Reply
We agree with Dr Klingenberg, that our study is open to potential bias due to missing data. We appreciate the chance to discuss this further. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 6, 2020 Category: Pediatrics Authors: Gorm Greisen, Ren é Liang Shen, Per Torp Sangild Tags: Letters to the Editor Source Type: research

Increased Odds of Ventricular Arrhythmias Associated with Selective Serotonin Reuptake Inhibitor Use among the Pediatric & Young Adult Population: A Case-Control Study
To Measure the association between selective serotonin reuptake inhibitors (SSRI) use and out-of-hospital ventricular arrhythmia among pediatric and young adult population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 6, 2020 Category: Pediatrics Authors: Angela S. Czaja, Heather D. Anderson, Debashis Ghosh, Jesse Davidson, Jonathan D. Campbell, Robert J. Valuck Tags: Original Articles Source Type: research

Seven-Year Case-Control Study in California of Risk Factors for Infant Botulism
To ascertain possible risk factors for infant botulism, the intestinal infectious form of human botulism, in the years immediately following its initial recognition in California in 1976.. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 6, 2020 Category: Pediatrics Authors: Mayuri V. Panditrao, Haydee A. Dabritz, N. Neely Kazerouni, Karla H. Damus, Joyce K. Meissinger, Stephen S. Arnon Tags: Original Articles Source Type: research

Mediating Effects of Maternal Blood Triglycerides on the Relationship between Pre-Pregnancy Body Mass Index and Fetal Macrosomia
To examine whether the association of pre-pregnancy BMI with fetal macrosomia is mediated through maternal circulating lipids concentration during pregnancy. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 5, 2020 Category: Pediatrics Authors: Sha Lu, Yuanqing Fu, Ying-ying Wu, Ai-fen Mao, Meng-yan Xu, Guoying Zheng, Feng-cheng Cai, Xu-hong Wang, Mei-qi Shi, Wen-sheng Hu Tags: Original Articles Source Type: research

Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 from Adults to Children
Knowledge of transmission dynamics of severe acute respiratory syndrome coronavirus 2 from adults to children in household settings is limited. We found an attack rate among 213 children in 137 households to be 6.1% in households with a confirmed adult 2019 novel coronavirus disease case. Transmission from an adult to a child occurred in only 5.2% of households. Young children (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Chee Fu Yung, Kai-qian Kam, Chia Yin Chong, Karen Donceras Nadua, Jiahui Li, Natalie Woon Hui Tan, Sashikumar Ganapathy, Khai Pin Lee, Kee Chong Ng, Yoke Hwee Chan, Koh Cheng Thoon Tags: Brief Reports Source Type: research

Use of Automated Office Blood Pressure Measurement in the Evaluation of Elevated Blood Pressures in Children and Adolescents
To determine the level of agreement between AOBP, auscultated or manual office BP (MOBP) and 24 hour ABPM, and to explore the ability of AOBP and MOBP to correctly identify daytime ambulatory hypertension (HTN) in children. Study design: We retrospectively compared BPs obtained by AOBP and MOBP to predict daytime HTN on ABPM. Six BPs were taken by AOBP followed by MOBP. Office HTN was defined by BPs> 95th% for sex and height percentiles for those130/80 for ages> 13 years. Daytime ambulatory HTN was diagnosed if mean wake BPs were> 95thpercentile and BP loads were>25%. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Coral D. Hanevold, Anna Victoria Faino, Joseph Thomas Flynn Tags: Original Articles Source Type: research

Associations of Birth Weight for Gestational Age with Child Health and Neurodevelopment among Term Infants: A Nationwide Japanese Population-Based Study
To examine the association of specific Z-score categories of birth weight for gestational age (GA) with child health and neurodevelopment using a large nationwide survey in Japan, focusing on term infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Kei Tamai, Takashi Yorifuji, Akihito Takeuchi, Yu Fukushima, Makoto Nakamura, Naomi Matsumoto, Yosuke Washio, Misao Kageyama, Hirokazu Tsukahara Tags: Original Articles Source Type: research

