Remembering the Power of Stories in Pediatric Research
Pediatric research is detailed, exacting, and scientific. It provides a clear picture, a freeze frame of the study of a particular issue related to children in their infancy, toddlerhood, childhood, and adolescence. Within studies, the clinical statistics automatically mask faces, remove stories, and keep the focus on sterile data in hopes of educating colleagues on important health topics such as the quality of life for infants with bronchopulmonary dysplasia, as reported by Brady et  al1 in this volume of The Journal. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 7, 2019 Category: Pediatrics Authors: Jennifer Degl, Deb Discenza, Keira Sorrells Tags: Editorials Source Type: research

Cost Effectiveness of Early Treatment with Direct-Acting Antiviral Therapy in Adolescent Patients with Hepatitis C Virus Infection
To evaluate the cost effectiveness of early treatment with direct-acting antiviral therapy in adolescent patients with chronic hepatitis C virus (HCV) infection compared with treatment deferral. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 6, 2019 Category: Pediatrics Authors: Joehl Nguyen, A. Sidney Barritt IV, Ravi Jhaveri Tags: Original Article Source Type: research

Discordance in Antenatal Corticosteroid Use and Resuscitation Following Extremely Preterm Birth
To describe discordance in antenatal corticosteroid use and resuscitation following extremely preterm birth and its relationship with infant survival and neurodevelopment. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 6, 2019 Category: Pediatrics Authors: Matthew A. Rysavy, Edward F. Bell, Jay D. Iams, Waldemar A. Carlo, Lei Li, Brian M. Mercer, Susan R. Hintz, Barbara J. Stoll, Betty R. Vohr, Seetha Shankaran, Michele C. Walsh, Jane E. Brumbaugh, Tarah T. Colaizy, Abhik Das, Rosemary D. Higgins, Eunice Ke Tags: Original Article Source Type: research

Childhood Violence Is Associated with Forced Sexual Initiation Among Girls and Young Women in Malawi: A Cross-Sectional Survey
To describe associations between childhood violence and forced sexual initiation in young Malawian females. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 6, 2019 Category: Pediatrics Authors: Elizabeth A. Swedo, Steven A. Sumner, Wezi Msungama, Greta M. Massetti, McKnight Kalanda, Janet Saul, Andrew F. Auld, Susan D. Hillis Tags: Original Article Source Type: research

Pulmonary Hypertension Secondary to Scurvy in a Developmentally Typical Child
A healthy 17-year-old male patient presented to an emergency department with a 2-week history of leg pain, bruising without trauma, and chest pain. Additional history revealed gum bleeding, a diet devoid of fruits and vegetables, and hours spent indoors playing video games. Physical examination was notable for loud P2, symmetric pedal edema, bilateral lower extremity tender ecchymosis, petechiae, and corkscrew hairs (Figure). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 6, 2019 Category: Pediatrics Authors: Benjamin S. Frank, Martin Runciman, William A. Manning, D. Dunbar Ivy, Steven H. Abman, Lisa Howley Tags: Insights and Images Source Type: research

Nursery school as an environmental factor for body mass index
In an article by Jabakhanji et  al,1 the authors reported on longitudinal changes in body mass index (BMI) that spanned the first 5 years of life and associated risk factors in young children in Ireland. The authors found that differences in birth size and rapid weight gain in infancy are most strongly associated with BMI at al l ages; however, other factors, such as ethnicity, caregiver weight status, breast feeding, sex, sleep, and socioeconomic status, were also shown to have small independent effects on weight status. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 6, 2019 Category: Pediatrics Authors: Osamu Arisaka, Go Ichikawa, Satomi Koyama, Sairenchi Toshimi Tags: Letters to the Editor Source Type: research

Weight Gain Trajectories from Birth to Adolescence and Cardiometabolic Status in Adolescence
To assess the influence of the trajectory of weight gain from birth to adolescence on cardiovascular and metabolic risk. We studied childhood body mass index (BMI) trajectories from birth to age 14  years and cardiometabolic risk factors at age 14 years. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 6, 2019 Category: Pediatrics Authors: Jennifer Y. Barraclough, Frances L. Garden, Brett G. Toelle, Guy B. Marks, Louise A. Baur, Julian G. Ayer, David S. Celermajer Tags: Original Articles Source Type: research

