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(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Source Type: research

The impact of COVID-19 on the scientific community —Highlighting The Journal's editorial commitment and two publications
We first want to thank our world-wide readers for all that you are doing in your hospital and in your community to assist during these unprecedented times. Many of you are on the front line; your efforts are deeply appreciated. We also offer our thoughts and prayers to all the victims of this global pandemic. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Meghan McDevitt, William F. Balistreri, Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Changes in weight early in life are important
As obesity and its complications have become an increasingly important health concern for children and adolescents, questions have been asked about potential critical periods for weight gain. A critical period is one in which excess weight gain is more likely to occur or a period in which excess weight gained is more likely to be persistent. In this volume of The Journal, Stock et al report on a study to determine the age during infancy and early childhood at which greater than expected gain in weight is associated with overweight in adolescence. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Stephen R. Daniels Tags: The Editors' Perspectives Source Type: research

Non-inferiority: Not a double negative
In this volume of The Journal, Kumar et al report the results of a “non-inferiority trial” designed to compare the effectiveness of oral paracetamol with oral ibuprofen in the setting of a symptomatic patent ductus arteriosus. Key elements of this study are that this was a randomized, controlled, head-to-head trial. They found that oral paracetamol was not infe rior to oral ibuprofen. The choice of a “non-inferiority” design is an important element of the investigators' strategy. In an accompanying editorial, Hicks et al provide an outstanding overview of how we should interpret this study design an...
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: James F. Padbury Tags: The Editors' Perspectives Source Type: research

Liver and kidney disease associated —Again!
Liver and kidney injury have been associated in several diseases, such as hepato-renal syndrome. In this volume of The Journal Yodoshi et al describe another association of liver disease and kidney disease. The authors investigated the prevalence of renal impairment in a large cohort of youths with histologically confirmed nonalchoholic fatty liver disease (NAFLD) and determined the association of kidney injury with liver disease severity. Clinical, laboratory, and histologic data were collected on 179 children in a retrospective study between 2010 to 2017. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Sharon P. Andreoli Tags: The Editors' Perspectives Source Type: research

Is COVID-19 an adverse childhood experience (ACE): Implications for screening for primary care
The report by DiGangi et al supports the feasibility of primary-care screening for adverse childhood experiences (ACEs) in pediatric primary care, however, significant controversy persists about the wisdom and clinical utility of implementing universal screening in pediatric primary care. In fact, many experts suggest that universal ACEs screening may introduce more harm than good. Instead, the study's findings provide an opportunity to raise awareness. Such a high prevalence of ACEs among children carries practical implications for primary care and public policy (https://www.acesaware.org/treat/clinical-assessment-treatme...
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Lee M. Sanders Tags: The Editors' Perspectives Source Type: research

Multisystem Inflammatory Syndrome in Children and Kawasaki Disease: Two Different Illnesses with Overlapping Clinical Features
In late April 2020, alarming news emerged from Europe that a group of children with evidence of recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection had developed a severe illness, manifesting fever, hypotension requiring inotropic support, severe abdominal pain, and myocardial dysfunction with marked elevation in cardiac damage markers. This syndrome has been named pediatric multisystem inflammatory syndrome in Europe, and multisystem inflammatory syndrome in children (MIS-C) by the US Centers for Disease Control and Prevention. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Anne H. Rowley Tags: Commentary Source Type: research

Reply
In our interim report describing the first 177 SARS-CoV-2 positive symptomatic pediatric patients presenting for care at our institution, 5 patients (3%) had an underlying diagnoses of diabetes. All five of these patients were female, ranging from 13-20 years of age. Four (4) of the five patients had Type 2 diabetes and only 1 patient had Type 1 diabetes. All of the patients had been diagnosed with diabetes from 1.5 to 9 years prior to their SARS-CoV-2 infection; none of these patients had new onset diabetes and none presented in diabetic ketoacidosis (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Roberta L. DeBiasi Tags: Letters to the Editor Source Type: research

