The Link between miRNAs and PCKS9 in Atherosclerosis
Curr Med Chem. 2023 Nov 16. doi: 10.2174/0109298673262124231102042914. Online ahead of print.ABSTRACTCardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden...
Source: Current Medicinal Chemistry - November 22, 2023 Category: Chemistry Authors: Mirjana Macvanin Zoran Gluvic Aleksandra Klisic Mia Manojlovic Jasjit Suri Manfredi Rizzo Esma Isenovic Source Type: research

The Link between miRNAs and PCKS9 in Atherosclerosis
Curr Med Chem. 2023 Nov 16. doi: 10.2174/0109298673262124231102042914. Online ahead of print.ABSTRACTCardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden...
Source: Current Medicinal Chemistry - November 22, 2023 Category: Chemistry Authors: Mirjana Macvanin Zoran Gluvic Aleksandra Klisic Mia Manojlovic Jasjit Suri Manfredi Rizzo Esma Isenovic Source Type: research

Developing a RiskS-core Model based on Angiogenesis-related lncRNAs for Colon Adenocarcinoma Prognostic Prediction
CONCLUSION: We constructed a RiskS-core model based on angiogenesis-related lncRNAs, which could serve as potential prognostic predictors for COAD patients and may offer clues for the intervention of anti-angiogenic application. Our results may help evaluate the prognosis of COAD and provide better treatment strategies.PMID:37961859 | DOI:10.2174/0109298673277243231108071620 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xianguo Li Junping Lei Yongping Shi Zuojie Peng Minmin Gong Xiaogang Shu Source Type: research

Developing a RiskS-core Model based on Angiogenesis-related lncRNAs for Colon Adenocarcinoma Prognostic Prediction
CONCLUSION: We constructed a RiskS-core model based on angiogenesis-related lncRNAs, which could serve as potential prognostic predictors for COAD patients and may offer clues for the intervention of anti-angiogenic application. Our results may help evaluate the prognosis of COAD and provide better treatment strategies.PMID:37961859 | DOI:10.2174/0109298673277243231108071620 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xianguo Li Junping Lei Yongping Shi Zuojie Peng Minmin Gong Xiaogang Shu Source Type: research

Developing a RiskS-core Model based on Angiogenesis-related lncRNAs for Colon Adenocarcinoma Prognostic Prediction
CONCLUSION: We constructed a RiskS-core model based on angiogenesis-related lncRNAs, which could serve as potential prognostic predictors for COAD patients and may offer clues for the intervention of anti-angiogenic application. Our results may help evaluate the prognosis of COAD and provide better treatment strategies.PMID:37961859 | DOI:10.2174/0109298673277243231108071620 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xianguo Li Junping Lei Yongping Shi Zuojie Peng Minmin Gong Xiaogang Shu Source Type: research

Developing a RiskS-core Model based on Angiogenesis-related lncRNAs for Colon Adenocarcinoma Prognostic Prediction
CONCLUSION: We constructed a RiskS-core model based on angiogenesis-related lncRNAs, which could serve as potential prognostic predictors for COAD patients and may offer clues for the intervention of anti-angiogenic application. Our results may help evaluate the prognosis of COAD and provide better treatment strategies.PMID:37961859 | DOI:10.2174/0109298673277243231108071620 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xianguo Li Junping Lei Yongping Shi Zuojie Peng Minmin Gong Xiaogang Shu Source Type: research

Developing a RiskS-core Model based on Angiogenesis-related lncRNAs for Colon Adenocarcinoma Prognostic Prediction
CONCLUSION: We constructed a RiskS-core model based on angiogenesis-related lncRNAs, which could serve as potential prognostic predictors for COAD patients and may offer clues for the intervention of anti-angiogenic application. Our results may help evaluate the prognosis of COAD and provide better treatment strategies.PMID:37961859 | DOI:10.2174/0109298673277243231108071620 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xianguo Li Junping Lei Yongping Shi Zuojie Peng Minmin Gong Xiaogang Shu Source Type: research

Perineuronal Nets: From Structure to Neurological Disorders
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673258290231009111633. Online ahead of print.ABSTRACTPerineuronal nets (PNN) is condensed extracellular matrix (ECM) in the central nervous system (CNS), which surrounds cell soma, axon initial segments, and synapses. In the brain, most neurons surrounded by PNN are interneurons, especially the parvalbumin-expressing interneurons (PVI). The formation of PNN is involved in the PVI maturation as well as the onset and closure of critical periods for developmental plasticity end. Dysfunction of PVI can lead to some neurological disorders, such as schizophrenia, bipolar depression,...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Xianghe Li Nuojin Li Pingping Zhao Dongyan Ren Bin Luo Tian Zhou Source Type: research

