50 Years Ago in The Journal of Pediatrics
Madsen JA, Linker A. J Pediatr 1969;75:843-52 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Adriana M. Monta ño Source Type: research

50 Years Ago in The Journal of Pediatrics
Gordis L, Markowitz M, Lilienfeld AM. J Pediatr 1969;75:957-68. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Sarah A. Sobotka, Lainie Friedman Ross Source Type: research

50 Years Ago in The Journal of Pediatrics
Bray PF, Ziter FA, Lahey ME, Myers GF. J Pediatr 1969;75:983-90. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Paul Graham Fisher Source Type: research

50 Years Ago in The Journal of Pediatrics
Johanson AJ, Brasel JA, Blizzard RM. J Pediatr 1969;75:1015-21. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Anisha Gohil, John S. Fuqua Source Type: research

50 Years Ago in The Journal of Pediatrics
Chan J, Eleff MG, Campbell RA. J Pediatr 1969;75:1050-3 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Alejandro Martinez Herrada, Philip Toltzis Source Type: research

The Clinical and Molecular Spectrum of GM1 Gangliosidosis
To evaluate the clinical presentation of patients with GM1 gangliosidosis and to determine whether specific clinical or biochemical signs could lead to a prompt diagnosis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Laila Arash-Kaps, Katalin Komlosi, Marlene Seegr äber, Stefan Diederich, Eduard Paschke, Yasmina Amraoui, Skadi Beblo, Andrea Dieckmann, Martin Smitka, Julia B. Hennermann Tags: Original Article Source Type: research

Caregiver Burden Due to Pulmonary Exacerbations in Patients with Cystic Fibrosis
To describe the poorly understood burden of pulmonary exacerbations experienced by primary caregivers of children (aged 2-17  years) with cystic fibrosis (CF), who frequently require prolonged hospitalizations for treatment of pulmonary exacerbations with intravenous (IV) antibiotics. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Ellison Suthoff, Jochen G. Mainz, Desmond W. Cox, Teja Thorat, Daniel H. Grossoehme, Moshe Fridman, Gregory S. Sawicki, Margaret Rosenfeld Tags: Original Article Source Type: research

Baby NINJA (Nephrotoxic Injury Negated by Just-in-Time Action): Reduction of Nephrotoxic Medication-Associated Acute Kidney Injury in the Neonatal Intensive Care Unit
To test if acute kidney injury (AKI) is preventable in patients in the neonatal intensive care unit and if infants at high-risk of nephrotoxic medication-induced AKI can be identified using a systematic surveillance program previously used in the pediatric non-intensive care unit setting. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Christine Stoops, Sadie Stone, Emily Evans, Lynn Dill, Traci Henderson, Russell Griffin, Stuart L. Goldstein, Carl Coghill, David J. Askenazi Tags: Original Article Source Type: research

Corrigendum
In the article “Gaps and Factors Related to Receipt of Care within a Medical Home for Toddlers Born Preterm” (J Pediatr 2019;207:161-8.e1), several numbers in the Figure were incorrect. The correct version of the Figure appears below. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Tags: Correction Source Type: research

Lifelong Negative Influence of School Violence on Children
Violence in the school environment is a constant concern for educators and parents and is a serious and often lifelong burden for the young victims. School violence is not just a limited problem, variously affecting specific or isolated communities in economic advantaged or disadvantaged areas, but a global modern phenomenon involving, to various degrees, one of the core social institutions of our society.1-3 The European Paediatric Association-Union of National European Paediatric Societies and Associations (EPA/UNEPSA), through the working group on social pediatrics, supported by its European national pediatric societies...
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Pietro Ferrara, Giulia Franceschini, Leyla Namazova-Baranova, Mehmet Vural, Julije Mestrovic, Luigi Nigri, Ida Giardino, Tudor Lucian Pop, Michele Sacco, Massimo Pettoello-Mantovani Tags: European Paediatric Association Source Type: research

A Balanced Approach: Meeting the Needs of Medical Students and Faculty Educators in Pediatrics
Clinical training in medical school education has undergone many changes in recent years. Direct observation and hands-on teaching of physical skills by faculty, although recognized as optimal by students, has declined owing to increased patient turnover, heightened concerns related to patients' privacy, and increased reliance on technology for diagnostics.1-4 Furthermore, medical educators may feel overwhelmed trying to balance clinical duties with the growing number of learners seeking education at academic medical centers. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Shivani J. Patel, Leslie Farrell, Dominick DeBlasio, Ashlee K. Bolger, Jennifer M. Brady, Nicole M. Sheanon, Amy B. Guiot, Corinne Lehmann, Francis J. Real Tags: Notes from the Association of Medical School Pediatric Department Chairs, Inc. Source Type: research

