Reply
We appreciate the questions raised by Dr Nguyen about our clinical trial evaluating the safety and efficacy of intravenous umbilical cord blood infusion for the treatment of children with autism spectrum disorder (ASD). We did not target CD34 dosing in this clinical trial because our preclinical studies and early phase clinical trial data in children with ASD and children with cerebral palsy (CP) did not show any association between improvement and CD34 dosing. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Geraldine Dawson, Joanne Kurtzberg Tags: Letters to the Editor Source Type: research

Subacute Multifocal Abscesses Related to a Mycobacterium marinum Infection in a Child
An 8-year-old boy presented with multiple inflammatory cutaneous lesions on both hands that had been evolving for 4 weeks. At the onset, the child received a 10 days course of Amoxicillin clavulanic acid without improvement. Physical examination revealed multiple abscesses on both hands (Figure 1) and a suppurative adenopathy of the right arm (Figure 2). The child had no history of fever, and was in good health. He had no other symptoms or clinical signs. There were no laboratory abnormalities detected. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Cl émence Briand, Alice Gaudart, Diane Demonchy, Thomas Hubiche Tags: Rediscovering the Physical Exam Source Type: research

Considerations to Support Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures in Ambulatory Clinics
To identify challenges to the use of Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in the ambulatory pediatric setting and possible solutions to these challenges. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 29, 2020 Category: Pediatrics Authors: Elizabeth D. Cox, Sarah K. Dobrozsi, Christopher B. Forrest, Wendy E. Gerhardt, Harald Kliems, Bryce B. Reeve, Nan E. Rothrock, Jin-Shei Lai, Jacob M. Svenson, Lindsay A. Thompson, Thuy Dan N. Tran, Carole A. Tucker Tags: Original Articles Source Type: research

Considerations to Support Use of PROMIS Pediatric Measures in Ambulatory Clinics
To identify challenges to the use of Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in the ambulatory pediatric setting and possible solutions to these challenges. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 29, 2020 Category: Pediatrics Authors: Elizabeth D. Cox, Sarah K. Dobrozsi, Christopher B. Forrest, Wendy E. Gerhardt, Harald Kliems, Bryce B. Reeve, Nan E. Rothrock, Jin-Shei Lai, Jacob M. Svenson, Lindsay A. Thompson, Thuy Dan N. Tran, Carole A. Tucker Tags: Original Articles Source Type: research

Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age MRI in Infants Born Very Preterm
To identify perinatal clinical diseases and treatments that are associated with the development of objectively diagnosed diffuse white matter abnormality (DWMA) on structural MRI at term-equivalent age in very preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 28, 2020 Category: Pediatrics Authors: Nehal A. Parikh, Puneet Sharma, Lili He, Hailong Li, Mekibib Altaye, Venkata Sita Priyanka Illapani, Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators Tags: Original Articles Source Type: research

Tidal Breathing Measurements in Former Preterm Infants: A  Retrospective Longitudinal Study
To investigate, in infants born preterm with or without bronchopulmonary dysplasia (BPD), the trajectory of tidal breathing flow-volume (TBFV) parameters in the first 2  years of life; the association between TBFV parameters and perinatal risk factors; and the predictive value of TBFV parameters for rehospitalizations due to respiratory infections and wheeze. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Anna Lavizzari, Emanuela Zannin, Marijke Ophorst, Francesca Ciuffini, Silvana Gangi, Andrea Farolfi, Mariarosa Colnaghi, Raffaele Lorenzo Dellac à, Fabio Mosca Tags: Original Articles Source Type: research

Linking Parent Confidence and Hospitalization through Mobile Health: A  Multisite Pilot Study
To evaluate the associations between parent confidence in avoiding hospitalization and subsequent hospitalization in children with medical complexity (CMC); and feasibility/acceptability of a texting platform, Assessing Confidence at Times of Increased Vulnerability (ACTIV), to collect repeated measures of parent confidence. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Ryan J. Coller, Carlos F. Lerner, Jay G. Berry, Thomas S. Klitzner, Carolyn Allshouse, Gemma Warner, Carrie L. Nacht, Lindsey R. Thompson, Jens Eickhoff, Mary L. Ehlenbach, Andrea J. Bonilla, Melanie Venegas, Brigid M. Garrity, Elizabeth Casto, Terah Bowe Tags: Original Articles Source Type: research