Cerebral Oxygen Saturation and Negative Postoperative Behavioral Changes in Pediatric Surgery: A Prospective Observational Study
To evaluate if an intraoperative cerebral regional oxygen saturation (crSO2) decrease, less pronounced than 20% below baseline (the current threshold believed to be associated with cognitive dysfunction in adults), is associated with negative postoperative behavioral changes (NPOBC) in the pediatric population after noncardiac surgeries. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 5, 2019 Category: Pediatrics Authors: Estefan ía Gómez-Pesquera, Rodrigo Poves-Alvarez, Beatriz Martinez-Rafael, Pilar Liu, Javier Alvarez, Mario Lorenzo-López, Inmaculada Fierro, Esther Gómez-Sánchez, María Heredia-Rodriguez, José Ignacio Gómez-Herreras, Eduardo Tamayo Tags: Original Articles Source Type: research

Vesical Hemangioma in a Patient with Klippel-Trenaunay-Weber Syndrome
A 3-year-old child with Klippel-Trepanauy-Weber syndrome (KTWS), was admitted to our hospital with recurrent episodes of hematuria. Subsequent clinical history revealed 2 episodes of hematuria some weeks before, not initially mentioned by the parents. Urine analyses were negative for erythrocytes and proteinuria. The child manifested a normocytic anemia (hemoglobin, 9.9  g/dL; mean corpuscular volume, 74 μm3; iron, 13 μg/d). Coagulation tests were normal; her d-dimers were 2060. An ultrasound examination of the urinary tract demonstrated a giant mass in the vesical dome (Figure 1). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 5, 2019 Category: Pediatrics Authors: Olivier Opdenakker, Thomas Renson, Johan Vande Walle Tags: Insights and Images Source Type: research

Genetics of bronchopulmonary dysplasia: When things do not match up, it is only the beginning
Parad et  al1 speculate that, for extremely preterm infants, the roles of “immature lung structure and biochemical status” may trump genetic factors in bronchopulmonary dysplasia (BPD). Based on sample differences with previous twin studies, they propose that “if a genetic predisposition to BPD exists , it could play a more important role in infants born at or over 29 weeks gestational age.”1 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 5, 2019 Category: Pediatrics Authors: Vineet Bhandari, Jeffrey R. Gruen, Kerry L. Jang, Wolfgang G öpel, Mikko Hallman, Pascal M. Lavoie Tags: Letters to the Editor Source Type: research

Digital Amputation by Congenital Insensitivity to Pain with Anhidrosis
An 18-month-old boy was referred to the pediatric neurology clinic for evaluation of finger ulcers. He was born to nonconsanguineous parents with uncomplicated delivery. Detailed history revealed early dislocation of his first teeth, easy fatigability in summer, and autistic trait. On examination, the first and second digits of both hands were amputated distally (Figure). His palms were warm and dry. Thermal sweating test revealed complete anhidrosis. Palmar sympathetic skin response was not seen. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 5, 2019 Category: Pediatrics Authors: Itaru Hayakawa, Masaya Kubota Tags: Rediscovering the Physical Exam Source Type: research

Juvenile Idiopathic Arthritis —Education, Knowledge, and Patient Outcomes
Approximately 1 in 1000 children are affected by the various subtypes of juvenile idiopathic arthritis (JIA).1 As in other chronic diseases, confronting JIA involves physical, social, emotional, and psychological challenges for the child and the family.2,3 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 5, 2019 Category: Pediatrics Authors: Yosef Uziel Tags: Editorials Source Type: research

Use of a Probiotic to Enhance Iron Absorption in a Randomized Trial of Pediatric Patients Presenting with Iron Deficiency
To evaluate the efficacy of low dose ferrous sulfate for the treatment of iron deficiency and if the probiotic Lactobacillus plantarum 299v (LP299v) enhances treatment. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 4, 2019 Category: Pediatrics Authors: Gerald M. Rosen, Sue Morrissette, Amy Larson, Pam Stading, Kristen H. Griffin, Timothy L. Barnes Tags: Original Article Source Type: research

