Multifaceted Nature of HuR in Atherosclerosis Development
Curr Med Chem. 2024 Jan 15. doi: 10.2174/0109298673279032231214110313. Online ahead of print.ABSTRACTHuR (Human antigen R) is an RNA binding protein (RBP) that specifically binds to certain RNA sequences, influencing post-transcriptional regulation. HuR is primarily involved in tumor regulation, as well as cell growth, proliferation, inflammation, and angiogenesis. HuR is implicated in endothelial activation, smooth muscle proliferation, inflammatory response, macrophage apoptosis, lipid regulation, and autophagy, playing a crucial regulatory role in atherosclerosis. Accumulating evidence suggests that HuR has dual roles i...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Yan-Xia Wang Hong-Yu Zheng Kun Zhou Hai-Lin Xie Zhong Ren Hui-Ting Liu Huan Liu Zhi-Xiang Zhou Zhi-Sheng Jiang Source Type: research

Therapeutic Effect of Resveratrol and its Novel Formulations on Lung Cancer: Focus on Biological Aspects and Underlying Pathways
Curr Med Chem. 2024 Jan 31. doi: 10.2174/0109298673266259231229050937. Online ahead of print.ABSTRACTLung cancer is a leading cause of mortality and morbidity worldwide. Due to significant advances in therapeutic strategies, patients' survival and life quality have been improved, however there is still an urgent requirement for developing more effective therapeutic methods. Resveratrol, a natural polyphenol with numerous biological potentials, has been widely studied. It has shown therapeutic potetial in various diseases including neurodegenerative diseases, cardiovascular disorders, and cancers through the regulation of k...
Source: Current Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Hamidreza Poortalebi Mahta ZareDini Sima Foroughi-Nematollahi Tahereh Farkhondeh Saeed Samarghandian Mohammad Hossein Pourhanifeh Source Type: research

Cancer Pathways Targeted by Berberine: Role of microRNAs
Curr Med Chem. 2024 Jan 31. doi: 10.2174/0109298673275121231228124031. Online ahead of print.ABSTRACTCancer is a complex and heterogeneous malignant disease. Due to its multifactorial nature, including progressive changes in genetic, epigenetic, transcript, and protein levels, conventional therapeutics fail to save cancer patients. Evidence indicates that dysregulation of microRNA (miRNA) expression plays a crucial role in tumorigenesis, metastasis, cell proliferation, differentiation, metabolism, and signaling pathways. Moreover, miRNAs can be used as diagnostic and prognostic markers and therapeutic targets in cancer. Be...
Source: Current Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Mansoor Ali Deepali Mishra Rana P Singh Source Type: research

Therapeutical Approach to Arterial Hypertension - Current State of the Art
Curr Med Chem. 2024 Jan 31. doi: 10.2174/0109298673274823231220063652. Online ahead of print.ABSTRACTArterial hypertension (AH) is recognized as the most common illness within the group of cardiovascular diseases and the most massive chronic non-infectious disease in the world. The number of hypertensive patients worldwide has reached 1.28 billion, contributing to an increase in cardiovascular diseases and premature death globally. The high prevalence of hypertension emphasizes the importance of effectively treating this condition. Elevated blood pressure often leads to lethal complications (heart failure, stroke, renal di...
Source: Current Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Milica Radosavljevic Danijela Vu čević Janko Samard žić Miroslav Radenkovic Tatjana Radosavljevi ć Source Type: research

Effects of Herpud1 in Methamphetamine-Induced Neuronal Apoptosis
CONCLUSIONS: These results suggest that Herpud1 plays an essential role in METH-induced neuronal ERS and apoptosis and may represent a potential therapeutic gene target in METH-induced neurotoxicity.PMID:38299291 | DOI:10.2174/0109298673277857231221110453 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Shuang Lu Yan Li Lewen Wang Kun Xiong Jie Yan Zhihao Zhai Weitao Yan Source Type: research

Application Research Progress of Nanomaterial Graphene and its Derivative Complexes in Tumor Diagnosis and Therapy
Conclusion, graphene and its derivatives play an important role in tumor diagnosis and treatment.PMID:38299292 | DOI:10.2174/0109298673251648231106112354 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Li Wen Cui Lu Yao Fan Zhi Yong Shen Source Type: research

Liver-derived Exosomal miRNA in NAFLD: Mechanisms of Action, Biomarkers, and Therapeutic Applications
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673276581231210170332. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is of global concern due to its high prevalence worldwide. NAFLD, as one of the most common causes of liver function abnormalities, is associated with obesity, insulin resistance, and type 2 diabetes mellitus, and there are no medications available to treat NAFLD. Extracellular vesicles (EVs) are nanosized, membrane-bound vesicles that deliver biomolecules between cells. Exosomes are a subtype of EVs that mediate intercellular communication by delivering proteins and RNAs. MicroRNAs ...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Jun Yang Xiaolei Tang Liang Chen Junjie Hu Shan Li Ming Yuan Xianxiang Tian Zhenpeng Qiu Source Type: research

