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(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Source Type: research

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(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Source Type: research

Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial
We enrolled 98 infants (gestational age (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: J. Lauren Ruoss, Catalina Bazacliu, Jordan T. Russell, Diomel de la Cruz, Nan Li, Matthew J. Gurka, Stephanie L. Filipp, Richard A. Polin, Eric W. Triplett, Josef Neu Tags: Brief Reports Source Type: research

Pretransplantation and Post-Transplantation Liver Disease Assessment in Adolescents Undergoing Isolated Heart Transplantation for Fontan Failure
To describe the assessment of Fontan-associated liver disease and determine the clinical and imaging measures that may identify hepatic morbidity risk in isolated heart transplantation candidates and trend those measures post-isolated heart transplantation. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Dellys Soler Rodriguez, Chad Mao, William T. Mahle, Kirk R. Kanter, Adina Alazraki, Kiery Braithwaite, Heather Rytting, Shelley Caltharp, Joseph F. Magliocca, Ren é Romero Tags: Original Article Source Type: research

Does mask use affect the quantitative severe acute respiratory syndrome coronavirus 2 load in the nasopharynx?
Yonker et  al reported greater severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral loads in the nasopharynx of children during the initial symptomatic stage of disease.1 As these viral loads were significantly greater than adult viral loads despite variable angiotensin-converting enzyme 2 expr ession among children with disease, the question is whether this is related to an inadequately counter-offensive immune response by children and/or insufficient use of masks by symptomatic children confined to their homes due to school closures. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Deepak Gupta Tags: Letters to the Editor Source Type: research

Prolonged tracheal intubation and the association between patent ductus arteriosus and bronchopulmonary dysplasia: a secondary analysis of the PDA-TOLERATE trial
In the PDA-TOLERATE trial, persistent, moderate-to-large PDAs (even for several weeks) were not associated with an increased risk of BPD when infants required (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: Ronald I. Clyman, Joseph Kaempf, Melissa Liebowitz, Omer Erdeve, Ali Bulbul, Stellan H åkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C. Hassinger, Susa Tags: Brief Reports Source Type: research

Routine Early Antibiotic Use in SymptOmatic Preterm Neonates (REASON): A Pilot Randomized Controlled Trial
Antibiotics are routinely used in symptomatic preterm infants after birth for presumed early onset sepsis without clear evidence to guide this practice. Observational studies support an association between routine early antibiotic use in preterm infants and increased risk for morbidities.(1-4) Despite concerns for these morbidities and data showing low rates of culture-confirmed early onset sepsis, most preterm infants are treated with antibiotics in the first days after birth as a standard of care.(5, 6, 7) This practice is based on the hypothesis that preterm deliveries may be precipitated by an infection and that it may...
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: J. Lauren Ruoss, Catalina Bazacliu, Jordan T. Russell, Diomel de la Cruz, Nan Li, Matthew J. Gurka, Stephanie L. Filipp, Richard A. Polin, Eric W. Triplett, Josef Neu Tags: Brief Reports Source Type: research

Reply
We collected biospecimens from 192 children, under age22 years, who presented to the urgent care clinics or were hospitalized for concerns for SARS-CoV-2 infection or multisystem inflammatory disorder in children (MIS-C). We showed that children have high viral loads in day 1-2 of illness as compared with adults with severe disease with>7 days of symptoms. Although we did not observe viral load differences between children and adults when stratified by time (perhaps because of a small sample size of adults in this cohort with18 years of age2. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: Lael M. Yonker, Alessio Fasano Tags: Letters to the Editor Source Type: research

Use of tocilizumab in multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2
Kaushik et al provide a comprehensive overview of characteristics of the multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (1) All 33 children had evidence of SARS-CoV-2 infection in the form of positive reverse-transcription polymerase chain reaction and/or positive antibody test (1). Similar to routine (non-SARS-CoV-2 related) Kawasaki disease , the commonest treatment modality employed was intravenous immunoglobulin (IVIg). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: Aaqib Zaffar Banday, Vignesh Pandiarajan Tags: Letters to the Editor Source Type: research

