Steroid Free Treatment of Autoimmune Hepatitis in Selected Children
In this report, we describe our experience in treating selected asymptomatic children with autoimmune hepatitis using a steroid-free regimen; this treatment strategy was safe and effective in inducing remission. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: Andrew Wehrman, Orith Waisbourd-Zinman, Amit Shah, Didja Hilmara, Henry Lin, Elizabeth B. Rand Tags: Clinical and Laboratory Observations Source Type: research

Testing umbilical cord tissue for drugs: Lower analytical limits, better concordance with meconium results
Colby et  al discussed the equivalency of umbilical cord and meconium testing to evaluate in utero exposure to drugs.1 The authors applied “commercial” umbilical cord tissue and gold standard meconium toxicology tests for detection of several drugs in paired umbilical cord and meconium samples from 501 neonates. The results in both specimens were often discordant. However, the overall prevalence of drugs in umbilical cord and meconium was similar for several groups, and the agreement between both specimens ranged from 80% to 100%. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: Adam Negrusz, Joseph Jones Tags: Letters to the Editor Source Type: research

The Association of the Body Composition of Children with 24-Hour Activity Composition
To evaluate how the reallocation of time between sleep, sedentary time, light, and moderate-vigorous activities is associated with children's body composition. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 28, 2019 Category: Pediatrics Authors: Dorothea Dumuid, Melissa Wake, Susan Clifford, David Burgner, John B. Carlin, Fiona K. Mensah, Fran çois Fraysse, Kate Lycett, Louise Baur, Timothy Olds Tags: Original Article Source Type: research

Data Science for Child Health
Data science has revolutionized industry and academic fields including marketing,1 astronomy,2 and computer vision.3 It has not yet impacted medicine and biomedical research to the same degree. However, many observers4-6 believe that data science will improve the ability of health care systems to deliver personalized medicine,7 population health,8 and public health.9 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 24, 2019 Category: Pediatrics Authors: Tellen D. Bennett, Tiffany J. Callahan, James A. Feinstein, Debashis Ghosh, Saquib A. Lakhani, Michael C. Spaeder, Stanley J. Szefler, Michael G. Kahn Tags: Medical Progress Source Type: research

50 Years Ago in The Journal of Pediatrics
Strauss RG, Schubert WK, McAdams AJ. J Pediatr 1969;74:272-82 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Philip J. Hashkes Tags: 50 Years Ago Source Type: research

Corrigendum
In the article “An Ounce of Prevention May Be Worth Many Pounds of Cure” (J Pediatr 2018;195:13-15) one of the author's names was unfortunately misspelled. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Tags: Correction Source Type: research

50 Years Ago in The Journal of Pediatrics
Milman D. J Pediatr 1969;74:283-90 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Stephanie N. Ferrin, Mary A. Ott Tags: 50 Years Ago Source Type: research

50 Years Ago in The Journal of Pediatrics
White LR, Sever JL, Alepa FP. J Pediatr 1969;74:198-207. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Pooja Dewan, Piyush Gupta Tags: 50 Years Ago Source Type: research

50 Years Ago in The Journal of Pediatrics
Root AW, Saenz-Rodriguez C, Bongiovanni AM, Eberlein WR. J Pediatr 1969;74:187-97. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Walter Zegarra, Ron Rosenfeld, David M. Maahs Tags: 50 Years Ago Source Type: research

50 Years Ago in The Journal of Pediatrics
Rubin HM, Kramer R, Drash A. J Pediatr 1969;74:177-86. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: David W. Hansen Tags: 50 Years Ago Source Type: research

Fostering Resilience in Children: The Essential Role of Healthcare Professionals and Families
In our complex society, stressful or negative life experiences have typically been considered to induce a substantial change from one set of living conditions to another. Life remodeling, resulting from adversities, involves significant challenges because of the need to adapt to new circumstances. That may often impair the ability to cope with new life settings, exposing the risk of clinical distress and possible long-term psychological illnesses, resulting in symptoms of depression, anxiety, fatigue and stress. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Massimo Pettoello-Mantovani, Tudor Lucian Pop, Julije Mestrovic, Pietro Ferrara, Ida Giardino, Angel Carrasco-Sanz, Luigi Nigri, Leyla Namazova-Baranova, Mehmet Vural, F ügen Çullu Çokuğraş Tags: European Paediatric Association Source Type: research

