The Protective Effects of Curcumin against Renal Toxicity
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673271161231121061148. Online ahead of print.ABSTRACTCurcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustr...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Jianan Zhai Zhengguo Chen Qi Zhu Zhifang Guo Ningning Wang Cong Zhang Haoyuan Deng Shaopeng Wang Guang Yang Source Type: research

A Novel Perspective on PCSK9 in Alzheimer's Disease: A Focus on Amyloid Beta
This study focuses on the effects of PCSK9 on Aβ accumulation in the brain via multiple modalities to explore the potential role of PCSK9 in AD, which is characterized by progressive loss of brain cells by increasing Aβ accumulation. The study also explores the new mechanism by which PCSK9 is involved in the pathogenesis of AD, providing interesting and innovative guidance for the future of PCSK9-targeted therapy for AD.PMID:38549537 | DOI:10.2174/0109298673269288231123095215 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Huayu Zhang Qian Xu Yimeng Zhao Naiqi He Zhong Ren Qiong Xiang Zhihan Tang Lushan Liu Source Type: research

NADP+/NADPH in Metabolism and its Relation to Cardiovascular Pathologies
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673275187231121054541. Online ahead of print.ABSTRACTThe nicotinamide adenine dinucleotide phosphate (NADP+/NADPH) redox couple serves as a substrate or cofactor for many enzymes to maintain cellular redox homeostasis as well as to regulate biosynthetic metabolism. The deficiency or imbalance of NADP+/NADPH redox couple is strongly associated with cardiovascular-related pathologies. An imbalance in the NADP+/NADPH ratio can lead to either oxidative or reductive stress. Reductive stress complicates the cellular redox environment and provides new insights into the cellular redo...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Yuanyuan Sun Dan Wu Qingxun Hu Source Type: research

Alterations in Adipocytokine Signaling Pathway and Pyroptosis in Neonatal Hypoxic-ischemic Encephalopathy
CONCLUSION: These results indicated that the adipocytokine signaling pathway may promote HIE occurrence by upregulating the expression of pyroptosis-related genes, providing a novel mechanism for HIE.PMID:38549539 | DOI:10.2174/0109298673293975240214091034 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Min Ran Li Yin Yatu Guo Wei Zhang Source Type: research

Multi-omics Data Integration Analysis Identified Therapeutic Targets and Potential Reuse Drugs for Osteoporosis
CONCLUSION: This study provided a new network-based framework for drug reuse and identified initial insights into therapeutic agents targeting CD74 in osteoporosis, which may be meaningful for promoting the development of osteoporosis treatment.PMID:38551048 | DOI:10.2174/0109298673291526240322081017 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Mingdong Li Xing Gao Yuchen Zhang Jinglei Wang Run Dong Peng Li Yongxiong He Source Type: research

iACVP-MR: Accurate Identification of Anti-coronavirus Peptide based on Multiple Features Information and Recurrent Neural Network
CONCLUSION: The iACVP-MR model can be viewed as a powerful and intelligent tool for the accurate identification of ACVP. The datasets and source codes for iACVP-MR are freely downloaded at https://github.com/yunyunliang88/iACVP-MR.PMID:38549527 | DOI:10.2174/0109298673277663240101111507 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Yunyun Liang Xinyan Ma Shengli Zhang Jin Li Source Type: research

Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research

Modulatory Role of Phytochemicals/Natural Products in Cancer Immunotherapy
Curr Med Chem. 2024 Feb 15. doi: 10.2174/0109298673274796240116105555. Online ahead of print.ABSTRACTImmunotherapy is a newly emerging and effective approach to treating cancer. However, there are many challenges associated with using checkpoint inhibitors in this treatment strategy. The component of the tumor microenvironment plays a crucial role in antitumor immune response, regulating tumor immune surveillance as immunological evasion. Natural products/phytochemicals can modulate the tumor microenvironment and function as immunomodulatory agents. In clinical settings, there is a strong need to develop synergistic combin...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Kuzhuvelil B Harikumar Yadu Vijayan Jaskirat Singh Sandhu Source Type: research