Tidal Breathing Measurements in Former Preterm Infants: A Retrospective Longitudinal Study
To investigate in preterm infants with or without bronchopulmonary dysplasia (BPD the trajectory of tidal breathing flow-volume (TBFV) parameters in the first two years of life; the association between TBFV parameters and perinatal risk factors; and the predictive value of TBFV parameters for re-hospitalizations due to respiratory infections and wheeze,. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Anna Lavizzari, Emanuela Zannin, Marijke Ophorst, Francesca Ciuffini, Silvana Gangi, Andrea Farolfi, Mariarosa Colnaghi, Raffaele Dellac à, Fabio Mosca Tags: Original Articles Source Type: research

Thrombotic Microangiopathy Following Onasemnogene Abeparvovec for Spinal Muscular Atrophy: A Case Series
Spinal muscular atrophy is treated with onasemnogene abeparvovec, which replaces the missing survival motor neuron 1 gene via an adeno-associated virus vector. As of July 1, 2020, we had identified three infants who developed thrombotic microangiopathy (TMA) following onasemnogene abeparvovec . Early recognition and treatment of drug-induced TMA may lessen mortality and morbidity. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Deepa H. Chand, Craig Zaidman, Kapil Arya, Rachel Millner, Michelle A. Farrar, Fiona E. Mackie, Natalie L. Goedeker, Vikas R. Dharnidharka, Raja Dandamudi, Sandra P. Reyna Tags: Brief Reports Source Type: research

Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome
To identify predictors of hospitalization in pediatric patients presenting to an emergency department (ED) for a cyclic vomiting syndrome (CVS) attack. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Zeyad M. Abdulkader, Neetu Bali, Karla Vaz, Desalegn Yacob, Carlo Di Lorenzo, Peter L. Lu Tags: Original Articles Source Type: research

Linking Parent Confidence and Hospitalization through mHealth: A Multisite Pilot Study
To evaluate the associations between parent confidence in avoiding hospitalization and subsequent hospitalization in children with medical complexity (CMC); and feasibility/acceptability of a texting platform, ACTIV, to collect repeated measures of parent confidence. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Ryan J. Coller, Carlos F. Lerner, Jay G. Berry, Thomas S. Klitzner, Carolyn Allshouse, Gemma Warner, Carrie L. Nacht, Lindsey R. Thompson, Jens Eickhoff, Mary L. Ehlenbach, Andrea J. Bonilla, Melanie Venegas, Brigid M. Garrity, Elizabeth Casto, Terah Bowe Tags: Original Articles Source Type: research

Reply
We were pleased to receive the comments by Koyama and Sairenchi regarding our recent review of fetal growth restriction (FGR) and programmed hypertension. We agree that rapid weight gain, development of obesity, and high sodium intake during the first year of life and throughout childhood are likely major factors that further promote hypertension development in children with FGR in an additive or even multiplicative fashion, mediated in part through renin-angiotensin-system (RAS) alterations (Figure; available at www.jpeds.com) (3-8). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Andrew M. South, Barbara T. Alexander, Janna L. Morrison, Arvind Sehgal Tags: Letters to the Editor Source Type: research

Premature Congenital Heart Disease: Building a Comprehensive Database to Evaluate Risks and Guide Intervention
This study fills a major gap of knowledge with respect to understanding the link between certain CHD lesions and the insults to the fetal environment, and highlights that little is known in regards to the impact of perinatal risk factors on outcomes for this vulnerable preterm population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Paulomi M. Chaudhry, Molly K. Ball, Shannon E.G. Hamrick, Philip T. Levy, Children's Hospital Neonatal Consortium Cardiac Focus Group Tags: Letters to the Editor Source Type: research

Reply
We thank Chaudhry et al and the Children's Hospital Neonatal Consortium Cardiac Focus Group for the recognition and the interest in our recently published work. Moreover, we thank the authors for raising the important need for databases encompassing prenatal, neonatal, postnatal, and surgical data on patients with congenital heart defects. We agree that such databases are urgently needed in order to identify and stratify this patient population according to the risk of mortality and short-term complications such as neonatal morbidities, but also long-term complications such as neurodevelopmental disorders. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Niels B. Matthiesen, John R. Østergaard, Vibeke E. Hjortdal, Tine B. Henriksen Tags: Letters to the Editor Source Type: research