Parents of Children with Sickle Cell Disease Are Interested in Preimplantation Genetic Testing
To evaluate awareness of and attitudes toward preimplantation genetic testing (PGT) for sickle cell disease (SCD) among parents of children with SCD. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Monica Attia, Shawn Kripalani, Isha Darbari, Robert Sheppard Nickel Tags: Original Articles Source Type: research

National Variations in Recent Trends of Sudden Unexpected Infant Death Rate in Western Europe
to study recent epidemiological trends of sudden unexpected death in infancy (SUDI) in Western Europe. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Sophie de Visme, Martin Chalumeau, Karine Levieux, Hugues Patural, Inge Harrewijn, Elisabeth Briand Huchet, Gr égoire Rey, Claire Morgand, Béatrice Blondel, Christèle Gras-Le Guen, Matthieu Hanf Tags: Original Articles Source Type: research

Decreased Incidence of Hepatic Artery Thrombosis in Pediatric Liver Transplantation Utilizing Technical Variant Grafts: Report of the Society of Pediatric Liver Transplantation (SPLIT) Experience
To evaluate risk factors for hepatic artery thrombosis (HAT) and examine the long-term outcomes of graft and patient survival following HAT in pediatric recipients of liver transplantation. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Noelle H. Ebel, Evelyn K. Hsu, Andr é A.S. Dick, Michele L. Shaffer, Kristen Carlin, Simon P. Horslen Tags: Original Articles Source Type: research

Professional Obligations of Clinicians and Institutions in Pediatric Care Settings During a Public Health Crisis: A Review
Since March of 2020, pediatric clinicians have faced unprecedented disruption in the care of children due to the public health crisis caused by the coronavirus 2019 (COVID-19) pandemic, previously named 2019 novel coronavirus and abbreviated 2019-nCoV.1 Although serious illness following infection in children is rare, limitations in testing capability, unique symptomatology, and rapidly changing public health conditions have constrained our ability to fully grasp the direct impact of COVID-19 on child health. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Naomi T. Laventhal, Ratna B. Basak, Mary Lynn Dell, Nannette Elster, Gina Geis, Robert C. Macauley, Mark R. Mercurio, Douglas J. Opel, David I. Shalowitz, Mindy B. Statter, Douglas S. Diekema Tags: AMSPDC Source Type: research

Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki Disease: Two Different Illnesses with Overlapping Clinical Features
In late April 2020, alarming news emerged from Europe that a group of children with evidence of recent SARS-CoV-2 infection had developed a severe illness, manifesting fever, hypotension requiring inotropic support, severe abdominal pain, and myocardial dysfunction with marked elevation in cardiac damage markers. This syndrome has been named Pediatric Multisystem Inflammatory Syndrome in Europe, and Multisystem Inflammatory Syndrome in Children (MIS-C) by the U.S. Centers for Disease Control (CDC). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 22, 2020 Category: Pediatrics Authors: Anne H. Rowley Tags: Commentary Source Type: research

Reply
We thank Drs Roberts and Wald for their interest in our article. However, the calculations presented in the first paragraph of their letter are misleading because they assume the “best case scenario” in favor of the authors' argument. Only when both prevalence of urinary tract infection (UTI) and false positive rate of on currently-available point-of-care tests for pyuria are 5% would the prevalence of true missed UTI without pyuria (ie, 0.25%) approach that of asymptoma tic bacteriuria without pyuria (0.21%, the overall rate of asymptomatic bacteriuria without pyuria from our study). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2020 Category: Pediatrics Authors: Nader Shaikh Tags: Letter to the editor Source Type: research

Sitting Height to Standing Height Ratio Reference Charts for Children in the United States
To create reference charts for Sitting height to standing height ratio (SitHt/Ht) for children in the United States, and to describe the trajectory of SitHt/Ht during puberty. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2020 Category: Pediatrics Authors: Colin Patrick Hawkes, Sogol Mostoufi-Moab, Shana E. McCormack, Adda Grimberg, Babette S. Zemel Tags: Original Articles Source Type: research

Correction
In the article “The Contribution of the Adipose Tissue-Liver Axis in Pediatric Patients with Nonalcoholic Fatty Liver Disease after Laparoscopic Sleeve Gastrectomy” (J Pediatr 2020;216:117–127.e2) one of the author's names was listed incorrectly. The author's name should read Alessandra Salvatori, MD. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 20, 2020 Category: Pediatrics Tags: Correction Source Type: research

