Timing of Intervention for Post-Hemorrhagic Ventricular Dilatation: An Ongoing Debate
In this volume of The Journal , Lai et al1 report their meta-analysis of past studies examining the timing of initiation of temporizing neurosurgical procedures (TNP) and rates of ventriculo-peritoneal shunting (VPS) and neurodevelopmental impairment (NDI) in premature infants with post-hemorrhagic ventricular dilatation (PHVD). In this analysis, TNPs included lumbar punctures (LP), ventricular taps, insertion of a ventricular access device (VAD), ventriculo-subgaleal shunt, external ventricular drain, and neuroendoscopic lavage (NEL). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 13, 2021 Category: Pediatrics Authors: Mehmet N. Cizmeci, Floris Groenendaal, Linda S. de Vries Tags: Editorials Source Type: research

Early systemic steroids in preventing bronchopulmonary dysplasia: Are we moving closer to a benefit –risk adapted treatment strategy?
Northway, et al werethe first to describe bronchopulmonary dysplasia (BPD) in 1967 (1). advances in neonatal care characterize the following decades, largely because of the introduction of antenatal steroids in the 1970s and surfactant in the 1980s. Survival rates of smaller infants with lower gestational ages increased as well as the incidence of BPD. The incidence of BPD currently remains around 45% in extremely preterm infants (2). Effects on long-term pulmonary (more hospital admissions for respiratory infections in the first year, impaired lung function and exercise tolerance) and neurodevelopmental (poorer motoric an...
Source: The Journal of Pediatrics - February 13, 2021 Category: Pediatrics Authors: Jehudith R. Fontijn, Dirk Bassler Tags: Editorials Source Type: research

Sudden Hypotension and Increased Serum Interferon- γ and Interleukin-10 Predict Early Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis
To identify clinical and laboratory predictors for early macrophage activation syndrome (MAS) associated with systemic juvenile idiopathic arthritis (sJIA). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 10, 2021 Category: Pediatrics Authors: Li Guo, Yiping Xu, Xubo Qian, Lixia Zou, Rongjun Zheng, Liping Teng, Qi Zheng, Lawrence Kwok Leung Jung, Meiping Lu Tags: Original Articles Source Type: research

Sudden Hypotension and Increased Serum IFN- γ and IL-10 Predict Early Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis Patients
To identify clinical and laboratory predictors for early macrophage activation syndrome (MAS) associated with systemic juvenile idiopathic arthritis (sJIA). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 10, 2021 Category: Pediatrics Authors: Li Guo, Yiping Xu, Xubo Qian, Lixia Zou, Rongjun Zheng, Liping Teng, Qi Zheng, Lawrence Kwok Leung Jung, Meiping Lu Tags: Original Articles Source Type: research

Health Outcomes of Infants With Vitamin B12 Deficiency Identified by Newborn Screening and Early Treated
To evaluate the clinical outcomes at age 1.5 ± 0.5 years of infants with vitamin B12 deficiency identified by newborn screening (NBS). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 10, 2021 Category: Pediatrics Authors: Ulrike M ütze, Magdalena Walter, Mareike Keller, Gwendolyn Gramer, Sven F. Garbade, Florian Gleich, Dorothea Haas, Roland Posset, Sarah C. Grünert, Julia B. Hennermann, Eva Thimm, Junmin Fang-Hoffmann, Steffen Syrbe, Jürgen G. Okun, Georg F. Hoffmann, Tags: Original Articles Source Type: research

Prediction of Childhood obesity from nationwide health records
To evaluate body mass index (BMI) acceleration patterns in children and to develop a prediction model targeted to identify children at high risk for obesity prior to the critical time-window in which the largest increase in BMI percentile occurs (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 10, 2021 Category: Pediatrics Authors: Hagai Rossman, Smadar Shilo, Shiri Barbash-Hazan, Nitzan Shalom Artzi, Eran Hadar, Ran D. Balicer, Becca Feldman, Arnon Wiznitzer, Eran Segal Tags: Original Articles Source Type: research

