Risk factors of mortality and second fracture after elderly hip fracture surgery in Shanghai, China
ConclusionsThe 2-year mortality rate and second fracture rate after hip fracture in elderly remained high, which was related to old age and complications exists. Postoperative rehabilitation and improving ADL were very important to reduce mortality and second fracture. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 8, 2022 Category: Orthopaedics Source Type: research

Irisin improves delayed bone repair in diabetic female mice
ConclusionsWe first showed that local irisin administration with gelatin hydrogel sheets improves the delayed bone repair induced by diabetic state partially by enhancing osteoblastic differentiation. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 4, 2022 Category: Orthopaedics Source Type: research

Movement control during one-leg standing is important for the bone mineral density maintenance or improvement
ConclusionThis study suggested that adequate movement control during one-leg standing is important to maintain or improve neck BMD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 28, 2022 Category: Orthopaedics Source Type: research

Transcriptional regulation of FRZB in chondrocytes by Osterix and Msx2
ConclusionThese results suggest that BMP2 regulatesFRZB expression through Osterix and Msx2. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 28, 2022 Category: Orthopaedics Source Type: research

Positive association of fasting plasma glucose with bone mineral density in non-diabetic elderly females
ConclusionFPG was positively associated with BMD in non-diabetic elderly females. Low FPG may increase the risk of osteoporosis in the non-diabetic elderly females in China. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 28, 2022 Category: Orthopaedics Source Type: research

Real-world persistence of twice-weekly teriparatide and factors associated with the discontinuation in patients with osteoporosis
ConclusionOne year continuation rate of 2/W-TPD was higher than the previously reported value of the once-weekly formulation in real-world setting, probably due to the lower incidence of side effects. Introducing injection of 2/W-TPD may further improve the persistence of TPD therapy for osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 27, 2022 Category: Orthopaedics Source Type: research

Impact of adherence to CKD-MBD guidelines on mortality among Japanese dialysis patients: an ecological study
ConclusionA higher prefecture-level achievement rate of the target phosphate range recommended by the Japanese CKD-MBD guidelines was associated with a lower prefecture-specific SMR in the Japanese dialysis population. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 27, 2022 Category: Orthopaedics Source Type: research

Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review
ConclusionThis meta-analysis and systematic review seemed to support the hypothesis that vitamin K2 plays an important role in the maintenance and improvement of BMD, and it decreases uc-OC and increases OC significantly at a long-term follow-up. Vitamin K2 supplementation is beneficial and safe in the treatment of osteoporosis for postmenopausal women. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 16, 2022 Category: Orthopaedics Source Type: research

Correction to: Epidemiology of locomotive syndrome using updated clinical decision limits: 6-year follow-ups of the ROAD study
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 14, 2022 Category: Orthopaedics Source Type: research

Association of pentosidine and homocysteine levels with number of teeth present in Japanese postmenopausal women
ConclusionPostmenopausal women with higher homocysteine levels had fewer teeth at baseline. A higher pentosidine concentration increased the risk of subsequent tooth loss. High pentosidine or homocysteine concentrations may be associated with tooth loss in postmenopausal women. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 13, 2022 Category: Orthopaedics Source Type: research

Relationships between QUS and HR-pQCT, DXA, and bone turnover markers
ConclusionsModerate correlations were seen between QUS and Tb.vBMD and microarchitecture in the radius and tibia and aBMD of the proximal femur. On the other hand, practically no correlations were seen with Ct.vBMD or Ct.Po and the bone-related biochemical markers. Only in middle age, moderate correlations were seen with Ct.Th in the tibia and with aBMD of the lumbar spine. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 13, 2022 Category: Orthopaedics Source Type: research

Fractures within 2  years of an obstetric hospitalization: analysis of nationwide administrative data in Japan
ConclusionWe investigated fracture cases occurring within 2  years of an obstetrics hospitalization. This finding may be useful in selecting preventative measures for patients at risk of fractures within 2 years after obstetric hospitalization, including PLO. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 12, 2022 Category: Orthopaedics Source Type: research

Discussion of bonding strength of chitosan –tannic acid coating and its anti-osteoclast and anti-microbial mechanism
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 12, 2022 Category: Orthopaedics Source Type: research

CircPVT1 promotes the tumorigenesis and metastasis of osteosarcoma via mediation of miR-26b-5p/CCNB1 axis
ConclusionSilencing of circPVT1 notably suppressed the tumorigenesis and metastasis of OS via miR-26b-5p/CCNB1 axis. Therefore, circPVT1 might be used as a target for OS treatment. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 1, 2022 Category: Orthopaedics Source Type: research

Correlation between vitamin D metabolites and rheumatoid arthritis with osteoporosis by ultra-high-performance liquid chromatography –tandem mass spectrometry (UPLC–MS/MS)
ConclusionsVD deficiency and insufficient are common in RA patients. RA patients can be appropriately supplemented with VD. VD3 may be a better choice. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 1, 2022 Category: Orthopaedics Source Type: research