Composite or Modified Hydroxyapatite Microspheres as Drug Delivery Carrier for Bone and Tooth Tissue Engineering
Curr Med Chem. 2024 Mar 22. doi: 10.2174/0109298673303632240320073606. Online ahead of print.ABSTRACTSince hydroxyapatite (HAp) is an important constituent of bone and teeth, it has excellent biocompatibility and bioactivity, good osteoconductive effects and the ability to induce bone formation as a material for bone or tooth repair and replacement. At present, widely used HAp microspheres have some characteristics, such as large specific surface area, light mass, good injection properties, good fluidity, and low aggregation ability, but they are difficult to really meet the biological and clinical needs due to their own m...
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Zhe Wang Jiaxin Shang Zheng Zhang Source Type: research

Evaluation of Efficacy of Curcumin and Caffeic Acid Phenethyl Ester in Breast Cancer by Preclinical Studies
CONCLUSION: The observations suggest that the combination of curcumin plus CAPE may be better in comparison to individual molecules. Other: The study opens a window for analysing the efficacy of the combination of CAPE and curcumin in animal studies. This will provide a basis for examining the combined efficacy of two agents in a clinical trial.PMID:38523543 | DOI:10.2174/0109298673284600231230093955 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Sumit Singh Verma None Avadhesh Ankit Srivastava Anusmita Shekher Anupam Dhasmana Acharan Singh Narula Subash Chandra Gupta Source Type: research

Natural Herbal Compounds Exerting an Antidepressant Effect through Hypothalamic-Pituitary-Adrenal Axis Regulation
Curr Med Chem. 2024 Mar 21. doi: 10.2174/0109298673297253240316101649. Online ahead of print.ABSTRACTDepression is a common mental illness that damages the life and health of patients and causes economic burden, and HPA (hypothalamic-pituitary-adrenal) axis dysfunction is considered to be one of the important factors leading to depression. In this case, it is essential to explore possible treatment methods by using natural compounds with HPA axis regulating and antidepressant effects. However, no one has reviewed it so far. Therefore, the purpose of this review is to systematically sort out the related natural products tha...
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Nailong Wang Binrui Yu Jiayin Liu Wei Lan Source Type: research

Composite or Modified Hydroxyapatite Microspheres as Drug Delivery Carrier for Bone and Tooth Tissue Engineering
Curr Med Chem. 2024 Mar 22. doi: 10.2174/0109298673303632240320073606. Online ahead of print.ABSTRACTSince hydroxyapatite (HAp) is an important constituent of bone and teeth, it has excellent biocompatibility and bioactivity, good osteoconductive effects and the ability to induce bone formation as a material for bone or tooth repair and replacement. At present, widely used HAp microspheres have some characteristics, such as large specific surface area, light mass, good injection properties, good fluidity, and low aggregation ability, but they are difficult to really meet the biological and clinical needs due to their own m...
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Zhe Wang Jiaxin Shang Zheng Zhang Source Type: research

Evaluation of Efficacy of Curcumin and Caffeic Acid Phenethyl Ester in Breast Cancer by Preclinical Studies
CONCLUSION: The observations suggest that the combination of curcumin plus CAPE may be better in comparison to individual molecules. Other: The study opens a window for analysing the efficacy of the combination of CAPE and curcumin in animal studies. This will provide a basis for examining the combined efficacy of two agents in a clinical trial.PMID:38523543 | DOI:10.2174/0109298673284600231230093955 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Sumit Singh Verma None Avadhesh Ankit Srivastava Anusmita Shekher Anupam Dhasmana Acharan Singh Narula Subash Chandra Gupta Source Type: research

Natural Herbal Compounds Exerting an Antidepressant Effect through Hypothalamic-Pituitary-Adrenal Axis Regulation
Curr Med Chem. 2024 Mar 21. doi: 10.2174/0109298673297253240316101649. Online ahead of print.ABSTRACTDepression is a common mental illness that damages the life and health of patients and causes economic burden, and HPA (hypothalamic-pituitary-adrenal) axis dysfunction is considered to be one of the important factors leading to depression. In this case, it is essential to explore possible treatment methods by using natural compounds with HPA axis regulating and antidepressant effects. However, no one has reviewed it so far. Therefore, the purpose of this review is to systematically sort out the related natural products tha...
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Nailong Wang Binrui Yu Jiayin Liu Wei Lan Source Type: research