Thoracic Aortic Intima-Media Thickness in Preschool Children Born Small for Gestational Age
To assess thoracic aortic intima-media thickness (aIMT) as a marker of thoracic aortic remodeling in children born small for gestational age (SGA). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 4, 2019 Category: Pediatrics Authors: Manoel Mu ñiz Fontán, Ignacio Oulego Erroz, Daniela Revilla Orias, Ana Muñoz Lozón, Antonio Rodriguez Núñez, Empar Lurbe I. Ferrer Tags: Original Article Source Type: research

Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort
To determine the lifetime prevalence of allergies in childhood nephrotic syndrome, the seasonality of presentation and relapses, and the impact of allergies on subsequent relapses. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 4, 2019 Category: Pediatrics Authors: Shivraj Singh Riar, Tonny H.M. Banh, Karlota Borges, Padmaja Subbarao, Viral Patel, Jovanka Vasilevska-Ristovska, Rahul Chanchlani, Neesha Hussain-Shamsy, Damien Noone, Diane Hebert, Christoph P.B. Licht, Valerie Langlois, Rachel J. Pearl, Rulan S. Parekh Tags: Original Articles Source Type: research

Cardiac Autonomic Function in Adults Born Preterm
To evaluate cardiac autonomic function in adults born preterm. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 4, 2019 Category: Pediatrics Authors: Risto Karvonen, Marika Sipola, Antti Kiviniemi, Marjaana Tikanm äki, Marjo-Riitta Järvelin, Johan G. Eriksson, Mikko Tulppo, Marja Vääräsmäki, Eero Kajantie Tags: Original Article Source Type: research

Individual Participant Data Meta-Analysis Explained
In a study published in The Journal, Shaffer et  al1 report the results of a PRISMA-compliant individual participant data (IPD) meta-analysis2 on the effect of prophylaxis for early adrenal insufficiency using low-dose hydrocortisone in very preterm infants. The primary conclusion from this IPD meta-analysis, which included the pooling of data f rom 4 randomized controlled trials representing 982 participants, was that early low-dose hydrocortisone therapy is beneficial for survival without bronchopulmonary dysplasia (BPD) in very preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: George A. Kelley Tags: Statistics, Explained Source Type: research

Prenatal Maternal Psychological Distress and Offspring Risk for Recurrent Respiratory Infections
To assess the relation between maternal prenatal psychological distress, comprising depression and anxiety symptoms and relationship quality, and the risk of recurrent respiratory infections (RRIs) in children up to 2  years of age. Children with RRIs frequently use health care services and antibiotics. Prenatal maternal psychological distress can be one, previously unidentified risk factor for RRIs. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: Laura S. Korhonen, Linnea Karlsson, Noora M. Scheinin, Riikka Korja, Mimmi Tolvanen, Jussi Mertsola, Ville Peltola, Hasse Karlsson Tags: Original Articles Source Type: research

Re-conceptualizing Associations between Race and Morbidities of Extreme Prematurity
In this volume of The Journal, Ryan et  al report a secondary analysis from the 11 centers included in the Prematurity and Respiratory Outcome Program (PROP).1 The purpose of PROP was to identify biomarkers and other factors associated with long-term respiratory morbidity among preterm infants, and the goal of this secondary analysis wa s to determine whether black infants were at lower risk of bronchopulmonary dysplasia (BPD). In PROP, enrolled extremely low gestational age black infants had a lower incidence of BPD (38%) compared with white infants (45%). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: Heather H. Burris, Sunah S. Hwang, James W. Collins, Haresh Kirpalani, Clyde J. Wright Tags: Editorial Source Type: research

Caterpillar Sign in an Infant with Hypertrophic Pyloric Stenosis
A 7-week-old boy presented to the emergency department with a 2-week history of emesis. He was born at 39  weeks of gestation with a birth weight of 3495 g via normal spontaneous vaginal delivery. He had no history of taking macrolide antibiotics. He presented with postprandial, projectile, nonbilious vomitus after vigorously feeding on breast or formula milk. His weight decreased by 220 g, suggestin g more than 5% dehydration over the previous 2 weeks. Physical examination revealed dry mucous membranes, but no abdominal mass, abdominal distension, or high-pitched bowel sounds. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: Reiko Kawai, Kazuhiro Uda, Yuho Horikoshi, Hiroshi Hataya Tags: Insights and Images Source Type: research