Heparin-Induced Thrombocytopenia in a pediatric population: Implications for clinical probability scores and testing
To determine the applicability of the 4Ts score and the heparin-induced thrombocytopenia (HIT) Expert Probability (HEP) score in children with suspected HIT and to estimate the number of children potentially at risk of HIT. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Maria Laura Avila, Nour Amiri, Paul Yenson, Shirin Khan, Zahra Tofighi Zavareh, Anthony K.C. Chan, Suzan Williams, Leonardo R. Brand ão Tags: Original Articles Source Type: research

Development of Academic Pediatric Urgent Care Fellowships
Consumer demand for low-cost convenient care and consumer expectations that health services be easily accessible and efficient have led to the rapid expansion of urgent care over the last decade. Redirecting acute care visits to non-ED locations has the potential to decrease ED overcrowding, increase patient satisfaction, and generate cost savings.1As of 2017, there were 7639 urgent care centers in the United States, with 21% dedicated to the treatment of pediatric patients.2 In addition to the expansion of freestanding urgent care centers in the United States, hospital-based acute care centers distinct from emergency depa...
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Deena Berkowitz, Joanna Cohen, Haroon Shaukat, Emily Willner, Sixtine Herold, Teresa Coco, Amy Pattishall, Nehal Bandari, Chris Ramsook, Alexandra Vinograd, Terry Yen, Theresa Guins, Luciana Berg, Ioannis Koutroulis Tags: AMSPDC Source Type: research

Neural Tube Defects and Associated Anomalies Before and After Folic Acid Fortification
To examine the prevalence and types of neural tube defects and the types of anomalies co-occurring with neural tube defects in six years before fortification of cereal grain flour with folic acid (1992-1998) and 20 years after fortification (1999-2018) in South Carolina, a state with a historically high prevalence of these birth defects. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Jane H. Dean, Rini Pauly, Roger E. Stevenson Tags: Original Articles Source Type: research

Epidemiology of Birth Defects in Very Low Birth Weight Infants in Japan
To evaluate the mortality and morbidity of very low birth weight (VLBW) preterm infants with birth defects in Japan. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Hidenori Kawasaki, Takahiro Yamada, Yoshimitsu Takahashi, Takeo Nakayama, Takahito Wada, Shinji Kosugi, Neonatal Research Network of Japan Tags: Original Articles Source Type: research

Cost-Utility Analysis of Prophylactic Dextrose Gel vs. Standard Care for Neonatal Hypoglycemia In At-Risk Infants
To evaluate the long-term costs and impact on quality of life of using prophylactic dextrose gel in subjects at increased risk of developing neonatal hypoglycemia. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Matthew J. Glasgow, Richard Edlin, Jane E. Harding Tags: Original Articles Source Type: research

Household Transmission of SARS-CoV-2 from Adults to Children
Knowledge of transmission dynamics of SARS-CoV-2 from adults to children in household settings is limited. We found an attack rate among 213 children in 137 households to be 6.1% in households with a confirmed adult 2019 novel coronavirus disease (COVID-19) case. Transmission from an adult to a child occurred in only 5.2% of households. Young children (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 4, 2020 Category: Pediatrics Authors: Chee Fu Yung, Kai-qian Kam, Chia Yin Chong, Karen Donceras Nadua, Jiahui Li, Natalie Woon Hui Tan, Sashikumar Ganapathy, Khai Pin Lee, Kee Chong Ng, Yoke Hwee Chan, Koh Cheng Thoon Tags: Brief Reports Source Type: research

Utility of Neonatal Ophthalmologic Examination for Detection of Infectious Etiologies for Symmetric Intrauterine Growth Restriction
To determine the utility of ophthalmologic examination as part of evaluation for infection in infants with intrauterine growth restriction (IUGR). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 3, 2020 Category: Pediatrics Authors: Kara C. LaMattina, Melissa Schwedhelm, Maureen Lloyd, Alla Kushnir, Barry N. Wasserman Tags: Original Articles Source Type: research

