Complementary medicines are not always complimentary in Down syndrome
Complementary and alternative medicines are taken by both adult and pediatric patients. Use of these products is commonplace, roughly 1 in 3 or more, among children with cancer, infectious diseases, autoimmune disorders, and many other conditions. Is usage similar in children with genetic syndromes, such as Down syndrome? (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research

Do you have patients treated with adalimumab? Know the safety profile
Adalimumab, a fully human antibody to tumor necrosis factor (TNF), was first approved by the Food and Drug Administration (FDA) in 2002 for the treatment of rheumatoid arthritis. In 2008, it was approved for treatment of polyarthritis juvenile idiopathic arthritis and has since been approved for other pediatric indications that cross several subspecialties, including dermatology, gastroenterology and ophthalmology. Thus, it is important for a growing number of pediatricians, including those in primary care, to be aware of the safety profile of this widely used biologic medication. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Philip J. Hashkes Tags: The Editors' Perspectives Source Type: research

Growth effects of combined psychotropic regimens
The past decades have seen an increase in the use of psychotropic medications in children and adolescents. Side effects of these agents have been well-described, such as appetite suppression and poor weight gain in youth being treated with stimulants and rapid weight gain in children being treated with atypical antipsychotics. However, youth with complex mental and behavioral disorders are often treated with combinations of psychotropic agents and the potential for side effects particular to these combinations are less well-understood. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Philip S. Zeitler Tags: The Editors' Perspectives Source Type: research

Decline in otitis media associated ambulatory visits in the US
Tapping into the nationally representative databases from the National Center for Health Statistics at the US Centers for Disease Control and Prevention, Kawai et al from Boston queried the number of otitis media associated ambulatory visits in children up to 18 years of age over the years 1997 to 2014. This interval spans years before universal use of pneumococcal conjugate vaccine (PCV) (before 2000), during PCV7 use, and since PCV13 use beginning in late 2010 in children 2 months through 59 months of age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Post Kawasaki disease exercise capacity
There have been questions about the long-term impact of Kawasaki disease on the heart. This impact could take many forms, but one is a decrease in exercise capacity. It seems possible that the degree to which the coronary arteries are affected during the acute illness might be related. In this volume of The Journal, Tuan et  al sought to evaluate exercise capacity between patients post Kawasaki disease with different coronary artery diameters. The diameter was evaluated using the lambda-mu-sigma (LMS) method. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Stephen R. Daniels Tags: The Editors' Perspectives Source Type: research

Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Source Type: research

Covariation of Neonatal Intensive Care Unit-Level Patent Ductus Arteriosus Management and In-Neonatal Intensive Care Unit Outcomes Following Preterm Birth
To test the hypothesis that neonatal intensive care unit (NICU)-specific changes in patent ductus arteriosus (PDA) management are associated with changes in local outcomes in preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: James I. Hagadorn, Mihoko V. Bennett, Elizabeth A. Brownell, Kurlen S.E. Payton, William E. Benitz, Henry C. Lee Tags: Original Articles Source Type: research

Adiposity in Adolescents: The Interplay of Sleep Duration and Sleep Variability
To assess whether adiposity measures differed according to joint categories of sleep duration and sleep variability in a sample of Mexican adolescents. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Erica C. Jansen, Galit Levi Dunietz, Ronald D. Chervin, Ana Baylin, Jonggyu Baek, Margaret Banker, Peter X.K. Song, Alejandra Cantoral, Martha Maria Tellez Rojo, Karen E. Peterson Tags: Original Articles Source Type: research

Lifestyle Clusters in School-Aged Youth and Longitudinal Associations with Fatness: The UP & DOWN Study
To identify lifestyle clusters in children and adolescents, to analyze associations between lifestyle clusters and body fat percentage (BFP) at baseline and 2 years later, and to examine if BFP at baseline is associated with BFP 2 years later. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: David S ánchez-Oliva, Alberto Grao-Cruces, Ana Carbonell-Baeza, Verónica Cabanas-Sánchez, Oscar L. Veiga, José Castro-Piñero Tags: Original Articles Source Type: research