Analyzing Trends in the Global Surge of Coronavirus Disease 2019 Pandemic Submissions to The Journal of Pediatrics
During February to December 2020, there were 498 coronavirus disease 2019 (COVID-19) pandemic-focused brief report and original article submissions to The Journal of Pediatrics. The majority were from international authors (68.1%). Early in the pandemic, geographic origin of the corresponding author paralleled the path of COVID-19 infection both within the US and around the globe. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Wadsworth A. Williams, Alice Li, Denise M. Goodman, Lainie Friedman Ross Tags: Brief Reports Source Type: research

Availability of Pediatric Emergency Care Coordinators in United States Emergency Departments
To determine the availability of pediatric emergency care coordinators (PECCs) in US emergency departments (EDs) in 2015, and to determine the change in availability of PECCs in US EDs from 2015 to  2017. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Krislyn M. Boggs, Janice A. Espinola, Ashley F. Sullivan, Rachel D. Freid, Marc Auerbach, Kohei Hasegawa, Margaret E. Samuels-Kalow, Carlos A. Camargo Tags: Original Articles Source Type: research

Improvement in Liver Stiffness in Pediatric Patients with Hepatitis C Virus after Treatment with Direct Acting Antivirals
To assess the degree of liver stiffness using transient elastography in Egyptian children infected with hepatitis C virus (HCV) at baseline and 1  year after achievement of sustained virologic response (SVR) with direct acting antivirals. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Engy A. Mogahed, Hanaa El-Karaksy, Hala Abdullatif, Noha A. Yasin, Ahmed Nagy, Shereen Abdel Alem, Hadeel Gamal Eldeen, Mona S. El-Raziky Tags: Original Articles Source Type: research

Differences in Tobacco Product Use by Sexual Orientation and Violence Factors Among United States Youth
To assess differences in the relationship between violence factor exposure and tobacco product pattern use (exclusive and poly), we hypothesized that compared with heterosexuals, sexual minority youth would be more likely to report exclusive-tobacco and poly-tobacco use patterns, and controlling for violence factors would attenuate these associations. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Ariella R. Tabaac, Brittany M. Charlton, Andy S.L. Tan, Caroline O. Cobb, Megan E. Sutter Tags: Original Articles Source Type: research

Associations between Neonatal Magnetic Resonance Imaging and Short- and Long-Term Neurodevelopmental Outcomes in a Longitudinal Cohort of Very Preterm Children
To assess associations between neonatal brain injury assessed by magnetic resonance imaging and cognitive, motor, and behavioral outcomes at 2 and 10  years of age, in a longitudinal cohort of children born very preterm. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Lisette Jansen, Andrea van Steenis, Annette A. van den Berg-Huysmans, Sica T. Wiggers-de Bruine, Monique Rijken, Linda S. de Vries, Robert R.J.M. Vermeiren, Cacha M.P.C.D. Peeters-Scholte, Sylke J. Steggerda Tags: Original Articles Source Type: research

Analyzing Trends in the Global Surge of COVID-19 Pandemic Submissions to The Journal of Pediatrics
During February-December 2020 there were 498 COVID-19 pandemic-focused brief report and original article submissions to The Journal of Pediatrics. The majority were from international authors (68.1%). Early in the pandemic, geographical origin of the corresponding author paralleled the path of COVID-19 infection both within the US and around the globe. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Wadsworth A. Williams, Alice Li, Denise M. Goodman, Lainie Friedman Ross Tags: Brief Reports Source Type: research

Associations Between Neonatal MRI and Short- and Long-Term Neurodevelopmental Outcomes in a Longitudinal Cohort of Very Preterm Children
To assess associations between neonatal brain injury assessed by magnetic resonance imaging and cognitive, motor, and behavioral outcomes at two and ten years of age, in a longitudinal cohort of children born very preterm. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Lisette Jansen, Andrea van Steenis, Annette A. van den Berg – Huysmans, Sica T. Wiggers - de Bruine, Monique Rijken, Linda S. de Vries, Robert R.J.M. Vermeiren, Cacha M.P.C.D. Peeters – Scholte, Sylke J. Steggerda Tags: Original Articles Source Type: research

Analyzing Trends in the Global Surge of COVID-10 Pandemic Submissions to The Journal of Pediatrics
During February-December 2020 there were 498 COVID-19 pandemic-focused brief report and original article submissions to The Journal of Pediatrics. The majority were from international authors (68.1%). Early in the pandemic, geographical origin of the corresponding author paralleled the path of COVID-19 infection both within the US and around the globe. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Wadsworth A. Williams, Alice Li, Denise M. Goodman, Lainie Friedman Ross Tags: Brief Reports Source Type: research