Reply
We appreciate the important questions raised by Vignesh et al regarding the use of tocilizumab in patients with MIS-C and the follow up of coronary abnormalities. Our study was a multi-institutional observational study without any intervention in medical management. Treatment and supportive therapies were based on institutional protocols and medical team clinical judgment. Various treatment modalities were used by different centers. Intravenous immunoglobulin (IVIG) was used in 54% of patients, corticosteroids in 51%, and IL-1 receptor antagonist (Anakinra) in 12%. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: Shubhi Kaushik, Simone Jhaveri, Kim R. Derespina, Shivanand S. Medar, Kenan Stern, Scott I. Aydin Tags: Letters to the Editor Source Type: research

Pre and Post-Transplant Liver Disease Assessment in Adolescents Undergoing Isolated Heart Transplantation for Fontan Failure
To describe the assessment of Fontan associated liver disease and determine the clinical and imaging measures that may identify hepatic morbidity risk in isolated heart transplantation candidates and trend those measures post-IHT. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: Dellys Soler Rodriguez, Chad Mao, William T. Mahle, Kirk R. Kanter, Adina Alazraki, Kiery Braithwaite, Heather Rytting, Shelley Caltharp, Joseph F. Magliocca, Ren é Romero Tags: Original Articles Source Type: research

Does Mask Use Affect the Quantitative SARS-CoV-2 Load In the Nasopharynx?
The author declares no conflicts of interest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: Deepak Gupta Tags: Letters to the Editor Source Type: research

You say potato, I say tomato: Reassessing severe acute respiratory syndrome coronavirus 2 viral loads in children
Yonker et  al conclude that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nasopharyngeal viral load in children in the first 2 days of symptoms was significantly greater than in hospitalized adults with severe disease.1 Comparing the median viral load of 9 children in the first 2 days of ill ness with that of adults tested at least 7 days and as many as 26 days after symptom onset, a time point when viral load is always lower than at symptom onset and contagiousness has ceased, is inappropriate. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 21, 2020 Category: Pediatrics Authors: Benjamin Lee, William V. Raszka Tags: Letter to the Editor Source Type: research

Children with Heterozygous Familial Hypercholesterolemia in the United States: Data from the CASCADE FH Registry
To describe enrollment characteristics of youth in the CAscade SCreening for Awareness and DEtection (CASCADE) Familial Hypercholesterolemia Registry. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2020 Category: Pediatrics Authors: Sarah D. de Ferranti, Peter Shrader, MacRae F. Linton, Joshua W. Knowles, Lisa C. Hudgins, Irwin Benuck, Iris Kindt, Emily C. O ’Brien, Amy L. Peterson, Zahid S. Ahmad, Sarah Clauss, P. Barton Duell, Michael D. Shapiro, Katherine Wilemon, Samuel S. Gidd Tags: Original Articles Source Type: research

Temporal Clusters of Kawasaki Disease Cases Share Distinct Phenotypes That Suggest Response to Diverse Triggers
To test the hypothesis that cases of Kawasaki disease within a temporal cluster have a similar pattern of host response that is distinct from cases of Kawasaki disease in different observed clusters and randomly constructed clusters. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2020 Category: Pediatrics Authors: Jane C. Burns, Laurel L. DeHaan, Chisato Shimizu, Emelia V. Bainto, Adriana H. Tremoulet, Daniel R. Cayan, Jennifer A. Burney Tags: Original Articles Source Type: research