Steroid Free Treatment of Autoimmune Hepatitis in Selected Children
In this report, we describe our experience in treating selected asymptomatic children with autoimmune hepatitis using a steroid-free regimen; this treatment strategy was safe and effective in inducing remission. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: Andrew Wehrman, Orith Waisbourd-Zinman, Amit Shah, Didja Hilmara, Henry Lin, Elizabeth B. Rand Tags: Clinical and Laboratory Observations Source Type: research

Testing umbilical cord tissue for drugs: Lower analytical limits, better concordance with meconium results
Colby et  al discussed the equivalency of umbilical cord and meconium testing to evaluate in utero exposure to drugs.1 The authors applied “commercial” umbilical cord tissue and gold standard meconium toxicology tests for detection of several drugs in paired umbilical cord and meconium samples from 501 neonates. The results in both specimens were often discordant. However, the overall prevalence of drugs in umbilical cord and meconium was similar for several groups, and the agreement between both specimens ranged from 80% to 100%. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 2, 2019 Category: Pediatrics Authors: Adam Negrusz, Joseph Jones Tags: Letters to the Editor Source Type: research

The Association of the Body Composition of Children with 24-Hour Activity Composition
To evaluate how the reallocation of time between sleep, sedentary time, light, and moderate-vigorous activities is associated with children's body composition. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 28, 2019 Category: Pediatrics Authors: Dorothea Dumuid, Melissa Wake, Susan Clifford, David Burgner, John B. Carlin, Fiona K. Mensah, Fran çois Fraysse, Kate Lycett, Louise Baur, Timothy Olds Tags: Original Article Source Type: research

Data Science for Child Health
Data science has revolutionized industry and academic fields including marketing,1 astronomy,2 and computer vision.3 It has not yet impacted medicine and biomedical research to the same degree. However, many observers4-6 believe that data science will improve the ability of health care systems to deliver personalized medicine,7 population health,8 and public health.9 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 24, 2019 Category: Pediatrics Authors: Tellen D. Bennett, Tiffany J. Callahan, James A. Feinstein, Debashis Ghosh, Saquib A. Lakhani, Michael C. Spaeder, Stanley J. Szefler, Michael G. Kahn Tags: Medical Progress Source Type: research

50 Years Ago in The Journal of Pediatrics
Strauss RG, Schubert WK, McAdams AJ. J Pediatr 1969;74:272-82 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Philip J. Hashkes Tags: 50 Years Ago Source Type: research

Corrigendum
In the article “An Ounce of Prevention May Be Worth Many Pounds of Cure” (J Pediatr 2018;195:13-15) one of the author's names was unfortunately misspelled. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Tags: Correction Source Type: research

50 Years Ago in The Journal of Pediatrics
Milman D. J Pediatr 1969;74:283-90 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Stephanie N. Ferrin, Mary A. Ott Tags: 50 Years Ago Source Type: research

50 Years Ago in The Journal of Pediatrics
White LR, Sever JL, Alepa FP. J Pediatr 1969;74:198-207. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Pooja Dewan, Piyush Gupta Tags: 50 Years Ago Source Type: research

50 Years Ago in The Journal of Pediatrics
Root AW, Saenz-Rodriguez C, Bongiovanni AM, Eberlein WR. J Pediatr 1969;74:187-97. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Walter Zegarra, Ron Rosenfeld, David M. Maahs Tags: 50 Years Ago Source Type: research

50 Years Ago in The Journal of Pediatrics
Rubin HM, Kramer R, Drash A. J Pediatr 1969;74:177-86. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: David W. Hansen Tags: 50 Years Ago Source Type: research

Fostering Resilience in Children: The Essential Role of Healthcare Professionals and Families
In our complex society, stressful or negative life experiences have typically been considered to induce a substantial change from one set of living conditions to another. Life remodeling, resulting from adversities, involves significant challenges because of the need to adapt to new circumstances. That may often impair the ability to cope with new life settings, exposing the risk of clinical distress and possible long-term psychological illnesses, resulting in symptoms of depression, anxiety, fatigue and stress. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Massimo Pettoello-Mantovani, Tudor Lucian Pop, Julije Mestrovic, Pietro Ferrara, Ida Giardino, Angel Carrasco-Sanz, Luigi Nigri, Leyla Namazova-Baranova, Mehmet Vural, F ügen Çullu Çokuğraş Tags: European Paediatric Association Source Type: research