Drug Repurposing: Insights into Current Advances and Future Applications
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673266470231023110841. Online ahead of print.ABSTRACTDrug development is a complex and expensive process that involves extensive research and testing before a new drug can be approved for use. This has led to a limited availability of potential therapeutics for many diseases. Despite significant advances in biomedical science, the process of drug development remains a bottleneck, as all hypotheses must be tested through experiments and observations, which can be time-- consuming and costly. To address this challenge, drug repurposing has emerged as an innovative strategy for f...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Trisha Bhatia Shweta Sharma Source Type: research

Perineuronal Nets: From Structure to Neurological Disorders
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673258290231009111633. Online ahead of print.ABSTRACTPerineuronal nets (PNN) is condensed extracellular matrix (ECM) in the central nervous system (CNS), which surrounds cell soma, axon initial segments, and synapses. In the brain, most neurons surrounded by PNN are interneurons, especially the parvalbumin-expressing interneurons (PVI). The formation of PNN is involved in the PVI maturation as well as the onset and closure of critical periods for developmental plasticity end. Dysfunction of PVI can lead to some neurological disorders, such as schizophrenia, bipolar depression,...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Xianghe Li Nuojin Li Pingping Zhao Dongyan Ren Bin Luo Tian Zhou Source Type: research

Drug Repurposing: Insights into Current Advances and Future Applications
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673266470231023110841. Online ahead of print.ABSTRACTDrug development is a complex and expensive process that involves extensive research and testing before a new drug can be approved for use. This has led to a limited availability of potential therapeutics for many diseases. Despite significant advances in biomedical science, the process of drug development remains a bottleneck, as all hypotheses must be tested through experiments and observations, which can be time-- consuming and costly. To address this challenge, drug repurposing has emerged as an innovative strategy for f...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Trisha Bhatia Shweta Sharma Source Type: research

Perineuronal Nets: From Structure to Neurological Disorders
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673258290231009111633. Online ahead of print.ABSTRACTPerineuronal nets (PNN) is condensed extracellular matrix (ECM) in the central nervous system (CNS), which surrounds cell soma, axon initial segments, and synapses. In the brain, most neurons surrounded by PNN are interneurons, especially the parvalbumin-expressing interneurons (PVI). The formation of PNN is involved in the PVI maturation as well as the onset and closure of critical periods for developmental plasticity end. Dysfunction of PVI can lead to some neurological disorders, such as schizophrenia, bipolar depression,...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Xianghe Li Nuojin Li Pingping Zhao Dongyan Ren Bin Luo Tian Zhou Source Type: research

Drug Repurposing: Insights into Current Advances and Future Applications
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673266470231023110841. Online ahead of print.ABSTRACTDrug development is a complex and expensive process that involves extensive research and testing before a new drug can be approved for use. This has led to a limited availability of potential therapeutics for many diseases. Despite significant advances in biomedical science, the process of drug development remains a bottleneck, as all hypotheses must be tested through experiments and observations, which can be time-- consuming and costly. To address this challenge, drug repurposing has emerged as an innovative strategy for f...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Trisha Bhatia Shweta Sharma Source Type: research

Perineuronal Nets: From Structure to Neurological Disorders
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673258290231009111633. Online ahead of print.ABSTRACTPerineuronal nets (PNN) is condensed extracellular matrix (ECM) in the central nervous system (CNS), which surrounds cell soma, axon initial segments, and synapses. In the brain, most neurons surrounded by PNN are interneurons, especially the parvalbumin-expressing interneurons (PVI). The formation of PNN is involved in the PVI maturation as well as the onset and closure of critical periods for developmental plasticity end. Dysfunction of PVI can lead to some neurological disorders, such as schizophrenia, bipolar depression,...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Xianghe Li Nuojin Li Pingping Zhao Dongyan Ren Bin Luo Tian Zhou Source Type: research

Drug Repurposing: Insights into Current Advances and Future Applications
Curr Med Chem. 2023 Nov 8. doi: 10.2174/0109298673266470231023110841. Online ahead of print.ABSTRACTDrug development is a complex and expensive process that involves extensive research and testing before a new drug can be approved for use. This has led to a limited availability of potential therapeutics for many diseases. Despite significant advances in biomedical science, the process of drug development remains a bottleneck, as all hypotheses must be tested through experiments and observations, which can be time-- consuming and costly. To address this challenge, drug repurposing has emerged as an innovative strategy for f...
Source: Current Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: Trisha Bhatia Shweta Sharma Source Type: research