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Clinical risk factors for severity and prognosis of antiresorptive agent-related osteonecrosis of the jaw: a retrospective observational study
ConclusionOur findings suggest that age and hypoalbuminemia are associated with the severity of ARONJ, and cancer, high inflammation, and vitamin D analog may impair healing. In contrast, conservative surgical treatment can overcome the poor treatment outcomes associated with ARONJ. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 27, 2022 Category: Orthopaedics Source Type: research

Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
ConclusionOur results suggested that low expression of HDAC2 under SeD condition increased ROS content by decreasing FOXO3A in chondrocytes, which led to the activation of NF- κB pathway and ECM homeostasis imbalance. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 26, 2022 Category: Orthopaedics Source Type: research

Oxidative stress causes muscle structural alterations via p38 MAPK signaling in COPD mouse model
ConclusionsThis study provides first evidence in COPD mouse model that oxidative stress trigger a series of muscle structural changes. Our findings suggest a novel target for sarcopenia in COPD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 26, 2022 Category: Orthopaedics Source Type: research

Strontium-89 plus zoledronic acid versus zoledronic acid for patients with painful bone metastatic breast cancer
ConclusionThis trial showed the lack of benefits from Sr-89 addition to ZOL for breast cancer patients with painful bone metastases. However, safety and analgesic drug dose reduction were more evident in ZOL  + Sr-89, indicating its potential for pain control. Sr-89 therapy is safe, thus more effective radiopharmaceuticals are anticipated. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 30, 2022 Category: Orthopaedics Source Type: research

Wnt signaling: a double-edged sword in protecting bone from cancer
AbstractWnt signaling plays a critical role in loading-driven bone formation and bone homeostasis, whereas its activation in cancer cells promotes their progression. Currently, major research efforts in cancer treatment have been directed to the development of Wnt inhibitors. Recent studies on tumor –bone interactions, however, presented multiple lines of evidence that support a tumor-suppressive role of Lrp5, a Wnt co-receptor, and β-catenin, in Wnt signaling. This review describes the action of Wnt signaling as a double-edged sword in the bone microenvironment and suggests the possibility of a novel option for protect...
Source: Journal of Bone and Mineral Metabolism - August 30, 2022 Category: Orthopaedics Source Type: research

Trends in osteoporosis prevalence over a 10-year period in Japan: the ROAD study 2005 –2015
ConclusionsIn the population-based survey with a 10-year interval, the prevalence of osteoporosis at lumbar spine tended to decrease significantly. This preferable change in osteoporosis could contribute to the decrease in the occurrence of osteoporotic fracture in the future. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 29, 2022 Category: Orthopaedics Source Type: research

Unravelling hip –spine bone mineral density discordance in people living with HIV
ConclusionHip –spine BMD discordance is highly prevalent in PLWH and it is associated with classical and HIV-related risk factors, modifying the rate of osteoporosis and fracture risk estimation. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 29, 2022 Category: Orthopaedics Source Type: research

A novel serological biomarker are associated with disease severity in patients with osteoarthritis
ConclusionsSerum ApoD concentration was correlated with the presence and severity of KOA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 29, 2022 Category: Orthopaedics Source Type: research

Correction: Movement control during one-leg standing is important for the bone mineral density maintenance or improvement
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 27, 2022 Category: Orthopaedics Source Type: research

Risk factors for subchondral insufficiency fracture of the femoral head in renal transplant patients
ConclusionSince osteoporosis, the lumbar BMD, serum P, and serum Ca  × P were identified as risk factors for a post-RT SIF, these factors should be evaluated before RT for the prediction of the SIF risk. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 24, 2022 Category: Orthopaedics Source Type: research

Bone mass and biomarkers in young women with anorexia nervosa: a prospective 3-year follow-up study
ConclusionOur findings highlight the importance of early detection and organized long-term follow-up of bone health in young women with a history of AN. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 12, 2022 Category: Orthopaedics Source Type: research

CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF- κB pathway
ConclusionsHigh levels of TRAF1 in RA synovium play an important role in the synovial hyperplasia of RA by suppressing apoptosis through activating JNK/NF-kB-dependent signaling pathways in response to the engagement of CD40. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 12, 2022 Category: Orthopaedics Source Type: research

Defective bone repletion in aged Balb/cBy mice was caused by impaired osteoblastic differentiation
ConclusionThe bone repletion mechanism in aged Balb/cBy mice is defective that is caused by an impaired osteoblast differentiation through reducedactivation  of SOCE. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 10, 2022 Category: Orthopaedics Source Type: research

Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures
ConclusionMice with limb mesenchyme-specificTfam deletions exhibited spontaneous limb bone fractures, resulting in severe limb deformities. Bone fragility was caused by poor apatite orientation owing to impaired osteoblast differentiation and maturation. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 10, 2022 Category: Orthopaedics Source Type: research

Accuracy of the Fracture Risk Assessment Tool for judging pharmacotherapy initiation for primary osteoporosis
ConclusionThe FRAX® score can accurately assess the criteria for initiating pharmacotherapy for primary osteoporosis based on the current Japanese diagnostic criteria, especially when theT-score is used. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 10, 2022 Category: Orthopaedics Source Type: research