Variation in Oophorectomy Rates for Children with Ovarian Torsion across US Children's Hospitals
In this multicenter study of 1783 children diagnosed with ovarian torsion from 2012 to 2017, 402 children (22.5%) underwent oophorectomy. The odds of oophorectomy were higher in children under 11  years of age, children with public insurance, and children with complex chronic conditions. Future efforts should target a preservation-first approach. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: Susan C. Lipsett, Lalita Haines, Michael C. Monuteaux, Katherine Hayes, Kenneth A. Michelson Tags: Brief Reports Source Type: research

Prospective evaluation of the first option, second-line Therapy in childhood chronic immune thrombocytopenia: splenectomy or immunomodulation
To describe four subgroups of pediatric patients treated with splenectomy, hydroxychloroquine, azathioprine or rituximab as the first-option, second-line treatment for chronic immune thrombocytopenia (cITP). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: St éphane Ducassou, Helder Fernandes, Hélène Savel, Yves Bertrand, Thierry Leblanc, Wadih Abou Chahla, Marlène Pasquet, Guy Leverger, Vincent Barlogis, Caroline Thomas, Sophie Bayart, Isabelle Pellier, Corinne Armari-Alla, Corinne Guitton, Nathalie Ch Tags: Original Articles Source Type: research

Variation in Oophorectomy Rates for Children with Ovarian Torsion across U.S. Children ’s Hospitals
Portions of this study were presented at the Pediatric Academic Societies annual meeting, April 24-May 1, 2019, Baltimore, MD. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: Susan C. Lipsett, Lalita Haines, Michael C. Monuteaux, Katherine Hayes, Kenneth A. Michelson Tags: Brief Reports Source Type: research

Acute Kidney Injury Associated with Late-Onset Neonatal Sepsis: A Matched Cohort Study
To determine incidence and severity of acute kidney injury (AKI) within 7 days of sepsis evaluation and to assess AKI duration and the association between AKI and 30-day mortality. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: Sarah A. Coggins, Benjamin Laskin, Mary Catherine Harris, Robert W. Grundmeier, Molly Passarella, Kristin J. McKenna, Lakshmi Srinivasan Tags: Original Articles Source Type: research

Congenital Disorders of Glycosylation in Portugal – Two Decades of Experience
To describe the clinical, biochemical, and genetic features of both new and previously reported patients with congenital disorders of glycosylation (CDG) diagnosed in Portugal over the last 20 years. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: Dulce Quelhas PharmaD, Esmeralda Martins, Lu ísa Azevedo, Anabela Bandeira, Luísa Diogo, Paula Garcia, Sílvia Sequeira, Ana Cristina Ferreira, Elisa Leão Teles, Esmeralda Rodrigues, Ana Maria Fortuna, Carla Mendonça, Helena Cabral Fernandes, Ana Mede Tags: Original Articles Source Type: research

Trends in Nutrient and non-Nutrient containing Dietary Supplement Use among U.S. Children from 1999-2016
To characterize dietary supplement usage among U.S. children, including product type, motivations, user characteristics, and trends over time with a primary focus on non-vitamin/non-mineral dietary supplements (NVNM). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: Anita A. Panjwani, Alexandra E. Cowan, Shinyoung Jun, Regan L. Bailey Tags: Original Articles Source Type: research

Rates of developmental co-ordination disorder in children born very preterm
To examine the stability of developmental co-ordination disorder (DCD) throughout childhood in children born very preterm and term. Further, in the VPT group, to compare perinatal variables and neurobehavioral outcomes at 13 years for children with persisting DCD and those with typical motor development. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: Alicia J. Spittle, Deborah Dewey, Thi-Nhu-Ngoc Nguyen, Rachel Ellis, Alice Burnett, Amanda Kwong, Katherine Lee, Jeanie LY. Cheong, Lex W. Doyle, Peter J. Anderson Tags: Original Articles Source Type: research