Implementation of a Novel Curriculum and Fostering Professional Identity Formation of Pediatrician-Scientists
In 2014, the Baylor College of Medicine (BCM) and Texas Children's Hospital (TCH) made an institutional commitment to address concerns over the paucity of longitudinal support for physician-scientist career development and sustainability.1,2 Using the American Board of Pediatrics' Integrated Research Pathway framework, the Pediatrician-Scientist Training and Development Program (PSTDP) was developed at BCM and TCH.3 The program's goal was to produce research-oriented scholars who cultivate and sustain excellent clinical and research training through the tenets of mentorship, alternative didactic training, and academic adva...
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Audrea M. Burns, Satid Thammasitboon, Mark A. Ward, Mark W. Kline, Jean L. Raphael, Teri L. Turner, Jordan S. Orange Tags: Notes from the Association of Medical School Pediatric Department Chairs, Inc. Source Type: research

The Use of Bayesian Analysis Techniques in Pediatric Research
In a recent article appearing in The Journal, Faustino et  al reported the findings of a multicenter intensive care unit (ICU) study investigating the frequency of deep venous thrombosis (DVT) among critically ill adolescents (13-17 years of age).1 The authors indicate that DVT has been well studied in the adult population of critically ill patients, but such studies in the pediatric population are sparse. As such, the frequency of DVT among critically ill adolescents is not well known, and pediatric protocols to use pharmacologic prophylaxis to reduce risk of DVT vary widely from center to center. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Michael P. Anderson, M. Townsend Cooper Tags: Statistics, Explained Source Type: research

Introducing a new section: “Statistics, Explained”
Study designs and statistical analyses are becoming more complex, but they allow us to gain insight and answer challenging questions in pediatric research. That said, these new methods often can be difficult to understand, in particular how to discern strengths and limitations of these methods in ultimately determining the validity and importance of the results described in scientific publications. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Matthew J. Gurka, William F. Balistreri Tags: The Editors' Perspectives Source Type: research

Practical applications of circadian science in adolescents
Two studies published in this volume in The Journal highlight the contribution of circadian rhythms to seemingly disparate aspects of health in adolescents: driving safety and glycemic control. Both studies appropriately take into account sleep duration as necessary, but not sufficient, to explore the relationship of sleep with these topics. Owens et  al determined that for a cohort of teen drivers, not only was shorter sleep duration associated with drowsy driving, but also a more pronounced “night owl” tendency, or evening chronotype. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Jennifer Accardo Tags: The Editors' Perspectives Source Type: research

To sleep and dream without digital screens
Countless studies have documented the rise in digital screen usage from infancy to adolescence, and some of its consequences on child development. Przybylski reports in this volume of The Journal a cross-sectional study from the 2016 National Survey of Children's analyzing 50  212 children to determine how time spent with digital devices predicted meaningful variability in pediatric sleep. Each hour devoted to digital screens was associated with 3 to 8 fewer minutes of nightly sleep and significantly lowered levels of sleep consistency. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research

School performance in childhood leukemia survivors
The progress in treating childhood leukemia over the last 50 years represents a remarkable success story. Once universally fatal, some subgroups of childhood acute lymphoblastic leukemia now have cure rates exceeding 90%. However, as survival improves, the burden presented by the long-term physical and cognitive sequalae of leukemia and its treatment have become more problematic. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: William S. Ferguson Tags: The Editors' Perspectives Source Type: research