A Review on the use of Synthetic and Recombinant Antigens for the Immunodiagnosis of Tegumentary Leishmaniasis
Curr Med Chem. 2024 Mar 19. doi: 10.2174/0109298673298705240311114203. Online ahead of print.ABSTRACTImproving the diagnostic technology used to detect tegumentary leishmaniasis (TL) is essential in view of it being a widespread, often neglected tropical disease with cases reported from the southern United States to northern Argentina. Recombinant proteins, recombinant multiepitope proteins, and synthetic peptides have been extensively researched and used in disease diagnosis. One of the benefits of applying these antigens is a measurable increase in sensitivity and specificity, which improves test accuracy. The present re...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Kamila Silva Anna Julia Ribeiro Isadora Gandra Carlos Rezende Lucas Lopes Carolina Couto Ver ônica Freire Isabelle Barcelos Sabrina Pereira Sandra Xavier Mariana Campos-da-Paz Rodolfo Giunchetti Miguel Ch ávez-Fumagalli Ana Alice Gon çalves Eduardo Coe Source Type: research

Herbal Treatments for Obesity: A Review
Curr Med Chem. 2024 Mar 20. doi: 10.2174/0109298673287491240315055726. Online ahead of print.ABSTRACTObesity is the most pervasive metabolic disorder, further linked with many other diseases, including diabetes, hypertension, cardiovascular disorders, and sleep apnea. To control the increasing weight of obese individuals, experts usually recommend exercise and lifestyle alterations, but medication and surgeries are also advised in severe cases. FDA-approved obesity-controlling drugs are effective but possess certain adverse effects, including dry mouth, drug abuse, dysregulation in monoamine neurotransmitters, insomnia, an...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Amin Gasmi Sadaf Noor Pavan Kumar Mujawdiya Muhammad Akram Aisha Manzoor Geir Bj ørklund Source Type: research

A Review on the use of Synthetic and Recombinant Antigens for the Immunodiagnosis of Tegumentary Leishmaniasis
Curr Med Chem. 2024 Mar 19. doi: 10.2174/0109298673298705240311114203. Online ahead of print.ABSTRACTImproving the diagnostic technology used to detect tegumentary leishmaniasis (TL) is essential in view of it being a widespread, often neglected tropical disease with cases reported from the southern United States to northern Argentina. Recombinant proteins, recombinant multiepitope proteins, and synthetic peptides have been extensively researched and used in disease diagnosis. One of the benefits of applying these antigens is a measurable increase in sensitivity and specificity, which improves test accuracy. The present re...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Kamila Silva Anna Julia Ribeiro Isadora Gandra Carlos Rezende Lucas Lopes Carolina Couto Ver ônica Freire Isabelle Barcelos Sabrina Pereira Sandra Xavier Mariana Campos-da-Paz Rodolfo Giunchetti Miguel Ch ávez-Fumagalli Ana Alice Gon çalves Eduardo Coe Source Type: research

Herbal Treatments for Obesity: A Review
Curr Med Chem. 2024 Mar 20. doi: 10.2174/0109298673287491240315055726. Online ahead of print.ABSTRACTObesity is the most pervasive metabolic disorder, further linked with many other diseases, including diabetes, hypertension, cardiovascular disorders, and sleep apnea. To control the increasing weight of obese individuals, experts usually recommend exercise and lifestyle alterations, but medication and surgeries are also advised in severe cases. FDA-approved obesity-controlling drugs are effective but possess certain adverse effects, including dry mouth, drug abuse, dysregulation in monoamine neurotransmitters, insomnia, an...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Amin Gasmi Sadaf Noor Pavan Kumar Mujawdiya Muhammad Akram Aisha Manzoor Geir Bj ørklund Source Type: research