Medication safety in the home
Pediatricians in hospital-based specialties are well aware of the growing emphasis on patient safety, especially as it relates to medications. Most hospitals caring for children have adopted recognized best practices in medication ordering and administration, and track and report deviations from these practices to national databases. By many measures, these practices have improved the safety of inpatient pediatric care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Thomas R. Welch Tags: The Editors' Perspectives Source Type: research

To improve outcomes of prematurity, we must keep mothers healthy
Maternal mortality has steadily increased in the US over the last 2 decades, which has increased the focus on events that may threaten a mother's health and even her survival during pregnancy and childbirth. Although it is intuitive that a mother's health is linked to the outcome of her pregnancy, there are few studies that have explored the relationship between acute maternal illness at birth with long-term outcomes of prematurity. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Robin H. Steinhorn Tags: The Editors' Perspectives Source Type: research

Brain injury in congenital heart disease
Neurodevelopmental outcomes are quite important in patients with congenital heart disease. Studies with imaging have shown structural abnormalities that may be related to neurologic deficits. In this volume of The Journal, Claessens et al report on results comparing 2 cardiac surgery programs with different practice approaches to transition after birth, intensive care, and cardiac surgery. At both sites, MRI studies were done according to clinical protocol. The results confirm a high prevalence of brain injury at both sites. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Stephen R. Daniels Tags: The Editors' Perspectives Source Type: research

Exercise fitness at 14 years: Good news for antenatal corticosteroids
The lungs of infants born with very low birth weight (VLBW) are not normal at term, even without a history of prematurity associated lung disease. Their lungs can continue to remodel for perhaps 20 years to be functionally close to normal, but the effects of aging on the previously preterm lung remain essentially unknown. Lung function of infants born at normal term can be categorized into quartiles from lower to higher function. Remarkably, the children, and subsequently the adults, track within each quartile to at least 30 years of age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Alan H. Jobe Tags: The Editors' Perspectives Source Type: research

Predicting survival without disability after preterm birth: Some things we know, some things we should know more about
As a pediatrician, it is likely that at some point a patient's family, a friend, or a family member has asked you about a premature baby, and how that baby “will do.” They are likely interested in knowing more about their cognitive function and their neurodevelopmental outcomes. What can we expect, and what have we learned about affects these outcomes? These are difficult questions to answer, and we search for predictors that allow us to answer the se questions. In this volume of The Journal, Bourke et al present data from a large Western Australian registry covering ∼720 000 live births between 1983-2010 t...
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Clyde J. Wright Tags: The Editors' Perspectives Source Type: research

The clinical and genetic relationships of cystic fibrosis to immotile cilia syndrome
The symptomatology and clinical manifestations of cystic fibrosis (CF) lung disease and primary ciliary dyskinesia (PCD) are quite similar so that the diseases can masquerade as one another. Hannah et al evaluated the frequency of CFTR variants, the genetic basis for CG, in 1021 individuals referred for genetic testing for PCD and compared the results with 91 777 controls. The prevalence of single pathogenic CFTR variants was similar in the 2 groups so a single CFTR variant probably does not cause typical PCD symptoms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: Robert W. Wilmott Tags: The Editors' Perspectives Source Type: research

Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Source Type: research

How old am I really?
Telomeres are repetitive nucleotides sequences localized to the ends of each individual chromosome. They are replicated during each cellular division, but with each cell cycle they become progressively shorter. The problem is short telomeres are associated with dysregulation of cellular events such as senescence or cell death. The shortening process is accelerated by exposure to stress, smoking, obesity, lack of exercise, and poor diet. Many refer to this process as one of our “biological clocks.” In long-term studies, shortened telomeres are associated with adverse health outcomes including atherosclerosis, st...
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: James F. Padbury Tags: The Editors' Perspectives Source Type: research

Pulmonary Alveolar Microlithiasis in Children Less than 5  Years of Age
To collect all published cases up to January 2019 of pulmonary alveolar microlithiasis (PAM) in patients age 5  years and under and to compare their characteristics with those of the 1022 cases in the most recent all-age cohort published in 2015. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2019 Category: Pediatrics Authors: Elodie Sigur, Lea Roditis, Geraldine Labouret, Eric Bieth, Sophie Simon, Audrey Martin-Blondel, Marine Michelet, Marie Mittaine, Sylvain Blanchon Tags: Original Article Source Type: research