Advance of Metformin in Liver Disease
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673274268231215110330. Online ahead of print.ABSTRACTMetformin is a first-line drug for the treatment of type 2 diabetes with a good safety profile and relatively low cost. In recent years, many other effects of metformin have been discovered. In this review, we provide the research advances in metformin in liver disease. High-dose metformin can activate AMPK by inhibiting mitochondrial complex 1. In addition, low-dose metformin could activate lysosomal AMPK through PEN2. Activated AMPK can reduce fatty acid synthesis, inhibit tumor proliferation and metastasis, and reshape t...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Jiaqi Bao Yudi Zhao Xiao Xu Sunbin Ling Source Type: research

Association of MiRNA and Bone Tumors: Future Therapeutic Inroads
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673284932231226110754. Online ahead of print.ABSTRACTSmall endogenous non-coding RNA molecules known as micro-ribonucleic acids (miRNAs) control post-transcriptional gene regulation. A change in miRNA expression is related to various diseases, including bone tumors. Benign bone tumors are categorized based on matrix production and predominant cell type. Osteochondromas and giant cell tumors are among the most common bone tumors. Interestingly, miRNAs can function as either tumor suppressor genes or oncogenes, thereby determining the fate of a tumor. In the present review, we ...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Rashid Al-Shibli Mohammed AlSuleimani Ibrahim Ahmed Abdullah Al Lawati Srijit Das Source Type: research

3D Printing of Microfluidic-assisted Liposomes Production for Drug Delivery and Nanobiomedicine: A Review
Curr Med Chem. 2024 Jan 29. doi: 10.2174/0109298673285199231210170549. Online ahead of print.ABSTRACTNumerous techniques exist for the production of liposomes; however, these methods need to be revised due to their incapacity to achieve precise management of the dimensions and uniformity of liposomes and their inefficient utilization of reagents and resources. One particular challenge lies in replicating accurate form and size control seen in biological cells, as accomplishing this level of precision through macroscale approaches proves exceptionally arduous. The advent of microfluidic technology tackles this problem by lo...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Kave Mohammad-Jafari Seyed Morteza Naghib Source Type: research

Expression of Circulating miR-21 and -29 and their Association with Myocardial Fibrosis in Hypertrophic Cardiomyopathy
CONCLUSION: MiR-21 was overexpressed in patients with HCM and hypertensive cardiomyopathy. Importantly, in patients with HCM, more extensive myocardial fibrosis was associated with higher levels of miR-21.PMID:38299392 | DOI:10.2174/0109298673286017240103073130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Andreas Angelopoulos Evangelos Oikonomou Alexios Antonopoulos Panagiotis Theofilis Konstantinos Zisimos Ourania Katsarou Maria Gazouli George Lazaros Paraskevi Papanikolaou Gerasimos Siasos Dimitrios Tousoulis Konstantinos Tsioufis Charalambos Vlachopoulo Source Type: research

Analysis of Clinical Success and Molecular Mechanisms of Action of Novel Anti-glioblastoma Drugs: A Review
CONCLUSION: Combining anti-GBM drugs appears to be a key direction for increasing treatment effectiveness and overall survival. Radiotherapy of GBM can increase the effect of combination drug therapy.PMID:38299393 | DOI:10.2174/0109298673281283240101053940 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Sabina Abdullaeva Vladimir Chubarev Anna Valeeva Nina Preferanskaya Margarita Neganova Elena Smolyarchuk Junqi Liu Olga Sukocheva Mikhail Samsonov Renad Alyautdin Source Type: research

Current Trends in the Biomarker'sDiscovery for the Treatment and Management of Colorectal Cancer: A ComprehensiveReview
Curr Med Chem. 2024 Jan 31. doi: 10.2174/0109298673274455231219044728. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a significant health issue, with countless individuals suffering. With its bleak outlook, the number of deaths caused by CRC can only be reduced if new diagnostic and prognostic biomarkers are identified and developed quickly. Recent developments in screening programme development and patient management have been encouraging, but many unanswered questions still need to be addressed before a customized colorectal cancer approach can be implemented. Prevention of diseases, the detection of them in t...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Popat Mohite Abhijeet Puri Ramdas Pandhare Sudarshan Singh Bhupendra Prajapati Source Type: research

High-expression of FABP4 in Tubules is a Risk Factor for Poor Prognosis in DKD Patients
CONCLUSION: High-expression of FABP4 is involved in the pathogenesis of renal tubular lipid injury and is a risk factor for poor prognosis in DKD patients.PMID:38299395 | DOI:10.2174/0109298673268265231228125431 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Yao Huang Xinyuan Cui Zheng Li Shuguang Yuan Yachun Han Xiangqing Xu Xiao Fu Kewen Shi Zurong Zhang Jinying Wei Shiyu Xia Yang Xiao Song Xue Lin Sun Hong Liu Xuejing Zhu Source Type: research

lncRNA-056298 Regulates GAP43 and Promotes Cardiac Intrinsic Autonomic Nerve Remodelling in a Canine Model of Atrial Fibrillation Induction after Ganglionated Plexus Ablation
CONCLUSIONS: lncRNA-056298 regulates GAP43 by sponging miR-185, which affects cardiac intrinsic autonomic nerve remodelling and mediates atrial fibrillation induction after ganglionated plexus ablation.PMID:38299396 | DOI:10.2174/0109298673289298240129103537 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Shuting Bai Ximin Wang Yinglong Hou Yansong Cui Qiyuan Song Juanjuan Du Yujiao Zhang Jingwen Xu Source Type: research