Optimal Mean Arterial Blood Pressure in Extremely Preterm Infants within the First 24 Hours of Life
To define levels of mean arterial blood pressure (MABP) where cerebrovascular reactivity is strongest (MABPOPT) during the early transitional circulation in extremely preterm infants and to investigate the association between deviations above and below MABPOPT with intraventricular hemorrhage (IVH) and mortality. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Cristine Sortica da Costa, Marek Czosnyka, Peter Smielewski, Topun Austin Tags: Original Articles Source Type: research

Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity
To investigate the association between circulating 25-hydroxyvitamin D [25(OH)D] status at admission and disease severity among infants hospitalized for bronchiolitis and to determine whether the association differs by the form of 25(OH)D —total, bioavailable or free 25(OH)D. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Phuong Vo, Claire Koppel, Janice A. Espinola, Jonathan M. Mansbach, Juan C. Celed ón, Kohei Hasegawa, Megan Bair-Merritt, Carlos A. Camargo Tags: Original Articles Source Type: research

Reply
We thank Dr Kendall for his interest in our observational cohort study of 99 patients admitted to the pediatric cardiac ICU (CICU) of a tertiary care center, including 88 who underwent cardiac surgery and 11 who were admitted for medical reasons. We found an incidence of delirium of 57% (95% CI, 46%-67%) in the overall cohort, 59% (95% CI, 49%-69%; n = 52) in the surgical patients, and 36% (95% CI, 15%-65%; n = 4) in the medical patients. Delirious pediatric patients undergoing cardiac surgery were more likely to be male (P  = .018), to be younger (P  (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Rita V. Alvarez, Claire Levek Tags: Letters to the Editor Source Type: research

HIV –Associated Diffuse Intracranial Aneurysmal Arteriopathy
A 12-year-old boy presented with sudden weakness of his right upper and lower limbs, with facial deviation. He was HIV positive and was receiving antiretroviral therapy for 1 year. Cerebral computed tomography angiography of the brain revealed aneurysmal dilatation and dolichoectasia involving the intracranial vessels (Figure). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Sameer Vyas, Sandeep Moudgil, Ajay Kumar, Manoj Goyal Tags: Insights and Images Source Type: research

Reply
We appreciate the thoughtful letter by Drs Thienemann and Frankovich in response to our commentary in which we evaluated pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS) research and provided diagnostic and therapeutic recommendations. Their reply was framed in terms of decision-making under conditions of uncertainty, and they cogently described challenges faced by clinicians, particularly in the neurosciences, when we encounter suffering children and families and unclear underlying biology. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Donald L. Gilbert, Jonathan W. Mink, Frederick A. Horner, Harvey S. Singer Tags: Letters to the Editor Source Type: research

If You Build It, Will They Come? Getting Medical Professionals to Use the Bridge of Evidence for Improved Recognition of Physical Child Abuse
The old adage “you can prevent what you can predict” may very well be true, but only if the right people have access to the knowledge and if they apply it in a timely manner, correctly, consistently, and systematically. Unfortunately, the medical profession is known for its resistance to change and long lag t imes to adapt new evidence into practice.1,2 As reported by the Agency for Health Research and Quality, “It may take as long as one or two decades for original research to be put into routine clinical practice. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2018 Category: Pediatrics Authors: Mary Clyde Pierce Tags: Editorials Source Type: research

Executive Function and Psychosocial Quality of Life in School Age Children with Congenital Heart Disease
To test a model to predict psychosocial quality of life (QOL) in children with congenital heart disease (CHD) via executive dysfunction. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 19, 2018 Category: Pediatrics Authors: Jacqueline H. Sanz, Jichuan Wang, Madison M. Berl, Anna C. Armour, Yao I. Cheng, Mary T. Donofrio Tags: Original Articles Source Type: research

Development of a Dietary Methyl Donor Food Frequency Questionnaire to Assess Folate and Vitamin B12 Status in Children with Chronic Hepatitis B Virus Infection
To develop a dietary methyl donor food frequency questionnaire (DMD-FFQ) that is validated in a cohort of US children and to determine whether the consumption of folate and vitamin B12, principal DMDs, correlates with HBV DNA levels and its methylation density. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 19, 2018 Category: Pediatrics Authors: Douglas B. Mogul, Nga Brereton, Kathryn A. Carson, Maria Pittarelli, Hubert Daniel, Michael Torbenson, Kathleen B. Schwarz Tags: Original Articles Source Type: research