QTc Prolongation and Risk of Torsades de Pointes in Hospitalized Pediatric Oncology Patients
To evaluate the prevalence of torsades de pointes and to identify risk factors associated with QTc prolongation of ≥500 milliseconds in hospitalized pediatric oncology patients. A QTc prolongation of ≥500 milliseconds is associated with higher mortality in hospitalized adults but has not been demonstrated in pediatrics. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2019 Category: Pediatrics Authors: Tiffany R. Lim, Arun A. Rangaswami, Anne M. Dubin, Kristopher I. Kapphahn, Charlotte Sakarovitch, Jin Long, Kara S. Motonaga, Tony Trela, Scott R. Ceresnak Tags: Original Article Source Type: research

Transcranial Doppler Screening Adherence among Children with Sickle Cell Anemia Seen in the Emergency Department
To evaluate adherence to annual transcranial Doppler ultrasound (TCD) screening to prevent stroke among patients with sickle cell anemia (SCA) seen in the emergency department (ED). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2019 Category: Pediatrics Authors: Julie K. Weisman, Carrie E. Diamond, Sarah Kappa, Robert Sheppard Nickel Tags: Original Articles Source Type: research

Fitness and Fatness Are Both Associated with Cardiometabolic Risk in Preadolescents
To determine the associations between cardiorespiratory fitness (CRF) and fatness (overweight-obesity) with cardiometabolic disease risk among preadolescent children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 20, 2019 Category: Pediatrics Authors: Lee Stoner, Herman Pontzer, Bethany Barone Gibbs, Justin B. Moore, Nicholas Castro, Paula Skidmore, Sally Lark, Michelle A. Williams, Michael J. Hamlin, James Faulkner Tags: Original Article Source Type: research

Prenatal Exposure to Tobacco and Offspring Neurocognitive Development in the Healthy Start Study
To explore the associations between prenatal exposure to tobacco and neurocognitive development, in the absence of prematurity or low birth weight. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 20, 2019 Category: Pediatrics Authors: Brianna F. Moore, Allison L. Shapiro, Greta Wilkening, Sheryl Magzamen, Anne P. Starling, William B. Allshouse, John L. Adgate, Dana Dabelea Tags: Original Article Source Type: research

Reply
We thank van Summeren et  al for their interest in our systematic review on health-related quality of life (HRQoL) in children with functional constipation. They expressed their concerns on the use of either self-report or parent proxy report to assess HRQoL of children with functional constipation, and stress that a combi nation of both reports should be used in current clinical practice. This notion is largely based on their study on HRQoL in children with functional constipation and their parents in primary care practices. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 20, 2019 Category: Pediatrics Authors: Mana H. Vriesman, Ilan J. Koppen, Marieke van Dijk, Marc A. Benninga Tags: Letter to the Editor Source Type: research

Quality of life in children with functional constipation: Are child self-reports and parent proxy-reports interchangeable?
We thank Vriesman et  al for providing an extensive overview of the health-related quality of life (HRQoL) of children with functional constipation.1 HRQoL is identified as an important outcome when evaluating the effect of a treatment in both clinical trials and the doctor's office.2,3 As mentioned by the authors, the re is substantial debate who is the most appropriate respondent to assess children's HRQoL: the child itself or the parent(s).4 To examine the parent–child agreement, the authors compared the total HRQoL scores on the Pediatric Quality of Life Inventory questionnaire reported by children and paren...
Source: The Journal of Pediatrics - November 20, 2019 Category: Pediatrics Authors: Jojanneke J.G.T. Van Summeren, Gea A. Holtman, Janny H. Dekker, Marjolein Y. Berger Tags: Letters to the Editor Source Type: research

Corrigendum
In the article “A Total Sarnat Score in Mild Hypoxic-ischemic Encephalopathy Can Detect Infants at Higher Risk of Disability,” by Chalak et al (J Pediatr 2019;214:217-21.e1), the percent sensitivity for tone was incorrect. In the second paragraph in the Results section, the correct sentence should read “Of all categories examined, tone was the only one with an 86% sensitivity to detect disability but with a limited specificity of 30%.” Additionally, in Figure 1, the sensitivity and 95% CI for tone should read “.86 (0.42-0.99).” (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 20, 2019 Category: Pediatrics Tags: Correction Source Type: research

