Current Computational Methods for Protein-Peptide Complex Structure Prediction
Curr Med Chem. 2023 Oct 6. doi: 10.2174/0109298673263447230920151524. Online ahead of print.ABSTRACTPeptide-mediated protein-protein interactions (PPIs) play an important role in various biological processes. The development of peptide-based drugs to modulate PPIs has attracted increasing attention due to the advantages of high specificity and low toxicity. In the development of peptide-based drugs, one of the most important steps is to determine the interaction details between the peptide and the target protein. In addition to experimental methods, recently developed computational methods provide a cost-effective way for ...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Chao Yang Xianjin Xu Changcheng Xiang Source Type: research

A Structure-based Data Set of Protein-Peptide Affinities and its Nonredundant Benchmark: Potential Applications in Computational Peptidology
CONCLUSION: The PpI[S/A]DS set and PpI[S/A]BM benchmark can be considered a valuable data source in the computational peptidology community, aiming to relate the affinity to structure for PpIs.PMID:37881092 | DOI:10.2174/0929867331666230908102925 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 26, 2023 Category: Chemistry Authors: Shaozhou Wang Haiyang Ye Shuyong Shang Zilong Li Yue Peng Peng Zhou Source Type: research

A Structure-based Data Set of Protein-Peptide Affinities and its Nonredundant Benchmark: Potential Applications in Computational Peptidology
CONCLUSION: The PpI[S/A]DS set and PpI[S/A]BM benchmark can be considered a valuable data source in the computational peptidology community, aiming to relate the affinity to structure for PpIs.PMID:37881092 | DOI:10.2174/0929867331666230908102925 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 26, 2023 Category: Chemistry Authors: Shaozhou Wang Haiyang Ye Shuyong Shang Zilong Li Yue Peng Peng Zhou Source Type: research

Effects of Consuming Repeatedly Heated Edible Oils on Cardiovascular Diseases: A Narrative Review
Curr Med Chem. 2023 Oct 18. doi: 10.2174/0109298673250752230921090452. Online ahead of print.ABSTRACTEdible oils are inevitable requisites in the human diet as they are enriched with essential fatty acids, vitamins, carotenoids, sterols, and other antioxidants. Due to their nutritive value and commercial significance, edible oils have been used for food preparation for many centuries. The use of global consumption of edible oils has dramatically increased throughout the world in the 21st century owing to their incredible application in all kinds of food preparation. However, a variety of pollutants, such as pesticides, tox...
Source: Current Medicinal Chemistry - October 25, 2023 Category: Chemistry Authors: Prathyusha Soundararajan Srividya Parthasarathy Meenakumari Sakthivelu Kanchana Mala Karuppiah Palaniyandi Velusamy Subash C B Gopinath Pachaiappan Raman Source Type: research

DsbA-L: A Promising Therapeutic Target for Metabolic Diseases
Curr Med Chem. 2023 Oct 24. doi: 10.2174/0109298673252630231018044159. Online ahead of print.ABSTRACTThe increasing incidence of metabolic diseases, including obesity and diabetes, is a serious social public problem. Therefore, there is an urgent need to find effective prevention and treatment measures for these diseases. DsbA-L is a protein that is widely expressed in many tissues and is closely related to metabolism. Emerging evidence shows that DsbA-L plays an important role in antioxidative stress, promoting the synthesis and secretion of adiponectin and maintaining mitochondrial homeostasis, and the abnormalities of t...
Source: Current Medicinal Chemistry - October 25, 2023 Category: Chemistry Authors: Ming Yang Shilu Luo Jinfei Yang Wei Chen Liyu He Di Liu Xi Wang Li Xiao Lin Sun Source Type: research