Differences in Tobacco Product Use by Sexual Orientation and Violence Factors Among US Youth
To assess differences in the relationship between violence factor exposure and tobacco product pattern use (exclusive and poly), we hypothesized that compared with heterosexuals, sexual minority youth would be more likely to report exclusive-tobacco and poly-tobacco use patterns, and controlling for violence factors would attenuate these associations. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Ariella R. Tabaac, Brittany M. Charlton, Andy S.L. Tan, Caroline O. Cobb, Megan E. Sutter Tags: Original Articles Source Type: research

Improvement in liver stiffness in pediatric hcv patients after treatment with direct acting antivirals
To assess the degree of liver stiffness using transient elastography (TE) in hepatitis C virus (HCV) infected Egyptian children at baseline and one-year after achievement of sustained virologic response (SVR) with direct acting antivirals (DAAs). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Engy A. Mogahed, Hanaa El-Karaksy, Hala Abdullatif, Noha A. Yasin, Ahmed Nagy, Shereen Abdel Alem, Hadeel Gamal Eldeen, Mona S. El-Raziky Tags: Original Articles Source Type: research

Availability of pediatric emergency care coordinators in U.S. emergency departments
To determine the availability of pediatric emergency care coordinators (PECCs) in U.S. EDs in 2015, and to determine the change in availability of PECCs in U.S. EDs from 2015-2017. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 9, 2021 Category: Pediatrics Authors: Krislyn M. Boggs, Janice A. Espinola, Ashley F. Sullivan, Rachel D. Freid, Marc Auerbach, Kohei Hasegawa, Margaret E. Samuels-Kalow, Carlos A. Camargo Tags: Original Articles Source Type: research

Understanding Syndromic Leg Length Discrepancy
R.D. previously served as a consultant for Zimmer/Biomed and previously received royalties for an external fixator. Turtle Endowed Chair for Beckwith-Wiedemann Syndrome Research. This company was not a sponsor and had no involvement of this editorial. The study sponsor did not have any role in 1) study design; 2) the collection, analysis, and interpretation of data; 3) the writing of the report; and 4) the decision to submit the manuscript for publication. The other authors declare no conflicts of interest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 8, 2021 Category: Pediatrics Authors: Kelly A. Duffy, Richard S. Davidson, Jennifer M. Kalish Tags: Editorials Source Type: research

Perinatal Counseling at the Margin of Gestational Viability: Where We ’ve Been, Where We’re Going, and How to Navigate a Path Forward.
The year 2020 marked 60 years since the term “neonatologist” was first used, in which time the field of neonatology has seen remarkable improvements in the survival of extremely preterm neonates1. Advancements including antenatal steroids, improvements in nutrition (enteral and parenteral), and use of surfactant and advanced ventilation st rategies for infants born preterm have greatly impacted our ability to successfully resuscitate infants born even smaller and more prematurely2. More recent advancements, including the development of “small baby units” designed to standardize and optimize care hav...
Source: The Journal of Pediatrics - February 7, 2021 Category: Pediatrics Authors: Marin Arnolds, Naomi Laventhal Tags: Commentary Source Type: research

Correction to “Kawasaki-like disease among Italian children in the COVID-19 era”
After publication, the author of the Current Best Evidence article summary “Kawasaki-like disease among Italian children in the COVID-19 era” (J Pediatr 2020;224:180-1) requested a change to the listed affiliation. The corrected affiliation appears below and the online version of the article has since been updated. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 6, 2021 Category: Pediatrics Authors: Ho-Chang Kuo Tags: Correction Source Type: research

Low-Value Diagnostic Imaging in Children with Medicaid
To estimate rates and settings of low-value imaging among pediatric Medicaid beneficiaries, and estimate associated expenditures. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 5, 2021 Category: Pediatrics Authors: Jennifer R. Marin, Mara A.G. Hollander, Kristin N. Ray, Julie M. Donohue, Evan S. Cole Tags: Original Articles Source Type: research

