Journal of Bone and Mineral Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Retraction Note to: Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway
The authors have retracted this article. After publication the authors discovered that they were unable to repeat their results. In this article the authors concluded that silencing the rab31 gene inhibits hedgehog pathway activation, but in the repeated experiments the authors found that the Hedgehog pathway was not activated when the rab31 gene was over-expressed. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 3, 2022 Category: Orthopaedics Source Type: research

Sexual dimorphism in the relation between sex hormones and osteoporosis in patients with type 2 diabetes mellitus
ConclusionIn T2DM, the estrogen level was negatively correlated with osteoporosis in men, and the FSH level was positively correlated with the osteoporosis in women. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 2, 2022 Category: Orthopaedics Source Type: research

Polypharmacy and bone fracture risk
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 2, 2022 Category: Orthopaedics Source Type: research

CircTMOD3 promotes lipopolysaccharide-induced chondrocyte apoptosis in osteoarthritis by sponging miR-27a
ConclusionCircTMOD3 suppresses miR-27a maturation in OA to promote chondrocyte apoptosis induced by LPS. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 1, 2022 Category: Orthopaedics Source Type: research

Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3 β/Nrf2 pathway
ConclusionThese findings indicated hops and xanthohumol could ameliorate bone loss induced by iron overload via activating Akt/GSK3 β/Nrf2 pathway, which brought up a novel sight for senile osteoporosis therapy. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 1, 2022 Category: Orthopaedics Source Type: research

Alterations in the composition of the gut microbiota affect absorption of cholecalciferol in severe osteoporosis
ConclusionDifferences in the intestinal microecology, especiallyBifidobacterium, are associated with differences in the absorption of cholecalciferol and in the circulating 25(OH)D3 concentration, which may influence the progression of OP to SOP. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 1, 2022 Category: Orthopaedics Source Type: research

Emerging role of m6A modification in osteogenesis of stem cells
AbstractThe differentiation of stem cells into osteoblasts is a key link in the treatment of bone defects and other orthopedic diseases. N6-methyladenosine (m6A) modification, an important post-transcriptional modification, is a methylation that occurs at the N6 site of RNA adenylate. The modification plays a regulatory role in the growth and development of biological individuals, the directional differentiation of stem cells and the occurrence of diseases. It is involved in various processes of the fate decision of stem cells. And it regulates the development and constant renewal of bone and keeps bone homeostasis by cont...
Source: Journal of Bone and Mineral Metabolism - January 29, 2022 Category: Orthopaedics Source Type: research

Effects of teriparatide and low-intensity aerobic exercise on osteopenia in type 2 diabetes mellitus rats
ConclusionThe combination of TPTD and treadmill exercise increased BMD and trabecular and cortical bone strength of the femur with improved micro-architecture in T2DM model rats. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 28, 2022 Category: Orthopaedics Source Type: research

Histone methyltransferase EZH2 in proliferation, invasion, and migration of fibroblast-like synoviocytes in rheumatoid arthritis
ConclusionEZH2 bound to the miR-22-3p promoter and inhibited miR-22-3p expression by upregulating H3K27me3 level, thereby promoting CYR61 expression and inducing the proliferation, migration, and invasion of RA-FLSs. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 27, 2022 Category: Orthopaedics Source Type: research

Skeletal and gene-regulatory functions of nuclear sex steroid hormone receptors
AbstractThe wide variety of sex hormone actions underlie bone growth and health, and their actions mediate gene regulation by the cognate nuclear receptors. Nuclear androgen and estrogen receptors (AR, and ER α/ERβ) are hormone-dependent and DNA binding- transcription regulatory factors, and gene regulation by sex hormones often accompany with chromatin remodeling under aid of a number of co-regulators. As sex hormone biosynthesis is under highly regulated systemic and local regulations, the skeletal a ctions of sex hormones could be inferred from only the phenotypic abnormalities in skeleton in mouse genetic models defi...
Source: Journal of Bone and Mineral Metabolism - January 25, 2022 Category: Orthopaedics Source Type: research

Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome
ConclusionEnhanced inflammatory thrust by periodontitis increases CTX levels and decreases bone ALP and BMD levels in women with PCOS. Screening PCOS women for periodontal disease and vice versa may have a direct bearing on overall bone health. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 24, 2022 Category: Orthopaedics Source Type: research

Evaluation of bone health in patients with mucopolysaccharidosis
ConclusionThe low BMDz score prevalence reported with DXA was misleadingly higher in children with MPS and short stature. To prevent exposure to unnecessary antiresorptive treatments in these children, the effect of severe short stature and bone geometry on DXA measurements should be considered; further studies on bone health are warranted. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 23, 2022 Category: Orthopaedics Source Type: research

LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS
ConclusionLncRNA XIST promoted osteoclast differentiation via interacting with FUS and upregulating SPHK1/S1P/ERK pathway. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 23, 2022 Category: Orthopaedics Source Type: research

Osteoporosis increases the risk of rotator cuff tears: a population-based cohort study
ConclusionThis population-based study supports the hypothesis that compared with individuals without osteoporosis, those with osteoporosis have a higher risk of developing rotator cuff tears. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 21, 2022 Category: Orthopaedics Source Type: research

30-year trends of hip and vertebral fracture incidence in Japan: a systematic review and meta-analysis
ConclusionIRs of hip fractures continuously increased in the past 30-years in men and women despite improved the diagnosis, treatment, and care. Such data from Japan, a leading aging society, provide important information for other countries. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 21, 2022 Category: Orthopaedics Source Type: research