Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures

ConclusionMice with limb mesenchyme-specificTfam deletions exhibited spontaneous limb bone fractures, resulting in severe limb deformities. Bone fragility was caused by poor apatite orientation owing to impaired osteoblast differentiation and maturation.
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research