A Review on the use of Synthetic and Recombinant Antigens for the Immunodiagnosis of Tegumentary Leishmaniasis
Curr Med Chem. 2024 Mar 19. doi: 10.2174/0109298673298705240311114203. Online ahead of print.ABSTRACTImproving the diagnostic technology used to detect tegumentary leishmaniasis (TL) is essential in view of it being a widespread, often neglected tropical disease with cases reported from the southern United States to northern Argentina. Recombinant proteins, recombinant multiepitope proteins, and synthetic peptides have been extensively researched and used in disease diagnosis. One of the benefits of applying these antigens is a measurable increase in sensitivity and specificity, which improves test accuracy. The present re...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Kamila Silva Anna Julia Ribeiro Isadora Gandra Carlos Rezende Lucas Lopes Carolina Couto Ver ônica Freire Isabelle Barcelos Sabrina Pereira Sandra Xavier Mariana Campos-da-Paz Rodolfo Giunchetti Miguel Ch ávez-Fumagalli Ana Alice Gon çalves Eduardo Coe Source Type: research

Herbal Treatments for Obesity: A Review
Curr Med Chem. 2024 Mar 20. doi: 10.2174/0109298673287491240315055726. Online ahead of print.ABSTRACTObesity is the most pervasive metabolic disorder, further linked with many other diseases, including diabetes, hypertension, cardiovascular disorders, and sleep apnea. To control the increasing weight of obese individuals, experts usually recommend exercise and lifestyle alterations, but medication and surgeries are also advised in severe cases. FDA-approved obesity-controlling drugs are effective but possess certain adverse effects, including dry mouth, drug abuse, dysregulation in monoamine neurotransmitters, insomnia, an...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Amin Gasmi Sadaf Noor Pavan Kumar Mujawdiya Muhammad Akram Aisha Manzoor Geir Bj ørklund Source Type: research

A Review on the use of Synthetic and Recombinant Antigens for the Immunodiagnosis of Tegumentary Leishmaniasis
Curr Med Chem. 2024 Mar 19. doi: 10.2174/0109298673298705240311114203. Online ahead of print.ABSTRACTImproving the diagnostic technology used to detect tegumentary leishmaniasis (TL) is essential in view of it being a widespread, often neglected tropical disease with cases reported from the southern United States to northern Argentina. Recombinant proteins, recombinant multiepitope proteins, and synthetic peptides have been extensively researched and used in disease diagnosis. One of the benefits of applying these antigens is a measurable increase in sensitivity and specificity, which improves test accuracy. The present re...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Kamila Silva Anna Julia Ribeiro Isadora Gandra Carlos Rezende Lucas Lopes Carolina Couto Ver ônica Freire Isabelle Barcelos Sabrina Pereira Sandra Xavier Mariana Campos-da-Paz Rodolfo Giunchetti Miguel Ch ávez-Fumagalli Ana Alice Gon çalves Eduardo Coe Source Type: research

Herbal Treatments for Obesity: A Review
Curr Med Chem. 2024 Mar 20. doi: 10.2174/0109298673287491240315055726. Online ahead of print.ABSTRACTObesity is the most pervasive metabolic disorder, further linked with many other diseases, including diabetes, hypertension, cardiovascular disorders, and sleep apnea. To control the increasing weight of obese individuals, experts usually recommend exercise and lifestyle alterations, but medication and surgeries are also advised in severe cases. FDA-approved obesity-controlling drugs are effective but possess certain adverse effects, including dry mouth, drug abuse, dysregulation in monoamine neurotransmitters, insomnia, an...
Source: Current Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Amin Gasmi Sadaf Noor Pavan Kumar Mujawdiya Muhammad Akram Aisha Manzoor Geir Bj ørklund Source Type: research

Significance of Aneuploidy in Predicting Prognosis and Treatment Response of Uveal Melanoma
CONCLUSION: UM in this study was divided into three CNV subtypes, and a model based on eight aneuploidy score-related genes was established to evaluate the prognosis and drug treatment efficacy of UM patients. The current results may have the potential to help the clinical decision-making process for UM management.PMID:38504568 | DOI:10.2174/0109298673286788240123044411 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 20, 2024 Category: Chemistry Authors: Xiaoqian Zhang Ling Jin Chenchen Zhou Jinghua Liu Qin Jiang Source Type: research