Risk of bias in study on early antibiotics and necrotizing enterocolitis
Li et al present data on the association between antibiotic use and necrotizing enterocolitis (NEC) in 2831 very low birth weight (VLBW)-infants from 13 neonatal intensive care units (NICU) in five continents (1). Their main result is that early administration of antibiotics is associated with less NEC compared to no-early exposure to antibiotics. These results are in line with some studies (2, 3), but challenge the concept that early antibiotic exposure disturbs the intestinal microbiota and increase the subsequent risk for NEC in preterm infants (4, 5). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 3, 2020 Category: Pediatrics Authors: Claus Klingenberg Tags: Letters to the Editor Source Type: research

Parent Technology Use, Parent-Child Interaction, Child Screen Time, and Child Psychosocial Problems among Disadvantaged Families
To disentangle the pathways between parent technology use, parent-child interactions, child screen time, and child psychosocial difficulties among disadvantaged families in Hong Kong. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 3, 2020 Category: Pediatrics Authors: Rosa S. Wong, Keith TS. Tung, Nirmala Rao, Cynthia Leung, Anna NN. Hui, Winnie WY. Tso, King-Wa Fu, Fan Jiang, Jin Zhao, Patrick Ip Tags: Original Articles Source Type: research

Age-Dependent Costs and Complications in Pediatric Umbilical Hernia Repair
To characterize regional variation in the age of patients undergoing umbilical hernia repair to determine costs and subsequent care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 3, 2020 Category: Pediatrics Authors: Jonathan E. Kohler, Randi S. Cartmill, Dou-Yan Yang, Sara Fernandes-Taylor, Caprice C. Greenberg Tags: Original Articles Source Type: research

Adolescent Female with Severe Thigh Pain after Doing Splits
A 13-year-old girl presented with an abrupt onset of severe pain in the proximal part of the right thigh occurring during a gymnastics routine, performing “splits.” On arrival, the girl was not able to sit or stand. On physical examination, palpation of the right buttock and flexion of the right thigh evoked pain, as well as the extra-rotation and abduction of the right hip. A radiograph of the pelvis was performed, showing an inferior displacemen t of the right ischial tuberosity (Figure). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 2, 2020 Category: Pediatrics Authors: Andrea Trombetta, Egidio Barbi, Flora Maria Murru, Giorgio Cozzi Tags: Insights and Images Source Type: research

Hertoghe's Sign in Atopic Dermatitis
A 15-year-old boy presented to the clinic owing to a concern over the loss of hair in both eyebrows. Over the past 6  months, his preexisting atopic dermatitis had progressively flared, but he was not receiving treatment. In addition to severe facial and flexural eczema, he had prominent rarefaction of the lateral one-third of both eyebrows, a finding known as Hertoghe's sign (Figure, A).1 The patient denied eyeb row plucking or rubbing. Laboratory tests showed eosinophilia (1070 cells/mm3), normal thyroid function, and negative syphilis testing. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 2, 2020 Category: Pediatrics Authors: Arturo Borzutzky, Macarena Tejos-Bravo, Luis F. Venegas, Carolina Iturriaga Tags: Rediscovering the Physical Exam Source Type: research

The Hikikomori Phenomenon of Social Withdrawal: An Emerging Condition Involving Youth's Mental Health and Social Participation
The issue of social isolation and loneliness involving individuals during their developmental years has gathered increased attention from researchers, policymakers, and the public, raising concerns about the negative effects of this condition on youth's well-being. In youngsters, the use of media devices, including social network platforms, video games, and interactive apps, continues to increase exponentially and the initial use of social network is about 10  years of age.1,2 This is likely owing to the use of using these tools to build a social identity and develop new, unconventional forms of personal expression. (...
Source: The Journal of Pediatrics - July 2, 2020 Category: Pediatrics Authors: Pietro Ferrara, Giulia Franceschini, Giovanni Corsello, Julije Mestrovic, Ida Giardino, Michele Sacco, Mehmet Vural, Massimo Pettoello-Mantovani, Tudor Lucian Pop Tags: European Paediatric Association Source Type: research

