Multi-omics Combined with Machine Learning Facilitating the Diagnosis of Gastric Cancer
Curr Med Chem. 2024 Feb 13. doi: 10.2174/0109298673284520240112055108. Online ahead of print.ABSTRACTGastric cancer (GC) is a highly intricate gastrointestinal malignancy. Early detection of gastric cancer forms the cornerstone of precision medicine. Several studies have been conducted to investigate early biomarkers of gastric cancer using genomics, transcriptomics, proteomics, and metabolomics, respectively. However, endogenous substances associated with various omics are concurrently altered during gastric cancer development. Furthermore, environmental exposures and family history can also induce modifications in endoge...
Source: Current Medicinal Chemistry - February 14, 2024 Category: Chemistry Authors: Jie Li Siyi Xu Feng Zhu Fei Shen Tianyi Zhang Xin Wan Saisai Gong Geyu Liang Yonglin Zhou Source Type: research

Immunosuppressive Microenvironment in H3K27 Mutant Pediatric Diffuse Midline Glioma: Single-Cell and Bioinformatics Insights on CD8A, IL7R, and ICAM1
CONCLUSION: In conclusion, the collective findings of our study suggest the potential role of CD8A, IL7R, and ICAM1 as innovative biomarkers for diagnosing and prognosticating pediatric DMG. Moreover, these molecules hold promise as therapeutic targets in the management of this disease. The implications of our research underscore the importance of exploring these novel avenues for improved patient outcomes.PMID:38347782 | DOI:10.2174/0109298673280120240108045926 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Jianhuang Huang Guiting You Quan Chen Yunpeng Lin Yijing Lin Yu Liang Caihou Lin Jianwu Chen Source Type: research

Synthesis and Biological Evaluations of Granulatamide B and its Structural Analogues
CONCLUSION: Since modification of the side chain did not significantly alter the change in biological activities compared to the parent compound, granulatamide B (4b), the substitution of the indole ring needs to be considered. Our group is currently carrying out new syntheses focusing on the functionalization of the indole core.PMID:38347783 | DOI:10.2174/0109298673272687231226111132 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Dario Matulja Petra Grb čić Gabrijela Matijevi ć Sanja Babi ć Krunoslav Bojani ć Sylvain Laclef Valerije Vr ček Rozelindra Čož-Rakovac Sandra Kraljevi ć Pavelić Dean Markovi ć Source Type: research

Research Progress on the Antioxidant Activity of Natural Diarylheptanoids: Mechanisms and Structure-activity Relationships
Curr Med Chem. 2024 Feb 12. doi: 10.2174/0109298673282309231226111037. Online ahead of print.ABSTRACTAntioxidant research has recently become a popular topic. Medicinal plants are important sources of novel active compounds. Diarylheptanoids, a typical family of secondary plant metabolites, are of great interest owing to their extensive spectrum of biological activities. They possess a unique 1,7-diphenylmethane structural skeleton. Thus, this review summarizes the natural linear or macrocyclic diarylheptanoids with antioxidant activity in the last two decades. In addition, the relationships between the structural characte...
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: An-Na Ma Tie Yao Ya-Jing Guo Chong-Yan Zhao Bing-Jie Wang Gen Li Feng Qiu Source Type: research

TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen Doxorubicin Resistance of Colorectal Cancer Cells
CONCLUSION: TRIP13 was highly expressed in CRC, which enhanced the DOX resistance of CRC cells by activating glycolysis to promote cell stemness. These findings offer new insights into the pathogenesis of DOX resistance in CRC and suggest that TRIP13 may be a new target for reversing DOX resistance in CRC.PMID:38347785 | DOI:10.2174/0109298673255498231117100421 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Guangyi Liu Huan Wang Ran Rui Yicheng Wang Yang Li Source Type: research

Binding of Nucleotide Inhibitors to the NS5 RdRp of the ZIKA Virus in the Replication Initiation State
CONCLUSION: However, experimental studies are required to measure the potency of RTP and other drugs before their clinical use.PMID:38347786 | DOI:10.2174/0109298673259914231213052438 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: S Pant N R Jena Source Type: research

Activation of Stimulator of Interferon Genes (STING): Promising Strategy to Overcome Immune Resistance in Prostate Cancer
Curr Med Chem. 2024 Feb 12. doi: 10.2174/0109298673273303231208071403. Online ahead of print.ABSTRACTProstate cancer (PCa) is the most frequent and second-lethal cancer among men. Despite considerable efforts to explore treatments like autologous cellular immunotherapy and immune checkpoint inhibitors, their success remains limited. The intricate tumor microenvironment (TME) and its interaction with the immune system pose significant challenges in PCa treatment. Consequently, researchers have directed their focus on augmenting the immune system's anti-tumor response by targeting the STimulator of the Interferon Genes (STIN...
Source: Current Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Mohammed Alnukhali Omar Altabbakh Ammad Ahmad Farooqi Alan Pollack Sylvia Daunert Sapna Deo Wensi Tao Source Type: research

Georgian Medicinal Plants as Rich Natural Sources of Antioxidant Derivatives: A Review on the Current Knowledge and Future Perspectives
Curr Med Chem. 2024 Feb 9. doi: 10.2174/0109298673262575231127034952. Online ahead of print.ABSTRACTThe study of antioxidants is of pivotal importance in biomedicine as these molecules could be involved in biological pathways associated with disease. The identification of new antioxidants together with the acquisition of a deeper knowledge on their biology, could lead to the use of these compounds as drugs for innovative treatments. Plants are an important source of phytodrugs that in many cases can be isolated with good extraction yields directly from the vegetal source and are often endowed with a low toxicity profile. G...
Source: Current Medicinal Chemistry - February 12, 2024 Category: Chemistry Authors: Marina Pirtskhalava Valentina Mittova Zurab R Tsetskhladze Rosanna Palumbo Raffaele Pastore Giovanni N Roviello Source Type: research