Doc, my tummy hurts
Great progress has been made in the diagnosis and management of many significant neonatal diseases. This includes respiratory distress syndrome, bronchopulmonary dysplasia, interventricular hemorrhage, retinopathy of prematurity, and patent ductus arteriosus. One major morbidity however has escaped progress in terms of incidence, prediction, management, and outcome. That disorder is necrotizing enterocolitis (NEC), an inflammatory condition typically of the distal small intestine associated with ischemic injury. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: James F. Padbury Tags: The Editors' Perspectives Source Type: research

Umbilical cord tissue vs meconium for neonatal toxicology testing
Most perinatal hospitals use a combination of maternal risk assessment and neonatal toxicology testing to identify infants at risk for substance withdrawal symptoms and to confirm the types of drugs that may have been used during pregnancy. Although meconium has been used for many years as the specimen of choice for toxicology testing, screening can also be performed on umbilical cord tissue. Due to the easy availability of umbilical cord tissue, this method is growing in popularity but there have been few studies that compare the equivalence of umbilical cord tissue with meconium. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Raye-Ann deRegnier Tags: The Editors' Perspectives Source Type: research

I screen, you screen, we all scream for risk screens
Ever since the 1998 publication of the groundbreaking Adverse Childhood Events study by Felitti et  al (Am J Prev Med 1998;14:245-58), researchers and clinicians have been working to expand the science and develop tools that screen for factors associated with the development of toxic stress. The science is well established that adverse childhood experiences (ACEs) can lead to disrupted neurodeve lopment. If not buffered or mitigated, impairment in the social, emotional, and cognitive domains follow leading to high risk behaviors and their sequelae. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Jane A. Oski Tags: The Editors' Perspectives Source Type: research

Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Source Type: research

Missed Diagnosis of New-Onset Systolic Heart Failure at First Presentation in Children with No Known Heart Disease
To determine frequency of missed heart failure diagnosis at first presentation among children with no known heart disease admitted with new-onset heart failure. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Kriti Puri, Hardeep Singh, Susan W. Denfield, Antonio G. Cabrera, William J. Dreyer, Hari P. Tunuguntla, Jack F. Price Tags: Original Articles Source Type: research

A Comparison of Pediatric and Adult Safety Studies for Antipsychotic and Antidepressant Drugs Submitted to the United States Food and Drug Administration
To examine the differences in the adverse drug reaction (ADR) profile of antipsychotic and antidepressant agents between pediatric and adult patients in studies submitted to the Food and Drug Administration (FDA) during the drug development process. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Xiaomei I. Liu, Paul Schuette, Gilbert J. Burckart, Dionna J. Green, Julie La, Janelle M. Burnham, Natella Rakhmanina, Adelaide Robb, Shiew Mei Huang, John N. van den Anker Tags: Original Articles Source Type: research

Pediatrician Beliefs about Juvenile Idiopathic Arthritis May Result in Referral Delays: A Spanish National Survey
We explored, through a national survey, pediatrician beliefs and misconceptions that could interfere with early referral of patients with juvenile idiopathic arthritis. A total of 831 pediatricians participated. Approximately one-half of the respondents underestimated the incidence of the disease and thought that pain was the leading symptom of oligoarticular forms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Mar ía Rosa Pavo, Jaime de Inocencio Tags: Clinical and Laboratory Observations Source Type: research

Disability Is Not Delay: Precision Communication about Intellectual Disability
Sammy (a true story; the names and details have been anonymized). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Eyal Cohen, Amy Houtrow Tags: Commentary Source Type: research

Reply
We appreciate the comments from Dr Tauber concerning our study on prevention of parenteral nutrition associated cholestasis (PNAC) using a mixed lipid emulsion based on soybean-oil, medium chain triglycerides, olive oil, and fish oil (SMOF-LE) in extremely low birth weight infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Andreas Repa, Eleonore Pablik Tags: Letter to the Editor Source Type: research

Fish oil lipid emulsion to prevent cholestasis in preterm infants
Prolonged parenteral nutrition using a soy-based lipid emulsion is thought to play a role in the development of cholestasis in premature infants.1,2 Previous studies have demonstrated a reversal of parenteral nutrition associated cholestasis (PNAC) in both term and preterm infants after switching infants to a fish oil-based lipid preparation.3-5 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Kate Tauber Tags: Letters to the Editor Source Type: research