Adolescent Female with Severe Thigh Pain after the Splits
A 13-year-old girl presented because of an abrupt onset of severe pain in the proximal part of the right thigh occurring during a gymnastics routine, performing “the splits.” At arrival, the girl was not able to sit nor stand. At physical examination, palpation of the right buttock and flexion of the right thigh evoked pain, as well as the extra-rotation and abduction of the right hip. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 2, 2020 Category: Pediatrics Authors: Trombetta Andrea, Egidio Barbi, Flora Maria Murru, Giorgio Cozzi Tags: Insights and Images Source Type: research

Hertoghe ’s Sign in Atopic Dermatitis
A 15-year-old boy presented to clinic due to concern over the loss of hair in both eyebrows. Over the past 6 months, his pre-existing atopic dermatitis had progressively flared, but he was not receiving treatment. In addition to severe facial and flexural eczema, he had prominent rarefaction of the lateral one-third of both eyebrows, a finding known as Hertoghe ’s sign (Figure, A).1 The patient denied eyebrow plucking or rubbing. Laboratory tests showed eosinophilia (1070 cells/mm3), normal thyroid function, and negative syphilis testing. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 2, 2020 Category: Pediatrics Authors: Arturo Borzutzky, Macarena Tejos-Bravo, Luis F. Venegas, Carolina Iturriaga Tags: Rediscovering the Physical Exam Source Type: research

The Hikikomori Phenomenon of Social Withdrawal: An Emerging Condition Involving Youth ’s Mental Health and Social Participation
The issue of social isolation and loneliness involving individuals during their developmental years has gathered increased attention from researchers, policymakers, and the public, raising concerns about the negative effects of this condition on youth ’s wellbeing. In youngsters, the use of media devices, including social network platforms, video games and interactive apps continues to increase exponentially and the initial use of social network is about 10 years of age1,2. This is likely due to the use of using these tools to build a social id entity and develop new, unconventional forms of personal expression. (Sou...
Source: The Journal of Pediatrics - July 2, 2020 Category: Pediatrics Authors: Pietro Ferrara, Giulia Franceschini, Giovanni Corsello, Julije Mestrovic, Ida Giardino, Michele Sacco, Mehmet Vural, Massimo Pettoello-Mantovani, Tudor Lucian Pop Source Type: research

Congenital Disseminated Pyogenic Granuloma: Characterization of an Aggressive Multisystemic Disorder.
To describe the clinical, radiological and histopathological features of “congenital disseminated pyogenic granuloma” (CDPG) involving various organs with high morbidity related to cerebral hemorrhagic involvement. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 1, 2020 Category: Pediatrics Authors: Mohammed H. Alomari, Harry P.W. Kozakewich, Cindy L. Kerr, Wibke Uller, Scott L. Davis, Gulraiz Chaudry, Marilyn G. Liang, Darren B. Orbach, John B. Mulliken, Arin K. Greene, Salim Afshar, Steven J. Fishman, Amir H. Taghinia, Alya Al-Ibraheemi, Ahmad I. A Tags: Original Articles Source Type: research

Patterns of Osteopontin Expression in Abusive Head Trauma Compared With Other Causes of Pediatric Traumatic Brain Injury
To examine levels of plasma osteopontin (OPN), a recently described neuroinflammatory biomarker, in children with abusive head trauma compared with other types of traumatic brain injury. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 1, 2020 Category: Pediatrics Authors: Laura S. Blackwell, Margaret Martinez, Ashley Fournier-Goodnight, Janet Figueroa, Andrew Appert, Atul Vats, Bushra Wali, Iqbal Sayeed, Andrew Reisner Tags: Original Articles Source Type: research