Body mass index rebound, weight gain in puberty, and risk of cardiovascular disease
Yuan et al [1] identified 3 groups with distinct trajectories in body mass index (BMI) related to cardiovascular disease (CVD) risk in adulthood by analyses of a dataset with 30 years of follow-up in a population in northern China. Among the three groups characterized as low-, moderate-, and high-increasing, based on the rate of BMI increase, the high-increasing group (11.9% of 2,789 total participants) had the highest rate of CVD in adulthood. This group had relatively moderate initial BMI levels, but BMI then increased steeply from about age 12 years and exceeded BMI in the moderate-increasing group at age 18 years. (Sou...
Source: The Journal of Pediatrics - June 19, 2020 Category: Pediatrics Authors: Osamu Arisaka, Go Ichikawa, Satomi Koyama, Toshimi Sairenchi Tags: Letters to the Editor Source Type: research

Reply
Osamu et al identified a distinct increase in BMI after puberty that is probably not related to early adiposity rebound. We consider this to be a valuable point. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 19, 2020 Category: Pediatrics Authors: Yue Yuan, Jian-Jun Mu, Yang Wang, Chen Chen Tags: Letters to the Editor Source Type: research

Anticipating Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Testing, Licensure, and Recommendations for Use
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China and its rapid spread throughout the world, inflicting enormous morbidity and mortality, clearly highlights the need for safe and effective vaccines.1 Many countries and pharmaceutical companies are moving rapidly to design and test such vaccines; the World Health Organization has listed more than 120 candidates in various stages of development.2 As we quickly embark on the pursuit of vaccines to prevent coronavirus disease 2019 (COVID-19), many are concerned that the rapidity with which these studies are being conducted will mean that va...
Source: The Journal of Pediatrics - June 18, 2020 Category: Pediatrics Authors: Kathryn M. Edwards, Walter A. Orenstein Tags: Commentary Source Type: research

Anticipating SARS-CoV-2 Vaccine Testing, Licensure, and Recommendations for Use
K.E. receives contract funding from the NIH and CDC and is a consultant to BioNet, IBM, and Merck and is on Data Safety and Monitoring Committees for Sanofi, Moderna, Pfizer, and X-4 Pharma. W.O. declares no conflicts of interest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 18, 2020 Category: Pediatrics Authors: Kathryn M. Edwards, Walter A. Orenstein Tags: Commentary Source Type: research

SARS-CoV-2 Infection in Infants Less than 90  Days Old
This is a single-center US case series of 18 infants (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 17, 2020 Category: Pediatrics Authors: Leena B. Mithal, Kerri Z. Machut, William J. Muller, Larry K. Kociolek Tags: Brief Reports Source Type: research

A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003
To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in 2 Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 17, 2020 Category: Pediatrics Authors: Xiaoli Xiong, Gilbert T. Chua, Shuiqing Chi, Mike Yat Wah Kwan, Wilfred Hing Sang Wong, Aifen Zhou, Chi Chiu Shek, Keith T.S. Tung, Huan Qin, Rosa S. Wong, Xue Li, Peng Chen, Shuai Li, Celine S. Chui, Winnie W.Y. Tso, Marco H.K. Ho, Ian C.K. Wong, Godfrey Tags: Original Articles Source Type: research

A Comparison Between Chinese Children Infected with COVID-19 and with SARS
To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in two Chinese pediatric cohorts, given that the causative pathogens and are biologically similar., (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 17, 2020 Category: Pediatrics Authors: Xiaoli Xiong, Gilbert T. Chua, Shuiqing Chi, Mike Yat Wah Kwan, Wilfred Hing Sang Wong, Aifen Zhou, Chi Chiu Shek, Keith TS. Tung, Huan Qin, Rosa S. Wong, Xue Li, Peng Chen, Shuai Li, Celine S. Chui, Winnie WY. Tso, Marco HK. Ho, Ian CK. Wong, Godfrey CF. Tags: Original Articles Source Type: research