Statewide Pediatric Facility Recognition Programs and Their Association with Pediatric Readiness in Emergency Departments in the United States
To describe the relationship between statewide pediatric facility recognition (PFR) programs and pediatric readiness in emergency departments (EDs) in the US. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 19, 2019 Category: Pediatrics Authors: Travis M. Whitfill, Katherine E. Remick, Lenora M. Olson, Rachel Richards, Kathleen M. Brown, Marc A. Auerbach, Marianne Gausche-Hill Tags: Original Article Source Type: research

Provider Experience Recommending HPV Vaccination Before Age 11 Years
To describe health care providers' experiences recommending human papillomavirus (HPV) vaccination before age 11 years as part of a multisession intervention to improve HPV vaccination coverage. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 19, 2019 Category: Pediatrics Authors: Dea L. Biancarelli, Mari-Lynn Drainoni, Rebecca B. Perkins Tags: Original Article Source Type: research

Effect of Aspiration and Evaluation of Gastric Residuals on Intestinal Inflammation, Bleeding, and Gastrointestinal Peptide Level
To determine the effect of gastric residual aspiration and evaluation on preterm very low birth weight infants ’ gastrointestinal function, intestinal inflammation, and gastrointestinal mucosal bleeding. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 19, 2019 Category: Pediatrics Authors: Leslie A. Parker, Michael Weaver, Roberto J. Murgas Torrazza, Jonathon Shuster, Nan Li, Charlene Krueger, Josef Neu Tags: Original Article Source Type: research

Hiatal Hernia Presenting as Difficulty in Inserting Feeding Tube in a Neonate Born Preterm
A male infant was born preterm (28  weeks and 4 days gestation) by emergency cesarean delivery to a 40-year-old gravida 9, para 7 mother who presented with preterm premature rupture of membranes and breech presentation in labor. The Apgar scores were 5 and 8 at 1 and 5 minutes, respectively. Birth weight was 1130 g, and initial e xamination was unremarkable. He was intubated and treated with surfactant for respiratory distress syndrome and extubated to continuous positive airway pressure within 24 hours. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 19, 2019 Category: Pediatrics Authors: Sunil Joghee, Amuchou Singh Soraisham Tags: Insights and Images Source Type: research

Age-Specific Estimates and Comparisons of Youth Tri-Ponderal Mass Index and Body Mass Index in Predicting Adult Obesity-Related Outcomes
To estimate and compare tri-ponderal mass index (TMI) and body mass index (BMI) at each age from childhood to young adulthood in the prediction of adulthood obesity-related outcomes. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 19, 2019 Category: Pediatrics Authors: Feitong Wu, Marie-Jeanne Buscot, Harri Niinikoski, Suvi P. Rovio, Markus Juonala, Matthew A. Sabin, Antti Jula, Tapani R önnemaa, Jorma S.A. Viikari, Olli T. Raitakari, Costan G. Magnussen, Katja Pahkala Tags: Original Articles Source Type: research

Trends in Breastfeeding Interventions, Skin-to-Skin Care, and Sudden Infant Death in the First 6  Days after Birth
To determine if implementation of skin-to-skin care and the Baby-Friendly Hospital Initiative (BFHI) contributes to sudden unexpected infant death (SUID) and asphyxia in the first 6  days after birth. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 18, 2019 Category: Pediatrics Authors: Melissa Bartick, Mary Ellen Boisvert, Barbara L. Philipp, Lori Feldman-Winter Tags: Original Article Source Type: research

Alagille Syndrome and Chronic Arthritis: An International Case Series
We describe 10 children with Alagille syndrome and inflammatory arthritis. In our centers, the prevalence of chronic arthritis in patients with Alagille syndrome is approximately 50 times higher compared with the general population. Arthritis was refractory to most treatment. Patients with Alagille syndrome should routinely be screened for musculoskeletal symptoms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 17, 2019 Category: Pediatrics Authors: Giovanna Ferrara, Teresa Giani, Scott M. Lieberman, Courtney Kremer, Sandy Hong, Giuseppe Indolfi, Grant Schulert, Randy Q. Cron, Melissa L. Mannion, Sivia Lapidus, Wineke Armbrust, Emmanuel Gonzales, Emmanuel Jacquemin, Isabelle Kon é-Paut, Rolando Cima Tags: Brief Reports Source Type: research

