Factors affecting 2-(2-phenylethyl)chromones in artificial agarwood
AbstractRecently, “artificial agarwood” manufactured by the artificial treatment on cultivated agarwood trees is popular in agarwood-producing countries. Although there are various treatment methods, they are not standardized. Moreover, factors that may affect the generated chemical compounds have not been invest igated. In this research, the effects of different treatment methods and individual differences on the quantities and types of 2-(2-phenylethyl)chromone in agarwood were investigated to experimentally produce artificial agarwood usingAquilaria sinensis. Each solvent-extracted agarwood sample was analyzed using...
Source: Journal of Natural Medicines - August 6, 2021 Category: Drugs & Pharmacology Source Type: research
Comparison of various commercially available cinnamon barks using NMR metabolomics and the quantification of coumarin by quantitative NMR methods
This study indicated that1H NMR metabolomics could deduce spices, utility, and producing area of commercially available cinnamon barks. Furthermore, combining quantitative1H NMR methods with1H NMR metabolomics enable quantification of coumarin in cinnamon bark on a single measurement. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - August 6, 2021 Category: Drugs & Pharmacology Source Type: research
Walsogynes H –O from Walsura chrysogyne
AbstractEight new limonoids, walsogynes H –O (1–8) were isolated from the barks ofWalsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H –M (1–6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c′]difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc:5,4-b′c′]difuran skeleton. Walsogynes H–O (1–8) exhibited potent antimalarial activity againstPlasmodium falciparum 3D7 strain with IC50 value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1 µM, respectively...
Source: Journal of Natural Medicines - August 5, 2021 Category: Drugs & Pharmacology Source Type: research
The phenolic acids from Oplopanax elatus Nakai stems and their potential photo-damage prevention activity
Abstract25 phenolic acids, including four new isolates, eurylophenosides A –D (1–4) and 21 known ones (5–25) were isolated and identified from the stems ofOplopanax elatus Nakai. Among the known compounds5–9,11–13,16,18–25 were isolated from the genus for the first time;17 was first obtained from the plant; and the NMR data of22 was reported here first. Meanwhile, the UVB-induced photodamage model of HaCaT cells was used to study the prevent-photodamage abilities of compounds1–2,4–8,11–13 and15–25 with a nontoxic concentration at 50 μM. Moreover, a dose-dependent experiment was conducted for active c...
Source: Journal of Natural Medicines - August 3, 2021 Category: Drugs & Pharmacology Source Type: research
Diversity in principal constituents of plants with a lemony scent and the predominance of citral
In this study, we extracted essential oils from four species of plants with lemony scents (Melissa officinalis L.,Aloysia citriodora Palau (= Lippia citriodora (Palau) Kunth),Thymus × citriodorus,Perilla citriodora (Makino) Nakai). We then examined the components of extracts using gas chromatography (GC) and GC –mass spectrometry (GC–MS). A comparison of components indicated that the largest proportions of essential oils were caryophyllene (25%) inM. officinalis, geraniol (50%) inT. citriodorus, and citral (61 and 82%) inA. citriodora andP. citriodora. Moreover, we used a sensory evaluation method using dilute ...
Source: Journal of Natural Medicines - August 2, 2021 Category: Drugs & Pharmacology Source Type: research
Drug-interaction between paclitaxel and goshajinkigan extract and its constituents
In this study, we evaluated the inhibitory or inducing effects of goshajinkigan extract (GJG) and its representative and bioavailable constituents, geniposidic acid, plantagoguanidinic acid, paeoniflorin, catalpol, logan in, and neoline, on the metabolism of paclitaxel via CYP2C8 and CYP3A4 using pooled human liver microsomes and cultured human cryopreserved hepatocytes to provide the drug information about the pharmacokinetic interaction of this combination therapy. GJG significantly inhibited the production of 3’ -p-hydroxypaclitaxel and 6α-hydroxypaclitaxel in vitro in a concentration-dependent manner. The half maxim...
Source: Journal of Natural Medicines - July 25, 2021 Category: Drugs & Pharmacology Source Type: research
Bie Jia Jian pill enhances the amelioration of bone mesenchymal stem cells on hepatocellular carcinoma progression
ConclusionsThese results proved the inhibitory role of BJJP + BMSCs in HCC development through regulating miR-140 and Wnt/β-catenin signal pathway. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - July 23, 2021 Category: Drugs & Pharmacology Source Type: research
22-O-(N-Boc-l-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial –mesenchymal transition in human lung cancer cells
In this study, the effect of 22-O-(N-Boc-l-glycine) ester of renieramycin M (22-Boc-Gly-RM), a semi-synthetic amino ester derivative of bistetrahydroisoquinolinequinone alkaloid isolated fromXestospongia sp., on migratory behavior of human lung cancer cells was investigated. Following 24 h of treatment, 22-Boc-Gly-RM at non-toxic concentrations (0.5–1 μM) effectively restrained motility of human lung cancer H460 cells assessed through wound healing, transwell migration, and multicellular spheroid models. The capability to invade through matrix component was also repressed in H 460 cells cultured with 0.1–1 µM 22-...
