The Role and Therapeutic Potential of Non-coding RNAs in Resistance to EGFR-TKIs targeted therapy for Non-small Cell Lung Cancer
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673275752231219080500. Online ahead of print.ABSTRACTLung cancer is the leading cause of cancer-related deaths worldwide, of which non-small cell lung cancer (NSCLC) is the most common type, and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are widely used for the treatment of NSCLC. EGFR-TKIs are known to develop a drug-resistant response after a certain number of cycles of dosing, and how to alleviate or even reverse EGFR-TKI resistance is an urgent problem at present. This review focuses on the role of ncRNAs in the resistance of NSCLC to EGFR-TKI...
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Yang Zhang Ye Chen Li-Li Lu Xiu-Li Xie Ren Huan Li-Fang Wu Li-Na Tan Tao Xu Yong Jin Source Type: research
Mycobacterial Targets for Thiourea Derivatives: Opportunities for Virtual Screening in Tuberculosis Drug Discovery
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673276076231124104513. Online ahead of print.ABSTRACTTuberculosis (TB) remains a primary global health concern, necessitating the discovery and development of new anti-TB drugs, mainly to combat drug-resistant strains. In this context, thiourea derivatives have emerged as promising candidates in TB drug discovery due to their diverse chemical structures and pharmacological properties. This review aimed to explore this potential, identifying and exploring molecular targets for thiourea derivatives in Mycobacterium tuberculosis (Mtb) and the potential application of virtual scr...
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Vinicius de Melo Milani Mariana Luiza Silva Priscila Goes Camargo Marcelle de Lima Ferreira Bispo Source Type: research
Advanced Targeted Drug Delivery of Bioactive Nanomaterials in the Management of Cancer
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673283362231220115050. Online ahead of print.ABSTRACTCancer is defined as the unchecked expansion of aberrant cells. Radiation, chemotherapy, and surgery are currently used in combination to treat cancer. Traditional drug delivery techniques kill healthy proliferating cells when used over prolonged periods of time in cancer chemotherapy. Due to the fact that the majority of tumor cells do not infiltrate right away, this is particularly true when treating solid tumors. A targeted drug delivery system (TDDS) is a tool that distributes medication to a selected bioactive location...
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Biswajit Basu Kevin Kumar Garala Rajeshri Patel Ayon Dutta Dipanjana Ash Bhupendra Prajapati Sudarshan Singh Sajal Kumar Jha Source Type: research
Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach
CONCLUSION: This review arouses interest in the isolation of phenolic compounds that may allow a new approach for the prevention of both arterial and venous thrombosis, with the potential to become alternatives in the prevention and treatment of cardiovascular diseases.PMID:38375850 | DOI:10.2174/0109298673268452231108061008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Di égina Araújo Fernandes Ayala Nara Pereira Gomes Camila Macaubas da Silva Isabelly Soares de Medeiros Henriques Renata Priscila Barros de Menezes Marcus Tullius Scotti Yanna Carolina Ferreira Teles RuAngelie Edrada-Ebel Maria de Fatima Vanderlei de So Source Type: research
The Use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization
Curr Med Chem. 2024 Feb 1. doi: 10.2174/0109298673278897231229121524. Online ahead of print.ABSTRACTEpidemiological trends in cancer research show that lung cancer can affect up to 1 in 15 men and 1 in 17 women. With incidence rates as high as these and significant associated mortality and morbidity, it is no wonder that lung cancer is one of the main areas of research focused on cancer. Advances in targeted treatments and specialized irradiation protocols have allowed the treatment of more advanced cases. However, as the patient numbers grow, so does the need for cancer-preventive strategies. The present narrative review ...
Source: Current Medicinal Chemistry - February 19, 2024 Category: Chemistry Authors: Efstratios Athanasiou Savvas Papageorgiou Marianna Foteini Dafni Ioannis Kelesis Maria Vasileiou Theodora Tatsiou Vasiliki Kouveloglou Panagiotis Kanatas Ioannis Stouras Athanasios Gatsis Vasiliki Taxiarchoula Agiassoti Petros Nasimpian Dimitrios Dafnoudi Source Type: research
The Use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization
Curr Med Chem. 2024 Feb 1. doi: 10.2174/0109298673278897231229121524. Online ahead of print.ABSTRACTEpidemiological trends in cancer research show that lung cancer can affect up to 1 in 15 men and 1 in 17 women. With incidence rates as high as these and significant associated mortality and morbidity, it is no wonder that lung cancer is one of the main areas of research focused on cancer. Advances in targeted treatments and specialized irradiation protocols have allowed the treatment of more advanced cases. However, as the patient numbers grow, so does the need for cancer-preventive strategies. The present narrative review ...
Source: Current Medicinal Chemistry - February 19, 2024 Category: Chemistry Authors: Efstratios Athanasiou Savvas Papageorgiou Marianna Foteini Dafni Ioannis Kelesis Maria Vasileiou Theodora Tatsiou Vasiliki Kouveloglou Panagiotis Kanatas Ioannis Stouras Athanasios Gatsis Vasiliki Taxiarchoula Agiassoti Petros Nasimpian Dimitrios Dafnoudi Source Type: research
A Comprehensive Review of Therapeutic Compounds from Plants for Neurodegenerative Diseases
Curr Med Chem. 2024 Feb 6. doi: 10.2174/0109298673272435231204072922. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) comprise a large number of disorders that affect the structure and functions of the nervous system. The major cause of various neurodegenerative diseases includes protein aggregation, oxidative stress and inflammation. Over the last decade, there has been a gradual inclination of neurological research in order to find drugs that can prevent, slow down, or treat these diseases. The most common NDDs are Alzheimer's, Parkinson's, and Huntington's illnesses which claims the lives of 6.8 million ...
