Design and synthesis of analogues of RA-VII —an antitumor bicyclic hexapeptide from Rubiae radix

In this study, an efficient method for the synthesis of cycloisodityrosines from commercially availablel-tyrosine derivatives was developed. Using synthetic cycloisodityrosines and cycloisodityrosines with modified structures, several RA-VII analogues were designed and synthesized to explore structure –activity relationships of the cycloisodityrosine moiety of the RA-series peptides, and newly isolated natural peptides were synthesized to establish their structures.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research