The Application of Graphene Oxide Nanoarchitectures in the Treatment of Cancer: Phototherapy, Immunotherapy, and the Development of Vaccines
Curr Med Chem. 2024 Feb 15. doi: 10.2174/0109298673288750240117115141. Online ahead of print.ABSTRACTNanoparticles have been crucial in redesigning tumour eradication techniques, and recent advances in cancer research have accelerated the creation and integration of multifunctional nanostructures. In the fight against treatment resistance, which has reduced the effectiveness of traditional radiation and chemotherapy, this paradigm change is of utmost importance. Graphene oxide (GO) is one of several nanoparticles made of carbon that has made a splash in the medical field. It offers potential new ways to treat cancer thanks...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Sankha Bhattacharya Sateesh Belemkar Bhupendra Prajapati Source Type: research

Anticancer Potential of ACEIs/ARBs Administration in Colorectal Cancer
CONCLUSION: This review suggests that using ACEIs/ARBs medicine could help people with CC live longer and lower their chances of dying. These results highlight the potential benefits of utilizing ACE inhibitors in the management of CC, warranting further investigation and consideration in clinical practice.PMID:38549531 | DOI:10.2174/0109298673249782231226101119 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Xin Wang Haiyun Jing Source Type: research

Research and Development Progression of Oridonin for Hematological Malignancies Therapy
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673273034231215190811. Online ahead of print.ABSTRACTOridonin is a tetracyclic diterpenoid compound extracted from the medicinal herb Isodon and related species. Since 1976, studies have reported the significant anti-tumor activity of oridonin in vivo. Recently, an increasing number of studies have confirmed the anti-tumor effects of oridonin in various types of cancers, and its effect on hematological malignancies stands out. Herein, we have systematically reviewed the anti-- tumor effects of oridonin and its specific mechanisms in hematological malignancies, including the r...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hui Feng Runyu Yang Yue Du Yi Liu Fan Niu Source Type: research

Recent Advances in Signaling Pathways and Kinase Inhibitors for Leukemia Chemotherapy
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673267738231129104216. Online ahead of print.ABSTRACTLeukemia is a malignant clonal disease of hematopoietic stem cells, which accounts for about 3% of the total incidence of tumors and is particularly prevalent among children and adolescents. It mainly includes four types of leukemia, namely ALL, AML, CLL, and CML, which are often aggressive and challenging diseases to treat. Several signaling pathways are dysregulated in almost all types of leukemia, such as JAK, PI3K, and MAPK, and others are dysregulated in specific types of leukemia, like Wnt/β-catenin, Hedgehog, FLT3, ...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Yuying Liu Zeyu Yang Qingqing Zhang Ping Hai Yongbiao Zheng Jie Zhang Xiaoyan Pan Source Type: research

LncRNA XIST: A Breakthrough in Inflammation-related Diseases
CONCLUSION: In this paper, we summarize the mechanism of action of XIST in different types of inflammation-related diseases and propose new protocols for the future clinical treatment of these diseases.PMID:38549534 | DOI:10.2174/0109298673270188231122065649 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hailin Wang Lijun Wang Yiyang Luo Yibei Gui Wei Wu Jiale Zhao Xueqing Li Ruisi Xiong Yumin He Ding Yuan Chengfu Yuan Source Type: research

Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673270372231130071320. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS ...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alicia Beatriz Motta Source Type: research

The Protective Effects of Curcumin against Renal Toxicity
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673271161231121061148. Online ahead of print.ABSTRACTCurcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustr...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Jianan Zhai Zhengguo Chen Qi Zhu Zhifang Guo Ningning Wang Cong Zhang Haoyuan Deng Shaopeng Wang Guang Yang Source Type: research