies that may improve diagnostic sensitivity for atypical brain volume in youth with fetal alcohol spectrum disorder (FASD). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 6, 2023 Category: Pediatrics Authors: Blake A. Gimbel, Donovan J. Roediger, Abigail M. Ernst, Mary E. Anthony, Bryon A. Mueller, Erik de Water, Madeline N. Rockhold, Jeffrey R. Wozniak Tags: Original Articles Source Type: research

Clinical Decision Support for Improved Neonatal Care: The Development of a Machine Learning Model for the Prediction of Late-Onset Sepsis and Necrotizing Enterocolitis.
To develop an artificial intelligence (AI)-based software system for predicting late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) in infants admitted to the neonatal intensive care unit (NICU). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 6, 2023 Category: Pediatrics Authors: Marisse Meeus, Charlie Beirnaert, Ludo Mahieu, Kris Laukens, Pieter Meysman, Antonius Mulder, David Van Laere Tags: Original Articles Source Type: research