Comparison of Initial Pediatric Outpatient Echocardiogram Indications between Community and Academic Practice
To compare the appropriateness and diagnostic yield of initial outpatient transthoracic echocardiography (TTE) between a community pediatric cardiology practice and an academic children's hospital. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 17, 2019 Category: Pediatrics Authors: Sowmya Balasubramanian, Faustine D. Ramirez, Yen Bui, Elif Seda Selamet Tierney, Sarina K. Behera Tags: Original Articles Source Type: research

Reply
We thank Oakley et  al for contributing to the debate on this important contemporary child health and development topic. Like us, they recognize that guidelines should support the best interests of children, and that having conflicting guidelines that are pitted against each other is not helpful. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 17, 2019 Category: Pediatrics Authors: Leon Straker, Juliana Zabatiero, Susan Danby, Karen Thorpe, Susan Edwards Tags: Letters to the Editor Source Type: research

Frequency Domain Indices of Heart Rate Variability are Useful for Differentiating Vasovagal Syncope and Postural Tachycardia Syndrome in Children
To explore the value of frequency domain indices of heart rate variability (HRV) in the differential diagnosis between pediatric vasovagal syncope and postural tachycardia syndrome (POTS). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 7, 2019 Category: Pediatrics Authors: Yuanyuan Wang, Chunyu Zhang, Selena Chen, Xueying Li, Hongfang Jin, Junbao Du Tags: Original Articles Source Type: research

Obesity in Adolescents and Youth: The Case for and against Bariatric Surgery
Obesity and its associated sequelae of hypertension, dyslipidemia, cardiovascular disease, type 2 diabetes mellitus (T2DM), disturbances of reproduction, sleep apnea, and nonalcoholic steatohepatitis has been termed the plague of the 21st century and is increasing throughout the world in both adults and children.1-12 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 7, 2019 Category: Pediatrics Authors: Ahmed Khattab, Mark A. Sperling Tags: Medical progress Source Type: research

Advocating for a cautious, conservative approach to screen time guidelines in young children
The commentary by Straker et  al1 purports that there are conflicting guidelines about children's screen time among 2 current early years policy documents in Australia. In our opinion, pitting potential health harms against potential education benefits is not in the best interest of children, as systematic reviews of the evide nce show that their learning, development, and health are tightly interconnected.2-4 We agree that it would be ideal to have better evidence about the impact of newer technologies such as mobile phones and tablets. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 7, 2019 Category: Pediatrics Authors: Anthony D. Okely, Mark S. Tremblay, John J. Reilly, Catherine Draper, Thomas N. Robinson Tags: Letters to the Editor Source Type: research

Higher Body Mass Index Is Associated with Iron Deficiency in Children 1 to 3 Years of Age
To examine the association between body mass index (BMI) and iron deficiency in early childhood, while considering the influence of low-grade systemic inflammation. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 7, 2019 Category: Pediatrics Authors: Emma E. Sypes, Patricia C. Parkin, Catherine S. Birken, Sarah Carsley, Colin MacArthur, Jonathon L. Maguire, Cornelia M. Borkhoff, TARGet Kids! Collaboration Tags: Original Articles Source Type: research

Prevalence and Characteristics of Pediatric Opioid Exposures and Poisonings in the United States
To examine the prevalence and characteristics of pediatric opioid exposures and poisonings in the US. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 4, 2019 Category: Pediatrics Authors: Anisha M. Patel, David C. Wheeler, S. Rutherfoord Rose, Pramit A. Nadpara, Amy L. Pakyz, Norman V. Carroll Tags: Original Articles Source Type: research

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia
To use a large current prospective cohort of infants (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 4, 2019 Category: Pediatrics Authors: Rita M. Ryan, Rui Feng, Catalina Bazacliu, Thomas W. Ferkol, Clement L. Ren, Thomas J. Mariani, Brenda B. Poindexter, Fan Wang, Paul E. Moore, Prematurity and Respiratory Outcome Program (PROP) Investigators Tags: Original Articles Source Type: research

