Kidney Injury: Focus on Molecular Signaling Pathways
Curr Med Chem. 2024 Jan 17. doi: 10.2174/0109298673271547231108060805. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a syndrome in which kidney function reduces suddenly. This syndrome which includes both structural changes and loss of function may lead to chronic kidney disease (CKD). Kidney regeneration capacity depends on the cell type and severity of the injury. However, novel studies indicated that regeneration mostly relies on endogenous tubular cells that survive after AKI. Regenerative pharmacology requires a great knowledge of fundamental processes involved in the development and endogenous regenerati...
Source: Current Medicinal Chemistry - February 5, 2024 Category: Chemistry Authors: Wei Liu MengDi Hu Le Wang Hamed Mirzaei Source Type: research
Pan-cancer Multi-omics Analysis Reveals HMGN1 as a Potential Prognostic and Immune Infiltration-associated Biomarker
CONCLUSION: This study highlighted the potential of HMGN1 as a biomarker for pan- - cancer analysis.PMID:38310387 | DOI:10.2174/0109298673268718231122103638 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Yangyang Guo Rongrong Zhang Hongjie Xu Kai Hong Kenan Cen Yifeng Mai Zhixuan Wu Source Type: research
A Five-gene Signature Based on MicroRNA for Predicting Prognosis and Immunotherapy in Stomach Adenocarcinoma
CONCLUSION: This study promotes the underlying mechanisms of miRNA-based genes in STAD and offers directions for classification. A five-gene signature accurately predicts the prognosis and helps therapeutic options.PMID:38310388 | DOI:10.2174/0109298673281631231127051017 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Tianwei Wang Piji Chen Tingting Li Jianong Li Dong Zhao Fanfei Meng Yujie Zhao Zhendong Zheng Xuefei Liu Source Type: research
Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications
This article provides a comprehensive analysis of this hydroxamate siderophore, rhodotorulic acid, its synthesis, physicochemical properties, and biological significance. It also explores its applications in antifungal and plant protection strategies. Insights into RA derivatives reveal distinct biological effects and applications with potential in various fields, from antioxidants to antifungals. Rhodotorulic acid and its derivatives show promise for novel therapies, plant protection strategies, and iron supplementation in agriculture. Understanding their properties could advance science and medicine with sustainable prac...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Joanna Stefaniak Micha ł G Nowak Andrzej S Skwarecki Source Type: research
SLC4A4 moulds the inflammatory tumor microenvironment and predicts therapeutic expectations in colorectal cancer
CONCLUSION: Overall, upregulation of SLC4A4 expression promoted an inflammatory tumor microenvironment in CRC, and RiskScore predicted therapeutic expectancy. SLC4A4 could be a potentially clinically valuable target for CRC therapy.PMID:38310390 | DOI:10.2174/0109298673277357231218070812 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Dan Xiang Huiyu Li Jun Pan Yitian Chen Source Type: research
Role of Ferroptosis in the Progression of COVID-19 and the Development of Long COVID
CONCLUSION: Ferroptosis is activated during the progression of COVID-19, and a low baseline level of a ferroptosis marker (SLC7A11) may indicate an increased risk for long COVID-19. Ferroptosis has potential as a clinical indicator of long COVID and as a therapeutic target.PMID:38310391 | DOI:10.2174/0109298673281662231208102354 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Wen Zhao Siyuan Wang Yuxin Han Hongkun Zhang Jiacen Cao Shasha Dong Dongdong Li Miao Lei Chuanmiao Liu Yu Gao Source Type: research
Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors
Curr Med Chem. 2024 Jan 2. doi: 10.2174/0109298673289984231127062528. Online ahead of print.ABSTRACTInflammasomes are multimeric protein complexes that can detect various phys-iological stimuli and danger signals. As a result, they perform a crucial function in the in-nate immune response. The NLRP3 inflammasome, as a vital constituent of the inflam-masome family, is significant in defending against pathogen invasion and preserving cell-homeostasis. NLRP3 inflammasome dysregulation is connected to various pathological conditions, including inflammatory diseases, cancer, and cardiovascular and neurodegen-erative diseases. T...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Shengying Lou Miaolian Wu Sunliang Cui Source Type: research
Treatment of MRSA Infection: Where are We?
