Discovery of Novel Inhibitors of Cruzain Cysteine Protease of Trypanosoma cruz
Curr Med Chem. 2023 Oct 6. doi: 10.2174/0109298673254864230921090519. Online ahead of print.ABSTRACTChagas disease (CD) is a parasitic disease endemic in several developing countries. According to the World Health Organization, approximately 6-8 million people worldwide are inflicted by CD. The scarcity of new drugs, mainly for the chronic phase, is the main reason for treatment limitation in CD. Therefore, there is an urgent need to discover new targets for which new therapeutical agents could be developed. Cruzain cysteine protease (CCP) is a promising alternative because this enzyme exhibits pleiotropic effects by actin...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Jo ão Lucas Bruno Prates Juliana Romano Lopes Chung Man Chin Elizabeth Igne Ferreira Jean Leandro Dos Santos Cau ê Benito Scarim Source Type: research

Advances in the Treatment of Autism Spectrum Disorder: Current and Promising Strategies
Curr Med Chem. 2023 Oct 5. doi: 10.2174/0109298673252910230920151332. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is an umbrella term for developmental disorders characterized by social and communication impairments, language difficulties, restricted interests, and repetitive behaviors. Current management approaches for ASD aim to resolve its clinical manifestations based on the type and severity of the disability. Although some medications like risperidone show potential in regulating ASD-associated symptoms, a comprehensive treatment strategy for ASD is yet to be discovered. To date, identifying appropri...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Konstantin Yenkoyan Zadik Ounanian Margarita Mirumyan Liana Hayrapetyan Naira Zakaryan Raisa Sahakyan Geir Bj ørklund Source Type: research

An Investigation of Pharmacokinetic Interaction of Vericiguat with Apigenin based on a Newly Developed Ultra-performance Liquid Chromatography-tandem Mass Spectrometry Assay
CONCLUSION: These results would help us to further understand the pharmacokinetic properties of vericiguat when co-administration with apigenin, and to avoid unexpected clinical risks in the future.PMID:37888816 | DOI:10.2174/0109298673258387230921090445 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: En Zhang Chaojie Chen Yu Wang Qinghua Weng Ren-Ai Xu Jingjing Lin Source Type: research

Current Computational Methods for Protein-Peptide Complex Structure Prediction
Curr Med Chem. 2023 Oct 6. doi: 10.2174/0109298673263447230920151524. Online ahead of print.ABSTRACTPeptide-mediated protein-protein interactions (PPIs) play an important role in various biological processes. The development of peptide-based drugs to modulate PPIs has attracted increasing attention due to the advantages of high specificity and low toxicity. In the development of peptide-based drugs, one of the most important steps is to determine the interaction details between the peptide and the target protein. In addition to experimental methods, recently developed computational methods provide a cost-effective way for ...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Chao Yang Xianjin Xu Changcheng Xiang Source Type: research

Marine Fungi: A Prosperous Source of Novel Bioactive Natural Products
Curr Med Chem. 2023 Oct 25. doi: 10.2174/0109298673266304231015070956. Online ahead of print.ABSTRACTAs the number of viruses, bacteria, and tumors that are resistant to drugs continues to rise, there is a growing need for novel lead compounds to treat them. Marine fungi, due to their unique secondary metabolic pathways and vast biodiversity, have become a crucial source for lead compounds in drug development. This review utilizes bibliometric methods to analyze the research status of natural products from marine fungi in the past decade, revealing the hotspots and trends in this field from Web of Science database. Further...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Rong Ji Xiangru Zha Songlin Zhou Source Type: research

Discovery of Novel Inhibitors of Cruzain Cysteine Protease of Trypanosoma cruz
Curr Med Chem. 2023 Oct 6. doi: 10.2174/0109298673254864230921090519. Online ahead of print.ABSTRACTChagas disease (CD) is a parasitic disease endemic in several developing countries. According to the World Health Organization, approximately 6-8 million people worldwide are inflicted by CD. The scarcity of new drugs, mainly for the chronic phase, is the main reason for treatment limitation in CD. Therefore, there is an urgent need to discover new targets for which new therapeutical agents could be developed. Cruzain cysteine protease (CCP) is a promising alternative because this enzyme exhibits pleiotropic effects by actin...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Jo ão Lucas Bruno Prates Juliana Romano Lopes Chung Man Chin Elizabeth Igne Ferreira Jean Leandro Dos Santos Cau ê Benito Scarim Source Type: research

Advances in the Treatment of Autism Spectrum Disorder: Current and Promising Strategies
Curr Med Chem. 2023 Oct 5. doi: 10.2174/0109298673252910230920151332. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is an umbrella term for developmental disorders characterized by social and communication impairments, language difficulties, restricted interests, and repetitive behaviors. Current management approaches for ASD aim to resolve its clinical manifestations based on the type and severity of the disability. Although some medications like risperidone show potential in regulating ASD-associated symptoms, a comprehensive treatment strategy for ASD is yet to be discovered. To date, identifying appropri...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Konstantin Yenkoyan Zadik Ounanian Margarita Mirumyan Liana Hayrapetyan Naira Zakaryan Raisa Sahakyan Geir Bj ørklund Source Type: research

