Georgian Medicinal Plants as Rich Natural Sources of Antioxidant Derivatives: A Review on the Current Knowledge and Future Perspectives
Curr Med Chem. 2024 Feb 9. doi: 10.2174/0109298673262575231127034952. Online ahead of print.ABSTRACTThe study of antioxidants is of pivotal importance in biomedicine as these molecules could be involved in biological pathways associated with disease. The identification of new antioxidants together with the acquisition of a deeper knowledge on their biology, could lead to the use of these compounds as drugs for innovative treatments. Plants are an important source of phytodrugs that in many cases can be isolated with good extraction yields directly from the vegetal source and are often endowed with a low toxicity profile. G...
Source: Current Medicinal Chemistry - February 12, 2024 Category: Chemistry Authors: Marina Pirtskhalava Valentina Mittova Zurab R Tsetskhladze Rosanna Palumbo Raffaele Pastore Giovanni N Roviello Source Type: research

Potential Role of Bone Metabolism Markers in Kidney Transplant Recipients
CONCLUSION: Kidney transplantation significantly improves mineral and bone disorders associated with end-stage kidney disease by modulating MBD markers and reducing bone metabolism markers, such as Dickkopf-related protein 1, osteoprotegerin, osteocalcin, osteopontin, and sclerostin. Moreover, the panel of bone biomarkers effectively predicted hypercalcemia and dyslipidemia in transplant recipients.PMID:38332694 | DOI:10.2174/0109298673250291231121052433 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Fl ávia Maria Borges Vigil Pedro Alves Soares Vaz de Castro Ursula Gramiscelli Hasparyk Vict ória Soares Bartolomei Ana Cristina Sim ões E Silva Source Type: research

Bacterial Proteins and Peptides as Potential Anticancer Agents: A Novel Search for Protein-based Therapeutics
This study includes the most recent information on the characteristics and mechanism of action of the bacterial peptides that have anti-cancer activities, some of which are now being employed in cancer therapy while some are still undergoing research.PMID:38333973 | DOI:10.2174/0109298673253414231127162817 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Mahitha Pyla Sanjana Kankipati B Sumithra Piyush Kumar Mishra Bishwambhar Mishra Sanjeeb Kumar Mandal Jibanjyoti Panda Hitesh Chopra Avula Satya Kumar Mohamed Salah Yugal Kishore Mohanta Mohammad Amjad Kamal Source Type: research

P53 Regulation upon Lipid Peroxidation and Ferroptosis for Intervention against Atherogenesis
Curr Med Chem. 2024 Feb 7. doi: 10.2174/0109298673272862231230194711. Online ahead of print.ABSTRACTTumor protein 53 (P53), as an intracellular regulator of antioxidant responses, participates in the expression of antioxidant defense and lipid metabolism as well as the synthesis of genes in cells. The balance of oxidation and reduction can be disrupted by many pathological conditions, and the role of the antioxidant system in protecting the equilibrium state from pathological effects, such as reactive lipids, is crucial. In particular, the excessive accumulation of lipid peroxidation products is a key factor driving the oc...
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Yuanqin Zhao Wei Deng Zhaoyue Wang Yanxia Wang Hongyu Zheng Nianhua Deng Kun Zhou Zhong Ren Zhisheng Jiang Source Type: research

Application of Nanomedicine in Tumor Targeting Inflammatory Pathway
Curr Med Chem. 2024 Feb 7. doi: 10.2174/0109298673277325231229093344. Online ahead of print.ABSTRACTGiven the threat of ever-growing cancer morbidity, it is a cutting-edge frontier for multiple disciplines to apply nanotechnology in cancer therapy. Nanomedicine is now perpetually influencing the diagnosis and treatment of cancer. Meanwhile, tumorigenesis and cancer progression are intimately associated with inflammation. Inflammation can implicate in various tumor progression via the same or different pathways. Therefore, current nanomedicines exhibit tumor-suppressing function through inflammatory pathways. At present, th...
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Fangshun Tan Zhuoying Du Juanjuan Zhong Yinxin Wu Jie Mou Fangnan Zhao Yuling Liu Jinlan Chen Zihan Liang Yunxi Zhou Wanling Lv Yuxuan Cai Bei Wang Wen Xu Chengfu Yuan Source Type: research

Therapeutic Potential of Iron Chelators in Viral Diseases: A Systematic Review
CONCLUSION: Natural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.PMID:38321902 | DOI:10.2174/0109298673259596231211113211 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 7, 2024 Category: Chemistry Authors: Maryam Shamsadini Lori Azade Kalantari Khandani Gholamreza Dehghannoudeh Mandana Ohadi Mehdi Ansari Source Type: research

Clinical Trials of High-Intensity Focused Ultrasound for Cancer: Concerns Arising from Low Post-Hoc Power
The objective response rate was not a substitute for survival time for estimating the sample size and assessing the efficacy. The present data can interpret a paradox: HIFU is considered to have slighter cytotoxicity to non-cancer tissues and no radiation but is frequently combined with chemotherapy and/or radiotherapy in practice.PMID:38323616 | DOI:10.2174/0109298673281773240104142757 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 7, 2024 Category: Chemistry Authors: Tinghe Yu Xinya Li Source Type: research