Social-Emotional Functioning Explains the Effects of Physical Activity on Academic Performance among Chinese Primary School Students: A Mediation Analysis
To examine the mediating effects of socioemotional and behavioral functioning in the association between physical activity and academic achievement in Chinese children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 4, 2019 Category: Pediatrics Authors: Yunting Zhang, Li Niu, Donglan Zhang, Patrick Ip, Frederick Ho, Yanrui Jiang, Wanqi Sun, Qi Zhu, Fan Jiang Tags: Original Articles Source Type: research

Association of Home Respiratory Equipment and Supply Use with Health Care Resource Utilization in Children
To compare health care use and spending in children using vs not using respiratory medical equipment and supplies (RMES). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 4, 2019 Category: Pediatrics Authors: Jay G. Berry, Denise M. Goodman, Ryan J. Coller, Rishi Agrawal, Dennis Z. Kuo, Eyal Cohen, Joanna Thomson, Danielle DeCourcey, Neal DeJong, Anna Agan, Dipika Gaur, Madeline Coquillette, Charis Crofton, Amy Houtrow, Matt Hall Tags: Original Articles Source Type: research

Contingencies on the workshop for bronchopulmonary dysplasia classification
We read with interest the executive summary of the workshop on bronchopulmonary dysplasia (BPD).1 The authors provided a comprehensive review on the incidence and pathogenesis of BPD and summarized the historical aspects in the definition of BPD. The workshop suggested refining the definition of BPD to include different grades based on the amount of respiratory support that an infant receives. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 24, 2018 Category: Pediatrics Authors: Hany Aly, Mohamed A. Mohamed, Jen Tien Wung Tags: Letters to the Editor Source Type: research

Reply
Aly and Mohamed have submitted itemized comments on the summary of the NIH sponsored workshop on bronchopulmonary dysplasia (BPD). The comments reflect on the definition of BPD and its implications. A well-recognized concern is that all currently used definitions only include the oxygen and ventilatory treatments being delivered at a single gestational age, generally 36 weeks postconceptional age.1 There are currently no objective assessments of alveolar, vascular, and airway injuries. The inadequacy of using the therapy to define the disease can be resolved only with the development of predictive biomarkers and imaging te...
Source: The Journal of Pediatrics - December 24, 2018 Category: Pediatrics Authors: Rosemary D. Higgins, Alan H. Jobe Tags: Letters to the Editor Source Type: research

Effects of Daily Zinc, Daily Multiple Micronutrient Powder, or Therapeutic Zinc Supplementation for Diarrhea Prevention on Physical Growth, Anemia, and Micronutrient Status in Rural Laotian Children: A Randomized Controlled Trial
To evaluate the optimal zinc supplementation strategy for improving growth and hematologic and micronutrient status in young Laotian children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2018 Category: Pediatrics Authors: Maxwell A. Barffour, Guy-Marino Hinnouho, Sengchanh Kounnavong, K. Ryan Wessells, Kethmany Ratsavong, Bangone Bounheuang, Bigphone Chanhthavong, Dalaphone Sitthideth, Khanpaseuth Sengnam, Charles D. Arnold, Kenneth H. Brown, Sonja Y. Hess Tags: Original Articles Source Type: research

The Association of Hydrocortisone Dosage on Mortality in Infants Born Extremely Premature
To characterize common dosing strategies and to investigate the association between hydrocortisone dosage and in-hospital mortality in infants born extremely premature. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2018 Category: Pediatrics Authors: Veeral N. Tolia, Timothy M. Bahr, Monica M. Bennett, Gregory Martin, Rachel G. Greenberg, Matthew M. Laughon, Reese H. Clark Tags: Original Articles Source Type: research

