Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape
AbstractThree new pentacyclic triterpenes, trivially named sandkoetjapic acids A –C (1–3), have been isolated from the leaves extract ofSandoricum koetjape, along with the known triterpenes 3-oxo-olean-12-en-29-oic (4), bryonolic (5), and bryononic (6) acids. The structures of the new triterpenes were determined mainly by NMR spectroscopic and mass spectroscopic data. The isolation of these pentacyclic triterpenes in the plant ’s leaves is for the first time. Preliminary biological evaluation of1–6 was done against eight receptor tyrosine kinases (RTKs), including EGFR, HER2, HER4 (epidermal growth factor receptor)...
Source: Journal of Natural Medicines - April 30, 2022 Category: Drugs & Pharmacology Source Type: research
Relationship between ephedrine alkaloid profile in Ephedra gerardiana and soil characteristics of glacial landforms in southeastern Tibetan Plateau, China
AbstractIn the Kaluxung River catchment of the southeastern Tibetan Plateau in China, we identified threeEphedra gerardiana communities on different soils and glacial landforms from 4842 to 4899 Â m above sea level: a moraine community located on constantly collapsing sandy gravel alpine steppe slopes with exposed bedrock on the outer slope of the terminal moraine of the Qiangyong Glacier on Mt. Kaluxung; an outwash plain community located on a gentle alpine steppe slope with exposed bedroc k at the terminal end of the outwash plain in the glacial valley of the southeast side of Mt. Noijinkangsang; and a river terrace comm...
Source: Journal of Natural Medicines - April 24, 2022 Category: Drugs & Pharmacology Source Type: research
Cinnamon bark extract suppresses metastatic dissemination of cancer cells through inhibition of glycolytic metabolism
AbstractMetastasis is responsible for approximately 90% of cancer-associated mortality and proceeds through multiple steps. Several herbal medicines are reported to inhibit primary tumor growth, but the suppressor effects of the medicines on metastasis progression are still not fully elucidated. Here we report that cinnamon bark extract (CBE) has a suppressor effect on metastatic dissemination of cancer cells. Through a phenotypic screening using zebrafish embryos, CBE was identified to interfere with the gastrulation progression of zebrafish embryos, of which the molecular mechanisms are conserved in metastasis progressio...
Source: Journal of Natural Medicines - April 21, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Phytomedicinal therapeutics for male infertility: critical insights and scientific updates
(Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - April 18, 2022 Category: Drugs & Pharmacology Source Type: research
Marine natural products that inhibit osteoclastogenesis and promote osteoblast differentiation
We describe the marine-derived secondary metabolites that can inhibit receptor activator of nuclear factor- κB ligand (RANKL)-induced osteoclastogenesis and promote osteoblast differentiation. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - April 10, 2022 Category: Drugs & Pharmacology Source Type: research
Phytomedicinal therapeutics for male infertility: critical insights and scientific updates
AbstractInfertility is a significant cause of anxiety, depression, and social stigma among couples and families. In such cases, male reproductive factors contribute widely to the extent of 20 –70%. Male infertility is a multifactorial disease with several complications contributing to its diagnosis. Although its management encompasses both modern and traditional medicine arenas, the first line of treatment, adopted by most males, focuses on the reasonably successful medicinal plant-bas ed conventional therapies. Phyto-therapeutics, which relies on active ingredients from traditionally known herbs, influences sexual behav...
Source: Journal of Natural Medicines - April 4, 2022 Category: Drugs & Pharmacology Source Type: research
A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species
AbstractFeruloylated acylglycerols (FAGs) have recently garnered a lot of interest as water –oil-miscible ferulic acid derivatives. A novel FAG derivate, 1-feruloyl-3-hexadecanoylglycerol (1), was isolated fromWikstroemia pilosa and its structure was elucidated from extensive physiochemical and spectroscopic analysis. Since the limited distribution of FAGs in plant species has been reported, a high-resolution accurate mass (HRAM) LC –MS quantitative analysis was carried out to determine the contents of1 in ten plants ofWikstroemia species. As a result, compound1 was detected in all species at contents of 1.29 –50.96Â...
