High-Resolution Profiling of Head and Neck Squamous Cells Carcinoma Identifies Specific Biomarkers and Expression Subtypes of Clinically Relevant Vulnerabilities
CONCLUSION: Overall, our HNSC typing approach identified robust tumor-expressing subtypes, and data from multiple screens also revealed subtype-specific biology and vulnerabilities. These HNSC expression subtypes and their biomarkers will help develop more effective therapeutic strategies.PMID:37936459 | DOI:10.2174/0109298673276128231031112655 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Yingying Zhu Bi Peng Xiaoxiao Luo Wei Sun Dongbo Liu Na Li Ping Qiu Guoxian Long Source Type: research

Anti-migratory Properties of Cryoprotective Isoliquiritigenin-zein Phosphatidylcholine Nanoparticles Prevent Triple-negative Breast Cancer through PI3K-mTOR and MMP2/9 Pathways
CONCLUSION: These results suggest that oral ingestion of cryopreserved ISL@ZLH NP has the potential for longterm storage and can be employed as a clinical therapeutic approach to treat TNBC.PMID:37936460 | DOI:10.2174/0109298673259973231023110945 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Cong Xu Chen Zhang Kumar Ganesan Qiu Chen Hailin Tang Fei Gao Qingqing Liu Jianming Wu Yue Sui Peng Li Jinming Zhang Jianping Chen Source Type: research

A New Dawn for Targeted Cancer Therapy: Small Molecule Covalent Binding Inhibitor Targeting K-Ras (G12C)
Curr Med Chem. 2023 Nov 2. doi: 10.2174/0109298673258913231019113814. Online ahead of print.ABSTRACTK-Ras is a frequently mutated oncogene in human malignancies, and the development of inhibitors targeting various oncogenic K-Ras mutant proteins is a major challenge in targeted cancer therapy, especially K-Ras(G12C) is the most common mutant, which occurs in pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other highly prevalent malignancies. In recent years, significant progress has been made in developing small molecule covalent inhibitors targeting K-Ras(G12C), tha...
Source: Current Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Na Li Chen-Fu Liu Wen Zhang Guo-Wu Rao Source Type: research

Does Laterality in Breast Cancer still have the Importance to be Studied? A Meta-analysis of Patients with Breast Cancer
CONCLUSION: Results suggest an increased rate of BC on the left side, with high-risk factors contributing to BC laterality, which may be useful in predicting prognosis. This study provides significant insights into the relationship between high-risk factors and BC laterality. By identifying potential risk factors associated with left-side BC, it may be possible to improve the ability to predict prognosis and develop more targeted treatment strategies. This information could be particularly useful for healthcare providers and patients, as it may guide decisions regarding screening, prevention, and treatment, ultimately impr...
Source: Current Medicinal Chemistry - November 7, 2023 Category: Chemistry Authors: Xiao Zheng Cong Xu Kumar Ganesan Haiyong Chen Yuen Shan Cheung Jianping Chen Source Type: research

Potentiality of Nucleoside as Antioxidant by Analysis on Oxidative Susceptibility, Drug Discovery, and Synthesis
Curr Med Chem. 2023 Nov 6. doi: 10.2174/0109298673264900231023050108. Online ahead of print.ABSTRACTNucleosides are sensitive sites towards oxidations caused by endogenous and exogenous oxidative resources, and a large number of the produced DNA lesions behave as pathogenesis event1ually. We herein analyze oxidative modes of nucleosides and structure-activity relationships of some clinical nucleoside drugs. Together with our previous findings on the inhibitory effects of nucleoside derivatives against DNA oxidation, all these results imply a possibility for nucleoside to be a new member in the family of antioxidants. Then,...
Source: Current Medicinal Chemistry - November 7, 2023 Category: Chemistry Authors: Zai-Qun Liu Source Type: research

Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?
CONCLUSION: Following comprehensive preclinical toxicity assessments, further evaluation of CAPE's efficacy and safety through clinical trials is highly recommended to elucidate its potential health benefits in diverse forms of human cancer.PMID:37933215 | DOI:10.2174/0109298673252993230921073502 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 7, 2023 Category: Chemistry Authors: Geir Bj ørklund Olha Storchylo Massimiliano Peana Tony Hangan Roman Lysiuk Larysa Lenchyk Oleh Koshovyi Halyna Antonyak Nataliia Hudz Salvatore Chirumbolo Source Type: research

Biomarkers for Diagnosing and Treating Fetal Growth Restriction
Curr Med Chem. 2023 Oct 25. doi: 10.2174/0109298673258444231019104656. Online ahead of print.ABSTRACTFetal growth restriction (FGR), a common obstetric complication, significantly increases the risks of fetal intrauterine death and neonatal death, and fetuses with growth restriction are prone to cognitive retardation and various diseases in adulthood. The early determination of FGR risk is contentious in clinical research, and few indicators are available for the early prediction and diagnosis of FGR. This review focuses on the prediction and diagnosis of FGR, as well as the significance of biomarkers for FGR, such as thos...
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Mengyao Wu Junyu He Yetao Chen Fangzhu Wan Hongbo Tang Chenghong Yin Haibo He Huifan Yu Chengfu Yuan Source Type: research

The Roles of Endogenous D2R Dopamine and μ-opioid Receptors of the Brain in Alcohol Use Disorder
Curr Med Chem. 2023 Oct 26. doi: 10.2174/0109298673248999231013043249. Online ahead of print.ABSTRACTAlcohol use disorder (AUD) affects millions of people worldwide. It is characterized by a strong physiological and psychological craving to consume large amounts of alcohol despite adverse consequences. Alcohol use disorder carries a large health and economic burden on society. Despite its prevalence, AUD is still severely undertreated. The precise molecular mechanisms of how alcohol addiction forms are yet unknown. However, previous studies on animal models show that along with the μ-opioid receptors, the D2R dopamine rec...
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Kamila Khikhmetova Yuliya Semenova Geir Bj ørklund Source Type: research