Neighborhood Inequality and Emergency Department Use in Neonatal Intensive Care Unit Graduates
Neonatal intensive care unit graduates residing in high-risk neighborhoods were at increased risk of emergency department use and had higher rates of social/environmental risk factors. Distances to primary care provider and emergency department did not contribute to emergency department use. Knowledge of neighborhood risk is important for preventative service reform. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 30, 2020 Category: Pediatrics Authors: Surya Manickam, Patrick M. Vivier, Michelle L. Rogers, Elisabeth C. McGowan, Raul Smego, Richard Tucker, Betty R. Vohr Tags: Brief Reports Source Type: research

Neighborhood Inequality and Emergency Department Utilization in Neonatal Intensive Care Unit Graduates
Neonatal intensive care unit graduates residing in high-risk neighborhoods were at increased risk of emergency department (ED) utilization and had higher rates of social/environmental risk factors. Distances to primary care provider and ED did not contribute to ED utilization. Knowledge of neighborhood risk is important for preventative service reform. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 30, 2020 Category: Pediatrics Authors: Surya Manickam, Patrick M. Vivier, Michelle L. Rogers, Elisabeth C. McGowan, Raul Smego, Richard Tucker, Betty R. Vohr Tags: Brief Reports Source Type: research

Reply
We thank Bassareo et al for their comments and agree that our community needs to come together to improve timely diagnosis and treatment of children with Kawasaki disease and KD like illnesses during the COVID-19 pandemic to prevent the development of coronary artery aneurysms (CAAs). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 30, 2020 Category: Pediatrics Authors: Ashraf S. Harahsheh, Nagib Dahdah, Jane W. Newburger, Michael A. Portman, Robert Tulloh, Brian W. McCrindle, Rolando Cimaz, Jane C. Burns Tags: Letters to the Editor Source Type: research

COVID-19 and the Editorial Process: Reflections from The Journal of Pediatrics
The ongoing SARS-CoV-2 pandemic and the associated novel coronavirus 2019 disease (COVID-19) shine a bright light on the critical role of peer-reviewed scientific publications in addressing health crises and informing action. As do most of our companion journals, The Journal of Pediatrics strives to advance what we assess to be important observations as rapidly as possible, while ensuring our readership and the public that what we publish is reliable. We reflect on the challenges to the core principles of the peer-review process and the responsibilities of journal leadership during the early phases of the medical Armageddo...
Source: The Journal of Pediatrics - June 30, 2020 Category: Pediatrics Authors: Thomas R. Welch, Sarah S. Long, Rebecca Pellett Madan, Meghan McDevitt, William F. Balistreri Source Type: research

Double Sutural Cataract
The authors declare no conflicts of interest. A 13-year -boy presented for a routine eye examination. His best corrected visual acuity was 20/20 OU. Right eye examination revealed a clear cornea with star shaped lenticular opacity along with multiple opacities in the cortex (Figure A). The left eye had a similar but denser star-shaped opacity in the center (Figure, B). Bilateral sutural cataracts, following upright anterior and inverted posterior sutures with knobs were diagnosed. Sutural cataracts are generally non-progressive congenital lens opacities that occur at the location of closure of the fetal optic nucleus. (Sou...
Source: The Journal of Pediatrics - June 29, 2020 Category: Pediatrics Authors: Savleen kaur, Jaspreet Sukhija Tags: Rediscovering the Physical Exam Source Type: research

Predictive Value of the Global School Adaptation Questionnaire at 5 Years of Age and Educational Support at 7 Years of Age in Very Preterm Children
To assess the Global School Adaptation (GSA) questionnaire of children ’s abilities and classroom behavior administered to teachers of very preterm children at 5 years of age as a predictor of the need for educational support (grade retention, special class, learning support) at age 7. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 29, 2020 Category: Pediatrics Authors: Jean-Baptiste Muller, Marion Olivier, Philippe Guimard, G éraldine Gascoin;, Jean-Christophe Roze, Cyril Flamant, Arnaud Roy Tags: Original Articles Source Type: research