Preventing Childhood Obesity Through a Mindfulness-Based Parent Stress Intervention: A Randomized Pilot Study
To assess the feasibility of engaging stressed, low-income parents with obesity in a novel mindfulness-based parent stress intervention aimed at decreasing the risk of early childhood obesity. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 18, 2018 Category: Pediatrics Authors: Ania M. Jastreboff, Tara M. Chaplin, Sheridan Finnie, Mary Savoye, Matthew Stults-Kolehmainen, Wendy K. Silverman, Rajita Sinha Tags: Original Articles Source Type: research

Caregiver Perceptions about their Decision to Pursue Tracheostomy for Children with Medical Complexity
To describe the perceptions of caregivers of children with medical complexity (CMC) about their decision to pursue tracheostomy for their children, in particular the satisfaction with their decision. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 17, 2018 Category: Pediatrics Authors: Savithri Nageswaran, Shannon L. Golden, W. Adam Gower, Nancy M.P. King Tags: Original Articles Source Type: research

Adverse Childhood Experiences Are Associated with Unmet Healthcare Needs among Children with Autism Spectrum Disorder
To explore associations between level of adverse childhood experiences (ACEs) and unmet healthcare needs among children with autism spectrum disorder (ASD) using a population-based sample. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 14, 2018 Category: Pediatrics Authors: Kristin L. Berg, Cheng-Shi Shiu, Rebecca T. Feinstein, Michael E. Msall, Kruti Acharya Tags: Original Articles Source Type: research

Morphine vs Methadone Treatment for Infants with Neonatal Abstinence Syndrome
To estimate the relationship of initial pharmacotherapy with methadone or morphine and length of stay (LOS) in infants with neonatal abstinence syndrome (NAS) admitted to the neonatal intensive care unit (NICU). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 14, 2018 Category: Pediatrics Authors: Veeral N. Tolia, Karna Murthy, Monica M. Bennett, Rachel G. Greenberg, Daniel K. Benjamin, P. Brian Smith, Reese H. Clark Tags: Original Articles Source Type: research

Transcranial Doppler Ultrasonography Provides Insights into Neurovascular Changes in Children with Cerebral Malaria
To evaluate neurovascular changes in pediatric patients with cerebral malaria. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 14, 2018 Category: Pediatrics Authors: Nicole Fortier O'Brien, Tshimanga Mutatshi Taty, Melissa Moore-Clingenpeel, Joseph Bodi Mabiala, Jean Mbaka Pongo, Davin Ambitapio Musungufu, Mananu Uchama, Marcel Yotebieng Tags: Original Articles Source Type: research

Does Mechanical Bowel Preparation Reduce the Risk of Developing Infectious Complications in Pediatric Colorectal Surgery? A Systematic Review and Meta-Analysis
To evaluate whether the application of mechanical bowel preparation (MBP) before colorectal surgery reduces the risk of developing infectious complications in children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 12, 2018 Category: Pediatrics Authors: Koen Zwart, Dirk-Jan Van Ginkel, Caroline C.C. Hulsker, Marieke J. Witvliet, Maud Y.A. Van Herwaarden-Lindeboom Tags: Original Articles Source Type: research

Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia
To predict incident bloodstream infection and urinary tract infection (UTI) in infants with congenital diaphragmatic hernia (CDH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 11, 2018 Category: Pediatrics Authors: Karna Murthy, Nicolas F.M. Porta, Eugenia K. Pallotto, Natalie Rintoul, Sarah Keene, Louis Chicoine, Jason Gien, Beverly S. Brozanski, Yvette R. Johnson, Beth Haberman, Robert DiGeronimo, Isabella Zaniletti, Theresa R. Grover, Children's Hospitals Neonata Tags: Original Articles Source Type: research

An Adolescent with Left Ventricular Noncompaction and Ebstein Anomaly Presenting with Advanced Heart Failure: Discharge from Hospital with a Biventricular Assist Device
A 15-year-old adolescent presented to our emergency department (ED) for evaluation of shortness of breath, nonbilious, nonbloody vomiting, and abdominal pain that began 3 weeks before presentation. He also reported weight loss and constant fatigue for about 1 month, which prevented him from attending school. He complained of difficulty breathing with minimal exertion and could not perform many activities of daily living. He had not been able to sleep lying flat. He denied experiencing chest pain, palpitations, near syncope, or syncope. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 11, 2018 Category: Pediatrics Authors: Bibhuti B. Das, Maryanne Chrisant, Gerald Lavandosky, Megan Zakrzewski, Robert Winchester, Immanuel Turner, Steven Bibevski, Frank Scholl Tags: Grandrrounds Source Type: research

