Nature's Elixir for Cancer Treatment: Targeting Tumor-induced Neovascularization
Curr Med Chem. 2024 Feb 29. doi: 10.2174/0109298673282525240222050051. Online ahead of print.ABSTRACTAngiogenesis, a multistep process, involves sprouting of new vessels from the pre-existing vessels in response to a stimulus in its microenvironment. Normally, angiogenesis is important for tissue maintenance and homeostasis, however it is also known to be associated with various pathologies, including cancer. Importantly, neovascularization is very crucial for tumors to grow and metastasize since it allows delivery of oxygen and nutrients as well as promotes tumor cell dissemination to distant sites. Activation of angiogen...
Source: Current Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Rani Kumari Saima Syeda Anju Shrivastava Source Type: research
Ranunculin, Protoanemonin, and Anemonin: Pharmacological and Chemical Perspectives
Curr Med Chem. 2024 Feb 28. doi: 10.2174/0109298673294080240221115830. Online ahead of print.ABSTRACTRanunculin, a glucoside, serves as a chemotaxonomic marker in Ranunculaceae plants. When these plants are damaged, an enzyme β-glucosidase triggers the conversion of ranunculin into protoanemonin through hydrolysis. Subsequently, protoanemonin undergoes cyclodimerization to form anemonin. The inherent instability of ranunculin and the rapid dimerization of protoanemonin render them unsuitable for use in biological assays. Conversely, anemonin stands out as the optimal molecule for bioassays and demonstrates diverse biologi...
Source: Current Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Betelhem Sirak Misgana Aragaw Solomon Tadesse Source Type: research
Nature's Elixir for Cancer Treatment: Targeting Tumor-induced Neovascularization
Curr Med Chem. 2024 Feb 29. doi: 10.2174/0109298673282525240222050051. Online ahead of print.ABSTRACTAngiogenesis, a multistep process, involves sprouting of new vessels from the pre-existing vessels in response to a stimulus in its microenvironment. Normally, angiogenesis is important for tissue maintenance and homeostasis, however it is also known to be associated with various pathologies, including cancer. Importantly, neovascularization is very crucial for tumors to grow and metastasize since it allows delivery of oxygen and nutrients as well as promotes tumor cell dissemination to distant sites. Activation of angiogen...
Source: Current Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Rani Kumari Saima Syeda Anju Shrivastava Source Type: research
Ranunculin, Protoanemonin, and Anemonin: Pharmacological and Chemical Perspectives
Curr Med Chem. 2024 Feb 28. doi: 10.2174/0109298673294080240221115830. Online ahead of print.ABSTRACTRanunculin, a glucoside, serves as a chemotaxonomic marker in Ranunculaceae plants. When these plants are damaged, an enzyme β-glucosidase triggers the conversion of ranunculin into protoanemonin through hydrolysis. Subsequently, protoanemonin undergoes cyclodimerization to form anemonin. The inherent instability of ranunculin and the rapid dimerization of protoanemonin render them unsuitable for use in biological assays. Conversely, anemonin stands out as the optimal molecule for bioassays and demonstrates diverse biologi...
Source: Current Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Betelhem Sirak Misgana Aragaw Solomon Tadesse Source Type: research
Nature's Elixir for Cancer Treatment: Targeting Tumor-induced Neovascularization
Curr Med Chem. 2024 Feb 29. doi: 10.2174/0109298673282525240222050051. Online ahead of print.ABSTRACTAngiogenesis, a multistep process, involves sprouting of new vessels from the pre-existing vessels in response to a stimulus in its microenvironment. Normally, angiogenesis is important for tissue maintenance and homeostasis, however it is also known to be associated with various pathologies, including cancer. Importantly, neovascularization is very crucial for tumors to grow and metastasize since it allows delivery of oxygen and nutrients as well as promotes tumor cell dissemination to distant sites. Activation of angiogen...
Source: Current Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Rani Kumari Saima Syeda Anju Shrivastava Source Type: research
Ranunculin, Protoanemonin, and Anemonin: Pharmacological and Chemical Perspectives
Curr Med Chem. 2024 Feb 28. doi: 10.2174/0109298673294080240221115830. Online ahead of print.ABSTRACTRanunculin, a glucoside, serves as a chemotaxonomic marker in Ranunculaceae plants. When these plants are damaged, an enzyme β-glucosidase triggers the conversion of ranunculin into protoanemonin through hydrolysis. Subsequently, protoanemonin undergoes cyclodimerization to form anemonin. The inherent instability of ranunculin and the rapid dimerization of protoanemonin render them unsuitable for use in biological assays. Conversely, anemonin stands out as the optimal molecule for bioassays and demonstrates diverse biologi...
Source: Current Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Betelhem Sirak Misgana Aragaw Solomon Tadesse Source Type: research
Nature's Elixir for Cancer Treatment: Targeting Tumor-induced Neovascularization
Curr Med Chem. 2024 Feb 29. doi: 10.2174/0109298673282525240222050051. Online ahead of print.ABSTRACTAngiogenesis, a multistep process, involves sprouting of new vessels from the pre-existing vessels in response to a stimulus in its microenvironment. Normally, angiogenesis is important for tissue maintenance and homeostasis, however it is also known to be associated with various pathologies, including cancer. Importantly, neovascularization is very crucial for tumors to grow and metastasize since it allows delivery of oxygen and nutrients as well as promotes tumor cell dissemination to distant sites. Activation of angiogen...