The Role of Genistein and its Derivatives in Ovarian Cancer: New Perspectives for Molecular Mechanisms and Clinical Applications
Curr Med Chem. 2023 Oct 25. doi: 10.2174/0109298673251713231019091910. Online ahead of print.ABSTRACTGenistein (GEN) is a member of the polyphenol family, known chiefly for its effects on metabolic diseases and gynecological disorders. GEN has anti-cancer properties by inhibiting tumor proliferation, tumor metastasis, invasion, migration, and inducing apoptosis. Ovarian cancer (OC) is ranked 7th among the most common gynecological cancers. Despite its low incidence compared to other cancers, it is the first cause of death among gynecologic malignancies. Surgery and chemotherapy are the main options for treating this fatal ...
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Shala Chaichian Banafsheh Nikfar Sepideh Arbabi Bidgoli Bahram Moazzami Source Type: research

Biochemical Markers of Early Renal Dysfunction in Patients with β-thalassemia Major: A Systematic Review and Meta-analysis
CONCLUSION: Urinary NAG, β2MG, ACR, and Scys-C may be early markers of renal dysfunction in patients with β-thalassemia major. An observation of elevated levels of these markers despite normal levels of other markers of renal dysfunction may indicate primary, subclinical injury to the renal tubules and glomeruli.PMID:37921173 | DOI:10.2174/0109298673250805230922054406 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Mahdieh Arian Mohammad Bagher Oghazian Mohammad Hassan A Noureldine Ali Valinejad Zahra Badiee Mohsen Soleimani Amirhossein Sahebkar Source Type: research

Targeting SmCB1: Perspectives and Insights to Design Antischistosomal Drugs
Curr Med Chem. 2023 Oct 25. doi: 10.2174/0109298673255826231011114249. Online ahead of print.ABSTRACTNeglected tropical diseases (NTDs) are prevalent in tropical and subtropical countries, and schistosomiasis is among the most relevant diseases worldwide. In addition, one of the two biggest problems in developing drugs against this disease is related to drug resistance, which promotes the demand to develop new drug candidates for this purpose. Thus, one of the drug targets most explored, Schistosoma mansoni Cathepsin B1 (SmCB1 or Sm31), provides new opportunities in drug development due to its essential functions for the p...
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Igor Nascimento Sonaly Albino Karla Menezes Misael Cavalcanti Mozaniel Oliveira Suraj Mali Ricardo Moura Source Type: research

An Update on Glutathione's Biosynthesis, Metabolism, Functions, and Medicinal Purposes
Curr Med Chem. 2023 Oct 26. doi: 10.2174/0109298673251025230919105818. Online ahead of print.ABSTRACTGlutathione (GSH) has been the focus of increased scientific interest in the last decades. It plays a crucial role in all major physiological processes by supplying antioxidant defenses through participating in cellular redox reactions in the human body and other living organisms. GSH also participates in detoxifying xenobiotics, protecting protein thiols from crosslinking and oxidation, regulating the cell cycle, storing cysteine, etc. The significant role of GSH in the most important physiological processes has been highl...
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Amin Gasmi Aniqa Nasreen Larysa Lenchyk Roman Lysiuk Massimiliano Peana Nataliya Shapovalova Salva Piscopo Mykola Komissarenko Mariia Shanaida Kateryna Smetanina Halyna Antonyak Liudmyla Fira Petro Lykhatskyi Dmytro Fira Geir Bj ørklund Source Type: research

Leukemia Inhibitory Factor Protects against Degeneration of Cone Photoreceptors Caused by RPE65 Deficiency
CONCLUSION: LIF is a potent factor that protects cones in rd12 mice. This finding implies that LIF can be used in combination with gene therapy to achieve better therapeutic outcomes for patients with RPE65-associated LCA.PMID:37921176 | DOI:10.2174/0109298673240896231027053716 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Shuqian Dong Fangyuan Zhen Tongdan Zou Yongwei Zhou Jiahui Wu Ting Wang Houbin Zhang Source Type: research

Strategic and Innovative Roles of lncRNAs Regulated by Naturally-Derived Small Molecules in Cancer Therapy
Curr Med Chem. 2023 Oct 26. doi: 10.2174/0109298673264372230919102758. Online ahead of print.ABSTRACTIn the field of precision and personalized medicine, the next generation sequencing method has begun to take an active place as genome-wide screening applications in the diagnosis and treatment of diseases. Studies based on the determination of the therapeutic efficacy of personalized drug use in cancer treatment in the size of the transcriptome and its extension, lncRNA, have been increasing rapidly in recent years. Targeting and/or regulating noncoding RNAs (ncRNAs) consisting of long noncoding RNAs (lncRNAs) are promisin...
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Ay şe Hale Alkan Mine Ensoy Demet Cansaran-Duman Source Type: research

The Role of Mitokines in Diabetic Nephropathy
Curr Med Chem. 2023 Oct 26. doi: 10.2174/0109298673255403230919061828. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) has gradually become one of the main causes of end-stage renal disease (ESRD). However, there is still a lack of effective preventive measures to delay its progression. As the energy factory in the cell, mitochondria play an irreplaceable role in maintaining cell homeostasis. Interestingly, recent studies have shown that in addition to maintaining homeostasis in cells in which mitochondria reside, when mitochondrial perturbations occur in one tissue, distal tissues can also sense and act through mi...
Source: Current Medicinal Chemistry - November 3, 2023 Category: Chemistry Authors: Ming Yang Wei Chen Liyu He Xi Wang Di Liu Li Xiao Lin Sun Source Type: research