Healthier Choices in School Cafeterias: A Systematic Review of Cafeteria Interventions
To describe school cafeteria interventions in terms of a behavioral economics scheme and to assess which system is more likely to be effective in improving food selection or consumption. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 10, 2018 Category: Pediatrics Authors: Katelyn Gordon, Linda Dynan, Robert Siegel Tags: Original Articles Source Type: research

Next-Generation Evaluation and Treatment of Pediatric Acute Lymphoblastic Leukemia
Advancement in the diagnosis and treatment of pediatric acute lymphoblastic leukemia (ALL) is one of the greatest successes of modern medicine. Over the past 50 years, there has been a rapid increase in overall survival for pediatric ALL (Figure  1). Several factors have led to these remarkable improvements. First is the development of risk-adapted therapy based on both clinical and biological presenting features, as well as early response to treatment.2 Second, the effectiveness of molecularly targeted agents for specific genetic abnorma lities has boosted outcomes for some high-risk groups. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 10, 2018 Category: Pediatrics Authors: Emily B. Heikamp, Ching-Hon Pui Tags: Medical progress Source Type: research

Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia
To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 10, 2018 Category: Pediatrics Authors: Rachel Kadakia, Denise M. Scholtens, Gerald W. Rouleau, Octavious Talbot, Olga R. Ilkayeva, Tabitha George, Jami L. Josefson Tags: Original Articles Source Type: research

Longitudinal Self-Management and/or Transition Readiness per the TRxANSITION Index among Patients with Chronic Conditions in Pediatric or Adult Care Settings
To evaluate the roles of key individual, family, and illness characteristics on the levels of and gains in longitudinal healthcare transition (HCT) readiness in the pediatric setting and/or self-management skills (SMS) in the adult-focused setting, we used a large dataset with longitudinal measurements from 2006 to 2015. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 7, 2018 Category: Pediatrics Authors: Yi Zhong, Donna B. Gilleskie, Miranda A.L. van Tilburg, Stephen R. Hooper, Eniko Rak, Karina Javalkar, Meaghan Nazareth, Brian Pitts, Maggwa Ndugga, Nina Jain, Laura Hart, Suneet Bhansali, Jordan Richards, Randal K. Detwiler, Karin True, Alexandre S.F. de Tags: Original Articles Source Type: research

Applying the neonatal Early-Onset Sepsis calculator in cases of clinical chorioamnionitis at or after 34 weeks of gestation
Carola et  al questioned the diagnostic utility and hence the safety of the neonatal Early-Onset Sepsis (EOS) calculator.1 In a retrospectively studied cohort of 1159 infants born to mothers with clinical chorioamnionitis, the calculator would have missed 2 of 5 infants with culture-proven, early-onset sepsi s. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 7, 2018 Category: Pediatrics Authors: Pieter Degraeuwe Tags: Letters to the Editor Source Type: research

Early Glycemic Profile Is Associated with Brain Injury Patterns on Magnetic Resonance Imaging in Hypoxic Ischemic Encephalopathy
To investigate whether the early glycemic profile in infants with hypoxic ischemic encephalopathy is associated with distinct patterns of brain injury on magnetic resonance imaging (MRI). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 6, 2018 Category: Pediatrics Authors: Sudeepta K. Basu, Katherine Ottolini, Vedavalli Govindan, Suleiman Mashat, Gilbert Vezina, Yunfei Wang, Michaelande Ridore, Taeun Chang, Jeffrey R. Kaiser, An N. Massaro Tags: Original Articles Source Type: research

Protecting Our Nutrient Safety Net
Food insecurity, part of the complex matrix of poverty and toxic stress, is a significant health risk. Embarrassingly, the US ranks among the highest of the developed countries in the prevalence of food insecurity, with the prevalence of food insecurity higher than Canada, Australia, Germany, France, Denmark, Spain, and the United Kingdom.1 In 2016, 16.5% of US households with children reported food insecurity2; that is, 4.2 million households were unable to provide adequate food for their children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 6, 2018 Category: Pediatrics Authors: Sarah Jane Schwarzenberg, Claudia K. Fox Tags: Editorials Source Type: research