SARS-CoV-2 Infection in Infants Less than 90 Days Old
This is a single-center US case series of 18 infants days old who tested positive for SARS-CoV-2. These infants had a mild febrile illness without significant pulmonary disease. One half were hospitalized; one had bacterial urinary tract co-infection. Nasopharyngeal viral loads were notably high. Latinx ethnicity was overrepresented. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 17, 2020 Category: Pediatrics Authors: Leena B. Mithal, Kerri Z. Machut, William J. Muller, Larry K. Kociolek Tags: Brief Reports Source Type: research

Early Weight Gain Forecasts Accelerated Eruption of Deciduous Teeth and Later Overweight Status during the First Year
To determine whether early diet and weight gain velocity have independent or interactive effects on deciduous teeth emergence and overweight status during the first year. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 15, 2020 Category: Pediatrics Authors: Julie A. Mennella, Ashley Reiter, Benjamin Brewer, Ryan T. Pohlig, Virginia A. Stallings, Jillian C. Trabulsi Tags: Original Articles Source Type: research

The Impact of Rapid Exome Sequencing on Medical Management of Critically Ill Children
To evaluate the clinical utility of rapid exome sequencing (rES) in critically ill children with likely genetic disease using a standardized process at a single institution. To provide evidence that rES with should become standard of care for this patient population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 15, 2020 Category: Pediatrics Authors: Amanda S. Freed, Sarah V. Clowes Candadai, Megan C. Sikes, Jenny Thies, Heather M. Byers, Jennifer N. Dines, Mesaki Kenneth Ndugga-Kabuye, Mallory B. Smith, Katie Fogus, Heather C. Mefford, Christina Lam, Margaret P. Adam, Angela Sun, John K. McGuire, Rob Tags: Original Articles Source Type: research

Reductions in Parent Interest in Receiving Antibiotics Following a 90-Second Video Intervention in Outpatient Pediatric Clinics
To assess the impact of a 90-second animated video on parents ’ interest in receiving an antibiotic for their child. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 15, 2020 Category: Pediatrics Authors: Kathy Goggin, Emily A. Hurley, Andrea Bradley-Ewing, Carey Bickford, Brian R. Lee, Kimberly Pina, Evelyn Donis De Miranda, Alexander Mackenzie, David Yu, Kirsten Weltmer, Sebastian Linnemayr, Christopher C. Butler, Melissa Miller, Jason G. Newland, Angela Tags: Original Articles Source Type: research

Adverse Childhood Experiences are Associated with Childhood-Onset Arthritis in a National Sample of US Youth: An Analysis of the 2016 National Survey of Children's Health
To determine whether there is an association between adverse childhood experiences (ACEs) and childhood-onset arthritis, comparing youth with arthritis to both healthy youth and youth with other acquired chronic physical diseases (OCPD); and to examine whether ACEs are associated with disease-related characteristics among children with arthritis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 15, 2020 Category: Pediatrics Authors: Tamar B. Rubinstein, Danielle R. Bullock, Kaveh Ardalan, Wenzhu B. Mowrey, Nicole M. Brown, Laurie J. Bauman, Ruth EK. Stein Tags: Original Articles Source Type: research

Age differentiation in children with asthma treated with intravenous magnesium sulphate
With great interest we read the article by Johnson et al regarding intravenous magnesium sulphate (IVMg) in children between 2 and 17 years with acute asthma.1 The authors reported that clinicians used IVMg in 10.5% of 60,000 children visiting with asthma. Other findings include highly variable use between centers, mostly in moderate and severe asthma cases, late administration of IVMg in the emergency department and low return rates of treated children within 72 hours after discharge. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2020 Category: Pediatrics Authors: Marlon van Weelden, Bart E. van Ewijk, Frans B. Pl ötz Tags: Letters to the Editor Source Type: research