Reply
We read with interest the letter from Drs. Clarke and. Ioannou regarding our study. While we acknowledge the risk of confounding given the retrospective nature of our manuscript, we feel it is highly unlikely that these factors had an impact on our results. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 16, 2020 Category: Pediatrics Authors: Michelle Perez, Bradley C. Clark Tags: Letters to the Editor Source Type: research

A Randomized Trial of Digitally Delivered, Self-administered Parent Training in Primary Care: Effects on Parenting and Child Behavior
To evaluate the effects of a self-administered, digital behavioral parent training program on parent and child behavior for parents of young children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 15, 2020 Category: Pediatrics Authors: Susan M. Breitenstein, Caitlin Fehrenbacher, Alicia F. Holod, Michael Schoeny Tags: Original Articles Source Type: research

Changes in hospitalization in children during COVID-19 pandemic quarantine in a single center in Turkey
Li et  al1 reported the variations in healthcare visits of children to hospitals during the coronavirus disease 2019 (COVID-19) pandemic in China. In Turkey, the first case of severe acute respiratory syndrome coronavirus 2 infection was authoritatively reported by the Ministry of Health on March 11, 202 0.2 The schools and universities were closed on March 16, 2020. The government took further steps to mitigate disease spread, including travel restrictions, social distancing, and home quarantine from March to June 2020. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Meltem Akcaboy, Harun Terin, Saliha Senel Tags: Letters to the Editor Source Type: research

Congenital Giant Juvenile Xanthogranuloma in a 3-Month-Old Boy
A 3-month-old boy was seen for evaluation of rapidly growing cutaneous orange-yellowish nodular lesions of variable diameters (from millimeters to few centimeters) on the right wall of the chest that had been present since birth (Figure  1, A and B). The patient was otherwise completely healthy and did not have any trauma history. There was no personal or family history of any skin tumors or infectious diseases. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Dolores Ferrara, Paolo Tom à, Mario Diplomatico, Maria Elena Errico, Massimo Zeccolini, Francesco Esposito Tags: Insights and Images Source Type: research

Macula as a Window to Diagnosis
A 4-year-old boy first born to consanguineous parents, presented with longstanding language delay and difficulty seeing objects, recurrent falls, and decline in social interaction with family members over the past year. During the next 12  months, he developed complete vision loss and became dependent for all activities of daily living. Physical examination revealed occipitofrontal circumference of 49 cm (0 to -1 z score, World Health Organization), pendular nystagmus, head tilt to the right and titubation, and bull's eye maculopat hy on funduscopic examination (Figure, A). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Thuppanattumadam Ananthasubramianian Sangeeth, Hansashree Padmanabha, Rashmi Santhosh-Kumar, Sadanandavalli R. Chandra, Debjyoti Dhar, Pooja Mailankody, Vani Santosh Tags: Rediscovering the Physical Exam Source Type: research

Changes in hospitalization in children during covid-19 pandemic quarantine in turkey
Li et al (1) reported the variations in healthcare visits of children to hospitals during the coronavirus disease-19 (COVID-19) pandemic in China. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Meltem Akcaboy, Harun Terin, Saliha Senel Tags: Letters to the Editor Source Type: research

“Macula as a window to diagnosis”
A 4-year-old boy first born to consanguineous parents, presented with longstanding language delay and difficulty seeing objects, recurrent falls, and decline in social interaction with family members over the past year. During the next 12 months he developed complete vision loss and became dependent for all activities of daily living. Physical examination revealed occipitofrontal circumference of 49 cm (0 to -1 Z score, WHO), pendular nystagmus, head tilt to the right and titubation, and bull ’s eye maculopathy on funduscopic examination (Figure, A). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: T.A. Sangeeth, Hansashree Padmanabha, Rashmi Santhosh-Kumar, Sadanandavalli R. Chandra, Debjyoti Dhar, Pooja Mailankody, Vani Santosh Tags: Rediscovering the Physical Exam Source Type: research

