Correction to: Profilin-1 negatively controls osteoclast migration by suppressing the protrusive structures based on branched actin filaments
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 19, 2023 Category: Orthopaedics Source Type: research

Correction to: Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 10, 2023 Category: Orthopaedics Source Type: research

Vitamin K insufficiency predicts incidence of frailty in community-dwelling older adults: The Otassha Study
ConclusionThe findings of this longitudinal study suggest that vitamin K insufficiency has nutritional importance in predicting the future incidence of frailty in the Japanese older adult population. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 31, 2023 Category: Orthopaedics Source Type: research

Cooperation between physicians and dentists for osteonecrosis of the jaw: a 2022 Japanese survey
ConclusionThis study confirmed increased cooperation between physicians and dentists for MRONJ in Japan. However, a more equal distribution of cooperation across Japan is necessary to optimally manage MRONJ. Discontinuation of antiresorptive agents is no longer necessary because fractures during discontinuation continue to increase in Japan. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 30, 2023 Category: Orthopaedics Source Type: research

Heel bone mineral density and various oral diseases: a bidirectional Mendelian randomization
ConclusionThis study showed that there was a negative relationship between heel bone density and periodontitis, and the decrease in heel bone density could promote the occurrence of periodontitis. In addition, there was no statistically significant relationship between heel bone density and other oral diseases. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 28, 2023 Category: Orthopaedics Source Type: research

Abaloparatide dose-dependently increases bone mineral density in postmenopausal women with osteoporosis: a phase 2 study
ConclusionIn postmenopausal Japanese women with osteoporosis at high fracture risk, abaloparatide for 48  weeks dose-dependently increased LS, TH, and FN BMDs, supporting further investigation with 80 μg abaloparatide for the treatment of osteoporosis in this population.Trial registration numberJapicCTI-132381. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 28, 2023 Category: Orthopaedics Source Type: research

Validation of JSBMR ’s CTIBL manual for Japanese men receiving androgen deprivation therapy for prostate cancer
ConclusionTaking preventive measures against fractures is necessary, including starting bone-modifying agents early in patients with a high fracture risk. The JSBMR CTIBL manual may be useful for this purpose. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 27, 2023 Category: Orthopaedics Source Type: research

Denosumab improves bone mineral density and microarchitecture in rheumatoid arthritis: randomized controlled trial by HR-pQCT
ConclusionDenosumab may be recommended for patients with RA treated with csDMARDs to increase BMD and improve bone microarchitecture. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 22, 2023 Category: Orthopaedics Source Type: research

Untreated osteoporosis and higher FRAX as risk factors for tooth loss: a 5-year prospective study
ConclusionIn this 5-year study, higher FRAX and untreated osteoporosis were risk factors for tooth loss. Women with normal BMD or treated for osteoporosis for  ≥ 3 years did not show increased risk. Management of skeletal conditions should be emphasized with periodontal care for the prevention of tooth loss in elderly women. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 11, 2023 Category: Orthopaedics Source Type: research

Association of serum uric acid levels with bone mineral density and the presence of osteoporosis in Chinese patients with Parkinson ’s disease: a cross-sectional study
ConclusionRelatively higher serum UA levels in the physiological range can work as a biomarker of higher BMD, and were strongly linked to lower prevalence of osteoporosis in Chinese PD patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 7, 2023 Category: Orthopaedics Source Type: research

Evaluation of the trabecular bone score in 35 children and adults with X-linked hypophosphatemic rickets
ConclusionThe higher LS-aBMDZ score, BMAD, and TBS result in the XLH patients compared to non-XLH subjects indicates an increased amount of trabecular bone within the lumbar spine, regardless of extraskeletal calcifications. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 7, 2023 Category: Orthopaedics Source Type: research

Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways
ConclusionThese results indicate that calcium oscillations triggered by extracellular ATP can activate aerobic oxidation through AMPK-related signaling pathways and thus promote osteoblast differentiation. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 7, 2023 Category: Orthopaedics Source Type: research

Negative impact on bone homeostasis in postmenopausal women with non-metastatic breast cancer during cytotoxic chemotherapy
ConclusionChemotherapy and dexamethasone as antiemetic resulted in significant bone loss, as evidenced by bone turnover markers. Further studies are required to understand the mechanism of chemotherapy-induced bone loss and the need for bone-strengthening agents during chemotherapy. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 6, 2023 Category: Orthopaedics Source Type: research

Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis
ConclusionLigandrol at high dose showed a subtle anabolic effect on structural properties without any improvement in biomechanical properties of osteoporotic bones. Considering side effects of ligandrol at this dose, its further investigation for the therapy of postmenopausal osteoporosis should be reevaluated. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 6, 2023 Category: Orthopaedics Source Type: research

Association of alcohol and bone mineral density dependent on type of alcohol consumed
ConclusionWhen consumed at quantities in the usual social range, alcohol was not associated with whole-body BMD. However, low-strength beer consumption was inversely related to spinal BMD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 6, 2023 Category: Orthopaedics Source Type: research