Correction to: Solubility enhancement of berberine –baicalin complex by the constituents of Gardenia Fruit
The article"Solubility enhancement of berberine –baicalin complex by the constituents of Gardenia Fruit", written by Kazuki Okoshi, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi, was originally published Online First without Open Access. After publication in volume 75, issue 1, page 76 –83 the author decided to opt for Open Choice and to make the article an Open Access publication. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 19, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Metabolic fingerprinting for discrimination of DNA-authenticated Atractylodes plants using 1H NMR spectroscopy
(Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Quality evaluation of Angelicae acutilobae radix: individual differences and localization of (Z)-ligustilide in Angelica acutiloba root
(Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
AbstractThe methanol extract from the leaves ofIlex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, mat é, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses the plasma triglyceride elevation in olive oil-treated mice. Three new triterpene saponins, termed mateosides I (1), II (2), and III (3), were isolated from the extract along with 29 known compounds. The structures of1–3 were elucidated based on chemical and spectroscopic evidence. Among the isolates, principal saponin constituents,2 and matesaponins 1 (7) and 2 (9), potently inhibited the triglyc...
Source: Journal of Natural Medicines - March 15, 2022 Category: Drugs & Pharmacology Source Type: research
Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital
This study aimed to examine the effect of Yokukansan on the pentobarbital-induced loss of righting reflex duration extended with lipopolysaccharide (LPS)-induced neuroinflammation and diazepam-induced gamma-aminobutyric acid receptor stimulation in a mouse model. The active ingredients in Yokukansan and its anti-neuroinflammatory effect on the hippocampus were also investigated. Furthermore, we examined the in vitro anti-inflammatory effects of Yokukansan on LPS-stimulated BV2 cells, a murine microglial cell line. Findings revealed that treatment with Yokukansan significantly decreased the duration of pentobarbital-induced...
Source: Journal of Natural Medicines - March 8, 2022 Category: Drugs & Pharmacology Source Type: research
Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines
AbstractTo explore useful natural compounds from indigenous medicinal plants, the cytotoxic properties from a methanolic extract ofBoehmeria sieboldiana leaves against human cancer cell lines were isolated in the present study. After purification of the extract,seco-dehydroantofine B (1) together with two known phenanthroindolizine alkaloids,seco-dehydroantofine A (2) and septicine (3), were isolated. The structure ofseco-dehydroantofine B was elucidated by performing comprehensive one- and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The cytotoxicit...
Source: Journal of Natural Medicines - March 6, 2022 Category: Drugs & Pharmacology Source Type: research
Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice
This study aims to clarify the bioactive constituents responsible for the anti-dementia effects ofOcimum sanctum Linn. ethanolic extract (OS) using olfactory bulbectomized (OBX) mice, an animal model of dementia. The effects of OS or its extract further fractionated with n-hexane (OS-H), ethyl acetate (OS-E), and n-butanol (OS-B) on the spatial cognitive deficits of OBX mice were elucidated by the modified Y-maze tests. The effects of the major constituents of the most active OS fraction were also elucidated using the reference drug donepezil. The administration of OS and OS-E ameliorated the spatial cognitive deficits cau...
Source: Journal of Natural Medicines - February 26, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis
(Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - February 25, 2022 Category: Drugs & Pharmacology Source Type: research
Conventional and molecular pharmacognostic characters integrated with chemical profiles of five Piper plants in the Thai herbal pharmacopoeia and their admixture/adulteration/substitution situations in Thailand
In conclusion, the conventional and molecular pharmacognostic data combined with chemical profile of authentic fivePiper plants could be applied to indicate the plant origin and clarify the situations of admixture, adulteration, and substitution of the commercialPiper products launched in Thailand.Graphical abstract (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - February 24, 2022 Category: Drugs & Pharmacology Source Type: research
Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients
The objective of the present study is to evaluate the effectiveness of PA on muscle atrophy and to find its active ingredients using dexamethasone-induced muscle ring finger protein-1 (MuRF1) mRNA expression in murine myoblast C2C12 cells. Dexamethasone-induced MuRF1 expression was significantly suppressed by methanol-soluble part of boiling water extract of PA in a concentration-dependent manner with its IC50 value of 1.5 mg/ml. By the activity-guided fractionations of PA extract using the partition between organic solvents and its aqueous solution, the activity of PA did not transfer into the fraction containing aconit...
