Human Umbilical Cord Mesenchymal Stem Cell Exosome-derived miR-335-5p Alleviated Lipopolysaccharide-induced Acute Lung Injury by Regulating the m6A Level of ITG β4 Gene
CONCLUSION: This study reveals the mechanism by which miR-335-5p derived from HucMSC-Exo could alleviate LPS-induced ALI by regulating the m6A modification of ITGβ4, providing a new direction for the treatment of ALI.PMID:38310394 | DOI:10.2174/0109298673273833231220062213 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Linrui Li Xi Zhang Yanping Chen Source Type: research

Increased ACSL6 Expression Predicts a Favorable Prognosis in Triple-negative Breast Cancer
CONCLUSION: Altogether, the current findings highlight the potential value of ACSL6 as a diagnostic and prognostic marker in the treatment of TNBC.PMID:38310395 | DOI:10.2174/0109298673278846231222103420 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Hui Hua Shuaikang Pan Haizhou Diao Yueyue Cao Xiaojun Qian Jinguo Zhang Source Type: research

N, N'-disubstituted Ureas as Novel Antiplatelet Agents: Synthesis, Pharmacological Evaluation and In Silico Studies
CONCLUSION: Therefore, these results demonstrated that N,N'-disubstituted ureas are promising candidates for the development of novel antiplatelet agents.PMID:38310396 | DOI:10.2174/0109298673262854231215065541 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Priscila de Souza Furtado Gil Mendes Viana Alana Agnes Silva Camargo de Oliveira Vitor Won-Held Rabelo Ingryd Wenderroschy Cerqueira Caroline Reis Santiago Paschoal Thiago da Silva Hon ório Alice Simon Carlos Rangel Rodrigues Paula Alvarez Abreu Lucio Me Source Type: research

Pharmacokinetics of Anti-Rheumatic drugs Methotrexate and Tofacitinib with its metabolite M9 in Rats by UPLC-MS/MS
CONCLUSION: The currently established analytical method exhibited great potential for the evaluation of plasma concentrations of methotrexate, tofacitinib and M9 simultaneously, greatly reducing the detection time, which would serve as a supplementary role in formulating dose decisions to achieve personalized treatment, identify drugs that cause adverse reactions and finally, to assess drug-drug interactions on clinical studies.PMID:38310397 | DOI:10.2174/0109298673256258231219060950 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Er-Min Gu Lingjie Xue Chenjian Zhou Yang Xia Ge-Xin Dai Source Type: research

MNK: A Novel Promising Target for Cancer Immunotherapy
Curr Med Chem. 2024 Jan 16. doi: 10.2174/0109298673260837231120101508. Online ahead of print.ABSTRACTCancer immunotherapy has demonstrated remarkable success in the treatment of multiple advanced malignancies, especially approaches to target the immune checkpoint. Nonetheless, the limited response rate remains a barrier to broader application. Identifying other ways to extend the beneficiaries to a large extent is needed. Emerging evidence has shown that mitogen-activated protein kinase-interacting kinases (MNKs) could be regarded as a novel, attractive target for cancer immunotherapy that is closely correlated with cancer...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Pei Shu Yanna Lei Ge Gao Xiaoyu Li Diyuan Qin Benxia Zhang Yue Chen Qizhi Ma Yongsheng Wang Source Type: research

Nepetin Attenuates Atopic Dermatitis in HaCaT Cells and BALB/c Mice Through MyD88-MKK3/6-Akt Signaling
Curr Med Chem. 2024 Jan 9. doi: 10.2174/0109298673244967231101114033. Online ahead of print.ABSTRACTNepetin is a type of O-methylated flavone (6-hydroxy luteolin) and has been found in many herbal medicines that exhibit various pharmacological properties, including anti-inflammatory responses. Here, we aimed to investigate the efficacy of nepetin in attenuating inflammatory responses in cultured keratinocytes and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in BALB/c mice. Various assay methods including cell viability, flow cytometry, fluorometry, confocal microscopy, western blot, ELISA techniques, stai...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Guowei Gong Kumar Ganesan Yuzhong Zheng Jian Xiao Tina Dong Karl Tsim Source Type: research

Multifaceted Nature of HuR in Atherosclerosis Development
Curr Med Chem. 2024 Jan 15. doi: 10.2174/0109298673279032231214110313. Online ahead of print.ABSTRACTHuR (Human antigen R) is an RNA binding protein (RBP) that specifically binds to certain RNA sequences, influencing post-transcriptional regulation. HuR is primarily involved in tumor regulation, as well as cell growth, proliferation, inflammation, and angiogenesis. HuR is implicated in endothelial activation, smooth muscle proliferation, inflammatory response, macrophage apoptosis, lipid regulation, and autophagy, playing a crucial regulatory role in atherosclerosis. Accumulating evidence suggests that HuR has dual roles i...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Yan-Xia Wang Hong-Yu Zheng Kun Zhou Hai-Lin Xie Zhong Ren Hui-Ting Liu Huan Liu Zhi-Xiang Zhou Zhi-Sheng Jiang Source Type: research