Assessment of Peak Inspiratory Flow in Young Infants with Acute Viral Bronchiolitis: Physiological Basis for Initial Flow Setting in Patients Supported with High-Flow Nasal Cannula
To assess the inspiratory demand in young infants with acute viral bronchiolitis, in order to provide a physiological basis for initial flow setting for patients supported with high flow nasal cannula (HFNC). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Christophe Mil ési, Anne Requirand, Aymeric Douillard, Julien Baleine, Erika Nogué, Stephan Matecki, Pascal Amedro, Marti Pons-Odena, Gilles Cambonie Tags: Original Articles Source Type: research

Median Arcuate Ligament Syndrome with Orthostatic Intolerance: Intermediate-Term Outcomes Following Surgical Intervention
To report the intermediate-term outcome following surgical intervention for Median Arcuate Ligament Syndrome (MALS) in adolescents and young adults with Orthostatic Intolerance (OI) to) assess clinical improvement in the gastrointestinal and five other functional domains and if relief of arterial obstruction is associated with resolution of clinical symptoms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Jeffrey P. Moak, Carolyn Ramwell, Robin Fabian, Sridhar Hanumanthaiah, Anil Darbari, Timothy D. Kane Tags: Original Articles Source Type: research

A Graded Approach to Intravenous Dextrose for Neonatal Hypoglycemia Decreases Blood Glucose Variability, Time in the Neonatal Intensive Care Unit, and Cost of Stay
To determine associations between a graded approach to intravenous (IV) dextrose treatment for neonatal hypoglycemia and changes in blood glucose (BG), length of stay (LOS) and cost of care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Sarbattama Sen, Sara Cherkerzian, Daria Turner, Carmen Month é-Drèze, Elisa Abdulhayoglu, John A.F. Zupancic Tags: Original Articles Source Type: research

Characterizing Pain in Children with Acute Gastroenteritis Who Present for Emergency Care
To characterize the pain experienced by children with acute gastroenteritis in the 24-hours prior to emergency department (ED) presentation. Secondary objectives included characterizing ED pain, discharge recommendations, overall analgesic use, and factors that influenced analgesic use and pain severity. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Samina Ali, Claudia Maki, Jianling Xie, Bonita E. Lee, James Dickinson, Shannon E. MacDonald, Naveen Poonai, Jennifer Thull-Freedman, Otto Vanderkooi, Manasi Rajagopal, Mithra Sivakumar, Linda Chui, Timothy A.D. Graham, Alberto Nettel-Aguirre, Lawrence W. Tags: Original Articles Source Type: research

Congenital giant juvenile xanthogranuloma in a 3-month-old male
A 3-month-old boy was seen for evaluation of rapidly growing cutaneous orange-yellowish nodular lesions of variable diameters (from millimeters to few centimeters) on the right wall of the chest that had been present since birth (Figure 1, A and B). The patient was otherwise completely healthy and did not have any trauma history. There was no personal or family history of any skin tumors or infectious diseases. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Dolores Ferrara, Paolo Tom à, Mario Diplomatico, Maria Elena Errico, Massimo Zeccolini, Francesco Esposito Tags: Insights and Images Source Type: research

Could the QTc prolongation seen in diabetic ketoacidosis be due to more than just a raised anion gap?
Perez et al [1] demonstrated that nearly one third of patients presenting with diabetic ketoacidosis (DKA) had QTc prolongation. The authors demonstrated a significant correlation between the QTc and anion gap, and therefore hypothesised that the QTc prolongation seen was secondary to an elevated anion gap and metabolic acidosis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 14, 2020 Category: Pediatrics Authors: Rebecca Clarke, Adam Ioannou Tags: Letters to the Editor Source Type: research

Are Breastfed Infants Iron Deficient? The Question That Won't Go Away
Though iron is one of the most abundant elements in the earth's environment, iron deficiency is the most common single nutrient deficiency in the world. Given the very low iron content of human milk, there continues to be concern and controversy about the iron needs of the breastfed infant, particularly after 4-6  months of age when human milk alone will not supply the infant's requirement for iron.1,2 In this volume of The Journal, Abrams et al3 report on the potential iron deficiency in US breastfed infants 6-12 months of age, utilizing the database of dietary intakes from the 2016 Feeding Infants and T od...
Source: The Journal of Pediatrics - December 11, 2020 Category: Pediatrics Authors: Frank R. Greer Tags: Editorial Source Type: research