Oxygenation Instability Assessed by SpO2 Histograms during Supine vs. Prone Position in Very Low Birthweight Infants Receiving Non-invasive Respiratory Support
To evaluate the effect of prone vs supine position on the oxygenation instability among VLBW infants receiving non-invasive respiratory support, as assessed by the SpO2 histograms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 29, 2020 Category: Pediatrics Authors: Adi Miller-Barmak, Arieh Riskin, Ori Hochwald, Julie Haddad, Gil Dinur, Rita Vortman, Amir Kugelman, Liron Borenstein-Levin Tags: Original Articles Source Type: research

Did the rising tide float all boats?
In the current volume of The Journal, Guttman et al report the effect of a pediatric value-based purchasing intervention, one that introduced a pay-for-performance program that ran for nine years in the province of Ontario, Canada.1 The goal of this program was to improve the frequency with which 18 month old children received developmental screening as part of an “enhanced” well-child visit compared with a standard one that does not include screening. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 28, 2020 Category: Pediatrics Authors: Alyna T. Chien Tags: Editorials Source Type: research

Hospital-care Cost & Resource Use of Early Discharge of Healthy Late Preterm & Term Singletons: A Population-based Cohort Study and Cost Analysis
To assess the hospital-care cost and resource use associated with discharge timings after late preterm and term births. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 28, 2020 Category: Pediatrics Authors: Tetsuya Isayama, Daria O ’Reilly, Joseph Beyene, Prakesh S. Shah, Shoo K. Lee, Sarah D. McDonald Tags: Original Articles Source Type: research

Plasma and CSF Candidate Biomarkers of Neonatal Encephalopathy Severity and Neurodevelopmental Outcomes
To identify candidate biomarkers in both plasma and cerebrospinal fluid (CSF) that are associated with neonatal encephalopathy severity measured by encephalopathy grade, seizures, brain injury by magnetic resonance imaging (MRI), and neurodevelopmental outcomes at 15-30 months. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 28, 2020 Category: Pediatrics Authors: Barbara Dietrick, Eleanor Molloy, An N. Massaro, Tammy Strickland, Jie Zhu, Marie Slevin, Veronica Donoghue, Deirdre Sweetman, Lynne Kelly, Mary O ’Dea, Meaghan McGowan, Gilbert Vezina, Penny Glass, Dhananjay Vaidya, Sandra Brooks, Frances Northington, Tags: Original Articles Source Type: research

The GLOW Study does not light up the true Pediatric Endocrine Society recommendations for management of hypoglycemia in newborns
Using intermittent plasma glucose testing combined with continuous interstitial glucose monitoring, Harris et  al1 demonstrate with unprecedented clarity, patterns of glucose concentrations in the first days of life in healthy term newborns. After a transitory decline following separation from the placenta, glucose concentrations increase in the first 18 hours, remaining stable at 59 ± 11 mg/dL for 48  hours, then rising to a new plateau of 83 ± 13 mg/dL by day 4. The authors report that by 72 hours a significant proportion of normal babies had at least one glucose...
Source: The Journal of Pediatrics - June 27, 2020 Category: Pediatrics Authors: Paul S. Thornton, Paul J. Rozance, Mark A. Sperling Tags: Letters to the Editor Source Type: research

Reply
We appreciate the interest of Thornton et  al in the findings of the GLOW study. We entirely agree that our study reports findings from healthy babies, and that these cannot be extrapolated to drawing conclusions about management of babies at risk of hypoglycemia. Although we have placed our findings about glucose concentrations in the con text of several international guidelines for treatment of at-risk babies, including those from the Pediatric Endocrine Society,1 and have noted that low glucose concentrations are common in healthy babies, we do not suggest this might indicate a change in the care of at-risk babies....
Source: The Journal of Pediatrics - June 27, 2020 Category: Pediatrics Authors: Deborah L. Harris, Philip J. Weston, Greg D. Gamble, Jane E. Harding Tags: Letters to the Editor Source Type: research