Pediatric Heart Failure: An Evolving Public Health Concern
The care of children suffering from heart failure presents unique challenges that are inadequately met at the present time. In the pediatric population, a wide variety of disease processes can result in heart failure, including primary cardiomyopathy as well as an expanding population of children with palliated complex congenital heart disease (CHD). Regardless of the underlying etiology of heart failure, pediatric heart failure outcomes remain poor despite growing resource utilization. In addition, given the overlap in symptomatology between heart failure and more common childhood illnesses, the diagnosis of new-onset hea...
Source: The Journal of Pediatrics - November 15, 2019 Category: Pediatrics Authors: Stephanie J. Nakano, Shelley D. Miyamoto, Jack F. Price, Joseph W. Rossano, Antonio G. Cabrera Tags: Commentary Source Type: research

Children with Congenital Heart Disease Are Active but Need to Keep Moving: A Cross-Sectional Study Using Wrist-Worn Physical Activity Trackers
To compare daily physical activity of children with congenital heart disease (CHD) with healthy peers measured using wearables bracelets in a large cohort. Additionally, subjectively estimated and objectively measured physical activity was compared. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 15, 2019 Category: Pediatrics Authors: Leon Brudy, Julia Hock, Anna-Luisa H äcker, Michael Meyer, Renate Oberhoffer, Alfred Hager, Peter Ewert, Jan Müller Tags: Original Article Source Type: research

Reply
Digilio et  al contribute additional insight identifying atrioventricular canal defects (AVCD) as a partial feature of heterotaxy in Bardet-Biedl syndrome (BBS). Other ciliopathies (eg, oral-facial-digital syndrome) and syndromes associated with disruption of normal processing of Hedgehog proteins (eg, Ellis- van Creveld) likewise may be associated with AVCD. BBS provides a mechanistic model for ciliopathies demonstrating that disruption of regulatory pathways during embryogenesis results in diverse midline defects. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 15, 2019 Category: Pediatrics Authors: Robert M. Haws, Andrew J. Olson, Uzoma C. Okorie, Anthony D. Krentz Tags: Letter to the Editor Source Type: research

Strongyloides stercoralis Hyperinfection and Intractable Pulmonary Hemorrhage
A 10-year-old previously healthy boy, hailing from an Indian village had a history of hematuria, proteinuria, and generalized swelling for 3  months. This was diagnosed as crescentic glomerulonephritis on renal biopsy, and the patient was started on steroids. He presented with hypotensive shock and respiratory distress after a massive episode of hemoptysis following recurrent episodes of hemoptysis of small amounts for a month prior to this episode. Evaluation for causes of recurrent hemoptysis such as tuberculosis and pulmonary vasculitis were inconclusive. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 15, 2019 Category: Pediatrics Authors: Jhuma Sankar, Samriti Gupta, Raghavendra Lingaiah Tags: Insights and Images Source Type: research

The Role of Healthy Lifestyle Promotion, Counseling, and Follow-up in Noncommunicable Diseases Prevention
Several countries worldwide recently have experienced considerable transition in demography and disease epidemiology, characterized by falling rates of preventable communicable diseases and increased life expectancy. However, various factors, including the economy, education, food security, and access to proper healthcare and immunization programs, have led to unhealthy behaviors, inappropriate diets, and lack of physical activity, which have favored the development of noncommunicable diseases (NCD). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 15, 2019 Category: Pediatrics Authors: Tudor Lucian Pop, Leyla Namazova-Baranova, Julije Mestrovic, Luigi Nigri, Mehmet Vural, Michele Sacco, Ida Giardino, Pietro Ferrara, Massimo Pettoello-Mantovani Tags: European Paediatric Association Source Type: research

Risk Assessment and Monitoring of Chronic Pulmonary Hypertension in Premature Infants
The original description of bronchopulmonary dysplasia (BPD) included the finding that pulmonary vascular disease and right ventricular hypertrophy are associated with the high mortality of the disease.1 Today, chronic pulmonary hypertension persists as a major cause of morbidity and mortality of extremely premature infants.2,3 Although pulmonary hypertension can present in premature infants at different stages with varying hemodynamic signatures during the neonatal course, chronic pulmonary hypertension is characterized by late, sustained, and often progressive elevation of pulmonary artery pressure (PAP) that is diagnose...
Source: The Journal of Pediatrics - November 14, 2019 Category: Pediatrics Authors: Philip T. Levy, Amish Jain, Hythem Nawaytou, David Teitel, Roberta Keller, Jeffery Fineman, Robin Steinhorn, Steven H. Abman, Patrick J. McNamara, Pediatric Pulmonary Hypertension Network (PPHNet) Tags: Workshop/Symposium Summary Source Type: research

