NAD Pathways in Diabetic Coronary Heart Disease: Unveiling the Key Players
Curr Med Chem. 2024 Feb 22. doi: 10.2174/0109298673293982240221050207. Online ahead of print.ABSTRACTDiabetic coronary heart disease is a global medical problem that poses a serious threat to human health, and its pathogenesis is complex and interconnected. Nicotinamide adenine dinucleotide (NAD) is an important small molecule used in the body that serves as a coenzyme in redox reactions and as a substrate for non-redox processes. NAD levels are highly controlled by various pathways, and increasing evidence has shown that NAD pathways, including NAD precursors and key enzymes involved in NAD synthesis and catabolism, exert...
Source: Current Medicinal Chemistry - February 27, 2024 Category: Chemistry Authors: Yuan Liu Wenjing Zhan Lexun Wang Weixuan Wang Source Type: research

Drug-target Affinity Prediction by Molecule Secondary Structure Representation Network
CONCLUSION: The effectiveness of the proposed method is verified by comparing it with other alternative methods and baseline models on two benchmark datasets.PMID:38409701 | DOI:10.2174/0109298673252287240215103035 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 27, 2024 Category: Chemistry Authors: Yuewei Tang Yunhai Li Pengpai Li Zhi-Ping Liu Source Type: research

Synthesis and Selective Anticancer Activity Evaluation of 2-phenylacrylonitrile Derivatives as Tubulin Inhibitors
CONCLUSION: Compound 1g2a shows outstanding antitumor activity both in vivo and in vitro and has the potential to be further developed into a highly effective antitumor agent with little toxicity to normal tissues.PMID:38384112 | DOI:10.2174/0109298673263854231009063053 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Ye-Zhi Jin Ya-Bing Xin Yuan Li Xin-Yuan Chen De-Ao Man Yu-Shun Tian Source Type: research

Combining Mendelian Randomization Analysis and 3D-QSAR to Investigate the Effectiveness of a New Series of Hydroxyquinolines in Osteoarthritis
CONCLUSION: The research unearthed a robust causal interrelation between ADAMTS-5 and osteoarthritis via Mendelian randomization. Furthermore, a credible drug model targeting ADAMTS-5 was constructed. Collectively, these findings illuminate a path forward in the pursuit of target-specific drugs for osteoarthritis management in subsequent investigations.PMID:38385247 | DOI:10.2174/0109298673287134231121050158 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Zheng Lian Kunpeng Su Hui Lu Changpeng Qu Xuexiao Ma Source Type: research

Synthesis and Selective Anticancer Activity Evaluation of 2-phenylacrylonitrile Derivatives as Tubulin Inhibitors
CONCLUSION: Compound 1g2a shows outstanding antitumor activity both in vivo and in vitro and has the potential to be further developed into a highly effective antitumor agent with little toxicity to normal tissues.PMID:38384112 | DOI:10.2174/0109298673263854231009063053 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Ye-Zhi Jin Ya-Bing Xin Yuan Li Xin-Yuan Chen De-Ao Man Yu-Shun Tian Source Type: research

Combining Mendelian Randomization Analysis and 3D-QSAR to Investigate the Effectiveness of a New Series of Hydroxyquinolines in Osteoarthritis
CONCLUSION: The research unearthed a robust causal interrelation between ADAMTS-5 and osteoarthritis via Mendelian randomization. Furthermore, a credible drug model targeting ADAMTS-5 was constructed. Collectively, these findings illuminate a path forward in the pursuit of target-specific drugs for osteoarthritis management in subsequent investigations.PMID:38385247 | DOI:10.2174/0109298673287134231121050158 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Zheng Lian Kunpeng Su Hui Lu Changpeng Qu Xuexiao Ma Source Type: research

Synthesis and Selective Anticancer Activity Evaluation of 2-phenylacrylonitrile Derivatives as Tubulin Inhibitors
CONCLUSION: Compound 1g2a shows outstanding antitumor activity both in vivo and in vitro and has the potential to be further developed into a highly effective antitumor agent with little toxicity to normal tissues.PMID:38384112 | DOI:10.2174/0109298673263854231009063053 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Ye-Zhi Jin Ya-Bing Xin Yuan Li Xin-Yuan Chen De-Ao Man Yu-Shun Tian Source Type: research

Combining Mendelian Randomization Analysis and 3D-QSAR to Investigate the Effectiveness of a New Series of Hydroxyquinolines in Osteoarthritis
CONCLUSION: The research unearthed a robust causal interrelation between ADAMTS-5 and osteoarthritis via Mendelian randomization. Furthermore, a credible drug model targeting ADAMTS-5 was constructed. Collectively, these findings illuminate a path forward in the pursuit of target-specific drugs for osteoarthritis management in subsequent investigations.PMID:38385247 | DOI:10.2174/0109298673287134231121050158 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Zheng Lian Kunpeng Su Hui Lu Changpeng Qu Xuexiao Ma Source Type: research