A Bladder Mass in a Patient with Henoch-Sch önlein Purpura
A 5-year-old girl presented with purpura and edema in her extremities for 3  days. A diagnosis of Henoch-Schönlein purpura (HSP) was made by her family doctor. One day after the diagnosis, she was admitted to our hospital because of abdominal pain, gross hematuria, and urinary retention. On examination, palpable purpura and mild abdominal tenderness were observed. A blood laboratory examination revealed no abnormalities. Her urine showed gross hematuria, and a urinary protein/creatinine ratio of 1.8 g/gCr. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 11, 2020 Category: Pediatrics Authors: Natsumi Inoue, Tadafumi Yokoyama, Naoto Sakumura, Yuko Tasaki, Taizo Wada Tags: Insights and Images Source Type: research

Are Breastfed Infants Iron Deficient? The Question That Won ’t Go Away.
Though iron is one of the most abundant elements in the earth ’s environment, iron deficiency is the most common single nutrient deficiency in the world. Given the very low iron content of human milk, there continues to be concern and controversy about the iron needs of the breast fed infant, particularly after four to six months of age when human milk alone will not supply the infant’s requirement for iron.1,2 In this volume of The Journal, Abrams et al3 report on the potential iron deficiency in U.S. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 11, 2020 Category: Pediatrics Authors: Frank R. Greer Tags: Editorials Source Type: research

A bladder mass in a patient with Henoch –Schönlein purpura
A 5-year-old girl presented with purpura and edema in her extremities for 3 days. A diagnosis of Henoch –Schönlein purpura (HSP) was made by her family doctor. One day after the diagnosis, she was admitted to our hospital because of abdominal pain, gross hematuria, and urinary retention. On examination, palpable purpura and mild abdominal tenderness were observed. A blood laboratory examination rev ealed no abnormalities. Her urine showed gross hematuria and a urinary protein/creatinine ratio of 1.8 g/gCr. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 11, 2020 Category: Pediatrics Authors: Natsumi Inoue, Tadafumi Yokoyama, Naoto Sakumura, Yuko Tasaki, Taizo Wada Tags: Insights and Images Source Type: research

Bitot ’s spots and a bilirubin ring
A 16 year-old girl presented with intermittent fever, progressively deepening jaundice for the last 6 weeks, and hematemesis. She presented in grade III hepatic encephalopathy. Eye examination showed Bitot ’s spots (foamy white triangular lesion on temporal conjunctiva) and a bilirubin ring (yellowish green circumferential hue) or pseudo Kayser-Fleischer (KF) ring at the corneo-scleral junction (Figure, A). Magnetic resonance cholangiography showed fusiform dilatation of the extrahepatic biliary sys tem suggestive of type I choledochal cyst. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 10, 2020 Category: Pediatrics Authors: Moinak Sen Sarma, Umesh Reddy Tags: Rediscovering the Physical Exam Source Type: research

Effect of Early Targeted Treatment of Ductus Arteriosus with Ibuprofen on Survival Without Cerebral Palsy at 2 years in Infants with Extreme Prematurity: A Randomized Clinical Trial
To examine the effects of early echocardiography-targeted ibuprofen treatment of large patent ductus arteriosus (PDA) on survival without cerebral palsy (CP) at 24 months corrected age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 8, 2020 Category: Pediatrics Authors: Jean-Christophe Roz é, Gilles Cambonie, Aurelie Le Thuaut, Thierry Debillon, Isabelle Ligi, Geraldine Gascoin, Juliana Patkai, Alain Beuchee, Geraldine Favrais, Cyril Flamant, Xavier Durrmeyer, Ronald Clyman Tags: Original Articles Source Type: research