Early Postnatal Ventricular Dysfunction Is Associated with Disease Severity in Patients with Congenital Diaphragmatic Hernia
To assess patterns of postnatal ventricular function and their relationship to prenatal and postnatal markers of disease severity in infants with congenital diaphragmatic hernia (CDH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 6, 2018 Category: Pediatrics Authors: Neil Patel, Anna Claudia Massolo, Anshuman Paria, Emily J. Stenhouse, Lindsey Hunter, Emma Finlay, Carl F. Davis Tags: Original Articles Source Type: research

Maternal Lifetime Trauma and Birthweight: Effect Modification by In Utero Cortisol and Child Sex
To evaluate associations between maternal lifetime traumatic stress and offspring birthweight and examine modifying effects of third trimester cortisol and fetal sex. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 6, 2018 Category: Pediatrics Authors: Julie D. Flom, Yueh-Hsiu Mathilda Chiu, Hsiao-Hsien Leon Hsu, Katrina L. Devick, Kelly J. Brunst, Rebecca Campbell, Michelle Bosquet Enlow, Brent A. Coull, Rosalind J. Wright Tags: Original Articles Source Type: research

Risk of Bacterial Coinfections in Febrile Infants 60 Days Old and Younger with Documented Viral Infections
To determine the risk of serious bacterial infections (SBIs) in young febrile infants with and without viral infections. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 6, 2018 Category: Pediatrics Authors: Prashant Mahajan, Lorin R. Browne, Deborah A. Levine, Daniel M. Cohen, Rajender Gattu, James G. Linakis, Jennifer Anders, Dominic Borgialli, Melissa Vitale, Peter S. Dayan, T. Charles Casper, Octavio Ramilo, Nathan Kuppermann, Febrile Infant Working Group Tags: Original Articles Source Type: research

Persistent Hypoglycemia in Children: Targeted Gene Panel Improves the Diagnosis of Hypoglycemia due to Inborn Errors of Metabolism
To evaluate the role of next generation sequencing in genetic diagnosis of pediatric patients with persistent hypoglycemia. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Emanuela Ponzi, Arianna Maiorana, Francesca Romana Lepri, Mafalda Mucciolo, Michela Semeraro, Roberta Taurisano, Giorgia Olivieri, Antonio Novelli, Carlo Dionisi-Vici Tags: Original Articles Source Type: research

Improved Outcomes in Preterm Infants Fed a Nonacidified Liquid Human Milk Fortifier: A Prospective Randomized Clinical Trial
To compare growth, feeding tolerance, and clinical and biochemical evaluations in human milk-fed preterm infants randomized to receive either an acidified or a nonacidified liquid human milk fortifier. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Richard J. Schanler, Sharon L. Groh-Wargo, Bridget Barrett-Reis, Robert D. White, Kaashif A. Ahmad, Jeffery Oliver, Geraldine Baggs, Larry Williams, David Adamkin Tags: Original Articles Source Type: research

Variability in Antibiotic Prescribing for Upper Respiratory Illnesses by Provider Specialty
To evaluate variation in antibiotic prescribing between pediatric and nonpediatric providers for common upper respiratory illnesses. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Holly M. Frost, Huong Q. McLean, Brian D.W. Chow Tags: Original Articles Source Type: research

Timing of Information-Seeking about Infant Vaccines
To assess among pregnant and recently delivered women the timing of thinking about and seeking information about childhood vaccines and the preferred modes of vaccine education. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Sean T. O'Leary, Sarah E. Brewer, Jennifer Pyrzanowski, Juliana Barnard, Carter Sevick, Anna Furniss, Amanda F. Dempsey Tags: Original Articles Source Type: research

Comorbidities of Rare Epilepsies: Results from the Rare Epilepsy Network
To describe the prevalence and characteristics of comorbidities in persons with rare epilepsies. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Nhan Thi Ho, Barbara Kroner, Zachary Grinspan, Brandy Fureman, Kathleen Farrell, Jingzhou Zhang, Janice Buelow, Dale C. Hesdorffer, Rare Epilepsy Network Steering Committee Tags: Original Articles Source Type: research