Cancer in children with inflammatory bowel disease: Are we making a difference?
inflammatory bowel disease (IBD) in childhood is increasingly common worldwide,[1] with incidence growing fastest among children diagnosed before their fifth birthday.[2] Understanding the long-term implications of this life-long inflammatory disease and its treatments are of vital importance. One potential long-term implication is the increased risk of malignancies. The link between IBD (particularly adult-onset IBD) and colorectal cancer is well-established and thought to be secondary to chronic under-treated inflammation of the colon. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 20, 2020 Category: Pediatrics Authors: M. Ellen Kuenzig, Eric I. Benchimol Tags: Editorials Source Type: research

You say potato, I say tomato: reassessing SARS-CoV-2 viral loads in children
Yonker et al conclude that SARS-CoV-2 nasopharyngeal viral load in children in the first two days of symptoms was significantly higher than in hospitalized adults with severe disease (1). Comparing the median viral load of nine children in the first two days of illness to that of adults tested at least seven days and as many as 26 days after symptom onset, a time point when viral load is always lower than at symptom onset and contagiousness has ceased, is inappropriate (2,3,4). SARS-CoV-2 viral load is highest at the onset of illness and wanes over time regardless of age or illness severity, as the authors themselves argue...
Source: The Journal of Pediatrics - September 20, 2020 Category: Pediatrics Authors: Benjamin Lee, William V. Raszka Tags: Letters to the Editor Source Type: research

Reply
COVID-19 carries significant morbidity and mortality for adults while children have been felt to be “spared”. The justification for the apparent difference in clinical response remains to be understood. We provide data pertinent to viral load, ACE2 expression and SARS-CoV-2 antibody responses for SARS-CoV-2-infected children1. Comparisons with adults probed for factors driving the apparent dic hotomous response between children and adults following infection with SARS-CoV-2. Our data show that children can, in fact, carry high viral loads despite mild symptoms, in contrast to adults who become quite ill even as...
Source: The Journal of Pediatrics - September 20, 2020 Category: Pediatrics Authors: Lael M. Yonker, Anne M. Neilan, Yannic Bartsch, Ankit B. Patel, James Regan, Puneeta Arya, Elizabeth Gootkind, Grace Park, Margot Hardcastle, Anita St. John, Lori Appleman, Michelle L. Chiu, Allison Fialkowski, Denis De La Flor, Rosiane Lima, Evan A. Bord Tags: Letters to the Editor Source Type: research

Cyst-like: An incongruent Chest Radiograph
A 10-month-old boy was admitted with cough and fever despite a course of oral antibiotics. Oxygen saturation was normal in air. There were reduced breath sounds posteriorly on the left side of the chest, with normal percussion. Bowel sounds were not heard in the chest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 19, 2020 Category: Pediatrics Authors: Andrew Hallett, Lena Uzunova, Lena Thia Tags: Insights and Images Source Type: research

Gastrointestinal Hemorrhage: A Manifestation of the Telomere Biology Disorders
To describe the clinical features, therapeutic interventions, and patient outcomes of GI hemorrhage in individuals with telomere biology disorders which include dyskeratosis congenita, Hoyeraal-Hreidarsson syndrome, Revesz syndrome and Coats plus. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 19, 2020 Category: Pediatrics Authors: Ryan W. Himes, Eric H. Chiou, Karen Queliza, Dror S. Shouval, Raz Somech, Suneet Agarwal, Kunal Jajoo, David S. Ziegler, Christian P. Kratz, James Huang, Tiffany L. Lucas, Kasiani C. Myers, Adam S. Nelson, Courtney D. DiNardo, Blanche P. Alter, Neelam Gir Tags: Original Articles Source Type: research

Prevention of Perinatal HIV Transmission in an Area of High HIV Prevalence in the United States
To evaluate the uptake of perinatal HIV preventive interventions by risk of perinatal HIV transmission in mother-infant pairs in a high HIV prevalence area in the United States (US). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 19, 2020 Category: Pediatrics Authors: Wei Li A. Koay, Jiaqi Zhang, Krishna V. Manepalli, Caleb J. Griffith, Amanda D. Castel, Rachel K. Scott, Kathleen T. Ferrer, Natella Y. Rakhmanina Tags: Original Articles Source Type: research