Paroxysmal Tonic Downgaze: A Pseudo Sunsetting Sign
A 30-day-old boy, born full-term, presented with a one day history of abnormal eye movements characterized by frequent, brief episodes of intermittent downgaze with vertical nystagmus that occurred while awake (Video/Figure). These episodes occurred both in supine and upright position without clear triggers. Neurological exam was otherwise normal. Increased intracranial pressure was considered due to similarity to the sunsetting eye sign, although our patient had preserved upgaze, and his downgaze was intermittent but not persistent. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 8, 2020 Category: Pediatrics Authors: Deepa Sirsi, Dallas Armstrong Tags: Insights and Images Source Type: research

The risks of adding orthostatic intolerance to the list of the differential diagnoses of somatic symptom disorder
Tarbell et al reported extra-intestinal co-morbidities in children with functional nausea1; we agree with their call for a holistic approach. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 8, 2020 Category: Pediatrics Authors: Luisa Cortellazzo Wiel, Giorgio Cozzi, Egidio Barbi Tags: Letters to the Editor Source Type: research

Pediatric Departmental Advocacy: Our Experience Addressing the Social Challenges of Coronavirus Disease 2019 and Racism
The coronavirus disease 2019 (COVID-19) pandemic and the unearthing of existing racism nationwide have revealed how health is inextricably linked to the community we call “home.” COVID-19 shelter-in-place regulations resulted in millions of jobs lost,1 rising food insecurity,2 increased difficulty paying for basic needs,2 and school closures that disrupted child learning.3 These indirect effects of COVID-19 will have long-term implications for child poverty and h ealth.3 Simultaneously, racial unrest exploded in America, revealing the persisting injustice from 400 years of unchecked racism. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 7, 2020 Category: Pediatrics Authors: Melanie R. Ramirez, Janine S. Bruce, Alexander J. Ball, Simran Gambhir, Katarzyna Zabrocka, Omar Sahak, Salma Dali, Kamaal A. Jones, Lisa J. Chamberlain Tags: Notes from the Association of Medical School Pediatric Department Chairs, Inc. Source Type: research

Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial
This study followed 173 newborn infants in the PREmedication Trial for Tracheal Intubation of the NEOnate  multicenter, double-blind, randomized controlled trial of atropine-propofol vs atropine-atracurium-sufentanil for premedication before nonemergency intubation. At 2 years of corrected age, there was no significant difference between the groups in death or risk of neurodevelopmental delay assessed with the Ages and Stages Questionnaire.Trial registration Clinicaltrials.gov: NCT01490580. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 7, 2020 Category: Pediatrics Authors: Manon Tauzin, Laetitia Marchand-Martin, C écile Lebeaux, Sophie Breinig, Olivier Claris, Pierre Tourneux, Cénéric Alexandre, Corinne Levy, Camille Jung, Agnès Dechartres, Xavier Durrmeyer, PREmedication Trial for Tracheal Intubation of the NEOnate Res Tags: Brief Reports Source Type: research

Pediatric Departmental Advocacy: Our Experience Addressing the Social Challenges of COVID-19 and Racism
The COVID-19 pandemic and the unearthing of existing racism nationwide have revealed how health is inextricably linked to the community we call “home.” COVID -19 shelter-in-place regulations resulted in millions of jobs lost,1 rising food insecurity,2 increased difficulty paying for basic needs,2 and school closures that disrupted child learning.3 These indirect effects of COVID-19 will have long-term implications for child poverty and health.3 Simultaneously, racial unrest exploded in America, revealing the persisting injustice from 400 years of unchecked racism. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 7, 2020 Category: Pediatrics Authors: Melanie R. Ramirez, Janine S. Bruce, Alexander J. Ball, Simran Gambhir, Katarzina Zabrocka, Omar Sahak, Salma Dali, Kamaal Jones, Lisa J. Chamberlain Source Type: research