Trajectory of Body Mass Index from Ages 2 to 7  Years and Age at Peak Height Velocity in Boys and Girls
To examine the associations between body mass index (BMI) at 2-4  years and 5-7 years and age at peak height velocity (APHV), an objective measure of pubertal timing, among boys and girls from predominantly racial minorities in the US that have been historically underrepresented in this research topic. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Li-Kuang Chen, Guoying Wang, Wendy L. Bennett, Yuelong Ji, Colleen Pearson, Sally Radovick, Xiaobin Wang Tags: Original Articles Source Type: research

Pediatric acute respiratory distress syndrome associated with respiratory viruses
A report of pediatric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in New York City included 21 patients with pediatric acute respiratory distress syndrome (PARDS).1 A diagnosis of PARDS mandates the presence of respiratory failure, defined as the use of positive pressure mechanical ventilation, either invasive or noninvasive. Therefore, it might be helpful to determine the incidence of PARDS in patients with respiratory failure and various respiratory viruses, as it is possible that specific viruses are more frequently associated with the development of PARDS. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: J. Scott Baird Tags: Letters to the Editor Source Type: research

Fetal growth restriction, nutrition, and the renin-angiotensin system
We read with interest the recent comprehensive review by Sehgal et  al on the mechanism of fetal growth restriction (FGR)-associated hypertension, focusing on prevention and therapeutic strategies across the life course to mitigate hypertension and cardiovascular disease.1 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Osamu Arisaka, Go Ichikawa, Satomi Koyama, Toshimi Sairenchi Tags: Letters to the Editor Source Type: research

Transient Angioedema of the Small Bowel because of Intravenous Nonionic Iodinated Contrast Media
A 14-year-old girl was referred to our hospital for suspected accessory spleen torsion. There was no history of allergy or medication use. Abdominal multiphase contrast-enhanced computed tomography (CT) was performed. The patient had mild abdominal discomfort after intravenous administration of nonionic iodinated contrast media (CM) for CT. CT images in the arterial phase showed normal proximal small bowel (Figure  1); however, CT images in the venous phase revealed that the proximal small bowel had circumferential thickening of the wall including the duodenum (Figure 2). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Tomohiro Wakabayashi, Yuta Sasaoka, Yoshiyuki Sakai, Shuichi Miyamoto, Takeshi Tsugawa, Yukihiko Kawasaki Tags: Insights and Images Source Type: research

Educational Coaches: Facilitating Academic Vitality and a Pathway to Promotion for Clinician-Educators
Department chairs want their faculty to experience vitality, thrive, and be promoted. Vitality has been described as “professional fulfillment, motivation, and commitment to ongoing intellectual and personal growth, full professional engagement, enthusiasm, positive feelings of aliveness and energy, and excitement about work.”1 Faculty, in turn, thrive when they are appreciated and supported by leadership, of which promotion is an important result. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Anne C. Gill, Geeta Singhal, Gordon E. Schutze, Teri L. Turner Source Type: research

Letter to the Editor: Pediatric acute respiratory distress syndrome associated with respiratory viruses.
A report of pediatric patients with SARS-CoV-2 infection in New York City included 21 patients with pediatric acute respiratory distress syndrome (PARDS)1. A diagnosis of PARDS mandates the presence of respiratory failure, defined as the use of positive pressure mechanical ventilation, either invasive or noninvasive. Therefore, it might be helpful to determine the incidence of PARDS in patients with respiratory failure and various respiratory viruses, as it is possible that specific viruses are more frequently associated with the development of PARDS. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: J. Scott Baird Tags: Letters to the Editor Source Type: research

Trajectory of BMI from Ages 2 to 7 Years and Age at Peak Height Velocity in Boys and Girls
To examine the associations between body-mass index (BMI) at 2-4 years and 5-7 years and age at peak height velocity (APHV), an objective measure of pubertal timing, among boys and girls from predominantly racial/ethnic minorities in the US that have been historically underrepresented in this research topic. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Li-Kuang Chen, Guoying Wang, Wendy L. Bennett, Yuelong Ji, Colleen Pearson, Sally Radovick, Xiaobin Wang Tags: Original Articles Source Type: research

