Inflammation and Stem Cell Stochasticity of HPV-induced Cervical Cancer: Epigenetics Based Biomarkers through Microbiome and Metabolome for Personalized Medicine: A Systematic Review
CONCLUSION: The review significantly described the correlation between microbial inflammation and stem cell stochasticity of HPV-Induced cervical cancer and the expression of epigenetics- based biomarkers through microbiome and metabolome to foster the cervical cancer progression. These are major risk factors that can cause cervical dysplasia with substantial therapy resistance in cervical cancer patients. The qualitative and quantitative examination of the spatial transcriptomic expression of these stemness markers in the dividing cervical cancer stem cells has significant implications in the clinical sector to develop ea...
Source: Current Medicinal Chemistry - November 29, 2023 Category: Chemistry Authors: Yufei Zheng Junqi Liu Narasimha M Beeraka Prasath Manogaran Hemanth Vikram P R Lakshmi Durga Yn Shaik Mohammed Suhail Bhupalam Pradeepkumar Mikhail Y Sinelnikov M V Greeshma Mahesh P A Namratha Mp Gurupadayya Bannimath Jie Zhao Ruitai Fan Source Type: research

Recent Updates on the Efficacy of Mitocans in Photo/Radio-Therapy for Targeting Metabolism in Chemo/Radio-Resistant Cancers: Nanotherapeutics
Curr Med Chem. 2023 Nov 24. doi: 10.2174/0109298673259347231019121757. Online ahead of print.ABSTRACTConventional therapeutic modalities against the cancers such as surgery, chemotherapy (CT) and radiotherapy (RT) have limited efficacy due to drug resistance, and adverse effects. Recent developments in nanoscience emphasized novel approaches to overcome the aforementioned limitations and subsequently improve overall clinical outcomes in cancer patients. Photodynamic therapy (PDT), photothermal therapy (PTT), and radiodynamic therapy (RDT) can be used as cancer treatments due to their high selectivity, low drug resistance, ...
Source: Current Medicinal Chemistry - November 29, 2023 Category: Chemistry Authors: Xiaoyan Wang Junqi Liu Lakshmi Durga Yn Narasimha M Beeraka Runze Zhou Pengwei Lu Ruixia Song Mikhail Sinelnikov Kuo Chen Ruitai Fan Di Zhao Source Type: research

Quercetin and microRNA Interplay in Apoptosis Regulation: A New Therapeutic Strategy for Cancer?
Curr Med Chem. 2023 Nov 24. doi: 10.2174/0109298673259466231031050437. Online ahead of print.ABSTRACTCancer is known as a global problem for the health and economy. Following cancer onset, apoptosis is the primary mechanism countering the tumor cells' growth. Most anticancer agents initiate apoptosis to remove tumor cells. Phytochemicals have appeared as a beneficial treatment option according to their less adverse effects. In recent decades, quercetin has been highlighted due to its high pharmacological benefits, and various literature has suggested it as a potential anti-proliferative agent against different kinds of can...
Source: Current Medicinal Chemistry - November 29, 2023 Category: Chemistry Authors: Zicheng Wang Yanqing Liu Zatollah Asemi Source Type: research

Structure and Function of the SARS-CoV-2 6-HB Fusion Core and Peptide-Based Fusion Inhibitors: A Review
Curr Med Chem. 2023 Nov 24. doi: 10.2174/0109298673265694231113061842. Online ahead of print.ABSTRACTSARS-CoV-2 has swept the world in recent years, triggering a global COVID-19 with a tremendous impact on human health and public safety. Similar to other coronaviruses, the six-helix bundle(6-HB) is not only a core structure driving the fusion of the SARS-CoV-2 envelope with the host cell membrane, but also the target of fusion inhibitors. The sequences from the HR1 or HR2 regions composing 6-HB are thus the original primary structures for the development of peptide-based fusion inhibitors. This review summarized the struct...
Source: Current Medicinal Chemistry - November 29, 2023 Category: Chemistry Authors: Guodong Liang Yue Li Ruijuan Li Yuheng Ma Heiya Na Source Type: research

Unlocking the Benefits of Fasting: A Review of Its Impact on Various Biological Systems and Human Health
Curr Med Chem. 2023 Nov 24. doi: 10.2174/0109298673275492231121062033. Online ahead of print.ABSTRACTFasting has gained significant attention in recent years for its potential health benefits in various body systems. This review aims to comprehensively examine the effects of fasting on human health, specifically focusing on its impact on different body's physiological systems. The cardiovascular system plays a vital role in maintaining overall health, and fasting has shown promising effects in improving cardiovascular health markers such as blood pressure, cholesterol levels, and triglyceride levels. Additionally, fasting ...
Source: Current Medicinal Chemistry - November 29, 2023 Category: Chemistry Authors: Rawan Mackieh Nadia Al-Bakkar Milena Kfoury Nathalie Okdeh Herv é Pietra Rabih Roufayel Christian Legros Ziad Fajloun Jean-Marc Sabatier Source Type: research