Mitochondrial Disease and Coenzyme Q10 Deficiency: Commentary
Mitochondrial disorders may present from birth to adulthood and are characterized by dysfunction of the mitochondrial respiratory chain due to pathogenic variants in mitochondrial DNA (mtDNA) or nuclear DNA, with an estimated incidence of 1/5000 1. Mitochondrial disorders have a broad phenotypic spectrum and may fall into one of several classic phenotypic presentations (e.g., mitochondrial encephalopathy with lactic acidosis and stroke-like episodes: MELAS; Leber hereditary optic neuropathy: LHON; myoclonic epilepsy with ragged red fibers: MERRF, Kearns-Sayre syndrome: KSS, among others) or may present with variable sympto...
Source: The Journal of Pediatrics - September 19, 2020 Category: Pediatrics Authors: Audrey C. Woerner, Jerry Vockley Tags: Editorials Source Type: research

Diagnosis and Acute Management of E-Cigarette or Vaping Product Use –Associated Lung Injury in the Pediatric Population: A Systematic Review
To assess quantitative data on the presentation, investigative findings, patterns of lung injury, and interventions of pediatric cases of e-cigarette or vaping –associated lung injury (EVALI) in the acute care setting. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 19, 2020 Category: Pediatrics Authors: Clarelle L. Gonsalves, Jie Wei Zhu, April J. Kam Tags: Original Articles Source Type: research

Diagnosis and Acute Management of E-cigarette or Vaping Product Use- Associated Lung Injury (EVALI) in the Pediatric Population: A Systematic Review
To assess quantitative data on the presentation, investigative findings, patterns of lung injury, and interventions of pediatric cases of e-cigarette or vaping associated lung injury (EVALI) in the acute care setting. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 18, 2020 Category: Pediatrics Authors: Clarelle L. Gonsalves, Jie Wei Zhu, April J. Kam Tags: Original Articles Source Type: research

Comment regarding pediatric severe acute respiratory syndrome coronavirus 2: clinical presentation, infectivity, and immune responses
In the report by Yonker et  al, despite having tested 11 asymptomatic children with 3 positives, there are no details about this group selection and there is no information about the viral load in this group.1 It would be important to compare this group with the group study, instead of comparing asymptomatic/early infection with adults at a later stage of the disease. One study found a higher viral load in adults during the first week of symptoms with a progressive decrease over time, as observed in the present study in children, reinforcing that comparing viral load at different stages of the disease may be inadequat...
Source: The Journal of Pediatrics - September 18, 2020 Category: Pediatrics Authors: Juliana Ferreira Ferranti, Natalia Viu Degaspare, Luciana Becker Mau, Artur Figueiredo Delgado, Werther Brunow de Carvalho Tags: Letters to the Editor Source Type: research

Hemophagocytic Lymphohistiocytosis Associated with Histiocytic Necrotizing Lymphadenitis: A Clinical Study of 13 Children and Literature Review
To analyze the clinical characteristics and prognosis of pediatric hemophagocytic lymphohistiocytosis associated with histiocytic necrotizing lymphadenitis (HNL-HNL). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 17, 2020 Category: Pediatrics Authors: Ying Yang, Hongyun Lian, Honghao Ma, Yunze Zhao, Qing Zhang, Li Zhang, Tianyou Wang, Zhigang Li, Rui Zhang Tags: Original Articles Source Type: research

Growth from Birth through Six Months for Infants of Mothers in the “Women First” Preconception Maternal Nutrition Trial
To evaluate whether the fetal linear growth effects of maternal nutrition supplementation would be maintained through 6 months postnatal age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 17, 2020 Category: Pediatrics Authors: Nancy F. Krebs, K. Michael Hambidge, Jamie L. Westcott, Ana L. Garc és, Lester Figueroa, Antoinette K. Tsefu, Adrien L. Lokangaka, Shivaprasad S. Goudar, Sangappa M. Dhaded, Sarah Saleem, Sumera Aziz Ali, Carl L. Bose, Richard J. Derman, Robert L. Golden Tags: Original Articles Source Type: research