Severe Acute Respiratory Syndrome Associated with Coronavirus 2 Infection in Patients with Down Syndrome, Congenital Heart Disease, and Pulmonary Hypertension: Is Down Syndrome a Risk Factor?
With increasing information available about the epidemiology, pathophysiology, and management of patients affected with severe acute respiratory syndrome corona virus-2 infection, patients with Down syndrome, congenital heart disease, airway obstruction, and pulmonary hypertension present a unique challenge. This case series describes 3 patients with Down syndrome and respiratory failure secondary to coronavirus infection. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 27, 2020 Category: Pediatrics Authors: Usha S. Krishnan, Sankaran S. Krishnan, Shipra Jain, Mara B. Chavolla-Calderon, Matthew Lewis, Wendy K. Chung, Erika B. Rosenzweig Tags: Brief Reports Source Type: research

SARS-CoV-2 Infection in Patients with Down Syndrome, Congenital Heart Disease, and Pulmonary Hypertension: Is Down Syndrome a Risk Factor?
The authors declare no conflicts of interest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 27, 2020 Category: Pediatrics Authors: Usha S. Krishnan, Sankaran S. Krishnan, Shipra Jain, Mara B. Chavolla-Calderon, Matthew Lewis, Wendy K. Chung, Erika B. Rosenzweig. Tags: Brief Reports Source Type: research

Response Letter
We appreciate the interest of Thornton et al in the findings of the GLOW study.1 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 27, 2020 Category: Pediatrics Authors: Deborah L. Harris, Philip J. Weston, Greg D. Gamble, Jane E. Harding Tags: Letters to the Editor Source Type: research

The GLOW study does not light up the true PES recommendations for management of hypoglycemia in newborns
Using intermittent plasma glucose testing combined with continuous interstitial glucose monitoring, Harris et al (1) demonstrate with unprecedented clarity, patterns of glucose concentrations in the first days of life in healthy term newborns. After a transitory decline following separation from the placenta, glucose concentrations increase in the first 18 hours, remaining stable at 59 + 11mg/dL for 48 hours, then rising to a new plateau of 83 + 13 mg/dL by day four. However, by 72 hours a significant proportion of normal babies had at least one glucose concentration below the Pediatric Endocrine Society (PES) thresholds f...
Source: The Journal of Pediatrics - June 27, 2020 Category: Pediatrics Authors: Paul S. Thornton, Paul J. Rozance, Mark A. Sperling Tags: Letters to the Editor Source Type: research

Trends in Sodium Intake in Children and Adolescents in the US and the Impact of US Department of Agriculture Guidelines: NHANES 2003-2016
To examine trends in sodium intake and the impact of nutritional guidelines in the US pediatric population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 26, 2020 Category: Pediatrics Authors: Adam M. Brouillard, Elena Deych, Charles Canter, Michael W. Rich Tags: Original Articles Source Type: research

Consent Rates Reported in Published Pediatric Randomized Controlled Trials
To determine the average reported consent rate for published pediatric randomized controlled trials and whether this rate varies by trial characteristics. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 26, 2020 Category: Pediatrics Authors: Julia A. Lonhart, Ashley R. Edwards, Swati Agarwal, Brian P. Lucas, Alan R. Schroeder Tags: Original Articles Source Type: research

Botulinum Toxin as a Treatment for Feeding Difficulties in Young Children
To determine the effectiveness of intrapyloric botulinum toxin injection (IPBI) for treatment of feeding disorders and associated gastrointestinal symptoms in very young children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 26, 2020 Category: Pediatrics Authors: Suzanna Hirsch, Samuel Nurko, Paul Mitchell, Rachel Rosen Tags: Original Articles Source Type: research