Curr Med Chem. 2024 Jan 19. doi: 10.2174/0109298673249381231130111352. Online ahead of print.ABSTRACTStaphylococcus aureus is a leading cause of septicemia, endocarditis, pneumonia, skin and soft tissue infections, bone and joint infections, and hospital-acquired infections. In particular, methicillin-resistant Staphylococcus aureus (MRSA) is associated with high morbidity and mortality, and continues to be a major public health problem. The emergence of multidrug-resistant MRSA strains along with the wide consumption of antibiotics has made anti-MRSA treatment a huge challenge. Novel treatment strategies (e.g., novel anti...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Adila Nazli Wenlan Tao Hengyao You Xiaoli He Yun He Source Type: research
Human Umbilical Cord Mesenchymal Stem Cell Exosome-derived miR-335-5p Alleviated Lipopolysaccharide-induced Acute Lung Injury by Regulating the m6A Level of ITG β4 Gene
CONCLUSION: This study reveals the mechanism by which miR-335-5p derived from HucMSC-Exo could alleviate LPS-induced ALI by regulating the m6A modification of ITGβ4, providing a new direction for the treatment of ALI.PMID:38310394 | DOI:10.2174/0109298673273833231220062213 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Linrui Li Xi Zhang Yanping Chen Source Type: research
Increased ACSL6 Expression Predicts a Favorable Prognosis in Triple-negative Breast Cancer
CONCLUSION: Altogether, the current findings highlight the potential value of ACSL6 as a diagnostic and prognostic marker in the treatment of TNBC.PMID:38310395 | DOI:10.2174/0109298673278846231222103420 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Hui Hua Shuaikang Pan Haizhou Diao Yueyue Cao Xiaojun Qian Jinguo Zhang Source Type: research
N, N'-disubstituted Ureas as Novel Antiplatelet Agents: Synthesis, Pharmacological Evaluation and In Silico Studies
CONCLUSION: Therefore, these results demonstrated that N,N'-disubstituted ureas are promising candidates for the development of novel antiplatelet agents.PMID:38310396 | DOI:10.2174/0109298673262854231215065541 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Priscila de Souza Furtado Gil Mendes Viana Alana Agnes Silva Camargo de Oliveira Vitor Won-Held Rabelo Ingryd Wenderroschy Cerqueira Caroline Reis Santiago Paschoal Thiago da Silva Hon ório Alice Simon Carlos Rangel Rodrigues Paula Alvarez Abreu Lucio Me Source Type: research
Pharmacokinetics of Anti-Rheumatic drugs Methotrexate and Tofacitinib with its metabolite M9 in Rats by UPLC-MS/MS
CONCLUSION: The currently established analytical method exhibited great potential for the evaluation of plasma concentrations of methotrexate, tofacitinib and M9 simultaneously, greatly reducing the detection time, which would serve as a supplementary role in formulating dose decisions to achieve personalized treatment, identify drugs that cause adverse reactions and finally, to assess drug-drug interactions on clinical studies.PMID:38310397 | DOI:10.2174/0109298673256258231219060950 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Er-Min Gu Lingjie Xue Chenjian Zhou Yang Xia Ge-Xin Dai Source Type: research
MNK: A Novel Promising Target for Cancer Immunotherapy
Curr Med Chem. 2024 Jan 16. doi: 10.2174/0109298673260837231120101508. Online ahead of print.ABSTRACTCancer immunotherapy has demonstrated remarkable success in the treatment of multiple advanced malignancies, especially approaches to target the immune checkpoint. Nonetheless, the limited response rate remains a barrier to broader application. Identifying other ways to extend the beneficiaries to a large extent is needed. Emerging evidence has shown that mitogen-activated protein kinase-interacting kinases (MNKs) could be regarded as a novel, attractive target for cancer immunotherapy that is closely correlated with cancer...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Pei Shu Yanna Lei Ge Gao Xiaoyu Li Diyuan Qin Benxia Zhang Yue Chen Qizhi Ma Yongsheng Wang Source Type: research
Nepetin Attenuates Atopic Dermatitis in HaCaT Cells and BALB/c Mice Through MyD88-MKK3/6-Akt Signaling
Curr Med Chem. 2024 Jan 9. doi: 10.2174/0109298673244967231101114033. Online ahead of print.ABSTRACTNepetin is a type of O-methylated flavone (6-hydroxy luteolin) and has been found in many herbal medicines that exhibit various pharmacological properties, including anti-inflammatory responses. Here, we aimed to investigate the efficacy of nepetin in attenuating inflammatory responses in cultured keratinocytes and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in BALB/c mice. Various assay methods including cell viability, flow cytometry, fluorometry, confocal microscopy, western blot, ELISA techniques, stai...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Guowei Gong Kumar Ganesan Yuzhong Zheng Jian Xiao Tina Dong Karl Tsim Source Type: research
Multifaceted Nature of HuR in Atherosclerosis Development
Curr Med Chem. 2024 Jan 15. doi: 10.2174/0109298673279032231214110313. Online ahead of print.ABSTRACTHuR (Human antigen R) is an RNA binding protein (RBP) that specifically binds to certain RNA sequences, influencing post-transcriptional regulation. HuR is primarily involved in tumor regulation, as well as cell growth, proliferation, inflammation, and angiogenesis. HuR is implicated in endothelial activation, smooth muscle proliferation, inflammatory response, macrophage apoptosis, lipid regulation, and autophagy, playing a crucial regulatory role in atherosclerosis. Accumulating evidence suggests that HuR has dual roles i...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Yan-Xia Wang Hong-Yu Zheng Kun Zhou Hai-Lin Xie Zhong Ren Hui-Ting Liu Huan Liu Zhi-Xiang Zhou Zhi-Sheng Jiang Source Type: research