Transient angioedema of the small bowel due to intravenous nonionic iodinated contrast media
A 14-year-old girl was referred to our hospital for suspected accessory spleen torsion. There was no history of allergy or medication use. Abdominal multiphase contrast-enhanced computed tomography (CT) was performed. The patient had mild abdominal discomfort after intravenous administration of nonionic iodinated contrast media (CM) for CT. CT images in the arterial phase showed normal proximal small bowel (Figure 1A, B); however, CT images in the venous phase revealed that the proximal small bowel had circumferential thickening of the wall including the duodenum (Figure 2A, B). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Tomohiro Wakabayashi, Yuta Sasaoka, Yoshiyuki Sakai, Shuichi Miyamoto, Takeshi Tsugawa, Yukihiko Kawasaki Tags: Insights and Images Source Type: research

Fetal Growth Restriction (FGR), Nutrition, and the Renin-Angiotensin System (RAS)
We read with interest the recent comprehensive review by Sehgal et al. [1] on the mechanism of FGR-associated hypertension, focusing on prevention and therapeutic strategies across the life course to mitigate hypertension and cardiovascular disease. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Osamu ARISAKA, Go ICHIKAWA, Satomi KOYAMA, Toshimi SAIRENCHI Tags: Letters to the Editor Source Type: research

Reply
The acute respiratory distress syndrome (ARDS) was originally described by Ashbaugh et al in 1967 as a syndrome of acute onset of tachypnea, hypoxemia, and loss of lung compliance. (1) In 2015, the Pediatric Acute Lung Injury Consensus Conference (PALICC) introduced a definition of ARDS specific for pediatric patients (PARDS) that includes invasive and noninvasive mechanical ventilation and uses invasive and non-invasive markers of oxygenation to diagnose and classify the severity of PARDS. (2) (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 26, 2020 Category: Pediatrics Authors: Kim R. Derespina, Shubhi Kaushik, Henry M. Ushay, Shivanand S. Medar Tags: Letters to the Editor Source Type: research

Trends in Bronchopulmonary Dysplasia Among Extremely Preterm Infants in Japan, 2003-2016
To investigate recent trends in bronchopulmonary dysplasia (BPD) and its risk factors among extremely preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 24, 2020 Category: Pediatrics Authors: Toshinori Nakashima, Hirosuke Inoue, Yoshihiro Sakemi, Masayuki Ochiai, Hironori Yamashita, Shouichi Ohga, Neonatal Research Network of Japan Tags: Original Article Source Type: research

Percent Body Fat Content Measured by Plethysmography in Infants Randomized to High- or Usual-Volume Feeding after Very Preterm Birth
We measured percent body fat by air-displacement plethysmography in 86 infants born at (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 24, 2020 Category: Pediatrics Authors: Ariel A. Salas, Colm P. Travers, Maggie L. Jerome, Paula Chandler-Laney, Waldemar A. Carlo Tags: Brief Reports Source Type: research

Trends in Bronchopulmonary Dysplasia among Extremely Preterm Infants in Japan, 2003 –2016
To investigate recent trends in bronchopulmonary dysplasia (BPD) and its risk factors among extremely preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 24, 2020 Category: Pediatrics Authors: Toshinori Nakashima, Hirosuke Inoue, Yoshihiro Sakemi, Masayuki Ochiai, Hironori Yamashita, Shouichi Ohga, Neonatal Research Network of Japan Tags: Original Articles Source Type: research

Obesity at Age 6  Months Is Associated with Shorter Preschool Leukocyte Telomere Length Independent of Parental Telomere Length
To assess whether early modifiable dietary factors and obesity measures are associated with leukocyte telomere length at 3-5  years of age after controlling for the heritability of leukocyte telomere length in a prospective cohort of low-income Latina mothers and their children in San Francisco. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2020 Category: Pediatrics Authors: Melanie J. Baskind, Jessica Hawkins, Melvin B. Heyman, Janet M. Wojcicki Tags: Original Articles Source Type: research

“Even When the Wound Is Healed, the Scar Remains”
The above maxim was coined by the Roman author Publilius Syrus when referring to wounds of most tissues or body parts.1 Because hepatic regeneration was recognized (as evidenced by the story of Prometheus's liver being eaten daily by an eagle only to regenerate the next day) in Syrus's time, his dictum was too far too simplistic when applied to the liver. One must delve more deeply into the mechanism of liver injury to ascertain just when hepatic scaring persists or when it disappears. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2020 Category: Pediatrics Authors: Samuel A. Kocoshis Tags: Editorial Source Type: research

