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Inherited Fanconi renotubular syndromes: unveiling the intricacies of hypophosphatemic rickets/osteomalacia
ConclusionOur findings underscore frequent under- and misdiagnosis of FRTS; hence, a high index of suspicion for FRTS in phosphopenic rickets/osteomalacia, with early consideration of genetic testing is essential to ensure timely diagnosis of FRTS. The novel variants and phenotypic manifestations described here expand the disease spectrum of FRTS. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 4, 2024 Category: Orthopaedics Source Type: research

Secondary fracture and mortality risk with very high fracture risk osteoporosis and proximal femoral fracture
ConclusionOver half of the female patients with proximal femoral fractures had very high fracture risk osteoporosis. Although, very high fracture risk osteoporosis demonstrated a notably increased risk of secondary fractures, particularly at 12  months post-surgery, the use of osteoanabolic agents was substantially low. Collectively, our findings highlight the need to consider the risk of very high fracture risk osteoporosis, expand the use of medications to include osteoanabolic agents, and reconsider the current healthcare approach for proximal femoral fractures. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 3, 2024 Category: Orthopaedics Source Type: research

Association of chronic liver disease with bone diseases and muscle weakness
AbstractThe liver is a vital organ involved in nutrient metabolism, hormone regulation, immunity, cytokine production, and gut homeostasis. Impairment in liver function can result in malnutrition, chronic inflammation, decreased anabolic hormone levels, and dysbiosis. These conditions eventually cause an imbalance in osteoblast and osteoclast activities, resulting in bone loss. Osteoporosis is a frequent complication of chronic liver disease (CLD) that adversely affects quality of life and increases early mortality. Sarcopenia is another common complication of CLD characterized by progressive loss of skeletal muscle mass a...
Source: Journal of Bone and Mineral Metabolism - February 1, 2024 Category: Orthopaedics Source Type: research

Safety and effectiveness of risedronate in Paget ’s disease of bone: postmarketing surveillance study in Japan
ConclusionTo conclude, risedronate 17.5  mg/day is safe and effective for treating patients with PDB in daily practice. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 10, 2024 Category: Orthopaedics Source Type: research

Psoas muscle area is associated with prognosis in elderly patients with hip fracture
ConclusionThe CSA of the psoas is associated with prognosis in elderly patients with hip fractures and shows a moderately positive correlation with ALM. Hence, the CSA of psoas is useful for predicting survival and muscle mass in elderly patients with hip fractures. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 9, 2024 Category: Orthopaedics Source Type: research

Bone mineral density and body mass composition measurements in premenopausal anorexic patients: the impact of lean body mass
ConclusionAnorexic patients have a very high risk of osteoporosis and fractures. Bone density is influenced by fat body mass and also significantly by lean body mass. Special consideration should be given to the sarcopenic condition since it is a worsening factor of bone health. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 9, 2024 Category: Orthopaedics Source Type: research

Medication-related osteonecrosis of the lower jaw without osteolysis on computed tomography images
ConclusionsSurgical treatment yielded good treatment outcomes in most patients with mandibular MRONJ; however, the cure rate was lower in patients with malignancy who showed no osteolysis on CT images. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 9, 2024 Category: Orthopaedics Source Type: research

Body mass index, height, and osteoporotic fracture risk in community-dwelling Japanese people aged 40 –74 years
ConclusionBMI and osteoporotic fracture risk showed a U-shaped association in men, whereas higher height was associated with higher vertebral fracture risk in women, suggesting sex-dependent differences in these associations. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 30, 2023 Category: Orthopaedics Source Type: research

Causal relationship between glycemic traits and bone mineral density in different age groups and skeletal sites: a Mendelian randomization analysis
ConclusionsIn the non-diabetic population, currently available evidence does not support a causal relationship between glycemic traits and BMD. However, further investigation is warranted considering the observed gender differences. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 29, 2023 Category: Orthopaedics Source Type: research

Effectiveness of romosozumab in patients with osteoporosis at high fracture risk: a Japanese real-world study
ConclusionThis large-scale, multicenter chart review provides clinically relevant insights into the profiles of patients initiating romosozumab, effectiveness of real-world romosozumab use, and sequential therapy in Japanese patients at high risk of fracture. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 12, 2023 Category: Orthopaedics Source Type: research

Crosstalk between muscle and bone
AbstractClinical studies revealed a relationship between osteoporosis and sarcopenia. Based on this background, crosstalk between muscle and bone has emerged as a novel research field in the past decade. Among the interactions that occur between muscle and bone, humoral factors, such as osteokines and myokines, affect distant muscles and bones, respectively. Recent studies proposed several important myokines that have an impact on bone, such as myostatin and irisin. Signaling by these myokines has potential as a target for drug development and biomarkers for exercise. Mechanical stress, endocrine disorders, and chronic kid...
Source: Journal of Bone and Mineral Metabolism - December 8, 2023 Category: Orthopaedics Source Type: research

Hypergravity stimulates mechanical behavior and micro-architecture of tibia in rats
ConclusionThe higher G values correspond to poorer macro-mechanical properties of the tibia, and a +  4G environment benefits the microstructure of the tibia. At the cellular level, bone resorption is enhanced in the + 4G group, but the bone remodeling capability gradually increases with further increments in G values. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 7, 2023 Category: Orthopaedics Source Type: research

Phenytoin is associated with increased risk of osteoporosis and fragility fractures in adult epileptic patients
ConclusionEpileptic patients on phenytoin therapy that were 18 –55 years old exhibited higher associated risk of osteoporosis and osteoporotic-fragility fractures of various regions. Patients that undergo phenytoin therapy for epilepsy treatment should be educated on the increased risk of bone fractures and have appropriate lifestyle and diet modifications. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 7, 2023 Category: Orthopaedics Source Type: research

Can TBS reference values be a valid indicator for clinical vertebral fracture? A cross-sectional study
ConclusionsThe reference value for low TBS ( ≤ 1.23) was useful as an indicator for CVF, especially in patients with osteoporosis. It is expected that reference values for TBS will be established in official guidelines in the future. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 6, 2023 Category: Orthopaedics Source Type: research

The effect of forearm rotation on the bone mineral density measurements of the distal radius
ConclusionSubtle rotational changes affected the BMD measurement of each region. The results showed the importance of forearm positioning when measuring the distal radius BMD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 6, 2023 Category: Orthopaedics Source Type: research