Source: Journal of Natural Medicines - July 21, 2021 Category: Drugs & Pharmacology Source Type: research
Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC –MS analysis and phytochemical investigation
AbstractMacrocyclic daphnane orthoesters (MDOs) have attracted significant research interest for the drug discovery to cure HIV infection based on the “Shock and Kill” strategy. In the present study, the first chemical study onWikstroemia ligustrina (Thymelaeaceae) was carried out by LC –MS analysis and phytochemical investigation. Nine daphnane diterpenoids (1−9) including seven MDOs were detected by LC –MS analysis. Further phytochemical investigation resulted in the isolation and structural elucidation of five daphnanes (1,2,5,8, and9) with potent anti-HIV activity. Taking the isolated MDO (1) as a model compo...
Source: Journal of Natural Medicines - July 21, 2021 Category: Drugs & Pharmacology Source Type: research
UHPLC-MS-based metabolomic approach for the quality evaluation of Pinellia ternata tubers grown in shaded environments
This study determined that shading probably improves the quality ofP.ternata tubers and laid a foundation for exploring the regulatory mechanism of the shade response inP.ternata. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - July 17, 2021 Category: Drugs & Pharmacology Source Type: research
Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish
In this study, we examined the acute, anxiolytic-like effects of nicotinic acetylcholine receptor (nAChR)-activating alkaloids with reported neuropharmacological effects but whose effects on anxiety are less well understood. Because α4β2 nAChRs can regulate anxiety, we first demonstrated the functional activities of alkaloids on these receptors in vitro. Their effects on anxiety-like behavior in zebrafish were then examined using the zebrafish novel tank test (NTT). The NTT is a relatively high-throughput behavioral paradigm that takes advantage of the natural tendency of fish to dive down when stressed or anxious. We re...
Source: Journal of Natural Medicines - July 15, 2021 Category: Drugs & Pharmacology Source Type: research
Picrotoxane sesquiterpene and α-pyrone derivative from Dendrobium signatum and their free radical scavenging potency
AbstractOne new picrotoxane sesquiterpene (1) and one new α-pyrone derivative (4), together with nine known compounds, were isolated from the aerial parts ofDendrobium signatum. The structures of the new compounds were elucidated based on the interpretation of 1D and 2D NMR, HRESIMS and electronic circular dichroism (ECD) data. The absolute configuration of1 was confirmed by single-crystal X-ray diffraction data. The new α-pyrone 4 exhibited promising ABTS scavenging activity with IC50 value of 0.7 μM.Graphic abstract (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - July 14, 2021 Category: Drugs & Pharmacology Source Type: research
Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies
AbstractTraditional herbal medicines, which have been used in the matured traditional medical systems as well as those have been used in ethnic medical systems, are invaluable resources of drug seeds. Ethnobotanical and ethnopharmacological survey may provide useful information of these herbal medicines, which are valuable for searching new bioactive molecules. From this viewpoint, we have been performing the ethnobotanical and ethnopharmacological field studies in Yunnan Province and Guangxi Zhuang Autonomous Region, China, and Mongolia. Phytochemical studies on traditional herbal medicines were performed based on the inf...
Source: Journal of Natural Medicines - July 13, 2021 Category: Drugs & Pharmacology Source Type: research
Design and synthesis of analogues of RA-VII —an antitumor bicyclic hexapeptide from Rubiae radix
In this study, an efficient method for the synthesis of cycloisodityrosines from commercially availablel-tyrosine derivatives was developed. Using synthetic cycloisodityrosines and cycloisodityrosines with modified structures, several RA-VII analogues were designed and synthesized to explore structure –activity relationships of the cycloisodityrosine moiety of the RA-series peptides, and newly isolated natural peptides were synthesized to establish their structures.Graphic abstract (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - July 10, 2021 Category: Drugs & Pharmacology Source Type: research
Cell death-inducing activities via Hsp inhibition of the sesquiterpenes isolated from Valeriana fauriei
AbstractThree new sesquiterpenes, valerianaterpenes I –III, and eight known compounds have been isolated from the methanol extract of the rhizomes and roots ofValeriana fauriei. The chemical structures of the three new sesquiterpenes were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry of valerianaterpene I was determined using X-ray crystallography. The cell death-inducing activity of isolated compounds alone or combination with Adriamycin (ADR) was observed by time-lapse cell imaging. Although the isolated compounds did not affect the number of mitotic entry cells and dead cells al...
Source: Journal of Natural Medicines - July 1, 2021 Category: Drugs & Pharmacology Source Type: research