An Investigation of Pharmacokinetic Interaction of Vericiguat with Apigenin based on a Newly Developed Ultra-performance Liquid Chromatography-tandem Mass Spectrometry Assay
CONCLUSION: These results would help us to further understand the pharmacokinetic properties of vericiguat when co-administration with apigenin, and to avoid unexpected clinical risks in the future.PMID:37888816 | DOI:10.2174/0109298673258387230921090445 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: En Zhang Chaojie Chen Yu Wang Qinghua Weng Ren-Ai Xu Jingjing Lin Source Type: research

Current Computational Methods for Protein-Peptide Complex Structure Prediction
Curr Med Chem. 2023 Oct 6. doi: 10.2174/0109298673263447230920151524. Online ahead of print.ABSTRACTPeptide-mediated protein-protein interactions (PPIs) play an important role in various biological processes. The development of peptide-based drugs to modulate PPIs has attracted increasing attention due to the advantages of high specificity and low toxicity. In the development of peptide-based drugs, one of the most important steps is to determine the interaction details between the peptide and the target protein. In addition to experimental methods, recently developed computational methods provide a cost-effective way for ...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Chao Yang Xianjin Xu Changcheng Xiang Source Type: research

Marine Fungi: A Prosperous Source of Novel Bioactive Natural Products
Curr Med Chem. 2023 Oct 25. doi: 10.2174/0109298673266304231015070956. Online ahead of print.ABSTRACTAs the number of viruses, bacteria, and tumors that are resistant to drugs continues to rise, there is a growing need for novel lead compounds to treat them. Marine fungi, due to their unique secondary metabolic pathways and vast biodiversity, have become a crucial source for lead compounds in drug development. This review utilizes bibliometric methods to analyze the research status of natural products from marine fungi in the past decade, revealing the hotspots and trends in this field from Web of Science database. Further...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Rong Ji Xiangru Zha Songlin Zhou Source Type: research

Discovery of Novel Inhibitors of Cruzain Cysteine Protease of Trypanosoma cruz
Curr Med Chem. 2023 Oct 6. doi: 10.2174/0109298673254864230921090519. Online ahead of print.ABSTRACTChagas disease (CD) is a parasitic disease endemic in several developing countries. According to the World Health Organization, approximately 6-8 million people worldwide are inflicted by CD. The scarcity of new drugs, mainly for the chronic phase, is the main reason for treatment limitation in CD. Therefore, there is an urgent need to discover new targets for which new therapeutical agents could be developed. Cruzain cysteine protease (CCP) is a promising alternative because this enzyme exhibits pleiotropic effects by actin...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Jo ão Lucas Bruno Prates Juliana Romano Lopes Chung Man Chin Elizabeth Igne Ferreira Jean Leandro Dos Santos Cau ê Benito Scarim Source Type: research

Advances in the Treatment of Autism Spectrum Disorder: Current and Promising Strategies
Curr Med Chem. 2023 Oct 5. doi: 10.2174/0109298673252910230920151332. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is an umbrella term for developmental disorders characterized by social and communication impairments, language difficulties, restricted interests, and repetitive behaviors. Current management approaches for ASD aim to resolve its clinical manifestations based on the type and severity of the disability. Although some medications like risperidone show potential in regulating ASD-associated symptoms, a comprehensive treatment strategy for ASD is yet to be discovered. To date, identifying appropri...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Konstantin Yenkoyan Zadik Ounanian Margarita Mirumyan Liana Hayrapetyan Naira Zakaryan Raisa Sahakyan Geir Bj ørklund Source Type: research

An Investigation of Pharmacokinetic Interaction of Vericiguat with Apigenin based on a Newly Developed Ultra-performance Liquid Chromatography-tandem Mass Spectrometry Assay
CONCLUSION: These results would help us to further understand the pharmacokinetic properties of vericiguat when co-administration with apigenin, and to avoid unexpected clinical risks in the future.PMID:37888816 | DOI:10.2174/0109298673258387230921090445 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: En Zhang Chaojie Chen Yu Wang Qinghua Weng Ren-Ai Xu Jingjing Lin Source Type: research

Current Computational Methods for Protein-Peptide Complex Structure Prediction
Curr Med Chem. 2023 Oct 6. doi: 10.2174/0109298673263447230920151524. Online ahead of print.ABSTRACTPeptide-mediated protein-protein interactions (PPIs) play an important role in various biological processes. The development of peptide-based drugs to modulate PPIs has attracted increasing attention due to the advantages of high specificity and low toxicity. In the development of peptide-based drugs, one of the most important steps is to determine the interaction details between the peptide and the target protein. In addition to experimental methods, recently developed computational methods provide a cost-effective way for ...
Source: Current Medicinal Chemistry - October 27, 2023 Category: Chemistry Authors: Chao Yang Xianjin Xu Changcheng Xiang Source Type: research

A Structure-based Data Set of Protein-Peptide Affinities and its Nonredundant Benchmark: Potential Applications in Computational Peptidology
CONCLUSION: The PpI[S/A]DS set and PpI[S/A]BM benchmark can be considered a valuable data source in the computational peptidology community, aiming to relate the affinity to structure for PpIs.PMID:37881092 | DOI:10.2174/0929867331666230908102925 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 26, 2023 Category: Chemistry Authors: Shaozhou Wang Haiyang Ye Shuyong Shang Zilong Li Yue Peng Peng Zhou Source Type: research