Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage

ConclusionOur results suggested that low expression of HDAC2 under SeD condition increased ROS content by decreasing FOXO3A in chondrocytes, which led to the activation of NF- κB pathway and ECM homeostasis imbalance.

Source: Journal of Bone and Mineral Metabolism - September 26, 2022 Category: Orthopaedics Source Type: research