Modulatory Role of Phytochemicals/Natural Products in Cancer Immunotherapy

Curr Med Chem. 2024 Feb 15. doi: 10.2174/0109298673274796240116105555. Online ahead of print.ABSTRACTImmunotherapy is a newly emerging and effective approach to treating cancer. However, there are many challenges associated with using checkpoint inhibitors in this treatment strategy. The component of the tumor microenvironment plays a crucial role in antitumor immune response, regulating tumor immune surveillance as immunological evasion. Natural products/phytochemicals can modulate the tumor microenvironment and function as immunomodulatory agents. In clinical settings, there is a strong need to develop synergistic combination regimens using natural products that can effectively enhance the therapeutic benefits of immune checkpoint inhibitors relative to their effectiveness as single therapies. The review discusses immunotherapy, its side effects, and a summary of evidence suggesting the use of natural products to modulate immune checkpoint pathways.PMID:38549529 | DOI:10.2174/0109298673274796240116105555
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research