Reply
As van Weelden et al recognize, there is ongoing debate and investigation to understand how best to treat children with wheezing, and whether young children with wheezing benefit from the same asthma treatment as older children. Though we did not subdivide our published analysis by age, analyzing children 2-5 years separately from those older than 5 years, our unpublished data includes 7,737 visits for asthma treatment in children younger than 2 years old. In 407 of these visits children received IVMg, and use of IVMg varied by site similar to the published dataset. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2020 Category: Pediatrics Authors: Michael D. Johnson, Joseph J. Zorc, for the Pediatric Emergency Care Applied Research Network (PECARN) Tags: Letters to the Editor Source Type: research

Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-institutional Study from New York City
To assess clinical characteristics and outcomes of severe acute respiratory syndrome coronavirus 2-associated multisystem inflammatory syndrome in children (MIS-C). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Shubhi Kaushik, Scott I. Aydin, Kim R. Derespina, Prerna B. Bansal, Shanna Kowalsky, Rebecca Trachtman, Jennifer K. Gillen, Michelle M. Perez, Sara H. Soshnick, Edward E. Conway, Asher Bercow, Howard S. Seiden, Robert H. Pass, Henry M. Ushay, George Ofori Tags: Original Articles Source Type: research

Changes in Physical Activity and Sedentary Patterns on Cardiometabolic Outcomes in the Transition to Adolescence: ICAD 2.0
To examine the associations of changes in physical activity and sedentary-patterns with changes in cardiometabolic outcomes from childhood to adolescence. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Pedro B. J údice, Megan Hetherington-Rauth, Kate Northstone, Lars Bo Andersen, Niels Wedderkopp, Ulf Ekelund, Luís B. Sardinha, International Children’s Accelerometry Database (ICAD) Collaborators Tags: Original Articles Source Type: research

Disseminated Intravascular Coagulation Is an Independent Predictor of Adverse Outcomes in Children in the Emergency Department with Suspected Sepsis
To evaluate the impact of early disseminated intravascular coagulation (DIC) on illness severity in children using a database of ED encounters for children with suspected sepsis, in view of similar associations in adults. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Leonora R. Slatnick, Dianne Thornhill, Sara J. Deakyne Davies, James B. Ford, Halden F. Scott, Marilyn J. Manco-Johnson, Beth Boulden Warren Tags: Original Articles Source Type: research

Cardiovascular Outcomes in Young Adulthood in a Population-Based Very Low Birth Weight Cohort
To assess differences in left heart structure and function, and endothelial function in a national cohort of very low birth weight (VLBW) young adults and term-born controls. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: S.L. Harris, H. Bray, R. Troughton, J. Elliott, C. Frampton, J. Horwood, B.A. Darlow Tags: Original Articles Source Type: research

Synthetic Surfactant CHF5633 compared with Poractant Alfa in the Treatment of Neonatal Respiratory Distress Syndrome: A Multicenter, Double Blind, Randomized, Controlled Clinical Trial
To compare efficacy and safety of a new synthetic surfactant, CHF5633, enriched with surfactant proteins, SP-B and SP-C peptide analogues, with porcine surfactant, poractant alfa for the treatment of respiratory distress syndrome (RDS) in preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Rangasamy Ramanathan, Manoj Biniwale, Krishnamurthy Sekar, Nazeeh Hanna, Sergio Golombek, Jatinder Bhatia, Martha Naylor, Laura Fabbri, Guido Varoli, Debora Santoro, Dorothea Del Buono, Annalisa Piccinno, Christiane E. Dammann Tags: Original Articles Source Type: research

Assessment of Platelet Thrombus Formation under Flow Conditions in Patients with Acute Kawasaki Disease
To assess platelet thrombus formation (T-TAS) under flow conditions in patients with Kawasaki disease. Previously available platelet activation data were limited for non-physiological shear stress condition. The total thrombus-formation analysis system (T-TAS ®) was developed for quantitative PTF analysis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Nobuyuki Tsujii, Keiji Nogami, Hiroyuki Yoshizawa, Toshiyuki Sakai, Kazuyoshi Fukuda, Akira Ishiguro, Midori Shima Tags: Original Articles Source Type: research

International Experience of US Pediatricians and Level of Comfort Caring for Immigrant Children and Children Traveling Internationally
To determine if international experience is associated with greater comfort in providing care to U.S. children who are immigrants, refugees, and traveling internationally. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Sabrina M. Butteris, JoAnna K. Leyenaar, Laurel K. Leslie, Adam L. Turner, Maneesh Batra, Global Health Task Force of the American Board of Pediatrics Tags: Original Articles Source Type: research