Pediatrics 2025: The AMSPDC Workforce Initiative
Over the past 2 decades important discussions and organizational efforts have focused on the topic of the pediatric workforce. Concerns have been raised about our ability to provide comprehensive care to children as models have predicted physician shortages, geographic maldistribution of both general and subspecialty pediatricians and raised important concerns regarding access to pediatric care in rural communities. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 5, 2021 Category: Pediatrics Authors: Robert J. Vinci, Laura Degnon, Sherin U. Devaskar Source Type: research

Infant Regulation: Associations with Child Language Development in a Longitudinal Cohort
To determine whether infants who have regulatory problems (eg, sleeping, crying, and feeding problems) at 1  year of age are at increased risk of experiencing language difficulties at ages 5 and 11 years, compared with settled infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 4, 2021 Category: Pediatrics Authors: Fallon Cook, Laura Conway, Emina Omerovic, Petrea Cahir, Rebecca Giallo, Harriet Hiscock, Fiona Mensah, Lesley Bretherton, Edith Bavin, Patricia Eadie, Stephanie Brown, Sheena Reilly Tags: Original Articles Source Type: research

Reply
We appreciate the insightful comments made by Kanwal et  al about our article and the opportunity to respond. Kanwal et al discuss that postnatal weight loss mainly depends on the contraction of fetal extracellular water volume. Although we agree about the important role of extracellular water contraction, several studies show that excessive postnatal weight loss occurs mostly when energy and protein intake is inadequate and providing early adequate nutrition minimizes postnatal weight loss.1-4 Regarding the lack of difference in the time to regain birthweight, our study was not powered to detect this difference....
Source: The Journal of Pediatrics - February 4, 2021 Category: Pediatrics Authors: Belal Alshaikh, Kamran Yusuf, Wissam Alburaki Tags: Letters to the Editor Source Type: research

Response to Letter to the Editor
We appreciate the insightful comments made by Kanwal et al. with regard to our article(1), and the opportunity to respond. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 4, 2021 Category: Pediatrics Authors: Belal Alshaikh, Kamran Yusuf, Wissam Alburaki Tags: Letters to the Editor Source Type: research

Infant Regulation: Associations with Child Language Development in a Longitudinal Cohort.
To determine whether infants who have regulatory problems (eg, sleeping, crying, and feeding problems) at one year of age are at increased risk of experiencing language difficulties at ages 5 and 11 years, compared with settled infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 4, 2021 Category: Pediatrics Authors: Fallon Cook, Laura Conway, Emina Omerovic, Petrea Cahir, Rebecca Giallo, Harriet Hiscock, Fiona Mensah, Lesley Bretherton, Edith Bavin, Patricia Eadie, Stephanie Brown, Sheena Reilly Tags: Original Articles Source Type: research

Mental Well-being and General Health in Adolescents with Asthma: The Prevention and Incidence of Asthma and Mite Allergy Birth Cohort Study
To assess whether adolescents with asthma experience a lower mental well-being and lower general health than their peers without asthma. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Sabine E.I. van der Laan, Marieke L.A. de Hoog, Sanne L. Nijhof, Ulrike Gehring, Judith M. Vonk, Cornelis K. van der Ent, Alet H. Wijga Tags: Original Articles Source Type: research

Randomized Trial of Oral Iron and Diet Advice versus Diet Advice Alone in Young Children with Nonanemic Iron Deficiency
To compare the effects of 2 treatment options on neurodevelopmental and laboratory outcomes in young children with nonanemic iron deficiency. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Patricia C. Parkin, Cornelia M. Borkhoff, Colin Macarthur, Kawsari Abdullah, Catherine S. Birken, Darcy Fehlings, Christine Koroshegyi, Jonathon L. Maguire, Eva Mamak, Muhammad Mamdani, Kevin E. Thorpe, Stanley H. Zlotkin, Fei Zuo, TARGet Kids! Collaborat Tags: Original Article Source Type: research

Racial and Ethnic Disparities in Utilization of Tonsillectomy among Medicaid-Insured Children
To examine racial differences in tonsillectomy ±adenoidectomy (T&A) for sleep-disordered breathing (SDB) among Medicaid-insured children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Phayvanh P. Pecha, Marshall Chew, Anne L. Andrews Tags: Original Articles Source Type: research

