Cell death-inducing activities via Hsp inhibition of the sesquiterpenes isolated from Valeriana fauriei

AbstractThree new sesquiterpenes, valerianaterpenes I –III, and eight known compounds have been isolated from the methanol extract of the rhizomes and roots ofValeriana fauriei. The chemical structures of the three new sesquiterpenes were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry of valerianaterpene I was determined using X-ray crystallography. The cell death-inducing activity of isolated compounds alone or combination with Adriamycin (ADR) was observed by time-lapse cell imaging. Although the isolated compounds did not affect the number of mitotic entry cells and dead cells alone, kessyl glycol, kessyl glycol diacetate, andiso-teucladiol significantly increased the number of dead cells on ADR treated human cervical cancer cells. One of the mechanisms of cell death-inducing activity for the kessyl glycol acetate was suggested to be the inhibition of heat-shock protein 105 (Hsp105) expression level. This paper first deals with the naturally occurring compounds as Hsp105 inhibitor.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research