Source: Journal of Natural Medicines - February 18, 2022 Category: Drugs & Pharmacology Source Type: research
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway
AbstractMedulloblastoma (MB), accounting for nearly 10% of all childhood brain tumors, are implicated with aberrant activation of the Hedgehog (Hh) signaling pathway. Saikosaponin B1 (SSB1) and Saikosaponin D (SSD), two bioactive constituents ofRadix Bupleuri, are reported to have many biological activities including anticancer activities. In our work, we evaluated the inhibition of SSB1 and SSD on MB tumor growth in allograft mice and explored the underlying mechanisms. The associated biological activity was investigated in Shh Light II cells, an Hh-responsive fibroblast cell line, using the Dual-Glo® Luciferase Assay Sy...
Source: Journal of Natural Medicines - February 16, 2022 Category: Drugs & Pharmacology Source Type: research
Lateral flow immunoassay for small-molecules detection in phytoproducts: a review
AbstractPhytoproducts are involved in various fields of industry. Small-molecule (Mw < 900 Da) organic compounds can be used to indicate the quality of plant samples in the perspective of efficacy by measuring the necessary secondary metabolites and in the perspective of safety by measuring the adulterant level of toxic compounds. The development of reliable detection methods for these compounds in such a complicated matrix is challenging. The lateral flow immunoassay (LFA) is one of the immunoassays well-known for its simplicity, portability, and rapidity. In this review, the general principle, components, forma...
Source: Journal of Natural Medicines - February 16, 2022 Category: Drugs & Pharmacology Source Type: research
Comparison of phenolic compounds contained in Aquilaria leaves of different species
AbstractLeaves ofAquilaria plants contain a variety of phenolic compounds such as iriflophenone glycosides, mangiferin, and genkwanin. Previous studies showed thatAquilaria leaf extracts exhibit many pharmacological activities, including antidiabetic and laxative effects. However, a few studies have reported differences in the chemical content and compositions ofAquilaria species. Here, threeAquilaria species were identified usingmatK andtrnL –trnF sequences and their leaves were analyzed by HPLC and LC/MS. Comparison of the chemical components andα-glucosidase inhibition activity of the three species showed that the le...
Source: Journal of Natural Medicines - February 14, 2022 Category: Drugs & Pharmacology Source Type: research
Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF- κB
AbstractThe anti-inflammatory and anti-apoptotic properties of crocetin have been widely demonstrated in numerous diseases. However, the exact role and mechanism of crocetin in acute pancreatitis have not been elucidated. Thus, this paper aims at exploring whether crocetin could be used to alleviate acute pancreatitis and further demonstrating the underlying mechanisms. Cell viability of caerulein-induced pancreatic exocrine cell line AR42J treated with crocetin was determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT). Apoptosis and inflammation of these treated cells were detected by termina...
Source: Journal of Natural Medicines - January 30, 2022 Category: Drugs & Pharmacology Source Type: research
Oxidation of methylophiopogonanone A on the surface of TLC plate
AbstractMethylophiopogonanone A (MOPNA,1) is a characteristic homoisoflavonoid, having two methyl groups on the A ring, isolated from Ophiopogon Root (enlarged part of the root ofOphiopogon japonicus Ker-Gawler, Liliaceae). Although MOPNA is chemically stable in various organic solvents, such as acetone, chloroform, methanol and dimethyl sulfoxide, it gave a spot of higher polarity in addition to the spot of MOPNA on the surface of TLC plate. The spot was isolated and the structure of the major compound was revealed to be a compound with an oxygen atom at C-6 of the A ring. This oxidation on the surface of TLC plate was ob...
Source: Journal of Natural Medicines - January 28, 2022 Category: Drugs & Pharmacology Source Type: research