Neurodevelopmental Outcomes after Premedication with Atropine/Propofol versus Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2 Year Follow Up of a Randomized Clinical Trial
Premedication for nonemergent tracheal intubation in newborn infants is strongly recommended to decrease pain and adverse events related to the procedure1. However, there is no consensus on which drugs to use1-3. A short-acting opioid associated with a muscle-blocker is recommended by several academic societies2,3 but prevents titration and assessment of proper sedation and analgesia4. Propofol is a short-acting anesthetic that has been proposed as an alternative1,5,6. Reported advantages of propofol are preservation of spontaneous ventilation, less frequent oxygen desaturation, possible titration and faster intubation4-6....
Source: The Journal of Pediatrics - December 7, 2020 Category: Pediatrics Authors: Manon Tauzin, Laetitia Marchand-Martin, C écile Lebeaux, Sophie Breinig, Olivier Claris, Pierre Tourneux, Cénéric Alexandre, Corinne Levy, Camille Jung, Agnès Dechartres, Xavier Durrmeyer, PRETTINEO Research Group Tags: Brief Reports Source Type: research

Time Course of Coronary Artery Aneurysms in Kawasaki Disease
To determine the timeframe in which coronary artery aneurysms (CAAs) caused by Kawasaki disease reach their maximum diameter, the timeframe in which they regress to normal size, and the cutoff point of the diameter for CAA regression (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 7, 2020 Category: Pediatrics Authors: Etsuko Tsuda, Shuji Hashimoto Tags: Original Articles Source Type: research

The Diagnostic Error Index: A Quality Improvement Initiative to Identify and Measure Diagnostic Errors
To develop a diagnostic error index (DEI) aimed at providing a practical method to identify and measure serious diagnostic errors. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 7, 2020 Category: Pediatrics Authors: Michael F. Perry, Jennifer E. Melvin, Rena T. Kasick, Kelly E. Kersey, Daniel J. Scherzer, Manmohan K. Kamboj, Robert J. Gajarski, Garey H. Noritz, Ryan S. Bode, Kimberly J. Novak, Berkeley L. Bennett, Ivor D. Hill, Jeffrey M. Hoffman, Richard E. McClead Tags: Original Articles Source Type: research

The Nimbleness and Resource Costs of Expedited Review and Concerns of Duplicate Publication: SARS-CoV-2 Manuscripts Submitted to The Journal of Pediatrics
The editorial office at The Journal of Pediatrics received the first manuscript regarding severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2) on February 13, 2020. Through November 30, 2020, nearly 550 manuscripts were submitted regarding SARS-CoV-2 in children and adolescents (Figure). We pause to consider the phases of the pandemic as reflected in manuscript submissions and take stock of the benefits, costs, and concerns of journal editors committed to the peer review process as well as to the rapid dissemination of new information. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 6, 2020 Category: Pediatrics Authors: Sarah S. Long, Thomas R. Welch, Rebecca Pellett Madan, Meghan McDevitt, William F. Balistreri Tags: Special Communication Source Type: research

SARS-CoV-2 Manuscripts Submitted to The Journal of Pediatrics: The Nimbleness and Resource Costs of Expedited Review and Concerns of Duplicate Publication
T.W. and S.L. serve as Associate Editors, R.M. serves on the Editorial Board, M.M. is a paid employee, and W.B. serves as the Editor-in-Chief of The Journal of Pediatrics. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 6, 2020 Category: Pediatrics Authors: Sarah S. Long, Thomas R. Welch, Rebecca Pellett Madan, Meghan McDevitt, William F. Balistreri Source Type: research

Reply
We thank Dr Wiel et al for their thoughtful comments on our report. To clarify, our study aimed to identify comorbidities in pediatric patients with functional nausea and evaluate the diagnostic yield of the GI tests they underwent. Our cohort was not a group of patients diagnosed with a somatic symptom disorder (SSD). We found these youth are often subjected to invasive diagnostic or surgical procedures performed based on “soft” indications putting them at risk for iatrogenic problems. Co-existing psychiatric symptoms were common in these patients. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 6, 2020 Category: Pediatrics Authors: Sally E. Tarbell, John E. Fortunato Tags: Letters to the Editor Source Type: research