Parent Perspectives on Family-Based Psychosocial Interventions for Congenital Heart Disease
To identify parents' preferences for goals and structure of intervention programs to support the psychosocial needs of families impacted by congenital heart disease (CHD). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 14, 2019 Category: Pediatrics Authors: Colette Gramszlo, Allison Karpyn, Abigail C. Demianczyk, Amanda Shillingford, Erin Riegel, Anne E. Kazak, Erica Sood Tags: Original Article Source Type: research

Development and Validation of a Predictive Model of the Risk of Pediatric Septic Shock Using Data Known at the Time of Hospital Arrival
To derive and validate a model of risk of septic shock among children with suspected sepsis, using data known in the electronic health record at hospital arrival. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 13, 2019 Category: Pediatrics Authors: Halden F. Scott, Kathryn L. Colborn, Carter J. Sevick, Lalit Bajaj, Niranjan Kissoon, Sara J. Deakyne Davies, Allison Kempe Tags: Original Article Source Type: research

Newborn Screening for Mucopolysaccharidoses: Results of a Pilot Study with 100  000 Dried Blood Spots
To test, in a newborn screening (NBS) laboratory, the performance of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to assay 5 enzymatic activities in dried blood spots (DBS) for NBS of 5 lysosomal storage diseases (mucopolysaccharidosis [MPS]-II, MPS-IIIB, MPS-IVA, MPS-VI, and MPS-VII). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 12, 2019 Category: Pediatrics Authors: Clifford Ronald Scott, Susan Elliott, Xinying Hong, Jie-Yu Huang, Arun Babu Kumar, Fan Yi, Nagendar Pendem, Naveen Kumar Chennamaneni, Michael H. Gelb Tags: Original Articles Source Type: research

Physiotherapy for Children with Functional Constipation: A Pragmatic Randomized Controlled Trial in Primary Care
To determine the effectiveness of physiotherapy plus conventional treatment compared with conventional treatment alone for the treatment of functional constipation in children age 4-17  years in primary care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 12, 2019 Category: Pediatrics Authors: Jojanneke J.G.T. van Summeren, Gea A. Holtman, Boudewijn J. Kollen, Yvonne Lisman-van Leeuwen, Alice H.C. van Ulsen-Rust, Merit M. Tabbers, Janny H. Dekker, Marjolein Y. Berger Tags: Original Articles Source Type: research

A Bayesian Analysis to Determine the Prevalence of Barth Syndrome in the Pediatric Population
To determine the prevalence of Barth syndrome in the pediatric population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 12, 2019 Category: Pediatrics Authors: Paighton C. Miller, Mindong Ren, Michael Schlame, Matthew J. Toth, Colin K.L. Phoon Tags: Original Article Source Type: research

Birth Weight Gradient in Parent-Reported Special Healthcare Needs among Children Born Preterm
To characterize the association of birth weight with parent-reported special healthcare needs (SHCN) and unmet healthcare needs among children born prematurely. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 12, 2019 Category: Pediatrics Authors: Jaclyn Havinga, Dmitry Tumin, Leslie Peedin Tags: Original Article Source Type: research

Disorders of Adjustment, Mood, and Anxiety in Children and Adolescents Undergoing Heart Transplantation and the Association of Ventricular Assist Device Support
To assess the prevalence of psychiatric disorders and associated therapies in children during their heart transplantation admission. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 12, 2019 Category: Pediatrics Authors: Isaura Diaz, Cary Thurm, Matt Hall, Scott Auerbach, David W. Bearl, Debra A. Dodd, Bret A. Mettler, Andrew H. Smith, D. Catherine Fuchs, Justin Godown Tags: Original Article Source Type: research

Risk Factors for Red Blood Cell Transfusions in Children Undergoing Cardiac Catheterization
To identify risk factors associated with risk of red blood cell transfusions (RBCTs) following pediatric cardiac catheterizations. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 12, 2019 Category: Pediatrics Authors: R. Allen Ligon, Laura A. Downey, David L. Gruenewald, Holly D. Bauser-Heaton, Dennis W. Kim, Meredith F. Roman, Robert N. Vincent, Christopher J. Petit Tags: Original Article Source Type: research