Seeking Normalcy as the Curve Flattens: Ethical Considerations for Pediatricians Managing Collateral Damage of COVID-19
Fearful. Uncertain. Overwhelmed. Committed. Hopeful. Pediatricians around the world have cycled through these emotions when considering the health and safety of patients and families during this coronavirus disease 2019 (COVID-19) pandemic. We worry about the direct medical effects of COVID-19. We also worry about the ancillary effects of the lockdowns, stay-at-home orders, closed clinics, schools, and daycare centers, and newly unemployed parents on the well-being of children. We will focuse on those concerns. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 26, 2020 Category: Pediatrics Authors: Dalia M. Feltman, Gregory P. Moore, Andrew F. Beck, Emily Siffermann, Carlo Bellieni, John Lantos Tags: Commentary Source Type: research

Dog Bites in Children Surge during Coronavirus Disease-2019: A Case for Enhanced Prevention
As the world grapples with the coronavirus disease 2019 (COVID-19) pandemic, unforeseen sequela and public health implications continue to mount. Hospitals battle to keep patients alive while balancing worker safety amid rationing of personal protective equipment. Researchers race to discover a vaccine while politicians, communities, and neighborhoods debate shelter-in-place and social distancing regulations. Families experience financial devastation and loss of loved ones, and parents and grandparents become full-time home care providers and educators. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 25, 2020 Category: Pediatrics Authors: Cinnamon A. Dixon, Rakesh D. Mistry Tags: Commentary Source Type: research

Dog Bites in Children Surge during COVID-19: A Case for Enhanced Prevention
As the world grapples with the coronavirus disease 2019 (COVID-19) pandemic, unforeseen sequela and public health implications continue to mount. Hospitals battle to keep patients alive while balancing worker safety amidst rationing of personal protective equipment. Researchers race to discover a vaccine while politicians, communities, and neighborhoods debate shelter-in-place and social-distancing regulations. Families experience financial devastation and loss of loved ones while parents and grandparents become full-time home care providers and educators. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 25, 2020 Category: Pediatrics Authors: Cinnamon A. Dixon, Rakesh D. Mistry Tags: Commentary Source Type: research

The Utility of IgA-Based Serologic Markers in Diagnosing Celiac Disease in Children 24  Months of Age or Younger
Current screening guidelines in North America for celiac disease recommend additional IgG based testing for younger children. Our multicenter retrospective study showed that the anti-tissue transglutaminase IgA antibody test should be the recommended initial test in all children, including those ≤24 months of age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 24, 2020 Category: Pediatrics Authors: Muhammad Rehan Khan, Jocelyn A. Silvester, Brandon Sparks, Zackary Hintze, Tracy Ediger, Joseph J. Larson, Ivor Hill, Imad Absah Tags: Brief Reports Source Type: research

Severe coronavirus disease 2019 in children and young adults
DeBiasi et  al1 report that 3% of the pediatric patients who tested positive with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at their center had a history of diabetes. Diabetes is currently listed by the Centers for Disease Control and Prevention as an underlying condition that places indivi duals at higher risk for severe illness. Two of the 5 patients with diabetes required hospitalization. Of the 2 patients, 1 patient with type 1 diabetes and brain injury required intensive care unit-level care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 23, 2020 Category: Pediatrics Authors: Meredith Wilkes, Rula Issa, Anna Aluf, Kara Beliard, Mabel Yau, Robert Rapaport, Osagie Ebekozien Tags: Letters to the Editor Source Type: research

Incarceration Exposure During Pregnancy and Infant Health: Moderation by Public Assistance
To assess the relationship between exposure to incarceration during pregnancy and adverse infant health outcomes: low birth weight ( (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 23, 2020 Category: Pediatrics Authors: Alexander Testa, Dylan B. Jackson Tags: Original Articles Source Type: research