Kidney Outcomes and Hypertension in Survivors of Wilms Tumor: A  Prospective Cohort Study
To assess the prevalence of therapy-related kidney outcomes in survivors of Wilms tumor (WT). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 5, 2020 Category: Pediatrics Authors: David I. Chu, Abdulla M. Ehlayel, Jill P. Ginsberg, Kevin E. Meyers, Maryjane Benton, Melissa Thomas, Claire Carlson, Thomas F. Kolon, Gregory E. Tasian, Jason H. Greenberg, Susan L. Furth, Michelle R. Denburg Tags: Original Articles Source Type: research

Kawasaki Disease Shock Syndrome versus Septic Shock: Early Differentiating Features Despite Overlapping Clinical Profiles
To compare the clinical features and resuscitative measures of children with Kawasaki disease shock syndrome versus septic shock. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 5, 2020 Category: Pediatrics Authors: Alyssa Power, Kyle Runeckles, Cedric Manlhiot, Andreea Dragulescu, Anne-Marie Guerguerian, Brian W. McCrindle Tags: Original Articles Source Type: research

Kidney Outcomes and Hypertension in Survivors of Wilms Tumor: A Prospective Cohort Study
Supported by a Pilot Grant from the Children ’s Hospital of Philadelphia Center for Pediatric Clinical Effectiveness (to D.C.). D.C. is also supported by the NIH/NIDDK (K23 DK125670). G.T. was supported by the NIH/NIDDK (K23 DK106428). Ja.G. was supported by NIH/NIDDK (K08 DK110536). M.D. was supported by the NIH/NIDDK (K23 DK093556). The NI H and NIDDK had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 5, 2020 Category: Pediatrics Authors: David I. Chu, Abdulla M. Ehlayel, Jill P. Ginsberg, Kevin E. Meyers, Maryjane Benton, Melissa Thomas, Claire Carlson, Thomas F. Kolon, Gregory E. Tasian, Jason H. Greenberg, Susan L. Furth, Michelle R. Denburg Tags: Original Articles Source Type: research

Integrating Public Health Ethics into Shared Decision Making for Children During the Novel Coronavirus Disease-19 Pandemic
Pediatricians often serve as interpreters and mediators of health guidelines when discussing vaccines, health screening, and lifestyle choices with parents of our patients. Outside of public health emergencies, these discussions nearly exclusively focus on optimizing the health of the individual child and a focus on family preferences. However, in the current pandemic, nearly everyone has experienced limitations of personal activities for the population health goal of curbing the spread of the novel coronavirus disease-2019 (COVID-19). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 1, 2020 Category: Pediatrics Authors: Angira Patel, Dalia M. Feltman, Erin Talati Paquette Tags: Commentary Source Type: research

Academic Challenges and School Service Utilization in Children with Sickle Cell Disease
To describe the academic concerns and risk strata of children with sickle cell disease (SCD) as identified through a parent-directed screening tool and to compare the rates of these concerns with actual school service utilization in the clinic population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 1, 2020 Category: Pediatrics Authors: Kristine A. Karkoska, Kenneth Haber, Megan Elam, Sarah Strong, Patrick T. McGann Tags: Original Articles Source Type: research

Population Improvement Bias Observed in Estimates of the Impact of Antenatal Steroids to Outcomes in Preterm Birth
To examine the hypothesis that increasing rates and differential uptake of antenatal steroids (would bias estimation of impact of ANS on neonatal death and severe (grade III-IV) intraventricular hemorrhage (IVH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 1, 2020 Category: Pediatrics Authors: Jeffrey B. Gould, Mihoko V. Bennett, Ciaran S. Phibbs, Henry C. Lee Tags: Original Articles Source Type: research

Integrating Public Health Ethics into Shared Decision-Making for Children during the COVID-19 pandemic
Pediatricians often serve as interpreters and mediators of health guidelines when discussing vaccines, health screening, and lifestyle choices with parents of our patients. Outside of public health emergencies, these discussions nearly exclusively focus on optimizing the health of the individual child and a focus on family preferences. However, in the current pandemic, nearly everyone has experienced limitations of personal activities for the population health goal of curbing the spread of COVID-19. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 1, 2020 Category: Pediatrics Authors: Angira Patel, Dalia M. Feltman, Erin Talati Paquette Tags: Commentary Source Type: research