Unilateral laterothoracic exanthema
A 10-year-old Caucasian boy was referred for evaluation of an acute eruption that had developed over the past 8 days. The eruption began in the right popliteal fossa, and then coalesced and spread along the right side of his body. Fever up to 38 ºC and joint pain were reported 3 days before the appearance of skin lesions. Physical examination showed erythematous and edematous macules and papules on his right hemibody (Figure). The left hemibody did not show any skin lesions. Laboratory test performed showed IgM positivity for parvovirus B1 9. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 17, 2020 Category: Pediatrics Authors: Francisco J. Navarro-Trivi ño, Israel Pérez-López, Ricardo Ruiz-Villaverde Tags: Insights and Images Source Type: research

Comment Regarding Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses
In the report by Yonker et al1, despite having tested 11 asymptomatic children with 3 positives, there are no details about this group selection and there is no information about the viral load in this group. It would be important to compare this group with the group study, instead of comparing asymptomatic/early infection with adults at a later stage of the disease. One study found higher viral load in adults during the first week of symptoms with progressive decreasing over time, as observed in the present study in children, reinforcing that comparing viral load at different stages of the disease may be inadequate2. (Sou...
Source: The Journal of Pediatrics - September 17, 2020 Category: Pediatrics Authors: Juliana Ferreira Ferranti, Natalia Viu Degaspare, Luciana Becker Mau, Artur Figueiredo Delgado, Werther Brunow de Carvalho Tags: Letters to the Editor Source Type: research

Reply
We reported symptomatology, viral load, ACE2 expression, and antibody responses in this pediatric population. High viral loads were detected in respiratory secretions from children, particularly within the first two days of illness. We also found that children with SARS-CoV-2 infection have very mild cold-like symptoms, indistinguishable from children who did not have SARS-CoV-2 infection. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 17, 2020 Category: Pediatrics Authors: Lael M. Yonker, Anne M. Neilan, Yannic Bartsch, Ankit B. Patel, James Regan, Puneeta Arya, Elizabeth Gootkind, Grace Park, Margot Hardcastle, Anita St. John, Lori Appleman, Michelle L. Chiu, Allison Fialkowski, Denis De la Flor, Rosiane Lima, Evan A. Bord Tags: Letters to the Editor Source Type: research

An Evidence-Based Ethical Approach to Parental Refusal of Screening Tests: The Case of Asymptomatic Neonatal Hypoglycemia
Since the advent of the phenylketonuria screen for newborns in the 1960s, there has been an explosion of new tests for the early detection of numerous genetic, cardiac, and metabolic diseases. The intent is to discover and treat these illnesses before symptoms develop and to prevent possible irreparable harm. Screenings are typically conducted with parental assent rather than explicit consent. However, parental refusal on the grounds of personal and religious beliefs are becoming increasingly more common. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 17, 2020 Category: Pediatrics Authors: Samantha J. Palmaccio, Alexis L. Rodriguez, Matthew J. Drago, Mark R. Mercurio Tags: Commentary Source Type: research

Mortality Determinants in Children with Biliary Atresia Awaiting Liver Transplantation
To determine risk factors for waitlist mortality in children with biliary atresia listed for liver transplantation. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 16, 2020 Category: Pediatrics Authors: Ioannis A. Ziogas, Fei Ye, Zhiguo Zhao, Shu Cao, Muhammad A. Rauf, Manhal Izzy, Lea K. Matsuoka, Lynette A. Gillis, Sophoclis P. Alexopoulos Tags: Original Articles Source Type: research

