Relationships between QUS and HR-pQCT, DXA, and bone turnover markers
ConclusionsModerate correlations were seen between QUS and Tb.vBMD and microarchitecture in the radius and tibia and aBMD of the proximal femur. On the other hand, practically no correlations were seen with Ct.vBMD or Ct.Po and the bone-related biochemical markers. Only in middle age, moderate correlations were seen with Ct.Th in the tibia and with aBMD of the lumbar spine. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 13, 2022 Category: Orthopaedics Source Type: research

Fractures within 2  years of an obstetric hospitalization: analysis of nationwide administrative data in Japan
ConclusionWe investigated fracture cases occurring within 2  years of an obstetrics hospitalization. This finding may be useful in selecting preventative measures for patients at risk of fractures within 2 years after obstetric hospitalization, including PLO. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 12, 2022 Category: Orthopaedics Source Type: research

Discussion of bonding strength of chitosan –tannic acid coating and its anti-osteoclast and anti-microbial mechanism
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 12, 2022 Category: Orthopaedics Source Type: research

CircPVT1 promotes the tumorigenesis and metastasis of osteosarcoma via mediation of miR-26b-5p/CCNB1 axis
ConclusionSilencing of circPVT1 notably suppressed the tumorigenesis and metastasis of OS via miR-26b-5p/CCNB1 axis. Therefore, circPVT1 might be used as a target for OS treatment. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 1, 2022 Category: Orthopaedics Source Type: research

Correlation between vitamin D metabolites and rheumatoid arthritis with osteoporosis by ultra-high-performance liquid chromatography –tandem mass spectrometry (UPLC–MS/MS)
ConclusionsVD deficiency and insufficient are common in RA patients. RA patients can be appropriately supplemented with VD. VD3 may be a better choice. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 1, 2022 Category: Orthopaedics Source Type: research

Improving osteoinductive properties and imparting antibacterial activity to titanium alloys
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 1, 2022 Category: Orthopaedics Source Type: research

Association between non-alcoholic fatty liver disease and bone turnover markers in southwest China
ConclusionThe degree of liver adipose deposition was found to be negatively associated with the serum levels of 25(OH)D3 (in both males and females) and osteocalcin (only in males) in southwest China. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 31, 2022 Category: Orthopaedics Source Type: research

Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis
ConclusionLow serum vitamin D levels in the elderly are associated with an increase in the odds of hip fracture. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 31, 2022 Category: Orthopaedics Source Type: research

Analysis of the subcellular location of FAM230B and its interaction with premature miR-302b in osteosarcoma
ConclusionFAM230B is accumulated to high levels in OS and may serve as an endogenous competing RNA for premature miR-302b in the nucleus to promote OS cell invasion and migration. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 31, 2022 Category: Orthopaedics Source Type: research

Hypocalcemia in hospitalized patients with COVID-19: roles of hypovitaminosis D and functional hypoparathyroidism
ConclusionVitamin D deficiency plays a major role in hypocalcemia among hospitalized patients with COVID-19. Inappropriately low/low-normal serum PTH may be a contributing factor in this disorder. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 31, 2022 Category: Orthopaedics Source Type: research

Efficacy and safety of romosozumab among Japanese postmenopausal women with osteoporosis and mild-to-moderate chronic kidney disease
ConclusionRomosozumab for 12  months is an effective and well-tolerated treatment option for Japanese patients with osteoporosis and mild-to-moderate CKD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 31, 2022 Category: Orthopaedics Source Type: research

Sarcopenia: an unsolved problem after hip fracture
ConclusionsAfter hip fracture, osteoporosis seemed to be well managed and the prevalence of osteoporosis did not increase. However, SMI decreased and the prevalence of sarcopenia increased. More active measures are warranted to prevent sarcopenia in elderly hip fracture patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 31, 2022 Category: Orthopaedics Source Type: research

The relationship between chronic kidney disease and denosumab-induced hypocalcemia in high-age osteoporotic patients
ConclusionAdvanced age combined with low eGFR and low serum Ca status appear to be associated with the incidence of hypocalcemia when using denosumab for the treatment of osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 31, 2022 Category: Orthopaedics Source Type: research

Ashing of bone: errors due to loss of CO2 and their correction
In conclusion, a satisfactory method is given for ash weight determination using small samples, and yielding highly reproducible data. If accepted widely, ash weight values between laboratories could be used to study variations due to diet, age, drug treatment, and disease. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 30, 2022 Category: Orthopaedics Source Type: research

Risk assessment of femoral pathological fracture in prostate cancer patients by computed tomography analysis
ConclusionThese results indicate that prostate cancer is less effective in inducing bone formation in the cortex than in the marrow and that the decrease in the cortical bone density at the medial trochanter region leads to an increased risk of pathological fracture. Therefore, a previously undocumented risk factor for pathological fracture in prostate cancer patients is presented. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 30, 2022 Category: Orthopaedics Source Type: research