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Upregulated miR-9-5p inhibits osteogenic differentiation of bone marrow mesenchymal stem cells under high glucose treatment
ConclusionMiR-9-5p knockdown promotes HG-induced osteogenic differentiation BMSCs in vitro and mitigates the DOP condition of rats in vivo by targeting DDX17. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 9, 2021 Category: Orthopaedics Source Type: research

List of reviewers 2020 –2021
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 8, 2021 Category: Orthopaedics Source Type: research

Polypharmacy, chronic kidney disease, and incident fragility fracture: a prospective cohort study
ConclusionHyperpolypharmacy is associated with an increased risk of fragility fracture regardless of CKD status, and has a strong impact on incident fragility fractures in dialysis-dependent CKD patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 3, 2021 Category: Orthopaedics Source Type: research

Journal of Bone and Mineral Metabolism Best Paper Award 2021
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 29, 2021 Category: Orthopaedics Source Type: research

Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling
ConclusionsThese findings demonstrated thatBmal1 negatively regulates endochondral ossification in heterotopic ossification of tendons and ligaments with aging via TGF β/BMP signaling, thereby identifying a new regulatory mechanism in age-related heterotopic ossification of tendons and ligaments. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 9, 2021 Category: Orthopaedics Source Type: research

Association between alcohol and bone mineral density in a Mendelian randomization study: the Dong-gu study
ConclusionIn our MR study, genetically predicted alcohol consumption was positively associated with BMD in men. This result suggests that the association between alcohol consumption and BMD is causal. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 9, 2021 Category: Orthopaedics Source Type: research

Kefir alters craniomandibular bone development in rats fed excess dose of high fructose corn syrup
ConclusionIn conclusion, dietary the excess dose of HFCS at an early age has been observed to pose a risk for cranial and mandible bone development. The healing effects of kefir may be a new approach to the treatment via kefir consumption in young's. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 6, 2021 Category: Orthopaedics Source Type: research

Correction to: Equivalent values between anterior vertebral height, wedge ratio, and wedge angle in osteoporotic vertebral fractures
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 30, 2021 Category: Orthopaedics Source Type: research

Wnt3a and ASCs are capable of restoring mineralization in staph aureus-infected primary murine osteoblasts
ConclusionsIn summary, we gained further osteoblast-related insights into pathomechanisms of reduced bone healing capacity upon infections. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 25, 2021 Category: Orthopaedics Source Type: research

Articular cartilage degeneration and bone adaptation due to lack of dystrophin in mice
ConclusionsThe morphological changes observed in the bone tissue of the MDX may be not only secondary to muscle weakness or chronic use of corticosteroids but also our results indicate connections between decrease of cartilage thickness, collagen network alteration and consequent subchondral changes that may lead to articular cartilage degeneration and bone adaptation mechanism in MDX mice. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 22, 2021 Category: Orthopaedics Source Type: research

The relat ıonshıp between serum hydroxyvıtamın D levels and postural stabılıty ın young adults
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 22, 2021 Category: Orthopaedics Source Type: research

The prevalence of vertebral fractures among Indian perimenopausal women and its association with ovarian biomarkers
ConclusionAbout one-fifth of the study subjects had prevalent vertebral fractures. AMH may be a menstrual cycle independent biomarker and may reflect bone loss in perimenopausal women. Further prospective studies are needed to validate these findings. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 17, 2021 Category: Orthopaedics Source Type: research

Impaired bone healing by enoxaparin via inhibiting the differentiation of bone marrow mesenchymal stem cells towards osteoblasts
Conclusion It was suggested that enoxaparin impaired bone healing through suppressing the differentiation of BMSCs towards osteoblasts. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 15, 2021 Category: Orthopaedics Source Type: research

Imaging findings and treatment outcomes of a rare subtype of medication-related osteonecrosis of the jaw
ConclusionAmong the MRONJ types, the PRd type has a poor prognosis. Therefore, accumulating and analyzing more PRd cases in the future is warranted. This is the first report to describe the presence of this specific subtype of MRONJ. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 12, 2021 Category: Orthopaedics Source Type: research

Association of serum 25OHD levels with risk of paediatric fractures
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 26, 2021 Category: Orthopaedics Source Type: research