Discovery of Pyroptosis-inducing Drugs and Antineoplastic Activity Based on the ROS/ER Stress/Pyroptosis Axis
CONCLUSION: Compound 7 exhibits antineoplastic activity by regulating the ROS/ER stress/pyroptosis axis and is a kind of promising pyroptosis inducer.PMID:38357947 | DOI:10.2174/0109298673281684240102072157 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Gan Jingwen Xie Zhaojun Dong Yuna Wu Xiaoqing Zeng Zhenzhen Yang Bo Liu Min Zhu Bozhen Wang Wulan Li Ledan Wang Huajie Zhang Jianzhang Wu Yue Hu Source Type: research

Prediction Model for Therapeutic Responses in Ovarian Cancer Patients Using Paclitaxel-Resistant Immune-Related lncRNAs
CONCLUSION: The novel prediction model with 9 DEir-lncRNAs is a valuable tool for predicting immunotherapeutic and chemotherapeutic responses and prognosis of patients with OC.PMID:38357948 | DOI:10.2174/0109298673281438231217151129 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Li Huiqiang Liu Fanchen Wang Jia Yuan Wencai Guan Guoxiong Xu Source Type: research

Structural-based Study to Identify the Repurposed Candidates Against Bacterial Infections
CONCLUSION: The identified drugs can be repurposed against Gram-positive and Gramnegative bacterial infections. However, further experimental studies are required to confirm their antibacterial potential.PMID:38357949 | DOI:10.2174/0109298673296749240207115303 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Debanjan Dey Anoop Kumar Source Type: research

Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways
CONCLUSION: The anticancer effects of HSE in BLCA may be attributed to its coordination of actions, inhibiting cell proliferation, migration, and invasion, inducing apoptosis, G0/G1 phase arrest, generating reactive oxygen species, causing MMP loss, and engaging the caspase protein family. These actions are likely mediated through the PI3K/AKT/FoxO3a and ER stress-mitochondrial pathways. Thus, our findings suggest that HSE is a promising novel therapeutic candidate for the prevention and treatment of BLCA.PMID:38357946 | DOI:10.2174/0109298673283888231217174702 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Yao Su Lin Chen Jin Yang Source Type: research

Discovery of Pyroptosis-inducing Drugs and Antineoplastic Activity Based on the ROS/ER Stress/Pyroptosis Axis
CONCLUSION: Compound 7 exhibits antineoplastic activity by regulating the ROS/ER stress/pyroptosis axis and is a kind of promising pyroptosis inducer.PMID:38357947 | DOI:10.2174/0109298673281684240102072157 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Gan Jingwen Xie Zhaojun Dong Yuna Wu Xiaoqing Zeng Zhenzhen Yang Bo Liu Min Zhu Bozhen Wang Wulan Li Ledan Wang Huajie Zhang Jianzhang Wu Yue Hu Source Type: research

Prediction Model for Therapeutic Responses in Ovarian Cancer Patients Using Paclitaxel-Resistant Immune-Related lncRNAs
CONCLUSION: The novel prediction model with 9 DEir-lncRNAs is a valuable tool for predicting immunotherapeutic and chemotherapeutic responses and prognosis of patients with OC.PMID:38357948 | DOI:10.2174/0109298673281438231217151129 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Xin Li Huiqiang Liu Fanchen Wang Jia Yuan Wencai Guan Guoxiong Xu Source Type: research

Structural-based Study to Identify the Repurposed Candidates Against Bacterial Infections
CONCLUSION: The identified drugs can be repurposed against Gram-positive and Gramnegative bacterial infections. However, further experimental studies are required to confirm their antibacterial potential.PMID:38357949 | DOI:10.2174/0109298673296749240207115303 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Debanjan Dey Anoop Kumar Source Type: research

Modulation of the HIF-1 α-NCOA4-FTH1 Signaling Axis Regulating Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the Anti-Hepatic Fibrosis Mechanism of Curcumol
CONCLUSION: Overall, curcumol induces ferroptosis and cellular senescence by increasing HIF-1α expression and increasing NCOA4 interaction with FTH1, leading to massive deposition of LIP and iron ions, which may be the molecular biological mechanism of its anti-liver fibrosis.PMID:38351696 | DOI:10.2174/0109298673271261231213051410 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 14, 2024 Category: Chemistry Authors: Yang Zheng Lei Wang Jiaru Wang Tiejian Zhao Jiahui Wang Source Type: research