Reply
We thank Koestenberger and Hansmann for their interest in our article on pulmonary artery acceleration time (PAAT) measures in preterm infants.1 The true prevalence of pulmonary vascular disease (PVD) and its most severe form, pulmonary hypertension (PH), in preterm infants has been difficult to discern due to the lack of reliable noninvasive indices to account for the main components of right ventricular (RV) afterload. Pulmonary artery acceleration time (PAAT) measures are validated, reliable estimates of invasive pulmonary hemodynamics in children and infants and provide a quantitative method for defining blood flow vel...
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Philip Thaler Levy, Meghna D. Patel, Gautam K. Singh Tags: Letters to the Editor Source Type: research

Familial Risk of Appendicitis: A Nationwide Population Study
To investigate the familial risk of appendicitis in the general population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Hao-Ming Li, Lee-Ren Yeh, Ying-Kai Huang, Mei-Yun Hsieh, Kuang-Hui Yu, Chang-Fu Kuo Tags: Original Articles Source Type: research

Advancement of Feeds in Preterm Low Birth Weight Infants
In the study by Singh et  al, the included subjects were infants born preterm with birth weights between 1500 and 2000 g.1 The swallowing reflex generally is developed in these neonates; thus, feeding by spoon, breast, or bottle is possible, and often they do not require gavage feeding. It would have been of more value and relevance had neonates of very low birth weight been included in the study, as necrotizing enterocolitis is more common in these tiny babies. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Apoorv Saxena, Subhash Chandra Shaw, Krishna M Adhikari Tags: Letters to the Editor Source Type: research

Timing of Umbilical Cord Clamping and Infant Brain Development
Delaying umbilical cord clamping (DCC) for at least 30-60  seconds after birth is recommended in preterm and full-term births.1,2 Compared with immediate cord clamping (ICC), DCC is associated with better hemodynamic stability, a decreased need for transfusions, and a lower risk of intraventricular hemorrhage and necrotizing enterocolitis in preterm infa nts.3 In full-term infants, DCC is associated with higher hemoglobin levels after birth, improved iron status at 4-6 months of age,4 and better neurodevelopment, especially in boys, at 4 years of age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Raghavendra Rao, Reeta Bora Tags: Editorials Source Type: research

Energy and Protein Intake During the Transition from Parenteral to Enteral Nutrition in Infants of Very Low Birth Weight
To evaluate the association between nutrition delivery practices and energy and protein intake during the transition from parenteral to enteral nutrition in infants of very low birth weight (VLBW). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 5, 2018 Category: Pediatrics Authors: Gustave H. Falciglia, Karna Murthy, Jane L. Holl, Hannah L. Palac, Yuliya Oumarbaeva, Donna M. Woods, Daniel T. Robinson Tags: Original Articles Source Type: research

Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth
To determine if measures of adverse childhood experiences and DNA methylation relate to indices of obesity in youth. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 31, 2018 Category: Pediatrics Authors: Joan Kaufman, Janitza L. Montalvo-Ortiz, Hannah Holbrook, Kerry O'Loughlin, Catherine Orr, Catherine Kearney, Bao-Zhu Yang, Tao Wang, Hongyu Zhao, Robert Althoff, Hugh Garavan, Joel Gelernter, James Hudziak Tags: Original Articles Source Type: research

Long-Term Academic Functioning following Cogmed Working Memory Training for Children Born Extremely Preterm: A Randomized Controlled Trial
To assess the effectiveness of Cogmed Working Memory Training compared with a placebo program in improving academic functioning 24 months post-training in extremely preterm/extremely low birth weight 7-year-olds. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 31, 2018 Category: Pediatrics Authors: Peter J. Anderson, Katherine J. Lee, Gehan Roberts, Megan M. Spencer-Smith, Deanne K. Thompson, Marc L. Seal, Chiara Nosarti, Andrea Grehan, Elisha K. Josev, Susan Gathercole, Lex W. Doyle, Leona Pascoe Tags: Original Articles Source Type: research

Racial Differences in Rates of Change of Childhood Body Mass Index and Blood Pressure Percentiles
To assess whether racial differences in rates of change in body mass index (BMI) and blood pressure (BP) percentiles emerge during distinct periods of childhood. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 31, 2018 Category: Pediatrics Authors: Ehimare Akhabue, Amanda M. Perak, Cheeling Chan, Philip Greenland, Norrina B. Allen Tags: Original Articles Source Type: research