Impact of Coronavirus Disease 2019 (COVID-19) Pandemic on Pediatric Infectious Disease Research
Since March 2020, all continents have been burdened with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which has led to a considerable health crisis.1 The magnitude of the challenges posed by the pandemic exceeded the expectations of the scientific community and public authorities, who rapidly developed strategies to properly manage the disease.2-4 However, the measures adopted to address the pandemic differed among European countries, including the type of lockdown, border closings, school closures, the use of facial masks, accessories protection, the use of SARS-CoV-2 reverse transcription po...
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Eden Bensoussan, Naim Ouldali, Shai Ashkenazi, Fran çois Angoulvant, Robert Cohen, Corinne Levy Tags: European Paediatric Association Source Type: research

Willingness of parents to vaccinate their children against influenza and the novel coronavirus disease-2019
Goldman et  al showed a 15.8% increase in parents' willingness to vaccinate their children against influenza after the coronavirus disease 2019 (COVID-19) pandemic.1 Herein, we report results of an online survey disseminated to adults living in Kuwait between August 26 and September 1, 2020 (n = 2368; 1038 participants with children aged (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Bedour AlHajri, Deema Alenezi, Heba Alfouzan, Saba Altamimi, Sayed Alzalzalah, Waleed Almansouri, Yosor Alqudeimat, Zain Almokhaizeem, Ali H. Ziyab Tags: Letters to the Editor Source Type: research

Reply
AlHajri et  al surveyed 1038 parents to determine their willingness to vaccinate against influenza as well as a coronavirus disease-2019 (COVID-19) future vaccine. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Ran D. Goldman, Julie C. Brown, International COVID-19 Parental Attitude Study (COVIPAS) Group Tags: Letters to the Editor Source Type: research

A phase II randomized clinical trial of the safety and efficacy of intravenous umbilical cord blood infusion for treatment of children with autism spectrum disorder
Dawson et  al have drawn attention to the outcomes of umbilical cord blood (UCB) administration for the treatment of 180 children with autism spectrum disorder (ASD).1 Because there is a substantial interest in stem cell therapy as a potential candidate or therapeutic approach for ASD, these outcomes are not eworthy. The authors provide findings from a large sample size, randomized process with a control group, and processing paradigms, although the results did not support the efficacy of UCB administration. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Liem Thanh Nguyen, Phuong Hoang Nguyen, Duc Minh Hoang Tags: Letters to the Editor Source Type: research

Impact of COVID-19 Pandemic on Pediatric Infectious Disease Research
Since March 2020, all continents have been burdened with the SARS-CoV-2 pandemic, which led to a considerable health crisis1. The magnitude of the challenges posed by the pandemic exceeded the expectations of the scientific community and public authorities, who rapidly developed strategies to properly manage the disease2-4. However, the measures adopted to address the pandemic differed among European countries, including the type of lockdown, border closings, school closures, the use of facial masks, accessories protection, the use of SARS-CoV-2 RT-PCR, and point-of-care for rapid-antigen detection diagnostic tests5. (Sour...
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Eden Bensoussan, Naim Ouldali, Shai Ashkenazi, Fran çois Angoulvant, Robert Cohen, Corinne Levy Source Type: research

Willingness of parents to vaccinate their children against influenza and COVID-19
Goldman et al showed a 15.8% increase in parents ’ willingness to vaccinate their children against influenza after the coronavirus disease 2019 (COVID-19) pandemic.1 Herein, we report results of an online survey disseminated to adults living in Kuwait between August 26th and September 1st, 2020 (n=2368; 1038 participants with children aged (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 30, 2020 Category: Pediatrics Authors: Bedour AlHajri, Deema Alenezi, Heba Alfouzan, Saba Altamimi, Sayed Alzalzalah, Waleed Almansouri, Yosor Alqudeimat, Zain Almokhaizeem, Ali H. Ziyab Tags: Letters to the Editor Source Type: research