Source: Journal of Natural Medicines - March 30, 2022 Category: Drugs & Pharmacology Source Type: research
Fruit body formation and intra-species DNA polymorphism in Japanese Wolfiporia cocos strains
AbstractPoria, the dried sclerotium ofWolfiporia cocos, is a medicinal mushroom that is widely used in traditional Japanese medicine. The fruit body ofW. cocos is rarely found in the natural environment in Japan, therefore an optimized technique for fruit body formation is essential for producing new strains through crossbreeding and for biological research. Here, we developed a cultivation technique for fruit body formation ofW. cocos using three strains collected from different areas of Japan. When mycelia were cultured on sawdust-based medium after liquid medium culture, all strains successfully formed fruit bodies as a...
Source: Journal of Natural Medicines - March 25, 2022 Category: Drugs & Pharmacology Source Type: research
Caloforines A –G, coumarins from the bark of Calophyllum scriblitifolium
AbstractBioactivity-guided separation of the methanol extract ofCalophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A –E (1–5) and two new coumarins, caloforines F and G (6 and7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A –F (1–6) showed moderate antimalarial activity againstPlasmodium falciparum 3D7 strain.Graphical abstract (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 22, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Solubility enhancement of berberine –baicalin complex by the constituents of Gardenia Fruit
The article"Solubility enhancement of berberine –baicalin complex by the constituents of Gardenia Fruit", written by Kazuki Okoshi, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi, was originally published Online First without Open Access. After publication in volume 75, issue 1, page 76 –83 the author decided to opt for Open Choice and to make the article an Open Access publication. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 19, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Metabolic fingerprinting for discrimination of DNA-authenticated Atractylodes plants using 1H NMR spectroscopy
(Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Quality evaluation of Angelicae acutilobae radix: individual differences and localization of (Z)-ligustilide in Angelica acutiloba root
(Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
AbstractThe methanol extract from the leaves ofIlex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, mat é, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses the plasma triglyceride elevation in olive oil-treated mice. Three new triterpene saponins, termed mateosides I (1), II (2), and III (3), were isolated from the extract along with 29 known compounds. The structures of1–3 were elucidated based on chemical and spectroscopic evidence. Among the isolates, principal saponin constituents,2 and matesaponins 1 (7) and 2 (9), potently inhibited the triglyc...
Source: Journal of Natural Medicines - March 15, 2022 Category: Drugs & Pharmacology Source Type: research
Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital
This study aimed to examine the effect of Yokukansan on the pentobarbital-induced loss of righting reflex duration extended with lipopolysaccharide (LPS)-induced neuroinflammation and diazepam-induced gamma-aminobutyric acid receptor stimulation in a mouse model. The active ingredients in Yokukansan and its anti-neuroinflammatory effect on the hippocampus were also investigated. Furthermore, we examined the in vitro anti-inflammatory effects of Yokukansan on LPS-stimulated BV2 cells, a murine microglial cell line. Findings revealed that treatment with Yokukansan significantly decreased the duration of pentobarbital-induced...
Source: Journal of Natural Medicines - March 8, 2022 Category: Drugs & Pharmacology Source Type: research
Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines
AbstractTo explore useful natural compounds from indigenous medicinal plants, the cytotoxic properties from a methanolic extract ofBoehmeria sieboldiana leaves against human cancer cell lines were isolated in the present study. After purification of the extract,seco-dehydroantofine B (1) together with two known phenanthroindolizine alkaloids,seco-dehydroantofine A (2) and septicine (3), were isolated. The structure ofseco-dehydroantofine B was elucidated by performing comprehensive one- and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The cytotoxicit...
Source: Journal of Natural Medicines - March 6, 2022 Category: Drugs & Pharmacology Source Type: research