Multi-omics Combined with Machine Learning Facilitating the Diagnosis of Gastric Cancer
Curr Med Chem. 2024 Feb 13. doi: 10.2174/0109298673284520240112055108. Online ahead of print.ABSTRACTGastric cancer (GC) is a highly intricate gastrointestinal malignancy. Early detection of gastric cancer forms the cornerstone of precision medicine. Several studies have been conducted to investigate early biomarkers of gastric cancer using genomics, transcriptomics, proteomics, and metabolomics, respectively. However, endogenous substances associated with various omics are concurrently altered during gastric cancer development. Furthermore, environmental exposures and family history can also induce modifications in endoge...
Source: Current Medicinal Chemistry - February 14, 2024 Category: Chemistry Authors: Jie Li Siyi Xu Feng Zhu Fei Shen Tianyi Zhang Xin Wan Saisai Gong Geyu Liang Yonglin Zhou Source Type: research

Immunosuppressive Microenvironment in H3K27 Mutant Pediatric Diffuse Midline Glioma: Single-Cell and Bioinformatics Insights on CD8A, IL7R, and ICAM1
CONCLUSION: In conclusion, the collective findings of our study suggest the potential role of CD8A, IL7R, and ICAM1 as innovative biomarkers for diagnosing and prognosticating pediatric DMG. Moreover, these molecules hold promise as therapeutic targets in the management of this disease. The implications of our research underscore the importance of exploring these novel avenues for improved patient outcomes.PMID:38347782 | DOI:10.2174/0109298673280120240108045926 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Jianhuang Huang Guiting You Quan Chen Yunpeng Lin Yijing Lin Yu Liang Caihou Lin Jianwu Chen Source Type: research

Synthesis and Biological Evaluations of Granulatamide B and its Structural Analogues
CONCLUSION: Since modification of the side chain did not significantly alter the change in biological activities compared to the parent compound, granulatamide B (4b), the substitution of the indole ring needs to be considered. Our group is currently carrying out new syntheses focusing on the functionalization of the indole core.PMID:38347783 | DOI:10.2174/0109298673272687231226111132 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Dario Matulja Petra Grb čić Gabrijela Matijevi ć Sanja Babi ć Krunoslav Bojani ć Sylvain Laclef Valerije Vr ček Rozelindra Čož-Rakovac Sandra Kraljevi ć Pavelić Dean Markovi ć Source Type: research

Research Progress on the Antioxidant Activity of Natural Diarylheptanoids: Mechanisms and Structure-activity Relationships
Curr Med Chem. 2024 Feb 12. doi: 10.2174/0109298673282309231226111037. Online ahead of print.ABSTRACTAntioxidant research has recently become a popular topic. Medicinal plants are important sources of novel active compounds. Diarylheptanoids, a typical family of secondary plant metabolites, are of great interest owing to their extensive spectrum of biological activities. They possess a unique 1,7-diphenylmethane structural skeleton. Thus, this review summarizes the natural linear or macrocyclic diarylheptanoids with antioxidant activity in the last two decades. In addition, the relationships between the structural characte...
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: An-Na Ma Tie Yao Ya-Jing Guo Chong-Yan Zhao Bing-Jie Wang Gen Li Feng Qiu Source Type: research

TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen Doxorubicin Resistance of Colorectal Cancer Cells
CONCLUSION: TRIP13 was highly expressed in CRC, which enhanced the DOX resistance of CRC cells by activating glycolysis to promote cell stemness. These findings offer new insights into the pathogenesis of DOX resistance in CRC and suggest that TRIP13 may be a new target for reversing DOX resistance in CRC.PMID:38347785 | DOI:10.2174/0109298673255498231117100421 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Guangyi Liu Huan Wang Ran Rui Yicheng Wang Yang Li Source Type: research

Binding of Nucleotide Inhibitors to the NS5 RdRp of the ZIKA Virus in the Replication Initiation State
CONCLUSION: However, experimental studies are required to measure the potency of RTP and other drugs before their clinical use.PMID:38347786 | DOI:10.2174/0109298673259914231213052438 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: S Pant N R Jena Source Type: research

Activation of Stimulator of Interferon Genes (STING): Promising Strategy to Overcome Immune Resistance in Prostate Cancer
Curr Med Chem. 2024 Feb 12. doi: 10.2174/0109298673273303231208071403. Online ahead of print.ABSTRACTProstate cancer (PCa) is the most frequent and second-lethal cancer among men. Despite considerable efforts to explore treatments like autologous cellular immunotherapy and immune checkpoint inhibitors, their success remains limited. The intricate tumor microenvironment (TME) and its interaction with the immune system pose significant challenges in PCa treatment. Consequently, researchers have directed their focus on augmenting the immune system's anti-tumor response by targeting the STimulator of the Interferon Genes (STIN...
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Mohammed Alnukhali Omar Altabbakh Ammad Ahmad Farooqi Alan Pollack Sylvia Daunert Sapna Deo Wensi Tao Source Type: research