Journal of Bone and Mineral Metabolism Journal of Bone and Mineral Metabolism RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Increased incidence among the very elderly in the 2020 Niigata Prefecture Osteoporotic Hip Fracture Study
ConclusionThe incidence of hip fractures in Niigata Prefecture has gradually increased over the past 35  years, with an increasing change observed in the very elderly recently in 2020. Although the treatment of osteoporotic hip fractures in Niigata Prefecture is adequate, improvements may include increasing the rate of adoption of osteoporosis treatment further and decreasing the number of days of pr eoperative waiting. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 22, 2023 Category: Orthopaedics Source Type: research

Low energy availability reduces bone mass and gonadal function in male mice
ConclusionsLow energy availability puts men at risk for stress injuries as well, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 13, 2023 Category: Orthopaedics Source Type: research

Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis
AbstractOsteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically acts as one of the anti-inflammatory, immune-modulating, and therapeutic drugs, whereas the long-term use of GC may cause rapid bone resorption, followed by prolonged and profound suppression of bone formation, resulting in the GC-induced OP (GIOP). GIOP ranks the first among secondary OP and is a pivotal risk for fracture, as well as high disability rate and mortality, at both societal and personal levels, vital costs. Gut microbiota ...
Source: Journal of Bone and Mineral Metabolism - March 13, 2023 Category: Orthopaedics Source Type: research

Factors associated with bone response to teriparatide in young postmenopausal women with osteoporosis
ConclusionA minority of treated women had no vertebral densitometric gain after 18  months of teriparatide therapy. Low levels of baseline bone remodeling were the main factor associated with poor response to treatment. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 9, 2023 Category: Orthopaedics Source Type: research

Differences between zoledronic acid and denosumab for breast cancer treatment
AbstractZoledronic acid and denosumab are bone-modifying agents that are clinically important in multiple aspects of bone management for breast cancer patients. These aspects include the prevention of osteoporosis induced by cancer-treatment bone loss, treatment and prevention of bone metastasis, and improvement of survival directly or indirectly by maintaining bone health. Interestingly, zoledronic acid and denosumab have different anticancer activities, and they may be associated with the improvement of survival of breast cancer patients under different mechanisms. Zoledronic acid is the most potent bisphosphonate. It pr...
Source: Journal of Bone and Mineral Metabolism - March 7, 2023 Category: Orthopaedics Source Type: research

Safety and effectiveness of once-yearly zoledronic acid in Japanese osteoporosis patients: three-year post-marketing surveillance
ConclusionThis 3-year post-marketing surveillance confirmed the real-world safety and effectiveness of ZOL. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 2, 2023 Category: Orthopaedics Source Type: research

Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy
DiscussionTherefore, these findings suggested that each variant has a significant role in chondrocyte hypertrophy, leading to suppression of bone formation. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 1, 2023 Category: Orthopaedics Source Type: research

Myeloma bone disease: pathogenesis and management in the era of new anti-myeloma agents
ConclusionsMM cells produce a variety of cytokines to stimulate receptor activator of nuclear factor- κB ligand-mediated osteoclastogenesis and suppress osteoblastic differentiation from bone marrow stromal cells, leading to extensive bone destruction with rapid loss of bone. MM cells alter the microenvironment through bone destruction where they colonize, which in turn favors tumor growth and surv ival, thereby forming a vicious cycle between tumor progression and bone destruction. Denosumab or zoledronic acid is currently recommended to be administered at the start of treatment in newly diagnosed patients with MM with b...
Source: Journal of Bone and Mineral Metabolism - March 1, 2023 Category: Orthopaedics Source Type: research

Association between pharmacotherapy and secondary hip fracture in a real-world setting: a nationwide database study
ConclusionSecondary hip fractures were less likely to occur with medication versus no medication. Differences in the crude incidence of secondary hip fracture based on medications usage might be attributed to background characteristics. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 28, 2023 Category: Orthopaedics Source Type: research

Efficacy of anti-osteoporosis treatment for men with osteoporosis: a meta-analysis
ConclusionFindings in this meta-analysis indicate that pharmacological treatment increases lumbar spine, femoral neck, total hip BMD, and decreases incident vertebral fractures in men with osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 27, 2023 Category: Orthopaedics Source Type: research

Impaired function of skeletal stem cells derived from growth plates in ovariectomized mice
ConclusionFunction of mSSCs was impaired by up-regulating pro-inflammatory genes in ovx-induced osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 27, 2023 Category: Orthopaedics Source Type: research

A mysterious triangle of blood, bones, and nerves
AbstractThe relationship between bone tissue and bone marrow, which is responsible for hematopoiesis, is inseparable. Osteoblasts and osteocytes, which produce and consist of bone tissue, regulate the function of hematopoietic stem cells (HSC), the ancestors of all hematopoietic cells in the bone marrow. The peripheral nervous system finely regulates bone remodeling in bone tissue and modulates HSC function within the bone marrow, either directly or indirectly via modification of the HSC niche function. Peripheral nerve signals also play an important role in the development and progression of malignant tumors (including he...
Source: Journal of Bone and Mineral Metabolism - February 8, 2023 Category: Orthopaedics Source Type: research

Immunotherapy as a potential treatment approach for currently incurable bone metastasis
AbstractOnce cancer metastasizes to the bone, the prognosis of cancer patients becomes extremely poor. Unfortunately, the current most successful treatment for bone metastasis can extend their survival by only a few months. Although recent studies have revealed promising impacts of cancer immunotherapies, their treatment efficacy on bone metastatic diseases remains controversial. Therefore, in this review, we discussed (i) preclinical and clinical evidence of the immunotherapeutic strategies for cancer bone metastasis, mainly focusing on cell-based immunotherapy, cytokine-based immunotherapy, and immune checkpoint blockade...
Source: Journal of Bone and Mineral Metabolism - February 8, 2023 Category: Orthopaedics Source Type: research

Denosumab prevented periprosthetic bone resorption better than risedronate after total hip arthroplasty
ConclusionDenosumab is more effective in preventing periprosthetic bone resorption than risedronate in the proximal femur. It also increased BMD around the stem implant following THA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 6, 2023 Category: Orthopaedics Source Type: research

Circulating biomarkers for diagnosis and therapeutic monitoring in bone metastasis
AbstractBone is a frequent site of metastasis for multiple types of solid tumors in organs such as prostate, breast, lung, etc., accounting for significant morbidities and mortalities of afflicted patients. One of the major problems of bone metastasis is lack of biomarkers for early diagnosis and for monitoring therapeutic responses. Medical imaging modalities such as computerized tomography, magnetic resonance imaging, and radioactive isotope-based bone scans are currently standard clinical practices, yet these imaging techniques are limited to detect early lesions or to accurately monitor the metastatic disease progressi...
Source: Journal of Bone and Mineral Metabolism - February 2, 2023 Category: Orthopaedics Source Type: research