Neurodevelopmental and Growth Outcomes of Extremely Preterm Infants with Short Bowel Syndrome
To determine if preterm infants with surgical necrotizing enterocolitis (sNEC) or spontaneous intestinal perforation (SIP) with short bowel syndrome (SBS) have worse neurodevelopmental and growth outcomes than those with sNEC/SIP without SBS, and those with no NEC, SIP, or SBS. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2020 Category: Pediatrics Authors: Mercedes Bell, Conrad R. Cole, Nellie I. Hansen, Andrea F. Duncan, Susan R. Hintz, Ira Adams-Chapman, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Tags: Original Articles Source Type: research

Even When the Wound is Healed, The Scar Remains
The above maxim was coined by the Roman author Publilius Syrus when referring to wounds of most tissues or body parts.1 Because hepatic regeneration was recognized (as evidenced by the story of Prometheus ’s liver being eaten daily by an eagle only to regenerate the next day) in Syrus’s time, his dictum was too far too simplistic when applied to the liver. One must delve more deeply into the mechanism of liver injury to ascertain just when hepatic scaring persists or when it disappears. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2020 Category: Pediatrics Authors: Samuel A. Kocoshis Tags: Editorials Source Type: research

Adverse Childhood Experiences and School Readiness Among Preschool-Aged Children
To examine the association between preschool-aged children ’s exposure to adverse childhood experiences (ACEs) and multiple, intersecting domains of school readiness using a nationally representative sample. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2020 Category: Pediatrics Authors: Dylan B. Jackson, Alexander Testa, Michael G. Vaughn Tags: Original Articles Source Type: research

Obesity at Age Six Months Is Associated with Shorter Preschool Leukocyte Telomere Length Independent of Parental Telomere Length
To assess whether early modifiable dietary factors and obesity measures are associated with leukocyte telomere length at 3-5 years after controlling for heritability of telomere length in a prospective cohort of low-income Latina mothers and their children in San Francisco. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2020 Category: Pediatrics Authors: Melanie Baskind, Jessica Hawkins, Melvin B. Heyman, Janet Wojcicki Tags: Original Articles Source Type: research

Understanding primary ciliary dyskinesia and other ciliopathies
Ciliopathies are a collection of disorders related to cilia dysfunction. Cilia are specialized organelles that project from the surface of most cells. Motile and primary (sensory) cilia are essential structures and have wide ranging functions. Our understanding of the genetics, pathophysiology, and clinical manifestations of motile ciliopathies, including primary ciliary dyskinesia (PCD), has rapidly advanced since the disease was linked to ciliary ultrastructural defects nearly five decades ago. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2020 Category: Pediatrics Authors: Amjad Horani, Thomas W. Ferkol Tags: Medical Progress Source Type: research

Partnering with Clinical Pharmacologists to Improve Medication  Use in Children
American children receive on average 3.5 prescriptions annually, with 62%-85% used off-label.1,2 Lack of formulations suitable for children is a major reason for off-label and unlicensed use of medications.3 Although this practice does not imply improper, illegal, contraindicated, or investigational use, it often lacks substantial evidence of effectiveness and/or safety from adequate and well-controlled studies. The passage of legislation (Best Pharmaceuticals for Children Act in 2002, the Pediatric Research Equity Act in 2003, the Food and Drug Administration Safety and Innovation Act in 2012; and the Food and Drug Admini...
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Shogo John Miyagi, Edwin Lam, Sonya Tang Girdwood Tags: Notes from the Association of Medical School Pediatric Department Chairs, Inc. Source Type: research

