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Cancer –nerve interplay in cancer progression and cancer-induced bone pain
ConclusionIt is suggested that SNs may be a newly-recognized important component of the bone microenvironment that contribute to not only in the pathophysiology of CIBP but also cancer progression in bone and dissemination from bone. Suppression of the activity of bone-innervating SNs, thus, may provide unique opportunities in the treatment of cancer progression and dissemination, as well as CIBP. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 30, 2023 Category: Orthopaedics Source Type: research

Distinct dietary risk factors for incident osteoporotic fractures in early and late postmenopausal phase women
ConclusionDistinct dietary risk factors for osteoporotic fractures were identified in early and late postmenopausal phase women. Appropriate nutritional guidance according to patient age will be important for maintaining bone health and quality of life. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 30, 2023 Category: Orthopaedics Source Type: research

Takuo Fujita, MD, PhD
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 18, 2023 Category: Orthopaedics Source Type: research

Possible involvement of CXCR3-CXCR6  + CD4 + T cells in Langerhans cell histiocytosis
ConclusionsWe found abundant peripheral blood-activated Th17 cells and high percentages of IL-17-producing cells in osteolytic bone lesions in LCH. This finding, together with the decrease in peripheral blood-activated Th17 cells following chemotherapy, suggests the potential involvement of activated Th17 cells in LCH-related osteolysis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 11, 2023 Category: Orthopaedics Source Type: research

Comparison of different parameters between daily and twice-weekly teriparatide in postmenopausal women with severe osteoporosis
ConclusionsLumbar spine BMD (LS-BMD) was significantly increased. Moreover, ΔLS-BMD in the D-TPTD group was higher than that in the W-TPTD group. This study showed that the persistence, ΔTH-BMD, ΔFN-BMD and incidence of vertebral fractures did not differ between the two groups. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 10, 2023 Category: Orthopaedics Source Type: research

Correction: Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 2, 2023 Category: Orthopaedics Source Type: research

Peripheral quantitative computed tomography-derived bone parameters in men with impaired fasting glucose and diabetes
ConclusionMen with T2DM had lower total bone area, trabecular area, cortical area and polar stress strain index than the other two groups; however, total density and cortical density were higher. Only one difference was observed between IFG and normoglycaemia; increased tibial cortical density. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 23, 2022 Category: Orthopaedics Source Type: research

Familial Paget ’s disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27)
ConclusionOur new findings might suggest a broad spectrum of phenotypes in bone disorders withTNFRSF11A duplication variants. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 15, 2022 Category: Orthopaedics Source Type: research

Hip and vertebral fracture risk after initiating antidiabetic drugs in Japanese elderly: a nationwide study
ConclusionsInitiating insulin increased the risk of not only hip fractures but also vertebral fractures. Patients initiating antidiabetic drugs had increased risks of hip and vertebral fractures compared with those initiating biguanide independently for age, gender, polypharmacy, and dementia in the Japanese elderly. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 14, 2022 Category: Orthopaedics Source Type: research

Loss of height predicts fall risk in elderly Japanese: a prospective cohort study
ConclusionsWe suggest that height loss of  ≥ 2 cm is a predictor of future falls in older adults, and the combination of height loss and fall experiences may be a useful screening tool for determining fall risk. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 13, 2022 Category: Orthopaedics Source Type: research

Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor- κB p65
ConclusionFGF8 enhanced the expression and activity of MMP2 and MMP9 in chondrocytes via NF- κB p65 signaling. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 13, 2022 Category: Orthopaedics Source Type: research

Efficacy of denosumab on bisphosphonate-treated osteoporosis and osteopenia in systemic rheumatic disease patients receiving glucocorticoids
ConclusionSwitching to denosumab demonstrated greater efficacy than continuing bisphosphonates in increasing BMD, inhibiting osteoclast activation, and enhancing patient satisfaction in Japanese bisphosphonate-treated osteoporosis and osteopenia patients with concomitant SRD receiving glucocorticoids. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 13, 2022 Category: Orthopaedics Source Type: research

Effect of vitamin D administration on muscle function improvement depending on vitamin D sufficiency status
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 13, 2022 Category: Orthopaedics Source Type: research

List of reviewers 2021 –2022
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 26, 2022 Category: Orthopaedics Source Type: research

Journal of Bone and Mineral Metabolism Best Paper Award 2022
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 25, 2022 Category: Orthopaedics Source Type: research