SGPocket: A New Graph Convolutional Neural Network for Ligand-protein Binding Site Prediction
CONCLUSION: Thus, SGPocket allows the reduction of the exploration surface in the molecular docking process by restricting the simulation only to the site(s) predicted to be interesting.PMID:38468517 | DOI:10.2174/0109298673289137240304165758 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Kevin Crampon Cedric Bourrasset Stephanie Baud Luiz Angelo Steffenel Source Type: research
3D Bioprinting and Microfluidic-Based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer
Curr Med Chem. 2024 Mar 8. doi: 10.2174/0109298673298382240307040239. Online ahead of print.ABSTRACTThe burden of increasing cancer incidence among the population, and, in particular, of prostate cancer in men living in highly developed countries, brings with it, on one hand, the need for new devices that allow a faster and earlier diagnosis, ideally in a non-invasive way and with low consumption of expensive reagents, and on the other the need for the assessment of new in vitro models that allow a more reliable assessment of cancer features, including its microenvironment and sensibility to different drugs. At the crossro...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Jay Sibbits Lucia Di Pietro Anna Privitera Vincenzo Cardaci Salvatore Maugeri Massimo Camarda Giuseppe Caruso Source Type: research
Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging
Curr Med Chem. 2024 Mar 11. doi: 10.2174/0109298673301552240305064259. Online ahead of print.ABSTRACTAfterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-- to-background ratio imaging. Despite the continued emergence of individual reports on RTP or TADF in recent years, comprehensive reviews addressing these two materials are rare. Therefore, this rev...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Zhipeng Zhao Rui Du Xiaodi Feng Zhengshuo Wang Tianjie Wang Zongzhao Xie Hua Yuan Yeqiang Tan Hanlin Ou Source Type: research
SGPocket: A New Graph Convolutional Neural Network for Ligand-protein Binding Site Prediction
CONCLUSION: Thus, SGPocket allows the reduction of the exploration surface in the molecular docking process by restricting the simulation only to the site(s) predicted to be interesting.PMID:38468517 | DOI:10.2174/0109298673289137240304165758 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Kevin Crampon Cedric Bourrasset Stephanie Baud Luiz Angelo Steffenel Source Type: research
3D Bioprinting and Microfluidic-Based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer
Curr Med Chem. 2024 Mar 8. doi: 10.2174/0109298673298382240307040239. Online ahead of print.ABSTRACTThe burden of increasing cancer incidence among the population, and, in particular, of prostate cancer in men living in highly developed countries, brings with it, on one hand, the need for new devices that allow a faster and earlier diagnosis, ideally in a non-invasive way and with low consumption of expensive reagents, and on the other the need for the assessment of new in vitro models that allow a more reliable assessment of cancer features, including its microenvironment and sensibility to different drugs. At the crossro...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Jay Sibbits Lucia Di Pietro Anna Privitera Vincenzo Cardaci Salvatore Maugeri Massimo Camarda Giuseppe Caruso Source Type: research
Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging
Curr Med Chem. 2024 Mar 11. doi: 10.2174/0109298673301552240305064259. Online ahead of print.ABSTRACTAfterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-- to-background ratio imaging. Despite the continued emergence of individual reports on RTP or TADF in recent years, comprehensive reviews addressing these two materials are rare. Therefore, this rev...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Zhipeng Zhao Rui Du Xiaodi Feng Zhengshuo Wang Tianjie Wang Zongzhao Xie Hua Yuan Yeqiang Tan Hanlin Ou Source Type: research
SGPocket: A New Graph Convolutional Neural Network for Ligand-protein Binding Site Prediction
CONCLUSION: Thus, SGPocket allows the reduction of the exploration surface in the molecular docking process by restricting the simulation only to the site(s) predicted to be interesting.PMID:38468517 | DOI:10.2174/0109298673289137240304165758 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Kevin Crampon Cedric Bourrasset Stephanie Baud Luiz Angelo Steffenel Source Type: research
Immunotherapy of Human Melanoma: Past, Present, Future
Curr Med Chem. 2024 Mar 6. doi: 10.2174/0109298673283943240227104122. Online ahead of print.ABSTRACTImmunotherapy with immune checkpoint inhibitors (ICIs) is a promising therapeutic schedule in advanced solid cancers. In this review, clinical trials from highly reputable journals are interpreted for safety and efficacy evaluation of the common anti-programmed death-1 (PD-1) inhibitor nivolumab and/or the most known anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) inhibitor ipilimumab in advanced melanoma. Current progress in the field of melanoma immunotherapy is the focus of this review. Solo nivolumab and combo ...
Source: Current Medicinal Chemistry - March 8, 2024 Category: Chemistry Authors: Keywan Mortezaee Jamal Majidpoor Source Type: research
Immunotherapy of Human Melanoma: Past, Present, Future
Curr Med Chem. 2024 Mar 6. doi: 10.2174/0109298673283943240227104122. Online ahead of print.ABSTRACTImmunotherapy with immune checkpoint inhibitors (ICIs) is a promising therapeutic schedule in advanced solid cancers. In this review, clinical trials from highly reputable journals are interpreted for safety and efficacy evaluation of the common anti-programmed death-1 (PD-1) inhibitor nivolumab and/or the most known anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) inhibitor ipilimumab in advanced melanoma. Current progress in the field of melanoma immunotherapy is the focus of this review. Solo nivolumab and combo ...