Adverse Childhood Experiences and Spanking Have Similar Associations with Early Behavior Problems
To examine whether adverse childhood experiences (ACEs) and physical punishment (ie, spanking) are unique risk factors for behavior problems in early childhood, and whether ACEs moderate the associations of spanking with child behavior problems. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Julie Ma, Shawna J. Lee, Andrew Grogan-Kaylor Tags: Original Articles Source Type: research

Randomized Trial of Oral Iron and Diet Advice versus Diet Advice Alone in Young Children with Non-Anemic Iron Deficiency
To compare the effects of two treatment options on neurodevelopmental and laboratory outcomes in young children with non-anemic iron deficiency (NAID). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Patricia C. Parkin, Cornelia M. Borkhoff, Colin Macarthur, Kawsari Abdullah, Catherine S. Birken, Darcy Fehlings, Christine Koroshegyi, Jonathon L. Maguire, Eva Mamak, Muhammad Mamdani, Kevin E. Thorpe, Stanley H. Zlotkin, Fei Zuo, TARGet Kids! Collaborat Tags: Original Articles Source Type: research

Mental Wellbeing and General Health in Adolescents with Asthma: The PIAMA Birth Cohort Study
To assess whether adolescents with asthma experience a lower mental wellbeing and lower general health than their non-asthmatic peers. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Sabine E.I. van der Laan, Marieke L.A. de Hoog, Sanne L. Nijhof, Ulrike Gehring, Judith M. Vonk, Cornelis K. van der Ent, Alet H. Wijga Tags: Original Articles Source Type: research

Plan for the Worst, but Hope for the Best: Investing in Pediatric Services
Millions of young children throughout the world are not reaching their full potential due to poor economic conditions, causing a variety of social disadvantages, including inadequate nutrition, lack of early stimulation and education, and major exposure to communicable and non-communicable diseases1. Adverse socioeconomic circumstances in childhood are not isolated experiences2,3, but rather co-factors predisposing children to a state of general disadvantage, resulting in various detrimental health consequences associated with increased morbidity and mortality later in life3. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Massimo Pettoello-Mantovani, Angel Carrasco-Sanz, Tudor Lucian Pop, Julije Mestrovic, Eli Somekh, Ida Giardino, Leyla Namazova-Baranova, Hilary Hoey, Mehmet Vural Source Type: research

Morbidity and Disability in Juvenile Localized Scleroderma: The Case for Early Recognition and Systemic Immunosuppressive Treatment
Juvenile localized scleroderma , also called morphea, is a chronic autoimmune and fibrosing disease that often causes severe damage in the growing child. Morbidities usually arise from extracutaneous involvement, and include joint contractures, hemiatrophy, seizures, and vision impairment. Studies have found extracutaneous involvement in 43-70% of jLS patients (1-4), and functional impairment in over a quarter of the 381 patients in a North American jLS registry (1). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 3, 2021 Category: Pediatrics Authors: Suzanne C. Li, Kathleen M. O ’Neil, Gloria C. Higgins Tags: Medical Progress Source Type: research

Longitudinal Health Care Utilization of Medicaid-Insured Children with a History of Neonatal Abstinence Syndrome
To describe longitudinal health care utilization of Medicaid-insured children with a history of neonatal abstinence syndrome (NAS) compared with similar children without NAS. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2021 Category: Pediatrics Authors: Tammy E. Corr, Xueyi Xing, Guodong Liu Tags: Original Article Source Type: research

Recognizing Adolescent Depression with Parent- and Youth-Report Screens in Pediatric Primary Care
To compare the use of the parent-report Pediatric Symptom Checklist (PSC-17P) and youth-report Patient Health Questionnaire-9 Modified for Teens (PHQ-9M) in compliance with recent quality standards for adolescent depression screening. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2021 Category: Pediatrics Authors: Michael Jellinek, Paul Bergmann, Juliana M. Holcomb, Alexa Riobueno-Naylor, Anamika Dutta, Haregnesh Haile, Raymond Sturner, Barbara Howard, J. Michael Murphy Tags: Original Articles Source Type: research

