Secondary fracture rates and risk factors 1  year after a proximal femoral fracture under FLS
ConclusionDuring the COVID-19 pandemic, secondary fractures can be prevented if the patients can be followed and osteoporosis treatment can be continued. Conversely, despite adequate osteoporosis drug examination and treatment, a certain number of secondary fractures still occurred. The finding that postoperative osteoporosis therapy using routine medications and rehabilitation is associated with secondary fractures may support the importance of establishing clinical standards consisting of a multidisciplinary collaboration for FLS. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 10, 2023 Category: Orthopaedics Source Type: research

Repurposing sarecycline for osteoinductive therapies: an in vitro and ex vivo assessment
ConclusionSummarizing, SA is a promising candidate for drug repurposing within therapies envisaging the enhancement of bone healing/regeneration. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 10, 2023 Category: Orthopaedics Source Type: research

Management of cancer treatment-induced bone loss (CTIBL) in patients with breast cancer or prostate cancer
AbstractBreast cancer and prostate cancer are sex hormone-dependent cancers, and estrogen or androgen suppression therapy is the standard treatment. Cancer treatment-induced bone loss (CTIBL): bone loss and osteoporosis have become important side effects of these therapies. To summarize the current evidences, (1) Endocrine therapy for breast cancer and prostate cancer is associated with a significant decrease in bone mineral density. (2) Aromatase inhibitors (AI) for breast cancer are associated with a significant increase in fractures, and androgen deprivation therapy (ADT) for prostate cancer is likely to be associated w...
Source: Journal of Bone and Mineral Metabolism - April 10, 2023 Category: Orthopaedics Source Type: research

Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide
Conclusion2A-Cre functions effectively in vivo, and Dmp1-T2A-Cre knock-in mice are a useful tool for studying the functioning of various genes in hard tissues. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 10, 2023 Category: Orthopaedics Source Type: research

Adiponectin overexpression promotes fracture healing through regulating the osteogenesis and adipogenesis balance in osteoporotic mice
ConclusionWe demonstrated that APN overexpression facilitates bone fracture healing in osteoporosis. Furthermore, APN overexpression promoted bone formation in OVX mouse BMSCs and bone fracture ends by regulating the balance between osteogenesis and adipogenesis both in vitro and in vivo. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 10, 2023 Category: Orthopaedics Source Type: research

Association between dietary intake of α-tocopherol and cadmium related osteoporosis in population ≥ 50 years
ConclusionHigh α-tocopherol intake may improve the Cd-related osteoporosis and loss of BMD that could provide some dietary reference for prevention of osteoporosis in population ≥ 50 years old. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 10, 2023 Category: Orthopaedics Source Type: research

Secreted microRNAs in bone metastasis
AbstractBone metastasis is a common complication in several solid cancers, including breast, prostate, and lung. In the bone microenvironment, metastatic cancer cells disturb bone homeostasis leading to osteolytic or osteosclerotic lesions. Osteolytic lesions are characterized by an increased osteoclast-mediated bone resorption while osteosclerotic lesions are caused by enhanced activity of osteoblasts and formation of poor-quality bone. A common feature in bone metastasis is the complex interplay between the cancer cells and the cells of the bone microenvironment, which can occur already before the cancer cells enter the ...
Source: Journal of Bone and Mineral Metabolism - April 8, 2023 Category: Orthopaedics Source Type: research

Resveratrol prevents ovariectomy-induced bone quality deterioration by  improving the microarchitectural and biophysicochemical properties of bone
ConclusionThis study revealed that administration of different doses of 80 mg/kg/day and 40 mg/kg/day of resveratrol had protective effects on bone quality deterioration caused by ovariectomy. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 8, 2023 Category: Orthopaedics Source Type: research

Relationship between the 25-question Geriatric Locomotive Function Scale and physical function in the elderly people
ConclusionThe GLFS-25 is useful for screening those with severe LS stages; however, evaluation of actual physical function is recommended for precise staging of LS in those with low GFLS-25 scores. Among the six subcategories of the GLFS-25, body pain and cognitive were independent of the other four subcategories. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 8, 2023 Category: Orthopaedics Source Type: research

Approaches to reduce periprosthetic bone resorption after total hip arthroplasty
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 8, 2023 Category: Orthopaedics Source Type: research

Bone mineral density and normal-weight obesity syndrome: beyond body weight and body mass index
ConclusionThe negative association of BMD with BF percentage may suggest a higher risk of bone alterations in individuals with NWO syndrome and should be monitored over time. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 23, 2023 Category: Orthopaedics Source Type: research

The association of lumbar disc degeneration with lumbar vertebral trabecular volumetric bone mineral density in an urban population of young and middle-aged community-dwelling Chinese adults: a cross-sectional study
ConclusionOur study found that the degree of LDD was negatively associated with lumbar trabecular vBMD, although (excepting the L5-S1 disc), the relationship was statistically significant only in men. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 22, 2023 Category: Orthopaedics Source Type: research

Increased incidence among the very elderly in the 2020 Niigata Prefecture Osteoporotic Hip Fracture Study
ConclusionThe incidence of hip fractures in Niigata Prefecture has gradually increased over the past 35  years, with an increasing change observed in the very elderly recently in 2020. Although the treatment of osteoporotic hip fractures in Niigata Prefecture is adequate, improvements may include increasing the rate of adoption of osteoporosis treatment further and decreasing the number of days of pr eoperative waiting. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 22, 2023 Category: Orthopaedics Source Type: research

Low energy availability reduces bone mass and gonadal function in male mice
ConclusionsLow energy availability puts men at risk for stress injuries as well, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 13, 2023 Category: Orthopaedics Source Type: research

Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis
AbstractOsteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically acts as one of the anti-inflammatory, immune-modulating, and therapeutic drugs, whereas the long-term use of GC may cause rapid bone resorption, followed by prolonged and profound suppression of bone formation, resulting in the GC-induced OP (GIOP). GIOP ranks the first among secondary OP and is a pivotal risk for fracture, as well as high disability rate and mortality, at both societal and personal levels, vital costs. Gut microbiota ...
Source: Journal of Bone and Mineral Metabolism - March 13, 2023 Category: Orthopaedics Source Type: research