Source: Current Medicinal Chemistry - March 8, 2024 Category: Chemistry Authors: Keywan Mortezaee Jamal Majidpoor Source Type: research
Immunotherapy of Human Melanoma: Past, Present, Future
Curr Med Chem. 2024 Mar 6. doi: 10.2174/0109298673283943240227104122. Online ahead of print.ABSTRACTImmunotherapy with immune checkpoint inhibitors (ICIs) is a promising therapeutic schedule in advanced solid cancers. In this review, clinical trials from highly reputable journals are interpreted for safety and efficacy evaluation of the common anti-programmed death-1 (PD-1) inhibitor nivolumab and/or the most known anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) inhibitor ipilimumab in advanced melanoma. Current progress in the field of melanoma immunotherapy is the focus of this review. Solo nivolumab and combo ...
Source: Current Medicinal Chemistry - March 8, 2024 Category: Chemistry Authors: Keywan Mortezaee Jamal Majidpoor Source Type: research
Immunotherapy of Human Melanoma: Past, Present, Future
Curr Med Chem. 2024 Mar 6. doi: 10.2174/0109298673283943240227104122. Online ahead of print.ABSTRACTImmunotherapy with immune checkpoint inhibitors (ICIs) is a promising therapeutic schedule in advanced solid cancers. In this review, clinical trials from highly reputable journals are interpreted for safety and efficacy evaluation of the common anti-programmed death-1 (PD-1) inhibitor nivolumab and/or the most known anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) inhibitor ipilimumab in advanced melanoma. Current progress in the field of melanoma immunotherapy is the focus of this review. Solo nivolumab and combo ...
Source: Current Medicinal Chemistry - March 8, 2024 Category: Chemistry Authors: Keywan Mortezaee Jamal Majidpoor Source Type: research
Unlocking the Immunomodulatory Potential of Rosmarinic Acid Isolated from Punica granatum L. Using Bioactivity-Guided Approach: In Silico, In Vitro, and In Vivo Approaches
CONCLUSION: Rosmarinic acid is a potential candidate, but extensive research needs to be done to translate this molecule from bench to bedside.PMID:38445701 | DOI:10.2174/0109298673291064240227094654 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 6, 2024 Category: Chemistry Authors: Rupesh K Gautam Shailesh Mani Tripathi Shopnil Akash Sanjay Sharma Komal Sharma Swapnil Goyal Sahar Behzad Rohit Gundamaraju Dinesh Kumar Mishra Yingbo Zhang Bairong Shen Sandeep Sundriyal Rajeev K Singla Source Type: research
Unlocking the Immunomodulatory Potential of Rosmarinic Acid Isolated from Punica granatum L. Using Bioactivity-Guided Approach: In Silico, In Vitro, and In Vivo Approaches
CONCLUSION: Rosmarinic acid is a potential candidate, but extensive research needs to be done to translate this molecule from bench to bedside.PMID:38445701 | DOI:10.2174/0109298673291064240227094654 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 6, 2024 Category: Chemistry Authors: Rupesh K Gautam Shailesh Mani Tripathi Shopnil Akash Sanjay Sharma Komal Sharma Swapnil Goyal Sahar Behzad Rohit Gundamaraju Dinesh Kumar Mishra Yingbo Zhang Bairong Shen Sandeep Sundriyal Rajeev K Singla Source Type: research
Defective Mitophagy Impairs Response to Inflammatory Activation of Macrophage-Like Cells
CONCLUSION: Data on the involvement of mitophagy, including defective mitophagy, in disturbances of the inflammatory response in sepsis, viral infections, autoimmune diseases and other pathologies have previously been reported. In this work, we studied the role of defective mitophagy in non-infectious chronic inflammatory diseases using the example of atherosclerosis. We showed a dramatic disruption of the inflammatory response associated with defective mitophagy. Compared with cybrids with normal mitophagy, in cybrids with defective mitophagy, the secretion of all studied cytokines changed significantly both quantitativel...
Source: Current Medicinal Chemistry - March 5, 2024 Category: Chemistry Authors: Alexander N Orekhov Alexander D Zhuravlev Andrey Y Vinokurov Nikita G Nikiforov Andrey V Omelchenko Vasily N Sukhorukov Vasily V Sinyov Igor A Sobenin Source Type: research
Defective Mitophagy Impairs Response to Inflammatory Activation of Macrophage-Like Cells
CONCLUSION: Data on the involvement of mitophagy, including defective mitophagy, in disturbances of the inflammatory response in sepsis, viral infections, autoimmune diseases and other pathologies have previously been reported. In this work, we studied the role of defective mitophagy in non-infectious chronic inflammatory diseases using the example of atherosclerosis. We showed a dramatic disruption of the inflammatory response associated with defective mitophagy. Compared with cybrids with normal mitophagy, in cybrids with defective mitophagy, the secretion of all studied cytokines changed significantly both quantitativel...
Source: Current Medicinal Chemistry - March 5, 2024 Category: Chemistry Authors: Alexander N Orekhov Alexander D Zhuravlev Andrey Y Vinokurov Nikita G Nikiforov Andrey V Omelchenko Vasily N Sukhorukov Vasily V Sinyov Igor A Sobenin Source Type: research