Synthesis and Selective Anticancer Activity Evaluation of 2-phenylacrylonitrile Derivatives as Tubulin Inhibitors
CONCLUSION: Compound 1g2a shows outstanding antitumor activity both in vivo and in vitro and has the potential to be further developed into a highly effective antitumor agent with little toxicity to normal tissues.PMID:38384112 | DOI:10.2174/0109298673263854231009063053 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Ye-Zhi Jin Ya-Bing Xin Yuan Li Xin-Yuan Chen De-Ao Man Yu-Shun Tian Source Type: research

Combining Mendelian Randomization Analysis and 3D-QSAR to Investigate the Effectiveness of a New Series of Hydroxyquinolines in Osteoarthritis
CONCLUSION: The research unearthed a robust causal interrelation between ADAMTS-5 and osteoarthritis via Mendelian randomization. Furthermore, a credible drug model targeting ADAMTS-5 was constructed. Collectively, these findings illuminate a path forward in the pursuit of target-specific drugs for osteoarthritis management in subsequent investigations.PMID:38385247 | DOI:10.2174/0109298673287134231121050158 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Zheng Lian Kunpeng Su Hui Lu Changpeng Qu Xuexiao Ma Source Type: research

Novel Perspectives of TSLP and RXR Signaling in Corticosteroid-Resistant Asthma: Updates on TSLP Blockers
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673268237231124064413. Online ahead of print.ABSTRACTPrevious studies described that asthma patients who received corticosteroid therapy have been constrained by the corticosteroid resistance subsequently fostered to severe refractory asthma. In this review, we discussed the implications of TSLP, RXR, the role of STAT5-activating cytokines, and IL-33/NH-cell signaling pathways, and recent clinical evidence on TSLP blockers in steroid-resistant asthma. We have searched several public databases such as Pubmed, Scopus, and Relemed and obtained information pertinent to the TSLP, ...
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Song Zhang Karen Dsouza Narasimha M Beeraka Junqi Liu Oksana Reshetniak Hemanth Vikram Pr L G Priyanka M V Greeshma Pradeep Kumar Bhupalam Mahesh Pa Prasath Manogaran Rajashree Deka Gurupadayya Bannimath Mikhail Y Sinelnikov Vladimir N Nikolenko Kirill Bu Source Type: research

The Role and Therapeutic Potential of Non-coding RNAs in Resistance to EGFR-TKIs targeted therapy for Non-small Cell Lung Cancer
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673275752231219080500. Online ahead of print.ABSTRACTLung cancer is the leading cause of cancer-related deaths worldwide, of which non-small cell lung cancer (NSCLC) is the most common type, and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are widely used for the treatment of NSCLC. EGFR-TKIs are known to develop a drug-resistant response after a certain number of cycles of dosing, and how to alleviate or even reverse EGFR-TKI resistance is an urgent problem at present. This review focuses on the role of ncRNAs in the resistance of NSCLC to EGFR-TKI...
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Yang Zhang Ye Chen Li-Li Lu Xiu-Li Xie Ren Huan Li-Fang Wu Li-Na Tan Tao Xu Yong Jin Source Type: research

Mycobacterial Targets for Thiourea Derivatives: Opportunities for Virtual Screening in Tuberculosis Drug Discovery
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673276076231124104513. Online ahead of print.ABSTRACTTuberculosis (TB) remains a primary global health concern, necessitating the discovery and development of new anti-TB drugs, mainly to combat drug-resistant strains. In this context, thiourea derivatives have emerged as promising candidates in TB drug discovery due to their diverse chemical structures and pharmacological properties. This review aimed to explore this potential, identifying and exploring molecular targets for thiourea derivatives in Mycobacterium tuberculosis (Mtb) and the potential application of virtual scr...
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Vinicius de Melo Milani Mariana Luiza Silva Priscila Goes Camargo Marcelle de Lima Ferreira Bispo Source Type: research

Advanced Targeted Drug Delivery of Bioactive Nanomaterials in the Management of Cancer
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673283362231220115050. Online ahead of print.ABSTRACTCancer is defined as the unchecked expansion of aberrant cells. Radiation, chemotherapy, and surgery are currently used in combination to treat cancer. Traditional drug delivery techniques kill healthy proliferating cells when used over prolonged periods of time in cancer chemotherapy. Due to the fact that the majority of tumor cells do not infiltrate right away, this is particularly true when treating solid tumors. A targeted drug delivery system (TDDS) is a tool that distributes medication to a selected bioactive location...
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Biswajit Basu Kevin Kumar Garala Rajeshri Patel Ayon Dutta Dipanjana Ash Bhupendra Prajapati Sudarshan Singh Sajal Kumar Jha Source Type: research

Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach
CONCLUSION: This review arouses interest in the isolation of phenolic compounds that may allow a new approach for the prevention of both arterial and venous thrombosis, with the potential to become alternatives in the prevention and treatment of cardiovascular diseases.PMID:38375850 | DOI:10.2174/0109298673268452231108061008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 20, 2024 Category: Chemistry Authors: Di égina Araújo Fernandes Ayala Nara Pereira Gomes Camila Macaubas da Silva Isabelly Soares de Medeiros Henriques Renata Priscila Barros de Menezes Marcus Tullius Scotti Yanna Carolina Ferreira Teles RuAngelie Edrada-Ebel Maria de Fatima Vanderlei de So Source Type: research