Therapeutic Effect of Resveratrol and its Novel Formulations on Lung Cancer: Focus on Biological Aspects and Underlying Pathways
Curr Med Chem. 2024 Jan 31. doi: 10.2174/0109298673266259231229050937. Online ahead of print.ABSTRACTLung cancer is a leading cause of mortality and morbidity worldwide. Due to significant advances in therapeutic strategies, patients' survival and life quality have been improved, however there is still an urgent requirement for developing more effective therapeutic methods. Resveratrol, a natural polyphenol with numerous biological potentials, has been widely studied. It has shown therapeutic potetial in various diseases including neurodegenerative diseases, cardiovascular disorders, and cancers through the regulation of k...
Source: Current Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Hamidreza Poortalebi Mahta ZareDini Sima Foroughi-Nematollahi Tahereh Farkhondeh Saeed Samarghandian Mohammad Hossein Pourhanifeh Source Type: research

Cancer Pathways Targeted by Berberine: Role of microRNAs
Curr Med Chem. 2024 Jan 31. doi: 10.2174/0109298673275121231228124031. Online ahead of print.ABSTRACTCancer is a complex and heterogeneous malignant disease. Due to its multifactorial nature, including progressive changes in genetic, epigenetic, transcript, and protein levels, conventional therapeutics fail to save cancer patients. Evidence indicates that dysregulation of microRNA (miRNA) expression plays a crucial role in tumorigenesis, metastasis, cell proliferation, differentiation, metabolism, and signaling pathways. Moreover, miRNAs can be used as diagnostic and prognostic markers and therapeutic targets in cancer. Be...
Source: Current Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Mansoor Ali Deepali Mishra Rana P Singh Source Type: research

Therapeutical Approach to Arterial Hypertension - Current State of the Art
Curr Med Chem. 2024 Jan 31. doi: 10.2174/0109298673274823231220063652. Online ahead of print.ABSTRACTArterial hypertension (AH) is recognized as the most common illness within the group of cardiovascular diseases and the most massive chronic non-infectious disease in the world. The number of hypertensive patients worldwide has reached 1.28 billion, contributing to an increase in cardiovascular diseases and premature death globally. The high prevalence of hypertension emphasizes the importance of effectively treating this condition. Elevated blood pressure often leads to lethal complications (heart failure, stroke, renal di...
Source: Current Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Milica Radosavljevic Danijela Vu čević Janko Samard žić Miroslav Radenkovic Tatjana Radosavljevi ć Source Type: research

Effects of Herpud1 in Methamphetamine-Induced Neuronal Apoptosis
CONCLUSIONS: These results suggest that Herpud1 plays an essential role in METH-induced neuronal ERS and apoptosis and may represent a potential therapeutic gene target in METH-induced neurotoxicity.PMID:38299291 | DOI:10.2174/0109298673277857231221110453 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Shuang Lu Yan Li Lewen Wang Kun Xiong Jie Yan Zhihao Zhai Weitao Yan Source Type: research

Application Research Progress of Nanomaterial Graphene and its Derivative Complexes in Tumor Diagnosis and Therapy
Conclusion, graphene and its derivatives play an important role in tumor diagnosis and treatment.PMID:38299292 | DOI:10.2174/0109298673251648231106112354 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Li Wen Cui Lu Yao Fan Zhi Yong Shen Source Type: research

Liver-derived Exosomal miRNA in NAFLD: Mechanisms of Action, Biomarkers, and Therapeutic Applications
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673276581231210170332. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is of global concern due to its high prevalence worldwide. NAFLD, as one of the most common causes of liver function abnormalities, is associated with obesity, insulin resistance, and type 2 diabetes mellitus, and there are no medications available to treat NAFLD. Extracellular vesicles (EVs) are nanosized, membrane-bound vesicles that deliver biomolecules between cells. Exosomes are a subtype of EVs that mediate intercellular communication by delivering proteins and RNAs. MicroRNAs ...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Jun Yang Xiaolei Tang Liang Chen Junjie Hu Shan Li Ming Yuan Xianxiang Tian Zhenpeng Qiu Source Type: research

Advance of Metformin in Liver Disease
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673274268231215110330. Online ahead of print.ABSTRACTMetformin is a first-line drug for the treatment of type 2 diabetes with a good safety profile and relatively low cost. In recent years, many other effects of metformin have been discovered. In this review, we provide the research advances in metformin in liver disease. High-dose metformin can activate AMPK by inhibiting mitochondrial complex 1. In addition, low-dose metformin could activate lysosomal AMPK through PEN2. Activated AMPK can reduce fatty acid synthesis, inhibit tumor proliferation and metastasis, and reshape t...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Jiaqi Bao Yudi Zhao Xiao Xu Sunbin Ling Source Type: research

Association of MiRNA and Bone Tumors: Future Therapeutic Inroads
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673284932231226110754. Online ahead of print.ABSTRACTSmall endogenous non-coding RNA molecules known as micro-ribonucleic acids (miRNAs) control post-transcriptional gene regulation. A change in miRNA expression is related to various diseases, including bone tumors. Benign bone tumors are categorized based on matrix production and predominant cell type. Osteochondromas and giant cell tumors are among the most common bone tumors. Interestingly, miRNAs can function as either tumor suppressor genes or oncogenes, thereby determining the fate of a tumor. In the present review, we ...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Rashid Al-Shibli Mohammed AlSuleimani Ibrahim Ahmed Abdullah Al Lawati Srijit Das Source Type: research