Implementation of a Novel Curriculum and Fostering Professional Identity Formation of Pediatrician-Scientists
In 2014, the Baylor College of Medicine (BCM) and Texas Children's Hospital (TCH) made an institutional commitment to address concerns over the paucity of longitudinal support for physician-scientist career development and sustainability.1,2 Using the American Board of Pediatrics' Integrated Research Pathway framework, the Pediatrician-Scientist Training and Development Program (PSTDP) was developed at BCM and TCH.3 The program's goal was to produce research-oriented scholars who cultivate and sustain excellent clinical and research training through the tenets of mentorship, alternative didactic training, and academic adva...
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Audrea M. Burns, Satid Thammasitboon, Mark A. Ward, Mark W. Kline, Jean L. Raphael, Teri L. Turner, Jordan S. Orange Tags: Notes from the Association of Medical School Pediatric Department Chairs, Inc. Source Type: research

The Use of Bayesian Analysis Techniques in Pediatric Research
In a recent article appearing in The Journal, Faustino et  al reported the findings of a multicenter intensive care unit (ICU) study investigating the frequency of deep venous thrombosis (DVT) among critically ill adolescents (13-17 years of age).1 The authors indicate that DVT has been well studied in the adult population of critically ill patients, but such studies in the pediatric population are sparse. As such, the frequency of DVT among critically ill adolescents is not well known, and pediatric protocols to use pharmacologic prophylaxis to reduce risk of DVT vary widely from center to center. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Michael P. Anderson, M. Townsend Cooper Tags: Statistics, Explained Source Type: research

Introducing a new section: “Statistics, Explained”
Study designs and statistical analyses are becoming more complex, but they allow us to gain insight and answer challenging questions in pediatric research. That said, these new methods often can be difficult to understand, in particular how to discern strengths and limitations of these methods in ultimately determining the validity and importance of the results described in scientific publications. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Matthew J. Gurka, William F. Balistreri Tags: The Editors' Perspectives Source Type: research

Practical applications of circadian science in adolescents
Two studies published in this volume in The Journal highlight the contribution of circadian rhythms to seemingly disparate aspects of health in adolescents: driving safety and glycemic control. Both studies appropriately take into account sleep duration as necessary, but not sufficient, to explore the relationship of sleep with these topics. Owens et  al determined that for a cohort of teen drivers, not only was shorter sleep duration associated with drowsy driving, but also a more pronounced “night owl” tendency, or evening chronotype. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Jennifer Accardo Tags: The Editors' Perspectives Source Type: research

To sleep and dream without digital screens
Countless studies have documented the rise in digital screen usage from infancy to adolescence, and some of its consequences on child development. Przybylski reports in this volume of The Journal a cross-sectional study from the 2016 National Survey of Children's analyzing 50  212 children to determine how time spent with digital devices predicted meaningful variability in pediatric sleep. Each hour devoted to digital screens was associated with 3 to 8 fewer minutes of nightly sleep and significantly lowered levels of sleep consistency. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research

School performance in childhood leukemia survivors
The progress in treating childhood leukemia over the last 50 years represents a remarkable success story. Once universally fatal, some subgroups of childhood acute lymphoblastic leukemia now have cure rates exceeding 90%. However, as survival improves, the burden presented by the long-term physical and cognitive sequalae of leukemia and its treatment have become more problematic. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: William S. Ferguson Tags: The Editors' Perspectives Source Type: research

Doc, my tummy hurts
Great progress has been made in the diagnosis and management of many significant neonatal diseases. This includes respiratory distress syndrome, bronchopulmonary dysplasia, interventricular hemorrhage, retinopathy of prematurity, and patent ductus arteriosus. One major morbidity however has escaped progress in terms of incidence, prediction, management, and outcome. That disorder is necrotizing enterocolitis (NEC), an inflammatory condition typically of the distal small intestine associated with ischemic injury. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: James F. Padbury Tags: The Editors' Perspectives Source Type: research