Source: Current Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Rani Kumari Saima Syeda Anju Shrivastava Source Type: research
Clinical Outcomes and Effectiveness of CRLX101 for Solid Tumors: A Systematic Review and Meta-analysis
CONCLUSION: Our meta-analysis shows that CRLX101 outperforms camptothecin in PFS despite its inferior OS. Unresolved pharmacology limits carrier-mediated drug therapeutic application. Carrier-mediated dosages may differ from normal formulations because they are rarely studied.PMID:38415437 | DOI:10.2174/0109298673263933231206101556 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Nahal Shamaeizadeh Erfan Sadeghi Jaleh Varshosaz Source Type: research
Discussion on the Influence of Gpx 4 Target in the Field of Cancer
This article summarizes all papers related to Gpx4; hope this review can provide some new insights and ideas for researchers aiming to develop efficient and low-- toxicity Gpx4 inhibitors and provide some new ideas for cancer treatment.PMID:38415438 | DOI:10.2174/0109298673288408240212051401 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Ya-Lan Wang Hong-Yan Guo Tong Zhou Ke Sun Qing-Kun Shen Xiao-Ting Li Source Type: research
Rituximab Combined with Steroid and Tacrolimus Treats Proliferative Glomerulonephritis with Monoclonal IgG Deposits: A Case Report and Review of the Literature
CONCLUSION: However, a larger pool of patients and a longer follow-up period are required to establish the role of rituximab and steroids in the treatment of PGNMID.PMID:38415439 | DOI:10.2174/0109298673272183240108093135 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Di Liu Ming Xia Chang Wang Xuejing Zhu Guochun Chen Hong Liu Source Type: research
Iron-related Biomarkers in the Diagnosis and Management of Iron Disorders
CONCLUSION: Using iron-related biomarkers in screening and monitoring programs can improve patient outcomes and reduce healthcare costs.PMID:38415440 | DOI:10.2174/0109298673263003231228060800 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Yuliya Semenova Geir Bj ørklund Monica Butnariu Massimiliano Peana Source Type: research
Advanced Targeted Drug Delivery of Bioactive Agents Fortified with Graft Chitosan in Management of Cancer: A Review
Curr Med Chem. 2024 Feb 19. doi: 10.2174/0109298673285334240112104709. Online ahead of print.ABSTRACTCancer is characterized by the uncontrolled proliferation and spread of abnormal cells in the body, resulting in the development of tumors or clusters of irregular cells. The factors contributing to cancer are intricate, involving a combination of genetic, environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine, excessive alcohol consumption, exposure to radiation or specific chemicals, and a family history of the disease. Common treatment methods for cancer encompass surgery, radiation th...
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Rukaiah Begum Sudarshan Singh Bhupendra Prajapati M Sumithra Ravish J Patel Source Type: research
Evidence for the Involvement of Gene Regulation of Inflammatory Molecules in the Accumulation of Intracellular Cholesterol: The Mechanism of Foam Cell Formation in Atherosclerosis
CONCLUSION: Thus, it was discovered that 5 inflammation-related master regulators may be involved in lipid accumulation in macrophages. Therefore, the pro-inflammatory response of macrophages may trigger foam cell formation rather than the other way around, where intracellular lipid accumulation causes an inflammatory response, as previously assumed.PMID:38415442 | DOI:10.2174/0109298673286400240206095814 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Vasily N Sukhorukov Victoria A Khotina Daria D Borodko Mariam Bagheri Ekta Yumiko Oishi Andrey V Omelchenko Kira I Kolmychkova Nikita G Nikiforov Igor A Sobenin Alexander N Orekhov Source Type: research
Analysis and Validation of Tyrosine Metabolism-related Prognostic Features for Liver Hepatocellular Carcinoma Therapy
CONCLUSION: Our study developed a tyrosine metabolism-related risk model that performed well in survival prediction, showing the potential to serve as an independent prognostic predictor for LIHC treatment.PMID:38415454 | DOI:10.2174/0109298673290101240223074545 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Zhongfeng Cui Chunli Liu Hongzhi Li Juan Wang Guangming Li Source Type: research
WSCD2 Expression: Its Relevance to Tumor-Infiltrating Immune Cells and Glioma Prognosis
CONCLUSION: This study highlights the correlation between WSCD2 expression and TILs and demonstrates the prognostic significance of WSCD2 in glioma. Furthermore, our results suggest that WSCD2 may be a potential immunotherapy target in glioma.PMID:38415455 | DOI:10.2174/0109298673282921240220101914 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Kaderya Abudusalam Yan Xu Pazilat Keyumu Tong Cheng Manyu Xu Bing Lu Pingping Sun Kadierjiang Musha Jianfei Huang Source Type: research