Potential Role of Bone Metabolism Markers in Kidney Transplant Recipients
CONCLUSION: Kidney transplantation significantly improves mineral and bone disorders associated with end-stage kidney disease by modulating MBD markers and reducing bone metabolism markers, such as Dickkopf-related protein 1, osteoprotegerin, osteocalcin, osteopontin, and sclerostin. Moreover, the panel of bone biomarkers effectively predicted hypercalcemia and dyslipidemia in transplant recipients.PMID:38332694 | DOI:10.2174/0109298673250291231121052433 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Fl ávia Maria Borges Vigil Pedro Alves Soares Vaz de Castro Ursula Gramiscelli Hasparyk Vict ória Soares Bartolomei Ana Cristina Sim ões E Silva Source Type: research

Bacterial Proteins and Peptides as Potential Anticancer Agents: A Novel Search for Protein-based Therapeutics
This study includes the most recent information on the characteristics and mechanism of action of the bacterial peptides that have anti-cancer activities, some of which are now being employed in cancer therapy while some are still undergoing research.PMID:38333973 | DOI:10.2174/0109298673253414231127162817 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Mahitha Pyla Sanjana Kankipati B Sumithra Piyush Kumar Mishra Bishwambhar Mishra Sanjeeb Kumar Mandal Jibanjyoti Panda Hitesh Chopra Avula Satya Kumar Mohamed Salah Yugal Kishore Mohanta Mohammad Amjad Kamal Source Type: research

P53 Regulation upon Lipid Peroxidation and Ferroptosis for Intervention against Atherogenesis
Curr Med Chem. 2024 Feb 7. doi: 10.2174/0109298673272862231230194711. Online ahead of print.ABSTRACTTumor protein 53 (P53), as an intracellular regulator of antioxidant responses, participates in the expression of antioxidant defense and lipid metabolism as well as the synthesis of genes in cells. The balance of oxidation and reduction can be disrupted by many pathological conditions, and the role of the antioxidant system in protecting the equilibrium state from pathological effects, such as reactive lipids, is crucial. In particular, the excessive accumulation of lipid peroxidation products is a key factor driving the oc...
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Yuanqin Zhao Wei Deng Zhaoyue Wang Yanxia Wang Hongyu Zheng Nianhua Deng Kun Zhou Zhong Ren Zhisheng Jiang Source Type: research

Application of Nanomedicine in Tumor Targeting Inflammatory Pathway
Curr Med Chem. 2024 Feb 7. doi: 10.2174/0109298673277325231229093344. Online ahead of print.ABSTRACTGiven the threat of ever-growing cancer morbidity, it is a cutting-edge frontier for multiple disciplines to apply nanotechnology in cancer therapy. Nanomedicine is now perpetually influencing the diagnosis and treatment of cancer. Meanwhile, tumorigenesis and cancer progression are intimately associated with inflammation. Inflammation can implicate in various tumor progression via the same or different pathways. Therefore, current nanomedicines exhibit tumor-suppressing function through inflammatory pathways. At present, th...
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Fangshun Tan Zhuoying Du Juanjuan Zhong Yinxin Wu Jie Mou Fangnan Zhao Yuling Liu Jinlan Chen Zihan Liang Yunxi Zhou Wanling Lv Yuxuan Cai Bei Wang Wen Xu Chengfu Yuan Source Type: research

Therapeutic Potential of Iron Chelators in Viral Diseases: A Systematic Review
CONCLUSION: Natural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.PMID:38321902 | DOI:10.2174/0109298673259596231211113211 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 7, 2024 Category: Chemistry Authors: Maryam Shamsadini Lori Azade Kalantari Khandani Gholamreza Dehghannoudeh Mandana Ohadi Mehdi Ansari Source Type: research

Clinical Trials of High-Intensity Focused Ultrasound for Cancer: Concerns Arising from Low Post-Hoc Power
The objective response rate was not a substitute for survival time for estimating the sample size and assessing the efficacy. The present data can interpret a paradox: HIFU is considered to have slighter cytotoxicity to non-cancer tissues and no radiation but is frequently combined with chemotherapy and/or radiotherapy in practice.PMID:38323616 | DOI:10.2174/0109298673281773240104142757 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 7, 2024 Category: Chemistry Authors: Tinghe Yu Xinya Li Source Type: research

Kidney Injury: Focus on Molecular Signaling Pathways
Curr Med Chem. 2024 Jan 17. doi: 10.2174/0109298673271547231108060805. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a syndrome in which kidney function reduces suddenly. This syndrome which includes both structural changes and loss of function may lead to chronic kidney disease (CKD). Kidney regeneration capacity depends on the cell type and severity of the injury. However, novel studies indicated that regeneration mostly relies on endogenous tubular cells that survive after AKI. Regenerative pharmacology requires a great knowledge of fundamental processes involved in the development and endogenous regenerati...
Source: Current Medicinal Chemistry - February 5, 2024 Category: Chemistry Authors: Wei Liu MengDi Hu Le Wang Hamed Mirzaei Source Type: research