50 Years Ago in The Journal of Pediatrics
Krauss AN, Albert RF, Kannan MM. Contamination of umbilical catheters in the newborn infant. J Pediatr 1970;77:965-9. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Jannicke H. Andresen, Ola Didrik Saugstad Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Hogan GR, Jones B. The relationship of koilonycbia and iron deficiency in infants. J Pediatr 1970;77:1054-7. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Kaitlin Strumph, Kerry Morrone Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Reed TE, Borgaonkar DS, Conneally PM, Yu P, Nance WE, Christian JC, et  al. Dermatoglyphic nomogram for the diagnosis of Down's syndrome. J Pediatr 1970;77:1024-32. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Sankar Vaikom Hariharan, Piyush Gupta Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Oski FA, Delivoria-Papadopoulos M. The red cell, 2,3-diphosphoglycerate, and tissue oxygen release. J Pediatr 1970;77:941-56. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Jannicke H. Andresen, Ola Didrik Saugstad Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Gordon RC, Barrett FF, Yow MD. Ampicillin treatment of listeriosis. J Pediatr 1970;77:1067-70. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Vikram Bhaskar, Piyush Gupta Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Pinkel D. Treatment of childhood acute lymphocytic leukemia. J Pediatr 1970;77:1089-91. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Mar ía Guadalupe García-Lima, Maricarmen Díaz-Gómez, José Eduardo Mares-Gil Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Engel RR, Elin RJ. Hypermagnesemia from birth asphyxia. J Pediatr 1970;77:631-7 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Jannicke H. Andresen, Ola Didrik Saugstad Tags: Original Article Source Type: research

Closing in on PFAPA syndrome as “bad luck”
Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) has been a fascinating condition since its description in 1987. Otherwise healthy young children have clockwork timing of episodes every 3-5 weeks in which sudden onset of high fever is followed by the other characteristic findings of the PFAPA name. After 3-4 days the episode ends just as abruptly and complete wellness ensues, until the next episode. After 4-6 years, intervals lengthen and in the majority of patients, episodes disappear. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Late prematurity, breastfeeding, and the neonatal intensive care unit
Neonatal intensive care unit (NICU) admission rates are variable for infants born at 34-36 weeks of gestation in the United States. Some hospitals admit only infants who have acute illnesses whereas other hospitals routinely admit all infants born below specific gestational age thresholds. The risks and benefits of these variable practices have not been fully evaluated but one concern is that routine admission to a NICU involves routine separation of mothers from their infants and this may have a negative impact on breastfeeding. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Raye-Ann deRegnier Tags: The Editors' Perspectives Source Type: research

What the heck ’s with NEC?
Necrotizing enterocolitis (NEC) is a thankfully infrequent complication among infants with low birthweight. Nonetheless, the 5-13% incidence makes it an important clinical problem. The severity can range from modest intestinal dysfunction to life-threatening abdominal catastrophe with multiorgan system failure. Thus, this vexing problem remains one of the “monsters under the bed.” Too-numerous-to-count publications have been written about its clinical presentation, pathogenesis, diagnosis, and treatment. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: James F. Padbury Tags: The Editors' Perspectives Source Type: research

Neuropsychological function with single ventricle physiology –The heart of the matter
The care of children with single ventricle heart disease has undergone substantial evolution over the past 2 decades, with improved surgical techniques and hemodynamic outcomes. Concurrently, attention is moving beyond immediate postoperative survival, to a greater emphasis on long term neuropsychological functioning, physiologic integrity, and quality of life. Wolfe et al in this volume of The Journal add to our understanding with a report on a large cohort of children seen, on average, about 6 years after Fontan procedure. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Denise M. Goodman Tags: The Editors' Perspectives Source Type: research

South African children living with HIV on ART: Can we do better?
One would hypothesize that through the modern lens of access to effective antiretroviral therapy (ART) from a young age with successful HIV suppression, outcomes for affected children would look to be very good. Shiau et al inform us that for South African children infected at birth, outcomes are better (certainly than before ART), may even be good (medically) but fall short of being very good. The current study is a report of findings at the exit visit approximately 4 years after enrollment beginning in 2014 of HIV vertically infected children and controls recruited in the same age bands from uninfected siblings, househol...
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Genetic testing for congenital heart disease
It is well understood that there is an important genetic component to the development of critical congenital heart disease. However, the genetics are complex and there is still much to be learned about genotype-phenotype relationships. In this volume of The Journal, Shikany et al report on an analysis of 293 infants with congenital heart disease, 213 of whom had isolated congenital heart diseases and 80 of whom who had multiple congenital anomalies. The yield of genetic testing was 39% in those with multiple congenital anomalies and 20% in those with isolated congenital heart disease. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Authors: Stephen R. Daniels Tags: The Editors' Perspectives Source Type: research

Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 21, 2020 Category: Pediatrics Source Type: research