An Evidence Based Ethical Approach to Parental Refusal of Screening Tests: The Case of Asymptomatic Neonatal Hypoglycemia
Since the advent of the phenylketonuria screen for newborns in the 1960s, there has been an explosion of new tests for the early detection of numerous genetic, cardiac, and metabolic diseases. The intent is to discover and treat these illnesses before symptoms develop and to prevent possible irreparable harm. Screenings are typically conducted with parental assent rather than explicit consent. However, parental refusal on the grounds of personal and religious beliefs are becoming increasingly more common. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 16, 2020 Category: Pediatrics Authors: Samantha J. Palmaccio, Alexis L. Rodriguez, Matthew J. Drago, Mark R. Mercurio Tags: Commentary Source Type: research

Development of a Stakeholder Driven Serious Illness Communication Program for Advance Care Planning in Children, Adolescents, and Young Adults with Serious Illness
To develop a generalizable advance care planning ACP intervention for children and children, adolescents, and young adults with serious illness using a multi-stage stakeholder driven approach. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 15, 2020 Category: Pediatrics Authors: Danielle D. DeCourcey, Lindsay Partin, Anna Revette, Rachelle Bernacki, Joanne Wolfe Tags: Original Articles Source Type: research

The Biological and Social Determinants of Childhood Obesity: Comparison of 2 Cohorts 50  Years Apart
To determine whether the same relationships between early-life risk factors and socioeconomic status (SES) with childhood body mass index (BMI) are observed in a modern cohort (2000) compared with a historic cohort (1947). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 15, 2020 Category: Pediatrics Authors: Natassia Robinson, Jill A. McKay, Mark S. Pearce, Viviana Albani, Charlotte M. Wright, Ashley J. Adamson, Heather Brown Tags: Original Article Source Type: research

The biological and social determinants of childhood obesity: comparison of two cohorts 50 years apart
To determine whether the same relationships between early life risk factors and socioeconomic status with childhood BMI are observed in a modern cohort (2000) compared with an historic cohort (1947). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 14, 2020 Category: Pediatrics Authors: N. Robinson, J.A. MCKay, M.S. Pearce, V. Albani, C.M. Wright, A.J. Adamson, H. Brown Tags: Original Articles Source Type: research

Osteochondrosis of Ischiopubic Synchondrosis: Van Neck –Odelberg Disease
A 14-year-old boy was evaluated in the pediatric rheumatology clinic for recurrent gluteal and perineal pain persisting for 1  year. He described an uncomfortable pain that persisted throughout the day and sometimes resulted in restriction of physical activity. He reported no trauma or disease. Physical examination revealed normal height and weight for his age and sex, and puberty consistent with Tanner stage IV. He compl ained of a stinging pain when pressure was applied to the right groin and to the right side of the perineum. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 14, 2020 Category: Pediatrics Authors: Nuran Sabir, Pinar Çakmak, Neslihan Yılmaz, Selçuk Yüksel Tags: Insights and Images Source Type: research

Osteochondrosis of ischiopubic synchondrosis —Van Neck-Odelberg Disease
A 14-year-old boy was evaluated in the pediatric rheumatology clinic for recurrent gluteal and perineal pain for one year. He described an uncomfortable pain that persisted throughout the day and sometimes resulted in restriction of physical activity. There were no trauma or disease reported. On physical examination, his height and weight based on age and sex were normal, and puberty consistent with Tanner stage IV. There was a stinging pain, when pressure was applied to his right groin and to the right side of the perineum. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 13, 2020 Category: Pediatrics Authors: Nuran Sabir, Pinar Çakmak, Neslihan Yılmaz, Selçuk Yüksel Tags: Insights and Images Source Type: research

Response to Outcomes from the Centers for Disease Control and Prevention 2018 Breastfeeding Report Card: Public Policy Implications
Thank you for publishing content highlighting the importance of evaluating breastfeeding programs and policies. We wish to raise several methodological concerns with the recent analysis1 of CDC ’s Breastfeeding Report Card data2 and percent Baby Friendly Hospital Initiative (BFHI) births:3 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 13, 2020 Category: Pediatrics Authors: Andrei Stefanescu, Betsy Dancisak, Jennifer Le, Marci Brewer, Paula Schreck Tags: Letters to the Editor Source Type: research

