Walsogynes H –O from Walsura chrysogyne

AbstractEight new limonoids, walsogynes H –O (1–8) were isolated from the barks ofWalsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H –M (1–6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c′]difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc:5,4-b′c′]difuran skeleton. Walsogynes H–O (1–8) exhibited potent antimalarial activity againstPlasmodium falciparum 3D7 strain with IC50 value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1  µM, respectively.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research