Imaging diagnosis of pneumonia in children
Ambroggio et  al1 report on lung ultrasonography as a viable alternative to chest radiography to detect pneumonia in children.2 They emphasize both the higher specificity of chest radiography for many findings compared with lung ultrasonography and the operator's skill in the diagnostic process. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2018 Category: Pediatrics Authors: Fernando Maria de Benedictis, Cecilia Lanza, Fabio Midulla Tags: Letters to the Editor Source Type: research

Age-Related Changes in Inferior Vena Cava Dimensions among Children and Adolescent with Syncope
To test the hypothesis that increased venous compliance manifested as inferior vena cava (IVC) dilation is an important substrate for syncope in children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2018 Category: Pediatrics Authors: Pushpa Shivaram, Sylvia Angtuaco, Aziez Ahmed, Joshua Daily, Deborah F. Grigsby, Ling Li, Mary Craft, David Danford, Shelby Kutty Tags: Original Articles Source Type: research

Surfactant Administration in Preterm Infants: Drug Development Opportunities
To evaluate how frequently surfactant is used off-label in preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2018 Category: Pediatrics Authors: Genevieve Taylor, Wesley Jackson, Christoph P. Hornik, Alec Koss, Sreekar Mantena, Kenya Homsley, Blair Gattis, Menefese Kudumu-Clavell, Reese Clark, P. Brian Smith, Matthew M. Laughon Tags: Original Articles Source Type: research

Age-Related Changes in Inferior Vena Cava Dimensions among Children and Adolescents with Syncope
To test the hypothesis that increased venous compliance manifested as inferior vena cava (IVC) dilation is an important substrate for syncope in children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2018 Category: Pediatrics Authors: Pushpa Shivaram, Sylvia Angtuaco, Aziez Ahmed, Joshua Daily, Deborah F. Grigsby, Ling Li, Mary Craft, David Danford, Shelby Kutty Tags: Original Articles Source Type: research

Early Indicators of Creatine Transporter Deficiency
Early identification is a goal for creatine transporter deficiency and will be critical for future treatment. Before their first birthday, one-half of this sample showed both a significant feeding/weight gain issue and delayed sitting or crawling. Combined, these early indicators could have alerted providers to conduct a urine screen. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 20, 2018 Category: Pediatrics Authors: Judith S. Miller, Rebecca P. Thomas, Amanda Bennett, Simona Bianconi, Aleksandra Bruchey, Robert J. Davis, Can Ficicioglu, Whitney Guthrie, Forbes D. Porter, Audrey Thurm Tags: Clinical and laboratory observations Source Type: research

Type 2 Congenital Generalized Lipodystrophy: The Diagnosis is in Your Hands
A 16-year-old girl from Northeastern Brazil presented with generalized lack of subcutaneous fat, high serum levels of triglycerides, and low levels of high-density lipoprotein cholesterol since birth. Her medical history included diabetes mellitus diagnosed at 6 years of age, which was uncontrolled despite the use of high doses of insulin (5  U/kg/day), and 3 previous hospitalizations for acute pancreatitis because of severe hypertriglyceridemia. Besides insulin, she was taking metformin and ciprofibrate. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 20, 2018 Category: Pediatrics Authors: Renan Magalh ães Montenegro, Virgínia Oliveira Fernandes, Jaquellyne Gurgel Penaforte Saboia, Ana Paula Dias Rangel Montenegro, Josivan Gomes Lima Tags: Insights and Images Source Type: research

Worse Metabolic Control and Dynamics of Weight Status in Adolescent Girls Point to Eating Disorders in the First Years after Manifestation of Type 1 Diabetes Mellitus: Findings from the Diabetes Patienten Verlaufsdokumentation Registry
To assess indications of eating disorders in girls with type 1 diabetes mellitus (T1DM). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 20, 2018 Category: Pediatrics Authors: Thomas Reinehr, Barbara Dieris, Angela Galler, Martin Teufel, Gabriele Berger, Rainer Stachow, Sven Golembowski, Ute Ohlenschl äger, Martin Holder, Michael Hummel, Reinhard W. Holl, Nicole Prinz Tags: Original Articles Source Type: research