Improving Cardiovascular Health in a Pediatric Preventive Cardiology Practice
Poor childhood cardiovascular health translates into poor adult CVH. We hypothesized care in a preventive cardiology clinic would improve CVH after lifestyle counseling. Over a median of 3.9 months, mean CVH score (range 0-11) improved from 5.8 (SD 2.2) to 6.3 (SD 2.1) (P (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2021 Category: Pediatrics Authors: Holly C. Gooding, Kimberlee Gauvreau, Jennifer Bachman, Annette Baker, S. Skylar Griggs, Jacob Hartz, Yisong Huang, Michael M. Mendelson, Hannah Palfrey, Sarah D. de Ferranti Tags: Brief Reports Source Type: research

Hepatic steatosis is negatively associated with bone mineral density in children
To evaluate the relationship between hepatic steatosis and bone mineral density (BMD) in children. Additionally, to assess 25-hydroxyvitamin D levels in the relationship between hepatic steatosis and BMD. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2021 Category: Pediatrics Authors: Lauren F. Chun, Elizabeth L. Yu, Mary Catherine Sawh, Craig Bross, Jeanne Nichols, Lynda Polgreen, Cynthia Knott, Alexandra Schlein, Claude B. Sirlin, Michael S. Middleton, Deborah M. Kado, Jeffrey B. Schwimmer Tags: Original Articles Source Type: research

Stratification of Culture-Proven Early-Onset Sepsis Cases by the Neonatal Early-Onset Sepsis Calculator: An Individual Patient Data Meta-Analysis
To provide a comprehensive assessment of case stratification by the Neonatal Early-Onset Sepsis (EOS) Calculator, a novel tool for reducing unnecessary antibiotic treatment. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2021 Category: Pediatrics Authors: Niek B. Achten, Frans B. Pl ötz, Claus Klingenberg, Martin Stocker, Robin Bokelaar, Merijn Bijlsma, Eric Giannoni, Annemarie M.C. van Rossum, William E. Benitz Tags: Original Articles Source Type: research

Longitudinal Healthcare Utilization of Medicaid-Insured Children with a History of Neonatal Abstinence Syndrome
To describe longitudinal healthcare utilization of Medicaid-insured children with a history of neonatal abstinence syndrome (NAS) compared with similar children without NAS.Study design: Retrospective, longitudinal cohort study. Data were extracted from the Medicaid Analytic eXtract files for all available states and D.C. from 2003-2013. Subjects were followed up to 11 years. 17,229 children with NAS were identified using the ICD-9 code 779.5. Children without NAS, matched on demographic and health variables, served as the comparison group. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2021 Category: Pediatrics Authors: Tammy E. Corr, Xueyi Xing, Guodong Liu Tags: Original Articles Source Type: research

A wrinkle in time to antibiotics in sepsis: when should ONE hour be the goal?
In 2020, the Surviving Sepsis Campaign (SSC) recommended administration of broad-spectrum antibiotics to children with septic shock within one hour of shock recognition. For children without clinical signs of shock, antibiotics are recommended as soon as possible after an expedited evaluation supports presence of sepsis-associated organ dysfunction, but not beyond three hours from initial suspicion of sepsis.1 Given the high prevalence of sepsis globally, coupled with reported mortality rates of up to 25%, evidence-based recommendations informing best practices for sepsis management are critically important. (Source: The J...
Source: The Journal of Pediatrics - February 2, 2021 Category: Pediatrics Authors: Kathleen Chiotos, Scott L. Weiss Tags: Editorials Source Type: research

The Electrocardiogram in Multisystem Inflammatory Syndrome in Children: Mind Your Ps and Qs
Since its first description in Wuhan province in December 2019, coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has disrupted the health and economic welfare of millions of people around the world. Children were initially thought to be spared from severe disease.1-3 However, in spring 2020, initial reports from Italy and the UK described a new multisystem inflammatory syndrome in children (MIS-C), with features of cardiovascular involvement and Kawasaki syndrome. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 1, 2021 Category: Pediatrics Authors: Audrey Dionne, Jane W. Newburger Tags: Editorials Source Type: research

Use of high-dose early parenteral lipid in very preterm infants
We read with great interest the prospective randomized trial on use of high dose early parenteral lipid in very preterm infants by the HELP trial investigators.1 This trial addresses the clinical dilemma regarding the optimal initial dose for lipid administration in preterm infants. The authors reported a decrease in early postnatal weight loss with higher starting dose of lipids, similar to previously published data.2 However, we would like to highlight a few issues and request a clarification. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 1, 2021 Category: Pediatrics Authors: Khushboo Kanwal, Anish Pillai, Nandkishor Kabra Tags: Letters to the Editor Source Type: research

