Natural Products in Liver Fibrosis Management: A Five-year Review
Curr Med Chem. 2024 Feb 14. doi: 10.2174/0109298673288458240203064112. Online ahead of print.ABSTRACTLiver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for understanding the molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our understanding of the interaction between various underlying conditions and the liver. Not...
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Tao Wang Zhuo Lu Gui-Feng Sun Kai-Yi He Zhi-Ping Chen Xin-Hui Qu Xiao-Jian Han Source Type: research

Does Gut Microbiome have an Effect on Wilson's Disease Phenotype?
This study may offer novel insights for further investigation into the mechanisms underlying the occurrence, development, and treatment of WD subtypes.PMID:38362687 | DOI:10.2174/0109298673282452240122103156 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Shan Gao Mei Zhou Hedong Zhang Zhenchu Tang Source Type: research

Cell-Penetrating Peptides as Keys to Endosomal Escape and Intracellular Trafficking in Nanomedicine Delivery
In conclusion, the article highlights the challenges associated with cytoplasmic delivery and the importance of understanding the mechanisms involved in endosomal escape. A better understanding of these processes could result in the creation of greater effectiveness and safe delivery systems for various cargoes, including proteins, peptides, and nucleic acids.PMID:38362688 | DOI:10.2174/0109298673278936240107121907 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Sakshi Soni Shivam K Kori Priyanshu Nema Arun K Iyer Vandana Soni Sushil K Kashaw Source Type: research

Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth Factor for C57BL/6 Mice
CONCLUSION: The MXD-NPs-receiving mice exhibited a greater rate of anagen/telogen follicular when compared with MXD-treated types, which verified the improvement of their hair re-growing and follicular-stimulative activities. Therefore, these outcomes confirmed the potential of MXD-NPs for substituting its commercial solution format as a safe and efficient iso-formulation structure.PMID:38362689 | DOI:10.2174/0109298673283413240116065844 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Ali Moradi Seyed Morteza Seifati Majid Darroudi Shiva Golmohammadzadeh Mahmood Dehghani Ashkezari Source Type: research

Novel Adiponectin Receptor Agonist Inhibits Cholangiocarcinoma via Adenosine Monophosphate-activated Protein Kinase
CONCLUSIONS: AdipoR1 and p-AMPK╬▒ are impaired in CCA tissues, and AdipoRon effectively inhibits CCA in vitro and in vivo. Thus, AdipoRon may be considered as a potential anti-tumor therapy in CCA.PMID:38361349 | DOI:10.2174/0109298673254969231122114107 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Khac Cuong Bui Mai Ly Thi Nguyen Samarpita Barat Tim Scholta Jun Xing Vikas Bhuria Bence Sipos Ludwig Wilkens Toan Nguyen Linh Song Le Huu Thirumalaisamy P Velavan Przemyslaw Bozko Ruben R Plentz Source Type: research

Progress of Influenza Viruses and Inhibitors
Curr Med Chem. 2024 Feb 15. doi: 10.2174/0109298673268314231204061224. Online ahead of print.ABSTRACTInfluenza is an acute respiratory disease caused by influenza viruses. It has the characteristics of fast transmission and strong infectivity, and it does great harm to human health and survival. It is estimated that the seasonal influenza epidemics every year will cause about one billion cases of infections and hundreds of thousands of deaths worldwide, while influenza A virus is the leading cause of infection and death. Currently, the main drugs used in clinics to treat influenza viruses are neuraminidase inhibitors, and ...
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Yuchen Xiao Jianping Yong Shaoji Lu Canzhong Lu Ruiwen Huang Source Type: research

Identification and Characterization of PrognosticMacrophage Subpopulations for HumanEsophagealCarcinoma
CONCLUSIONS: This study analyzed the diversity, distribution and differentiation trajectory of macrophages in ESCA tissues at single-cell level and classified a prognostic macrophage subtype (HSPA6+ macrophages) of ESCA, providing a theoretical basis for macrophage-targeted therapy in ESCA.PMID:38362682 | DOI:10.2174/0109298673284207240108105724 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Penghui Li Xiaohui Gao Di Huang Xinyu Gu Source Type: research