Reducing Abdominal Radiographs to Diagnose Constipation in the Pediatric Emergency Department
To determine the frequency of abdominal radiographs obtained in healthy children aged 6 months to 18 years to diagnose constipation in a pediatric emergency department, and evaluate the impact of quality improvement (QI) interventions on their use. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Gabriela Moriel, Theresa Tran, Phung K. Pham, Danica B. Liberman Tags: Original Articles Source Type: research

The Left Heart, Systemic Circulation and Bronchopulmonary Dysplasia: Relevance to Pathophysiology and Therapeutics
Improved survival at extremes of gestational age (GA) ( ≤25 weeks) has led to an increase in the number of infants with bronchopulmonary dysplasia (BPD), the most common respiratory complication of preterm birth. The consensus definition of ‘severe’ BPD is requirement of ≥30% oxygen and/or positive pressure respiratory support (1). BPD is a heter ogeneous disease, with variable contributions from parenchymal, pulmonary arterial and pulmonary venous components. In the post-surfactant era, the disease is mainly characterised histologically by fewer, larger and simplified alveoli with heavily muscularized pu...
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Arvind Sehgal, Jarno J. Steenhorst, Daniel I. Mclennan, Daphne Merkus, Dunbar Ivy, Patrick J. McNamara Tags: Medical Progress Source Type: research

Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants: Neomune-NeoNutriNet Cohort Study
To determine whether commencement of antibiotics within 3 postnatal days in preterm, very low birth weight infants (VLBW, ≤1500 g), is associated with the development of necrotizing enterocolitis (NEC). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Yanqi Li, Ren é Liang Shen, Adejumoke I. Ayede, Janet Berrington, Frank H. Bloomfield, Olubunmi O. Busari, Barbara E. Cormack, Nicholas D. Embleton, Johannes B. van Goudoever, Gorm Greisen, Zhongqian He, Yan Huang, Xiaodong Li, Hung-Chih Lin, Jiaping Mei Tags: Original Articles Source Type: research

Characteristics, Cardiac involvement, and Outcomes of Multisystem Inflammatory Disease of Childhood (MIS-C) Associated with SARS-CoV-2 Infection
We report on the presentation and course of 33 children with multisystem inflammatory syndrome in children (MIS-C) and confirmed SARS-CoV-2 infection. Hemodynamic instability and cardiac dysfunction were prominent findings, with most patients exhibiting rapid resolution following anti-inflammatory therapy. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Christine A. Capone, Anupama Subramony, Todd Sweberg, James Schneider, Sareen Shah, Lorry Rubin, Charles Schleien, the Northwell Health COVID-19 Research Consortium, Shilpi Epstein, Jennifer C. Johnson, Aaron Kessel, Nila Misra, Elizabeth Mitchell, Nancy Tags: Brief Reports Source Type: research

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection: A Multi-institutional Study from New York City
To assess clinical characteristics and outcomes of SARS-CoV-2 associated multisystem inflammatory syndrome in children (MIS-C). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Shubhi Kaushik, Scott I. Aydin, Kim R. Derespina, Prerna B. Bansal, Shanna Kowalsky, Rebecca Trachtman, Jennifer K. Gillen, Michelle M. Perez, Sara H. Soshnick, Edward E. Conway, Asher Bercow, Howard S. Seiden, Robert H. Pass, Henry M. Ushay, George Ofori Tags: Original Articles Source Type: research

Blacks/African Americans with Pediatric Crohn ’s Disease Report Less Anxiety and Fatigue than Whites
To compare patient reported outcomes in Blacks/African Americans with Whites participating in IBD Partners Kids& Teens, in order to identify possible racial health care disparities in pediatric inflammatory bowel disease (IBD) as future targets for improvement. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Arielle Grossman, Elizabeth Mauer, Linda M. Gerber, Millie D. Long, Michael D. Kappelman, Neera Gupta Tags: Original Articles Source Type: research