Increased Incidence of Inflammatory Bowel Disease after Hirschsprung Disease: A Population-based Cohort Study
Supported by a Foundation Grant from the Canadian Institutes of Health Research (CIHR) and a CIHR Operating Grant Reference Number PJT 162393. C.B. is supported in part by the Bingham Chair in Gastroenterology. E.B. was supported by a New Investigator Award from the Canadian Institutes of Health Research, Canadian Association of Gastroenterology and Crohn's and Colitis Canada and by the Career Enhancement Program of the Canadian Child Health Clinician Scientist Program. M.K. was supported by a Mitacs Elevate Post-Doctoral Fellowship. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 1, 2021 Category: Pediatrics Authors: Charles N. Bernstein, M. Ellen Kuenzig, Stephanie Coward, Zoann Nugent, Ahmed Nasr, Wael El-Matary, Harminder Singh, Gilaad G. Kaplan, Eric I. Benchimol Tags: Original Articles Source Type: research

The ECG in MIS-C: Mind Your P's and Q's
Since its first description in Wuhan province in December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has disrupted the health and economic welfare of millions of people around the world. Children were initially thought to be spared from severe disease.1-3 However, in spring 2020, initial reports from Italy and the United Kingdom described a new multisystem inflammatory syndrome in children (MIS-C), with features of cardiovascular involvement and Kawasaki syndrome. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 1, 2021 Category: Pediatrics Authors: Audrey Dionne, Jane W. Newburger Tags: Editorials Source Type: research

Pediatric subspecialists ’ practices and attitudes regarding sexual and reproductive healthcare for adolescent and young adult women prescribed teratogenic medications
To evaluate pediatric subspecialists ’ practices and attitudes regarding sexual and reproductive healthcare for adolescent and young adult women for whom they prescribe teratogens. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 1, 2021 Category: Pediatrics Authors: Laura Kirkpatrick, Hilary K. Michel, Allison Close, Amy Collins, Elizabeth Miller, Traci M. Kazmerski Tags: Original Articles Source Type: research

Use of high dose early parenteral lipid in very preterm infants
We read with great interest the prospective randomized trial on use of high dose early parenteral lipid in very preterm infants by the HELP trial investigators.[1] This trial addresses the clinical dilemma regarding the optimal initial dose for lipid administration in preterm infants. The authors reported a decrease in early postnatal weight loss with higher starting dose of lipids, similar to previously published data.[2] However, we would like to highlight a few issues and request clarification. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 1, 2021 Category: Pediatrics Authors: Khushboo Kanwal, Anish Pillai, Nandkishor Kabra Tags: Letters to the Editor Source Type: research

National Estimates of Chronic Musculoskeletal Pain and Its Treatment in Children, Adolescents, and Young Adults in the United States: Data From the 2007-2015 National Ambulatory Medical Care Survey
To portray physician office visits by young Americans with chronic musculoskeletal pain; to describe clinical management in this group; and to explore factors associated with prescribed treatments. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 29, 2021 Category: Pediatrics Authors: Debbie Ehrmann Feldman, Richard L. Nahin Tags: Original Articles Source Type: research

National Estimates of Chronic Musculoskeletal Pain and Its Treatment in Children, Adolescents and Young Adults in the United States: Data from the 2007 –2015 NAMCS
To portray physician office visits by young Americans with chronic musculoskeletal pain; to describe clinical management in this group; and to explore factors associated with prescribed treatments. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 29, 2021 Category: Pediatrics Authors: Debbie Ehrmann Feldman, Richard L. Nahin Tags: Original Articles Source Type: research

Racial Disparities in Diagnosis of Concussion and Minor Head Trauma and Mechanism of Injury in Pediatric Patients Visiting the Emergency Department
To determine if racial/ethnic differences exist in the diagnosis and mechanism of injury among children and adolescents visiting the emergency department (ED) for concussion and minor head trauma (MHT). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 29, 2021 Category: Pediatrics Authors: Jessica S. Wallace, Rebekah C. Mannix Tags: Original Articles Source Type: research