Recent Progress on Natural α-glucosidase Inhibitors Derived from the Plants and Microorganisms
Curr Med Chem. 2023 Nov 27. doi: 10.2174/0109298673272908231115101520. Online ahead of print.ABSTRACTα-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase inhibitors are mostly discovered from plants and microorganisms, the recent advance in natural αglucosidase inhibitors over the past five years has been reviewed in this article, and 139 distinct α-glucosidase inhibitors from the plants and microorganisms were classified into ten...
Source: Current Medicinal Chemistry - November 28, 2023 Category: Chemistry Authors: Changxuan Deng Nan Zhang Hanlin Lin Wangting Lu Fei Ding Yangguang Gao Yongmin Zhang Source Type: research

SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections
CONCLUSION: These compounds could serve as scaffolds for further lead-structure optimization for desirable potency, a larger margin of safety, and better oral activity.PMID:38013440 | DOI:10.2174/0109298673271674231109052709 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 28, 2023 Category: Chemistry Authors: Mohammad A Khanfar Mohammad I Saleh Source Type: research

Recent Progress on Natural α-glucosidase Inhibitors Derived from the Plants and Microorganisms
Curr Med Chem. 2023 Nov 27. doi: 10.2174/0109298673272908231115101520. Online ahead of print.ABSTRACTα-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase inhibitors are mostly discovered from plants and microorganisms, the recent advance in natural αglucosidase inhibitors over the past five years has been reviewed in this article, and 139 distinct α-glucosidase inhibitors from the plants and microorganisms were classified into ten...
Source: Current Medicinal Chemistry - November 28, 2023 Category: Chemistry Authors: Changxuan Deng Nan Zhang Hanlin Lin Wangting Lu Fei Ding Yangguang Gao Yongmin Zhang Source Type: research

SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections
CONCLUSION: These compounds could serve as scaffolds for further lead-structure optimization for desirable potency, a larger margin of safety, and better oral activity.PMID:38013440 | DOI:10.2174/0109298673271674231109052709 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 28, 2023 Category: Chemistry Authors: Mohammad A Khanfar Mohammad I Saleh Source Type: research

Multimodality Cardiac Imaging Biomarkers and Atrial Fibrillation Substrate: Are they Worthwhile?
Curr Med Chem. 2023 Nov 24. doi: 10.2174/0109298673265318231113095757. Online ahead of print.NO ABSTRACTPMID:38008948 | DOI:10.2174/0109298673265318231113095757 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 27, 2023 Category: Chemistry Authors: Emmanuel Androulakis Syed Ahsan Nikolaos Papageorgiou Source Type: research

The Link between miRNAs and PCKS9 in Atherosclerosis
Curr Med Chem. 2023 Nov 16. doi: 10.2174/0109298673262124231102042914. Online ahead of print.ABSTRACTCardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden...
Source: Current Medicinal Chemistry - November 22, 2023 Category: Chemistry Authors: Mirjana Macvanin Zoran Gluvic Aleksandra Klisic Mia Manojlovic Jasjit Suri Manfredi Rizzo Esma Isenovic Source Type: research

The Link between miRNAs and PCKS9 in Atherosclerosis
Curr Med Chem. 2023 Nov 16. doi: 10.2174/0109298673262124231102042914. Online ahead of print.ABSTRACTCardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden...
Source: Current Medicinal Chemistry - November 22, 2023 Category: Chemistry Authors: Mirjana Macvanin Zoran Gluvic Aleksandra Klisic Mia Manojlovic Jasjit Suri Manfredi Rizzo Esma Isenovic Source Type: research

The Link between miRNAs and PCKS9 in Atherosclerosis
Curr Med Chem. 2023 Nov 16. doi: 10.2174/0109298673262124231102042914. Online ahead of print.ABSTRACTCardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden...
Source: Current Medicinal Chemistry - November 22, 2023 Category: Chemistry Authors: Mirjana Macvanin Zoran Gluvic Aleksandra Klisic Mia Manojlovic Jasjit Suri Manfredi Rizzo Esma Isenovic Source Type: research

The Link between miRNAs and PCKS9 in Atherosclerosis
Curr Med Chem. 2023 Nov 16. doi: 10.2174/0109298673262124231102042914. Online ahead of print.ABSTRACTCardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden...
Source: Current Medicinal Chemistry - November 22, 2023 Category: Chemistry Authors: Mirjana Macvanin Zoran Gluvic Aleksandra Klisic Mia Manojlovic Jasjit Suri Manfredi Rizzo Esma Isenovic Source Type: research

The Link between miRNAs and PCKS9 in Atherosclerosis
Curr Med Chem. 2023 Nov 16. doi: 10.2174/0109298673262124231102042914. Online ahead of print.ABSTRACTCardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden...
Source: Current Medicinal Chemistry - November 22, 2023 Category: Chemistry Authors: Mirjana Macvanin Zoran Gluvic Aleksandra Klisic Mia Manojlovic Jasjit Suri Manfredi Rizzo Esma Isenovic Source Type: research