Umbilical cord tissue vs meconium for neonatal toxicology testing
Most perinatal hospitals use a combination of maternal risk assessment and neonatal toxicology testing to identify infants at risk for substance withdrawal symptoms and to confirm the types of drugs that may have been used during pregnancy. Although meconium has been used for many years as the specimen of choice for toxicology testing, screening can also be performed on umbilical cord tissue. Due to the easy availability of umbilical cord tissue, this method is growing in popularity but there have been few studies that compare the equivalence of umbilical cord tissue with meconium. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Raye-Ann deRegnier Tags: The Editors' Perspectives Source Type: research

I screen, you screen, we all scream for risk screens
Ever since the 1998 publication of the groundbreaking Adverse Childhood Events study by Felitti et  al (Am J Prev Med 1998;14:245-58), researchers and clinicians have been working to expand the science and develop tools that screen for factors associated with the development of toxic stress. The science is well established that adverse childhood experiences (ACEs) can lead to disrupted neurodeve lopment. If not buffered or mitigated, impairment in the social, emotional, and cognitive domains follow leading to high risk behaviors and their sequelae. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Authors: Jane A. Oski Tags: The Editors' Perspectives Source Type: research

Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2019 Category: Pediatrics Source Type: research

Missed Diagnosis of New-Onset Systolic Heart Failure at First Presentation in Children with No Known Heart Disease
To determine frequency of missed heart failure diagnosis at first presentation among children with no known heart disease admitted with new-onset heart failure. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Kriti Puri, Hardeep Singh, Susan W. Denfield, Antonio G. Cabrera, William J. Dreyer, Hari P. Tunuguntla, Jack F. Price Tags: Original Articles Source Type: research

A Comparison of Pediatric and Adult Safety Studies for Antipsychotic and Antidepressant Drugs Submitted to the United States Food and Drug Administration
To examine the differences in the adverse drug reaction (ADR) profile of antipsychotic and antidepressant agents between pediatric and adult patients in studies submitted to the Food and Drug Administration (FDA) during the drug development process. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Xiaomei I. Liu, Paul Schuette, Gilbert J. Burckart, Dionna J. Green, Julie La, Janelle M. Burnham, Natella Rakhmanina, Adelaide Robb, Shiew Mei Huang, John N. van den Anker Tags: Original Articles Source Type: research

Pediatrician Beliefs about Juvenile Idiopathic Arthritis May Result in Referral Delays: A Spanish National Survey
We explored, through a national survey, pediatrician beliefs and misconceptions that could interfere with early referral of patients with juvenile idiopathic arthritis. A total of 831 pediatricians participated. Approximately one-half of the respondents underestimated the incidence of the disease and thought that pain was the leading symptom of oligoarticular forms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Mar ía Rosa Pavo, Jaime de Inocencio Tags: Clinical and Laboratory Observations Source Type: research

Disability Is Not Delay: Precision Communication about Intellectual Disability
Sammy (a true story; the names and details have been anonymized). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Eyal Cohen, Amy Houtrow Tags: Commentary Source Type: research

Reply
We appreciate the comments from Dr Tauber concerning our study on prevention of parenteral nutrition associated cholestasis (PNAC) using a mixed lipid emulsion based on soybean-oil, medium chain triglycerides, olive oil, and fish oil (SMOF-LE) in extremely low birth weight infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Andreas Repa, Eleonore Pablik Tags: Letter to the Editor Source Type: research

Fish oil lipid emulsion to prevent cholestasis in preterm infants
Prolonged parenteral nutrition using a soy-based lipid emulsion is thought to play a role in the development of cholestasis in premature infants.1,2 Previous studies have demonstrated a reversal of parenteral nutrition associated cholestasis (PNAC) in both term and preterm infants after switching infants to a fish oil-based lipid preparation.3-5 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 21, 2019 Category: Pediatrics Authors: Kate Tauber Tags: Letters to the Editor Source Type: research

Comparison of Initial Pediatric Outpatient Echocardiogram Indications between Community and Academic Practice
To compare the appropriateness and diagnostic yield of initial outpatient transthoracic echocardiography (TTE) between a community pediatric cardiology practice and an academic children's hospital. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 17, 2019 Category: Pediatrics Authors: Sowmya Balasubramanian, Faustine D. Ramirez, Yen Bui, Elif Seda Selamet Tierney, Sarina K. Behera Tags: Original Articles Source Type: research