A eulogy for the late Dr. Hidehiro Ozawa
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 6, 2023 Category: Orthopaedics Source Type: research

Association between walking speed and calcaneus stiffness index in older adults
ConclusionOur findings suggest that UWS can be a sensitive indicator of calcaneal bone loss among an older population. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 23, 2023 Category: Orthopaedics Source Type: research

Musculoskeletal pain and muscular weakness as the main symptoms of adult hypophosphatasia in a Spanish cohort: clinical characterization and identification of a new ALPL gene variant
ConclusionMild HPP patients presenting with diffuse symptoms such as musculoskeletal pain may be undiagnosed or misdiagnosed as osteoporosis patients by routine diagnosis. It is important to identify these individuals, to avoid inappropriate treatment with antiresorptive drugs. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 23, 2023 Category: Orthopaedics Source Type: research

Correction: Is the LRINEC score useful for predicting necrotizing fasciitis as a complication of MRONJ?
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 23, 2023 Category: Orthopaedics Source Type: research

Correction: Effects of walking and sun exposure on bone density and balance in elderly with osteopenia
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 15, 2023 Category: Orthopaedics Source Type: research

Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005 –2010
ConclusionThis study found that CDAI correlated positively with femoral neck, trochanter, and total spine BMD. This suggests that intake of a diet rich in antioxidants can reduce the risk of low bone mass and osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 8, 2023 Category: Orthopaedics Source Type: research

Low-intensity pulsed ultrasound enhances the positive effects of high-intensity treadmill exercise on bone in rats
ConclusionLIPUS could augment the skeletal benefits of high-intensity exercise through Wnt/ β-catenin signal pathway. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 4, 2023 Category: Orthopaedics Source Type: research

Is the LRINEC score useful for predicting necrotizing fasciitis as a complication of MRONJ?
ConclusionOur results suggested that the LRINEC score may be a useful diagnostic tool to predict ONJ-NF but valuating only CRP and WBC may be sufficient particularly in patients with osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 4, 2023 Category: Orthopaedics Source Type: research

Response to letter to the editor on “Approach to reduce periprosthetic bone resorption after total hip arthroplasty”
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 3, 2023 Category: Orthopaedics Source Type: research

TNF α-dependent mTOR activity is required for tenotomy-induced ectopic ossification in mice
ConclusionThe TNF α-mTOR axis could be targeted therapeutically to prevent trauma-induced ectopic ossification in tendons. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 1, 2023 Category: Orthopaedics Source Type: research

Soft drinks, tea and coffee consumption in relation to risk of fracture: evidence from china health and nutrition survey
ConclusionOur findings suggest that high consumption of soft drinks, tea and coffee is associated with an increased risk of fracture in the Chinese population. Which has important public health implications given the widespread consumption of these beverages. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 1, 2023 Category: Orthopaedics Source Type: research

Mir-4699 promotes the osteogenic differentiation of mesenchymal stem cells
ConclusionOur findings indicated that miR-4699 supported and synergized the BMP2-induced osteoblast differentiation of mesenchymal stem cells. We suggest, thereof, the utilization of hsa-miR-4699 for further in vivo experimental investigation to reveal the potential therapeutic impact of regenerative medicine for different types of bone defects. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 29, 2023 Category: Orthopaedics Source Type: research

Decrease in osteoporotic fracture in the western Kitakyushu region by the STOP-Fx study
ConclusionAs the demographics and medical area served by six hospitals in the western Kitakyushu region have not changed significantly since the STOP-Fx study initiation, the STOP-Fx study may have contributed in decreasing the number of osteoporotic fractures. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 29, 2023 Category: Orthopaedics Source Type: research

Denosumab effect on bone mineral density and urinary-NTX in breast cancer patients receiving aromatase inhibitors
ConclusionDenosumab increased BMD in patients treated with aromatase inhibitors. The u-NTX level decreased soon after start of denosumab treatment, and its change ratio is predictive of improvement in BMD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 29, 2023 Category: Orthopaedics Source Type: research

Management of bone metastasis in prostate cancer
AbstractProgression of bone metastases is the primary cause of death in prostate cancer, and skeletal-related events (SREs), including pathologic fractures, spinal cord compression, radiation, or surgery to bone can impair patients ’ quality of life. Over the past decade, the development of cytotoxic agents, androgen-receptor-axis-targeted therapies (ARATs), and radioligand therapies has prolonged overall survival of prostate cancer patients with bone metastases and reduced the risk of SREs. The use of bone-modifying agents has also contributed to the reduced risk of SREs. Initial use of a cytotoxic agent, docetaxel, or ...
Source: Journal of Bone and Mineral Metabolism - May 10, 2023 Category: Orthopaedics Source Type: research