Reply
We appreciate the opportunity to respond to the thoughtful comments on the methodology we employed in our analysis of breastfeeding outcomes and their relationship to designation as a Baby Friendly Hospital. The authors state that they performed alternative analyses using the 2014 birth cohort and weighted regression as well as sensitivity analysis of the 2016 births and obtained results different from ours. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 12, 2020 Category: Pediatrics Authors: Joel L. Bass, Tina Gartley, Ronald Kleinman Tags: Letters to the Editor Source Type: research

Adult Cardiovascular Health Risk and Cardiovascular Phenotypes of Prematurity
Survival for extremely low birth weight (ELBW) infants has improved dramatically over the past 20 years.[1] The nature of these advances is multifactorial and relates to increased appreciation of organ vulnerability, improved understanding of disease mechanisms, enhanced diagnostic precision, and improved therapeutic options. Unfortunately, the advances that underlie enhanced survival do not guarantee avoidance of neonatal morbidity or adverse long-term outcomes. In addition, life-saving treatments may have unintended negative effects on organ development and performance. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 11, 2020 Category: Pediatrics Authors: Melissa L. Bates, Philip T. Levy, Anne Monique Nuyt, Kara N. Goss, Adam J. Lewandowski, Patrick J. McNamara Tags: Medical Progress Source Type: research

Normative Values for Cardiopulmonary Exercise Stress Testing Using Ramp Cycle Ergometry in Children and Adolescents
To provide sex, age, and race specific reference values for ramp cycle ergometer cardiopulmonary exercise test (CPET) in children in the United States. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 10, 2020 Category: Pediatrics Authors: Danielle S. Burstein, Michael G. McBride, Jungwon Min, Alexander A. Paridon, Sarah Perelman, Erika M. Huffman, Shannon O ’Malley, Julia Del Grosso, Herman Groepenhoff, Stephen M. Paridon, Julie A. Brothers Tags: Original Articles Source Type: research

Target-Based Care: An Intervention to Reduce Variation in Postoperative Length of Stay
To derive care targets and evaluate the impact of displaying them at the point of care on postoperative length of stay (LOS). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 10, 2020 Category: Pediatrics Authors: Andrew Y. Shin, Isabelle J. Rao, Hannah K. Bassett, Whitney Chadwick, Joseph Kim, Alaina K. Kipps, Komal Komra, Ling Loh, Katsuhide Maeda, Monica Mafla, Laura Presnell, Paul J. Sharek, Katherine M. Steffen, David Scheinker, Claudia A. Algaze Tags: Original Article Source Type: research

Development of a Risk Model for Pediatric Hospital-Acquired Thrombosis: A Report from the Children's Hospital-Acquired Thrombosis Consortium
To identify pertinent clinical variables discernible on the day of hospital admission that can be used to assess risk for hospital-acquired venous thromboembolism (HA-VTE) in children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 10, 2020 Category: Pediatrics Authors: Julie Jaffray, Brian Branchford, Neil Goldenberg, Jemily Malvar, Stacy E. Croteau, Michael Silvey, John H. Fargo, James D. Cooper, Nihal Bakeer, Richard Sposto, Lingyun Ji, Neil A. Zakai, E. Vincent S. Faustino, Amy Stillings, Emily Krava, Guy Young, Aras Tags: Original Article Source Type: research

Development of a Risk Model for Pediatric Hospital-Acquired Thrombosis: A Report from the CHAT Consortium
To identify pertinent clinical variables discernible on the day of hospital admission that can be used to assess risk for hospital-acquired-VTE (HA-VTE) in children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 9, 2020 Category: Pediatrics Authors: Julie Jaffray, Brian Branchford, Neil Goldenberg, Jemily Malvar, Stacy E. Croteau, Michael Silvey, John H. Fargo, James D. Cooper, Nihal Bakeer, Richard Sposto, Lingyun Ji, Neil A. Zakai, E. Vincent S. Faustino, Amy Stillings, Emily Krava, Guy Young, Aras Tags: Original Articles Source Type: research