Source: Current Medicinal Chemistry - February 17, 2024 Category: Chemistry Authors: Dhaya Shankaran P Abinaya K Meenakumari S Subash C B Gopinath Pachaiappan Raman Source Type: research
A Comprehensive Review of Therapeutic Compounds from Plants for Neurodegenerative Diseases
Curr Med Chem. 2024 Feb 6. doi: 10.2174/0109298673272435231204072922. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) comprise a large number of disorders that affect the structure and functions of the nervous system. The major cause of various neurodegenerative diseases includes protein aggregation, oxidative stress and inflammation. Over the last decade, there has been a gradual inclination of neurological research in order to find drugs that can prevent, slow down, or treat these diseases. The most common NDDs are Alzheimer's, Parkinson's, and Huntington's illnesses which claims the lives of 6.8 million ...
Source: Current Medicinal Chemistry - February 17, 2024 Category: Chemistry Authors: Dhaya Shankaran P Abinaya K Meenakumari S Subash C B Gopinath Pachaiappan Raman Source Type: research
Novel Adiponectin Receptor Agonist Inhibits Cholangiocarcinoma via Adenosine Monophosphate-activated Protein Kinase
CONCLUSIONS: AdipoR1 and p-AMPKα are impaired in CCA tissues, and AdipoRon effectively inhibits CCA in vitro and in vivo. Thus, AdipoRon may be considered as a potential anti-tumor therapy in CCA.PMID:38361349 | DOI:10.2174/0109298673254969231122114107 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Khac Cuong Bui Mai Ly Thi Nguyen Samarpita Barat Tim Scholta Jun Xing Vikas Bhuria Bence Sipos Ludwig Wilkens Toan Nguyen Linh Song Le Huu Thirumalaisamy P Velavan Przemyslaw Bozko Ruben R Plentz Source Type: research
Progress of Influenza Viruses and Inhibitors
Curr Med Chem. 2024 Feb 15. doi: 10.2174/0109298673268314231204061224. Online ahead of print.ABSTRACTInfluenza is an acute respiratory disease caused by influenza viruses. It has the characteristics of fast transmission and strong infectivity, and it does great harm to human health and survival. It is estimated that the seasonal influenza epidemics every year will cause about one billion cases of infections and hundreds of thousands of deaths worldwide, while influenza A virus is the leading cause of infection and death. Currently, the main drugs used in clinics to treat influenza viruses are neuraminidase inhibitors, and ...
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Yuchen Xiao Jianping Yong Shaoji Lu Canzhong Lu Ruiwen Huang Source Type: research
Identification and Characterization of PrognosticMacrophage Subpopulations for HumanEsophagealCarcinoma
CONCLUSIONS: This study analyzed the diversity, distribution and differentiation trajectory of macrophages in ESCA tissues at single-cell level and classified a prognostic macrophage subtype (HSPA6+ macrophages) of ESCA, providing a theoretical basis for macrophage-targeted therapy in ESCA.PMID:38362682 | DOI:10.2174/0109298673284207240108105724 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Penghui Li Xiaohui Gao Di Huang Xinyu Gu Source Type: research
Identifying Hub Genes for Glaucoma Based on Bulk RNA Sequencing Data and Multi-machine Learning Models
CONCLUSION: Our results systematically determined 8 hub genes and established a molecular diagnostic model that allowed the diagnosis of Glaucoma. Our study provided a basis for future systematic studies of Glaucoma pathogenesis.PMID:38362683 | DOI:10.2174/0109298673283658231130104550 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Yangyang Xie Kai Yu Source Type: research
Construction of a New Ferroptosis-related Prognosis Model for Survival Prediction in Colorectal Cancer
CONCLUSIONS: The present molecular signature established based on the 11 ferroptosis-related genes performed well in assessing CRC prognosis. The present discoveries could inspire further research on ferroptosis, providing a new direction for CRC management.PMID:38362684 | DOI:10.2174/0109298673296767240116215814 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Lin Chen Mengxiao Ge Shaocong Mo Menglin Shi Jun Zhang Jie Liu Source Type: research
Evolution and Trends of Aptamers in Cancer Research: A Bibliometric Analysis of the Literature over the Last Decade
CONCLUSION: The field of aptamers in cancer research has been steadily developing over the past decade, and future research may focus on aptamer application in cancer detection and therapy and the improvement of aptamer selection.PMID:38362685 | DOI:10.2174/0109298673280993240125091756 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Song Jiang Mao-Sheng Liu Ting Wang Kun-He Zhang Source Type: research
Natural Products in Liver Fibrosis Management: A Five-year Review
Curr Med Chem. 2024 Feb 14. doi: 10.2174/0109298673288458240203064112. Online ahead of print.ABSTRACTLiver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for understanding the molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our understanding of the interaction between various underlying conditions and the liver. Not...
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Tao Wang Zhuo Lu Gui-Feng Sun Kai-Yi He Zhi-Ping Chen Xin-Hui Qu Xiao-Jian Han Source Type: research