Risk Factors for Severe Anaphylaxis in Children
To identify risk factors associated with severe anaphylaxis in children (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2020 Category: Pediatrics Authors: Mikel Olabarri, Paula Vazquez, Aranzazu Gonzalez-Posada, Nuria Sanz, Sebasti à Gonzalez-Peris, Nuria Diez, Ana Vinuesa, Lorea Martinez-Indart, Javier Benito, Santiago Mintegi Tags: Original Articles Source Type: research

Neonatal antibiotics and infantile colic in term-born infants
Salvatore et  al1 assessed the prevalence of functional gastrointestinal disorders (FGIDs) in the first year of life and the influence of different neonatal factors on the development of FGIDs. In 42% of term-born infants, infantile colic was diagnosed by the Rome III criteria through standardized interviews at 1, 3, 6, and 12 months. A high percentage of full-term infants received antibiotics at birth (22%), although severe acute infection was an exclusion criterion for the study. An important finding was that antibiotic use in the first week of life was associated with an increased risk of infantile co lic in (...
Source: The Journal of Pediatrics - June 12, 2020 Category: Pediatrics Authors: Kim Kamphorst, Berthe C. Oosterloo, Arine M. Vlieger, Ruurd M. van Elburg Tags: Letters to the Editor Source Type: research

Coronavirus disease 2019, Kawasaki disease, and multisystem inflammatory syndrome in children
There has been a rise in the number of critically ill patients presenting with an unusual clinical picture; all have in common features of Kawasaki disease and a confirmed or suspected coronavirus disease 2019 (COVID-19) infection. According to Harahsheh et  al, the diagnosis/treatment of Kawasaki disease was missed or delayed owing to the forced lockdown and doctors being focused on treating patients with COVID-19.1 A similar concern was shared by adult cardiologists, who observed a significant drop of admissions to coronary intensive care units beca use patients with acute myocardial infarction were afraid to risk i...
Source: The Journal of Pediatrics - June 12, 2020 Category: Pediatrics Authors: Pier Paolo Bassareo, Giuseppe Calcaterra, Vassilios Fanos Tags: Letters to the Editor Source Type: research

Neonatal antibiotics and infantile colic in term born infants
Salvatore et al assessed the prevalence of functional gastrointestinal disorders (FGIDs) in the first year of life and the influence of different neonatal factors on development of FGIDs.(1) In 42% of term born infants, infantile colic was diagnosed by Rome III criteria through standardized interviews at 1, 3, 6, and 12 months. A high percentage of full-term infants received antibiotics at birth (22%) although severe acute infection was an exclusion criteria for the study. An important finding was that antibiotics in the first week of life was associated with an increased risk of infantile colic in (pre)term born infants (...
Source: The Journal of Pediatrics - June 12, 2020 Category: Pediatrics Authors: Kim Kamphorst, Berthe C. Oosterloo, Arine M. Vlieger, Ruurd M. van Elburg Tags: Letters to the Editor Source Type: research

Reply
We thank van Elburg et al for their interest and comment on our report. The authors pointed out that the INCA study reported an increased risk of infantile colic in term infants treated with a 7-day course of antibiotics compared with infants treated for a 2-days course and to healthy controls (2). We acknowledged that at the time of drafting our manuscript we could not retrieve their paper from Medline search. Moreover, we stated that our study was the first to assess the effect of both neonatal antibiotics and preterm delivery on all functional gastrointestinal disorders (FGIDs). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 12, 2020 Category: Pediatrics Authors: Maria Elisabetta Baldassarre, Silvia Salvatore, Antonio Di Mauro, Gianvincenzo Zuccotti, Nicola Laforgia, Massimo Agosti Tags: Letters to the Editor Source Type: research

Covid-19, Kawasaki disease, and Multisystem Inflammatory Syndrome in Children
There has been a rise in the number of critically ill patients presenting with an unusual clinical picture; all have in common features of Kawasaki disease and a confirmed or suspected Covid-19 infection. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 12, 2020 Category: Pediatrics Authors: Pier Paolo Bassareo, Giuseppe Calcaterra, Vassilios Fanos Tags: Letters to the Editor Source Type: research