Kidney Injury: Focus on Molecular Signaling Pathways
Curr Med Chem. 2024 Jan 17. doi: 10.2174/0109298673271547231108060805. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a syndrome in which kidney function reduces suddenly. This syndrome which includes both structural changes and loss of function may lead to chronic kidney disease (CKD). Kidney regeneration capacity depends on the cell type and severity of the injury. However, novel studies indicated that regeneration mostly relies on endogenous tubular cells that survive after AKI. Regenerative pharmacology requires a great knowledge of fundamental processes involved in the development and endogenous regenerati...
Source: Current Medicinal Chemistry - February 5, 2024 Category: Chemistry Authors: Wei Liu MengDi Hu Le Wang Hamed Mirzaei Source Type: research

Pan-cancer Multi-omics Analysis Reveals HMGN1 as a Potential Prognostic and Immune Infiltration-associated Biomarker
CONCLUSION: This study highlighted the potential of HMGN1 as a biomarker for pan- - cancer analysis.PMID:38310387 | DOI:10.2174/0109298673268718231122103638 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Yangyang Guo Rongrong Zhang Hongjie Xu Kai Hong Kenan Cen Yifeng Mai Zhixuan Wu Source Type: research

A Five-gene Signature Based on MicroRNA for Predicting Prognosis and Immunotherapy in Stomach Adenocarcinoma
CONCLUSION: This study promotes the underlying mechanisms of miRNA-based genes in STAD and offers directions for classification. A five-gene signature accurately predicts the prognosis and helps therapeutic options.PMID:38310388 | DOI:10.2174/0109298673281631231127051017 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Tianwei Wang Piji Chen Tingting Li Jianong Li Dong Zhao Fanfei Meng Yujie Zhao Zhendong Zheng Xuefei Liu Source Type: research

Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications
This article provides a comprehensive analysis of this hydroxamate siderophore, rhodotorulic acid, its synthesis, physicochemical properties, and biological significance. It also explores its applications in antifungal and plant protection strategies. Insights into RA derivatives reveal distinct biological effects and applications with potential in various fields, from antioxidants to antifungals. Rhodotorulic acid and its derivatives show promise for novel therapies, plant protection strategies, and iron supplementation in agriculture. Understanding their properties could advance science and medicine with sustainable prac...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Joanna Stefaniak Micha ł G Nowak Andrzej S Skwarecki Source Type: research

SLC4A4 moulds the inflammatory tumor microenvironment and predicts therapeutic expectations in colorectal cancer
CONCLUSION: Overall, upregulation of SLC4A4 expression promoted an inflammatory tumor microenvironment in CRC, and RiskScore predicted therapeutic expectancy. SLC4A4 could be a potentially clinically valuable target for CRC therapy.PMID:38310390 | DOI:10.2174/0109298673277357231218070812 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Dan Xiang Huiyu Li Jun Pan Yitian Chen Source Type: research

Role of Ferroptosis in the Progression of COVID-19 and the Development of Long COVID
CONCLUSION: Ferroptosis is activated during the progression of COVID-19, and a low baseline level of a ferroptosis marker (SLC7A11) may indicate an increased risk for long COVID-19. Ferroptosis has potential as a clinical indicator of long COVID and as a therapeutic target.PMID:38310391 | DOI:10.2174/0109298673281662231208102354 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Wen Zhao Siyuan Wang Yuxin Han Hongkun Zhang Jiacen Cao Shasha Dong Dongdong Li Miao Lei Chuanmiao Liu Yu Gao Source Type: research

Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors
Curr Med Chem. 2024 Jan 2. doi: 10.2174/0109298673289984231127062528. Online ahead of print.ABSTRACTInflammasomes are multimeric protein complexes that can detect various phys-iological stimuli and danger signals. As a result, they perform a crucial function in the in-nate immune response. The NLRP3 inflammasome, as a vital constituent of the inflam-masome family, is significant in defending against pathogen invasion and preserving cell-homeostasis. NLRP3 inflammasome dysregulation is connected to various pathological conditions, including inflammatory diseases, cancer, and cardiovascular and neurodegen-erative diseases. T...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Shengying Lou Miaolian Wu Sunliang Cui Source Type: research

Treatment of MRSA Infection: Where are We?
Curr Med Chem. 2024 Jan 19. doi: 10.2174/0109298673249381231130111352. Online ahead of print.ABSTRACTStaphylococcus aureus is a leading cause of septicemia, endocarditis, pneumonia, skin and soft tissue infections, bone and joint infections, and hospital-acquired infections. In particular, methicillin-resistant Staphylococcus aureus (MRSA) is associated with high morbidity and mortality, and continues to be a major public health problem. The emergence of multidrug-resistant MRSA strains along with the wide consumption of antibiotics has made anti-MRSA treatment a huge challenge. Novel treatment strategies (e.g., novel anti...
Source: Current Medicinal Chemistry - February 4, 2024 Category: Chemistry Authors: Adila Nazli Wenlan Tao Hengyao You Xiaoli He Yun He Source Type: research