Identifying Hub Genes for Glaucoma Based on Bulk RNA Sequencing Data and Multi-machine Learning Models
CONCLUSION: Our results systematically determined 8 hub genes and established a molecular diagnostic model that allowed the diagnosis of Glaucoma. Our study provided a basis for future systematic studies of Glaucoma pathogenesis.PMID:38362683 | DOI:10.2174/0109298673283658231130104550 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Yangyang Xie Kai Yu Source Type: research

Construction of a New Ferroptosis-related Prognosis Model for Survival Prediction in Colorectal Cancer
CONCLUSIONS: The present molecular signature established based on the 11 ferroptosis-related genes performed well in assessing CRC prognosis. The present discoveries could inspire further research on ferroptosis, providing a new direction for CRC management.PMID:38362684 | DOI:10.2174/0109298673296767240116215814 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Lin Chen Mengxiao Ge Shaocong Mo Menglin Shi Jun Zhang Jie Liu Source Type: research

Evolution and Trends of Aptamers in Cancer Research: A Bibliometric Analysis of the Literature over the Last Decade
CONCLUSION: The field of aptamers in cancer research has been steadily developing over the past decade, and future research may focus on aptamer application in cancer detection and therapy and the improvement of aptamer selection.PMID:38362685 | DOI:10.2174/0109298673280993240125091756 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Song Jiang Mao-Sheng Liu Ting Wang Kun-He Zhang Source Type: research

Natural Products in Liver Fibrosis Management: A Five-year Review
Curr Med Chem. 2024 Feb 14. doi: 10.2174/0109298673288458240203064112. Online ahead of print.ABSTRACTLiver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for understanding the molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our understanding of the interaction between various underlying conditions and the liver. Not...
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Tao Wang Zhuo Lu Gui-Feng Sun Kai-Yi He Zhi-Ping Chen Xin-Hui Qu Xiao-Jian Han Source Type: research

Does Gut Microbiome have an Effect on Wilson's Disease Phenotype?
This study may offer novel insights for further investigation into the mechanisms underlying the occurrence, development, and treatment of WD subtypes.PMID:38362687 | DOI:10.2174/0109298673282452240122103156 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Shan Gao Mei Zhou Hedong Zhang Zhenchu Tang Source Type: research

Cell-Penetrating Peptides as Keys to Endosomal Escape and Intracellular Trafficking in Nanomedicine Delivery
In conclusion, the article highlights the challenges associated with cytoplasmic delivery and the importance of understanding the mechanisms involved in endosomal escape. A better understanding of these processes could result in the creation of greater effectiveness and safe delivery systems for various cargoes, including proteins, peptides, and nucleic acids.PMID:38362688 | DOI:10.2174/0109298673278936240107121907 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Sakshi Soni Shivam K Kori Priyanshu Nema Arun K Iyer Vandana Soni Sushil K Kashaw Source Type: research

Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth Factor for C57BL/6 Mice
CONCLUSION: The MXD-NPs-receiving mice exhibited a greater rate of anagen/telogen follicular when compared with MXD-treated types, which verified the improvement of their hair re-growing and follicular-stimulative activities. Therefore, these outcomes confirmed the potential of MXD-NPs for substituting its commercial solution format as a safe and efficient iso-formulation structure.PMID:38362689 | DOI:10.2174/0109298673283413240116065844 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 16, 2024 Category: Chemistry Authors: Ali Moradi Seyed Morteza Seifati Majid Darroudi Shiva Golmohammadzadeh Mahmood Dehghani Ashkezari Source Type: research

Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways
CONCLUSION: The anticancer effects of HSE in BLCA may be attributed to its coordination of actions, inhibiting cell proliferation, migration, and invasion, inducing apoptosis, G0/G1 phase arrest, generating reactive oxygen species, causing MMP loss, and engaging the caspase protein family. These actions are likely mediated through the PI3K/AKT/FoxO3a and ER stress-mitochondrial pathways. Thus, our findings suggest that HSE is a promising novel therapeutic candidate for the prevention and treatment of BLCA.PMID:38357946 | DOI:10.2174/0109298673283888231217174702 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 15, 2024 Category: Chemistry Authors: Yao Su Lin Chen Jin Yang Source Type: research