Target Based Care: An Intervention to Reduce Variation in Postoperative Length of Stay
To derive care targets and evaluate the impact of displaying them at the point of care on postoperative length of stay (LOS). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 9, 2020 Category: Pediatrics Authors: Andrew Y. Shin, Isabelle J. Rao, Hannah K. Bassett, Whitney Chadwick, Joseph Kim, Alaina K. Kipps, Komal Komra, Ling Loh, Katsuhide Maeda, Monica Mafla, Laura Presnell, Paul J. Sharek, Katherine M. Steffen, David Scheinker, Claudia A. Algaze Tags: Original Articles Source Type: research

Evaluation of Gastroesophageal Reflux Disease 1  Year after Esophageal Atresia Repair: Paradigms Lost from a Single Snapshot?
To analyze the findings of both multichannel intraluminal impedance with pH (MII-pH) and endoscopy/histopathology in children with esophageal atresia at age 1  year, according to current recommendations for the evaluation of gastroesophageal reflux disease (GERD) in esophageal atresia. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 8, 2020 Category: Pediatrics Authors: Renato Tambucci, Sara Isoldi, Giulia Angelino, Filippo Torroni, Simona Faraci, Francesca Rea, Erminia Francesca Romeo, Tamara Caldaro, Luciano Guerra, Anna Chiara Iolanda Contini, Monica Malamisura, Giovanni Federici di Abriola, Paola Francalanci, Andrea Tags: Original Article Source Type: research

Mother's Own Milk Biomarkers Predict Coming to Volume in Pump-Dependent Mothers of Preterm Infants
To assess serial secretory activation biomarker concentrations (sodium [Na], potassium [K], Na:K, protein, lactose, and citrate) in mother's own milk (MOM) from breast pump –dependent mothers of preterm infants to determine associations with coming to volume (CTV), defined as producing at least 500 mL/day MOM by day 14 postpartum. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 8, 2020 Category: Pediatrics Authors: Rebecca Hoban, Clarisa Medina Poeliniz, Emily Somerset, Ching Tat Lai, Judy Janes, Aloka L. Patel, Donna Geddes, Paula P. Meier Tags: Original Article Source Type: research

Reassessing the Use of Proton Pump Inhibitors and Histamine-2 Antagonists in Critically Ill Children: A Systematic Review and Meta-Analysis
To determine the association between stress ulcer prophylaxis on gastrointestinal bleeding, nosocomial pneumonia, mortality, and length of stay in the pediatric intensive care unit (PICU). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 7, 2020 Category: Pediatrics Authors: Dominic Wen Jie Yao, Chengsi Ong, Nichola Mary Eales, Rehena Sultana, Judith Ju-Ming Wong, Jan Hau Lee Tags: Original Articles Source Type: research

Child Mouthing of Feces and Fomites and Animal Contact are Associated with Diarrhea and Impaired Growth among Young Children in the Democratic Republic of the Congo: A prospective cohort study
To identify exposure pathways to fecal pathogens that are significant contributors to diarrheal diseases and impaired growth in young children, and to evaluate scalable interventions to reduce fecal contamination from these pathways. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 7, 2020 Category: Pediatrics Authors: Christine Marie George, Lucien Bisimwa Cirhuza, Jennifer Kuhl, Camille Williams, Nicole Coglianese, Elizabeth Thomas, Sarah Bauler, Ruthly Fran çois, Ronald Saxton, Amani Sanvura Presence, Alves Birindwa, Bisimwa Rusanga Jean Claude, Jamie Perin, Patrick Tags: Original Articles Source Type: research